He aha ka Trastuzumab-dkst: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Trastuzumab-dkst he lāʻau lapaʻau i manaʻo ʻia e kōkua i ka hakakā ʻana i kekahi mau ʻano maʻi maʻi umauma a me ka ʻōpū. ʻO ia ka mea a nā kauka e kapa ai he "biosimilar" i ka trastuzumab mua (Herceptin), ʻo ia hoʻi, hana ia ma ke ʻano like akā hana ʻia e kahi mea hana ʻē aʻe.

Hoʻopili pololei kēia lāʻau lapaʻau i nā sela maʻi maʻi i loaʻa ka nui o ka protein i kapa ʻia ʻo HER2. E noʻonoʻo iā ia he missile alakaʻi e ʻimi a hoʻouka wale i nā sela maʻi maʻi me kēia pahuhopu kikoʻī, me ka waiho ʻana i kāu mau sela olakino.

No ke aha e hoʻohana ʻia ai ka Trastuzumab-dkst?

Hoʻomaʻamaʻa ʻo Trastuzumab-dkst i ka maʻi maʻi umauma HER2-positive a me ka maʻi maʻi ʻōpū HER2-positive. E hoʻāʻo kāu kauka i kāu ʻiʻo maʻi maʻi e hōʻoia i ka nui o ka protein HER2 ma mua o ke kau ʻana i kēia lāʻau.

No ka maʻi maʻi umauma, hiki ke hoʻohana ʻia i nā kūlana like ʻole. I kekahi manawa hāʻawi ʻia ma hope o ke ʻoki ʻana e pale i ka maʻi maʻi mai ka hoʻi ʻana mai. I nā manawa ʻē aʻe, hoʻohana ʻia ke laha ka maʻi maʻi i nā ʻāpana ʻē aʻe o kou kino.

I nā hihia maʻi maʻi ʻōpū, hui pū ʻia me ka chemotherapy ke laha ka maʻi maʻi a ʻaʻole hiki ke wehe ʻia me ke ʻoki. Kōkua ka lāʻau lapaʻau i ka hoʻolohi ʻana i ka ulu ʻana o ka maʻi maʻi a hiki ke kōkua iā ʻoe e ola lōʻihi me ka maikaʻi o ke ola.

Pehea e hana ai ka Trastuzumab-dkst?

Hana ʻo Trastuzumab-dkst ma ka ālai ʻana i ka protein HER2 ma nā sela maʻi maʻi. Ke hana nui ka HER2, haʻi ia i nā sela maʻi maʻi e ulu a māhele wikiwiki.

Hana kēia lāʻau lapaʻau e like me ka laka ma kēlā protein, e pale ana iā ia mai ka hoʻouna ʻana i nā hōʻailona ulu i nā sela maʻi maʻi. Kōkua kēia i ka hoʻolohi ʻana a i ʻole ka hoʻōki ʻana i ka maʻi maʻi mai ka ulu ʻana a me ka laha ʻana.

Manaʻo ʻia he lāʻau lapaʻau maʻi maʻi ikaika a maikaʻi hoʻi i hoʻohālikelike ʻia me ka chemotherapy kuʻuna. Nui ka poʻe e hiki ke mālama i kā lākou hana i kēlā me kēia lā i ka wā e loaʻa ana kēia lapaʻau, akā pono ʻoe i ka nānā mau.

Pehea wau e lawe ai i ka Trastuzumab-dkst?

Hāʻawi ʻia ʻo Trastuzumab-dkst ma ke ʻano he infusion IV pololei i loko o kou kahe koko ma kahi haukapila a i ʻole ke kikowaena maʻi ʻaʻai. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau ma ka home ma ke ʻano he pila a i ʻole nā ​​injection.

E lawe ana kāu infusion mua ma kahi o 90 mau minuke, ʻoiai e lawe maʻamau nā lapaʻau e hiki mai ana ma kahi o 30 mau minuke. E loaʻa iā ʻoe i kēlā me kēia pule a i ʻole i kēlā me kēia ʻekolu pule, ma muli o kāu hoʻolālā lapaʻau.

Ma mua o kēlā me kēia infusion, e loaʻa paha iā ʻoe nā lāʻau lapaʻau e pale ai i nā hopena maʻi. ʻAʻole pono ʻoe e pale i ka ʻai ʻana ma mua o ka lapaʻau ʻana, akā ʻo ka noho ʻana i ka wai maikaʻi ma ka inu ʻana i ka wai nui hiki ke kōkua iā ʻoe e ʻoi aku ka maikaʻi i ka wā a ma hope o ka infusion.

Pehea ka lōʻihi e pono ai au e lawe iā Trastuzumab-dkst?

He ʻokoʻa nui ka lōʻihi o ka lapaʻau ʻana ma muli o kou kūlana. No ka maʻi ʻaʻai umauma i ke kahua mua, maʻamau ka lapaʻau ʻana i hoʻokahi makahiki (52 pule) ma hope o ke ʻoki ʻana a me ka chemotherapy.

No ka maʻi ʻaʻai holomua a i ʻole metastatic, hiki iā ʻoe ke hoʻomau i ka lapaʻau ʻana i ka wā e hana ana a ke ʻae nei ʻoe iā ia. Loaʻa i kekahi poʻe ia no nā mahina he nui a i ʻole nā ​​makahiki.

E nānā mau kāu oncologist i ka maikaʻi o ka hana ʻana o ka lapaʻau ma o nā scans, nā hoʻokolohua koko, a me nā hoʻokolohua kino. E hoʻoponopono lākou i kāu hoʻolālā lapaʻau ma muli o ke ʻano o ka pane ʻana o kāu maʻi ʻaʻai a me ke ʻano o kou manaʻo.

He aha nā hopena ʻaoʻao o Trastuzumab-dkst?

ʻIke ka hapa nui o ka poʻe i kekahi mau hopena ʻaoʻao, akā hiki ke mālama ʻia a ʻoi aku ka liʻiliʻi ma mua o nā hopena ʻaoʻao chemotherapy kuʻuna. E hele kākou i ka mea āu e manaʻo ai, e hoʻomaka ana me nā ʻike maʻamau.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai:

• Luhi a me ka piʻi ʻana o ka luhi ma mua o ka maʻamau
• Nā poʻo e hele mai a hele
• Nausea, ʻoiai maʻalahi
• Pāpaʻa a i ʻole nā ​​hoʻololi i nā neʻe ʻana o ka ʻōpū
• ʻEha ʻiʻo a me ka ʻeha hui
• Nā hopena ma ke kahua infusion e like me ka ʻulaʻula a i ʻole ka pehu
• He pilikia i ka hiamoe
• Nalo o ka ʻai

ʻO kēia mau hōʻailona ke ala o kou kino e hoʻoponopono ai i ka lāʻau lapaʻau, a nui ka poʻe i ʻike e hoʻomaikaʻi ana lākou i ka wā. Hiki i kāu hui mālama ola ke hōʻike i nā ala e mālama ai i kēia mau hopena i mea e ʻoluʻolu ai ʻoe.

ʻO nā hopena ʻaoʻao koʻikoʻi e pono ai ka nānā koke ʻana, e komo pū ana:

• Nā pilikia o ka puʻuwai, me ka pōkole o ka hanu a i ʻole ka pehu ʻana i kou mau wāwae
• Nā hopena hoʻokomo koʻikoʻi me ka pilikia o ka hanu a i ʻole ka paʻa o ka umauma
• Nā hōʻailona o ka maʻi e like me ke kuni, nā anu, a i ʻole ka ʻū mau
• Nā pilikia o ka māmā e hōʻeha ana i nā pilikia hanu
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha

ʻOiai ʻaʻole maʻamau kēia mau hopena koʻikoʻi, e nānā pono kāu hui lapaʻau iā ʻoe a nānā mau i kāu hana puʻuwai. Hoʻopau ka hapa nui o ka poʻe i kā lākou lapaʻau me ka ʻole o nā pilikia nui.

ʻO wai ka mea pono ʻole e lawe iā Trastuzumab-dkst?

ʻAʻole kūpono ʻo Trastuzumab-dkst no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. ʻO ka hopohopo nui ka hōʻoia ʻana i ka maikaʻi o kou puʻuwai no kēia lapaʻau.

ʻAʻole pono ʻoe e loaʻa i kēia lāʻau lapaʻau inā he pilikia koʻikoʻi kou puʻuwai, me ka puʻuwai congestive a i ʻole ka hana puʻuwai i hōʻemi nui ʻia. E nānā kāu kauka i kou puʻuwai me nā hoʻokolohua e like me ka echocardiogram ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Pono ka poʻe me nā maʻi koʻikoʻi, ikaika e kali a hiki i ka pau ʻana o ka maʻi ma mua o ka hoʻomaka ʻana i ka lapaʻau. Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, hiki i kēia lāʻau lapaʻau ke hōʻeha i kāu pēpē e ulu nei, no laila pono ʻoe e hoʻohana i ka mana hānau kūpono i ka wā o ka lapaʻau a no ʻehiku mahina ma hope o kāu mahele hope loa.

E noʻonoʻo pū kāu kauka i kou olakino holoʻokoʻa, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me kekahi mōʻaukala o nā pilikia o ka māmā ma mua o ka ʻōlelo ʻana i kēia lapaʻau.

Inoa Brand Trastuzumab-dkst

Kūʻai ʻia ʻo Trastuzumab-dkst ma lalo o ka inoa inoa ʻo Ogivri. Hana ʻia e Mylan Pharmaceuticals a ua ʻae ʻia ma ke ʻano he biosimilar i ka Herceptin mua.

Hana like nā biosimilars e like me Ogivri me ka lāʻau lapaʻau mua akā ʻoi aku ka maʻalahi o ke kumukūʻai. Hiki i kāu ʻinikua ke makemake i ka mana biosimilar, a hiki i kāu kauka ke kōkua iā ʻoe e hoʻomaopopo i ka koho maikaʻi loa no kou kūlana.

Nā Koho ʻē aʻe o Trastuzumab-dkst

Nui nā lāʻau lapaʻau ʻē aʻe e mālama ana i nā maʻi maʻi HER2-positive, me kēlā me kēia me kona mau pono ponoʻī. Hana like ka trastuzumab mua (Herceptin) me ka trastuzumab-dkst a hiki ke hoʻololi pinepine ʻia.

ʻO nā koho HER2-targeted ʻē aʻe e komo pū ana me ka pertuzumab (Perjeta), i hui pinepine ʻia me ka trastuzumab no ka hopena ikaika, a me T-DM1 (Kadcyla), e hui pū ana i ka trastuzumab me ka chemotherapy i hoʻokahi lāʻau lapaʻau.

Hana ʻokoʻa nā koho hou e like me tucatinib (Tukysa) a me neratinib (Nerlynx) ma ka pale ʻana iā HER2 mai loko o ke keena maʻi maʻi. E koho kāu oncologist i ke koho maikaʻi loa e pili ana i kāu ʻano maʻi maʻi, nā lāʻau lapaʻau i hala, a me ke olakino holoʻokoʻa.

ʻOi aku ka maikaʻi o Trastuzumab-dkst ma mua o Herceptin?

Hana like ʻo Trastuzumab-dkst (Ogivri) a me Herceptin a loaʻa nā hopena like a me nā hopena ʻaoʻao. Hōʻike nā haʻawina lapaʻau he maikaʻi like lākou i ka mālama ʻana i nā maʻi maʻi HER2-positive.

ʻO ka ʻokoʻa nui ka pinepine o ke kumukūʻai - ʻoi aku ka liʻiliʻi o nā biosimilars e like me trastuzumab-dkst ma mua o ka lāʻau lapaʻau inoa inoa mua. Hiki i kēia ke maʻalahi i ka mālama ʻana a hoʻemi i kāu mau lilo mai ka ʻeke.

Hiki i kāu kauka ke koho i kekahi ma luna o kekahi e pili ana i kāu ʻinikua, ka loaʻa ʻana ma kāu kikowaena lapaʻau, a i ʻole ka makemake pilikino. He mau koho maikaʻi ʻelua no ka mālama ʻana i nā maʻi maʻi HER2-positive.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Trastuzumab-dkst

Q1. Palekana anei ʻo Trastuzumab-dkst no ka poʻe me ka maʻi puʻuwai?

Hiki i ka Trastuzumab-dkst ke hoʻopilikia i ka hana o ka naʻau, no laila, pono ka poʻe me nā pilikia o ka naʻau i ka nānā pono ʻana. E loiloi kāu kauka i ke olakino o kou naʻau ma mua o ka hoʻomaka ʻana i ka lāʻau a e hoʻomau i ka nānā mau ʻana.

Inā he mau pilikia iki kou naʻau, hiki nō paha iā ʻoe ke loaʻa kēia lāʻau me ka nānā pono ʻana. Eia naʻe, ʻaʻole hiki i ka poʻe me ka maʻi puʻuwai nui a i ʻole ka hana naʻau i hōʻemi nui ʻia ke loaʻa palekana i ka trastuzumab-dkst.

Q2. He aha kaʻu e hana ai inā ua hoʻohana au i ka nui o ka Trastuzumab-dkst?

No ka mea, hāʻawi ʻia ka trastuzumab-dkst e nā poʻe loea mālama ola i loko o kahi hoʻonohonoho lāʻau lapaʻau, ʻaʻole hiki ke loaʻa ka overdose. Ana pono ʻia ka lāʻau a hāʻawi ʻia e nā kahu hānai a me nā kauka i aʻo ʻia.

Inā hopohopo ʻoe e pili ana i kāu mahele a i ʻole e ʻike i nā hōʻailona maʻamau ma hope o ka lāʻau, e hoʻokaʻaʻike koke i kāu hui mālama ola. Hiki iā lākou ke loiloi i kou kūlana a hāʻawi i ka mālama kūpono inā pono.

Q3. He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Trastuzumab-dkst?

Inā ua hala ʻoe i kahi infusion i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui mālama ola i ka hiki wawe e hoʻonohonoho hou. E hoʻoholo lākou i ka manawa maikaʻi loa no kāu mahele aʻe e pili ana i ka lōʻihi o ka hala ʻana mai kāu lāʻau hope loa.

Mai ho'āʻo e

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana i ka trastuzumab-dkst, akā he mea nui ka manawa a me ke ʻano. Pono e pale ʻia nā lāʻau lapaʻau ola (e like me ka pīpī flu nasal), ʻoiai palekana nā lāʻau lapaʻau i hoʻopau ʻia (e like me ka pana flu).

E kamaʻilio me kāu hui mālama ola ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau. Hiki iā lākou ke aʻo iā ʻoe i ka manawa maikaʻi loa a me nā lāʻau lapaʻau i ʻōlelo ʻia e mālama iā ʻoe i ke olakino i ka wā o ka mālama ʻana.