He aha ʻo Trastuzumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i manaʻo ʻia ʻo Trastuzumab e kōkua ana i ka hakakā ʻana i kekahi mau ʻano maʻi maʻi umauma a me ka ʻōpū. Hana kēia lāʻau e like me ka pōkā i alakaʻi ʻia, e kuhikuhi pono ana i nā pūnaewele maʻi maʻi i loaʻa ka nui o ka protein i kapa ʻia ʻo HER2, me ka waiho ʻana i kāu mau pūnaewele olakino me ka hoʻopā ʻole ʻia.

Inā ua ʻōlelo kāu kauka iā trastuzumab, ʻo ia hoʻi ua maikaʻi kāu mau hoʻokolohua maʻi maʻi no ka HER2 overexpression. Hāʻawi maoli kēia iā ʻoe i ke komo ʻana i kahi koho lapaʻau maikaʻi loa i kōkua i nā poʻe he nui me nā maʻi maʻi like e ola lōʻihi a olakino.

He aha ʻo Trastuzumab?

He ʻano immunotherapy ʻo Trastuzumab i kapa ʻia he monoclonal antibody. E noʻonoʻo iā ia he protein i hoʻolālā kūikawā ʻia e hana e like me ka pōkā akamai, e ʻimi ana a pili ana i nā protein HER2 i hana nui ʻia i loko o kekahi mau pūnaewele maʻi maʻi.

No kēia lāʻau i kahi papa o nā lāʻau i kapa ʻia he mau lāʻau i manaʻo ʻia. ʻAʻole like me ka chemotherapy kuʻuna e pili ana i nā pūnaewele e mahele wikiwiki ana, kuhikuhi pono ʻo trastuzumab i nā pūnaewele maʻi maʻi me nā pae kiʻekiʻe o ka protein HER2. ʻO kēia ala i manaʻo ʻia e loaʻa pinepine nā hopena ʻaoʻao liʻiliʻi i hoʻohālikelike ʻia me ka chemotherapy maʻamau.

Hāʻawi ʻia ka lāʻau ma o ka IV infusion, maʻamau i ka haukapila a i ʻole ke kikowaena lapaʻau maʻi maʻi. E nānā pono kāu hui mālama ola iā ʻoe i ka wā o kēlā me kēia lapaʻau e hōʻoia i kou palekana a me kou hōʻoluʻolu.

No ke aha i hoʻohana ʻia ai ʻo Trastuzumab?

Hoʻomaʻamaʻa ʻo Trastuzumab i ka maʻi maʻi umauma HER2-positive a me kekahi mau maʻi maʻi ʻōpū. Ma kahi o 20-25% o nā maʻi maʻi umauma he HER2-positive, ʻo ia hoʻi, loaʻa iā lākou ka nui o ka protein HER2 ma ko lākou ʻili.

No ka maʻi maʻi umauma, hoʻohana nā kauka iā trastuzumab i kekahi mau kūlana. Hiki iā ia ke mālama i ka maʻi maʻi umauma i ke kahua mua ma hope o ke ʻoki ʻana e kōkua i ka pale ʻana i ka maʻi maʻi mai ka hoʻi ʻana mai. Hoʻohana ʻia nō hoʻi no ka maʻi maʻi umauma holomua a i ʻole metastatic i laha i nā ʻāpana ʻē aʻe o ke kino.

I ka maʻi 'aʻai ʻōpū, kōkua ka trastuzumab i ka mālama ʻana i ka adenocarcinoma gastric holomua ke hōʻike nui nā pūnaewele maʻi 'aʻai i ka HER2. E hoʻāʻo kāu kauka i kāu ʻiʻo maʻi 'aʻai e hōʻoia he HER2-positive ma mua o ka hoʻomaka ʻana i kēia lapaʻau.

Pehea ka Hana ʻana o Trastuzumab?

Hana ʻo Trastuzumab ma ka pale ʻana i ka protein HER2 ma nā pūnaewele maʻi 'aʻai, kahi e kāohi ai iā lākou mai ka ulu ʻana a me ka mahele ʻana. Ke nui loa ka HER2 o nā pūnaewele maʻi 'aʻai, ulu lākou a laha wikiwiki aʻe ma mua o nā pūnaewele maʻamau.

Hoʻopili kēia lāʻau i nā mea hoʻokipa HER2 e like me ke kī e komo ana i loko o ka laka. Ke hoʻopili ʻia, pale ia i nā hōʻailona ulu mai ka hiki ʻana i ka pūnaewele maʻi 'aʻai. Hoʻokomo maoli kēia i nā wāwae ma ka ulu ʻana o nā pūnaewele maʻi 'aʻai a hiki ke make nā pūnaewele maʻi 'aʻai.

Manaʻo ʻia ʻo Trastuzumab he lāʻau lapaʻau maʻi 'aʻai ikaika. ʻOiai ʻoi aku ka maʻalahi ma mua o ka chemotherapy kuʻuna, he lāʻau ikaika nō ia e pono ai ka nānā pono ʻana e kāu hui mālama ola.

Pehea wau e lawe ai iā Trastuzumab?

Hāʻawi ʻia ʻo Trastuzumab ma ke ʻano he IV infusion i kahi hoʻonohonoho lāʻau lapaʻau, ʻaʻole ma ke ʻano he pila āu e lawe ai ma ka home. E hoʻomākaukau a lawelawe kāu hui mālama ola i ka lāʻau lapaʻau nāu.

Ma mua o kāu infusion, ʻaʻole pono ʻoe e hoʻokē ʻai a pale i ka ʻai ʻana. ʻO ka ʻoiaʻiʻo, ʻo ka ʻai ʻana i ka ʻai māmā ma mua hiki ke kōkua iā ʻoe e ʻoluʻolu i ka wā o ka lapaʻau. E inu i ka wai nui e noho hydrated, a e ʻaʻahu i nā lole ʻoluʻolu no ka mea e noho ana ʻoe no kekahi manawa.

ʻO ka infusion mua e lawe ma kahi o 90 mau minuke, ʻoiai ʻo nā lapaʻau ma hope e lawe maʻamau i 30-60 mau minuke. E nānā pono kāu kahu maʻi iā ʻoe i ka wā o ka infusion a no kekahi manawa ma hope e nānā i nā hopena.

Pehea ka lōʻihi e lawe ai au iā Trastuzumab?

Aia ka lōʻihi o ka lapaʻau trastuzumab i kāu kūlana kikoʻī a me ke ʻano o ka maʻi 'aʻai. No ka maʻi 'aʻai umauma i ke kahua mua, maʻamau ka lapaʻau no hoʻokahi makahiki me nā infusions i kēlā me kēia ʻekolu pule.

No ka maʻi kanesa holomua a i ʻole metastatic, hiki iā ʻoe ke hoʻomau i ka lapaʻau inā e kōkua ana ia i ka mālama ʻana i kāu maʻi kanesa a ke ʻae maikaʻi nei ʻoe iā ia. E loiloi mau kāu kauka i ka maikaʻi o ka hana ʻana o ka lapaʻau ma o nā scans a me nā hoʻokolohua koko.

Mai hooki i ka lawe ʻana i ka trastuzumab me ka ʻole e kūkākūkā mua me kāu oncologist. ʻOiai inā maikaʻi ʻoe, hiki nō i ka lāʻau lapaʻau ke hana nei e mālama i kāu maʻi kanesa.

He aha nā hopena ʻaoʻao o Trastuzumab?

ʻO ka hapa nui o nā kānaka e ʻae maikaʻi i ka trastuzumab, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO ka lono maikaʻi, ʻaʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, a ʻike kāu hui mālama ola pehea e mālama ai iā lākou.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike i ka wā o ka lapaʻau:

• Luhi a me ka manaʻo nui o ka luhi ma mua o ka maʻamau
• Nā poʻo poʻo i ka maʻamau he maʻalahi a i ʻole
• Nausea, ʻoiai ʻaʻole koʻikoʻi
• Pāpaʻa a i ʻole nā ​​hoʻololi i nā hana ʻōpū
• ʻEha ʻiʻo a me ka ʻeha hui
• Nā hopena infusion e like me ke kuni, nā anu, a i ʻole ka ʻili

ʻO kēia mau hopena ʻaoʻao maʻamau e mālama ʻia a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lapaʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā lāʻau lapaʻau a me nā hoʻolālā e kōkua i ka hōʻemi ʻana i kēia mau hopena.

Aia kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e koi ai i ka lāʻau lapaʻau koke:

• Nā pilikia o ka naʻau, me ka nāwaliwali o ka ʻiʻo o ka naʻau
• Nā hopena maʻi maʻi koʻikoʻi i ka wā o ka infusion
• Nā pilikia o ka māmā e like me ka pilikia o ka hanu
• Nā maʻi koʻikoʻi ma muli o ka hana pale ʻole

E nānā kāu kauka i ka hana o kou naʻau me nā hoʻokolohua e like me nā echocardiograms a i ʻole MUGA scans. Inā ʻoe e ʻike i ka ʻeha o ka umauma, ka pōkole o ka hanu, a i ʻole ka pehu ʻana i kou mau wāwae, e hoʻokaʻaʻike koke i kāu hui mālama ola.

ʻO wai ka mea pono ʻole e lawe i ka Trastuzumab?

ʻAʻole kūpono ʻo Trastuzumab no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. ʻAʻole hiki i nā poʻe me kekahi mau maʻi puʻuwai ke lawe palekana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe i ka trastuzumab inā he maʻi maʻi koʻikoʻi ʻoe i ka lāʻau a i ʻole kekahi o kāna mea ʻai. E akahele nō hoʻi kāu kauka inā he moʻolelo kou o nā pilikia o ka puʻuwai, me ka hāʻule ʻana o ka puʻuwai a i ʻole nā ​​mea ʻino o ka puʻuwai.

ʻO ka hāpai ʻana kekahi mea nui e noʻonoʻo ai. Hiki i ka Trastuzumab ke hōʻeha i kahi pēpē i hānau ʻole ʻia, no laila he mea nui ka mana hānau maikaʻi i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope. Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, e kūkākūkā i kēia me kāu kauka.

Nā inoa inoa o Trastuzumab

Loaʻa ʻo Trastuzumab ma lalo o kekahi mau inoa inoa, ʻo Herceptin ka mea i ʻike nui ʻia. ʻO kēia ka trastuzumab mua i ʻae ʻia e ka FDA a ua kōkua i nā maʻi no nā makahiki he iwakālua.

Loaʻa i kēia manawa kekahi mau mana biosimilar, me Ogivri, Ontruzant, Herzuma, a me Trazimera. Ua like loa nā Biosimilars me ka lāʻau lapaʻau mua a hana like me ka maikaʻi, pinepine ma ke kumu kūʻai haʻahaʻa.

Hiki i kāu kauka a i ʻole ka ʻoihana ʻinikua ke makemake i kekahi mana ma luna o kekahi, akā ua manaʻo ʻia nā huahana trastuzumab i ʻae ʻia e ka FDA he kūpono a palekana no ka mālama ʻana.

Nā koho ʻē aʻe o Trastuzumab

Inā ʻaʻole kūpono ʻo trastuzumab iā ʻoe, aia nā lāʻau lapaʻau ʻē aʻe i hoʻopaʻa ʻia e HER2. ʻO Pertuzumab kekahi antibody monoclonal i hoʻohana pinepine ʻia me ka trastuzumab no ka hoʻomaikaʻi ʻana i ka pono.

ʻO T-DM1 (ado-trastuzumab emtansine) kahi koho hou e hui pū ana i ka trastuzumab me kahi lāʻau chemotherapy. Hāʻawi kēia lāʻau i ka chemotherapy pololei i nā sela maʻi HER2-positive me ka mālama ʻana i nā sela olakino.

No kekahi poʻe maʻi, hiki ke noʻonoʻo ʻia nā koho hou e like me tucatinib a i ʻole neratinib, ʻoiai inā ua laha ka maʻi maʻi i ka lolo a i ʻole inā ʻaʻole i hana maikaʻi nā lāʻau lapaʻau ʻē aʻe.

Ua ʻOi aku ka Maikaʻi o Trastuzumab ma mua o nā Lāʻau HER2 ʻē aʻe?

Ke noho nei ʻo Trastuzumab i ke kūlana gula no ka mālama ʻana i ka maʻi maʻi HER2-positive, akā ʻoi aku ka maikaʻi o nā lāʻau lapaʻau hou ke hoʻohana pū ʻia ma mua o ka pani ʻana. Loaʻa i kēlā me kēia lāʻau lapaʻau kona mau ikaika ponoʻī a ua koho ʻia ma muli o kou kūlana kikoʻī.

I ka hoʻohālikelike ʻana me ka pertuzumab wale nō, ʻoi aku ka lōʻihi o ka moʻolelo o trastuzumab a me ka noiʻi nui e kākoʻo ana i kāna hoʻohana. Eia naʻe, nui nā kauka e hoʻohana nei i nā lāʻau lapaʻau ʻelua no ka mea e hoʻokō ana lākou i nā hana a kekahi i kekahi.

Hiki ke makemake ʻia ʻo T-DM1 i kekahi mau kūlana, ʻoiai ke holomua ka maʻi maʻi i nā lāʻau lapaʻau ʻē aʻe. E noʻonoʻo kāu oncologist i nā mea e like me kou olakino holoʻokoʻa, ke kahua o ka maʻi maʻi, a me nā lāʻau lapaʻau i hala i ka wā e koho ai i ke ala maikaʻi loa no ʻoe.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Trastuzumab

He Palekana ʻo Trastuzumab no ka poʻe me ka maʻi puʻuwai?

Pono ʻo Trastuzumab i ka nānā pono ʻana i ka puʻuwai, akā hiki i ka poʻe he nui me nā maʻi puʻuwai maʻalahi ke loaʻa iā ia me ka palekana. E loiloi kāu kauka i kāu hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a nānā mau iā ia.

Inā he pilikia nui kou puʻuwai, hiki i kāu kauka ke hoʻoponopono i ka papa hana dosing a i ʻole ke koho ʻana i nā lāʻau lapaʻau ʻē aʻe. ʻO ke kī ka kamaʻilio hāmama me kāu hui mālama ola e pili ana i nā hōʻailona a i ʻole nā ​​hopohopo e pili ana i ka puʻuwai.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Trastuzumab?

E hoʻokaʻaʻike koke i kāu hui mālama ola inā ua hala ʻoe i kahi infusion trastuzumab i hoʻonohonoho ʻia. E kōkua lākou iā ʻoe e hoʻonohonoho hou i ka hiki wawe e mālama i ka pono o kāu lāʻau lapaʻau.

ʻAʻole pilikia nui ka nalo ʻana i nā lāʻau i kekahi manawa, akā he mea nui e pili kokoke i kāu papa manawa i hoʻonohonoho ʻia. Hiki i kāu kauka ke hoʻoponopono i ka lāʻau i ka wā e hiki mai ana e hoʻihoʻi iā ʻoe i ke ala.

He aha kaʻu e hana ai inā loaʻa iaʻu kahi hopena koʻikoʻi i ka wā o ka hoʻokomo ʻana?

ʻAʻole maʻamau nā hopena koʻikoʻi i ka wā o ka hoʻokomo ʻana, akā ua mākaukau kāu hui mālama ola e mālama koke iā lākou. Mālama lākou iā ʻoe i ka wā o kēlā me kēia hoʻokomo ʻana a loaʻa nā lāʻau lapaʻau i mākaukau e mālama i nā hopena.

Inā loaʻa iā ʻoe nā hōʻailona e like me ka pilikia o ka hanu ʻana, ka ʻili ʻili koʻikoʻi, a i ʻole ka ʻūlū i ka wā o ka hoʻokomo ʻana, e haʻi koke i kāu kahu. Hiki ke mālama ʻia ka hapa nui o nā hopena ma ka hoʻolohi ʻana i ka wikiwiki o ka hoʻokomo ʻana a i ʻole ka hāʻawi ʻana iā ʻoe i nā lāʻau lapaʻau e hōʻemi i ka hopena.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Trastuzumab?

Aia ka hoʻoholo e hooki i ka trastuzumab i kāu hoʻolālā lapaʻau a me ka maikaʻi o kāu pane ʻana. No ka maʻi maʻi umauma i ka wā mua, hoʻomau ka lapaʻau no hoʻokahi makahiki piha ke ʻole nā hopena ʻaoʻao koʻikoʻi.

No ka maʻi maʻi holomua, hiki iā ʻoe ke hoʻomau i ka lapaʻau inā e kāohi ana i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe. E loiloi mau kāu kauka i kāu holomua a kūkākūkā i nā loli i kāu hoʻolālā lapaʻau me ʻoe.

Hiki iaʻu ke lawe i nā lāʻau lapaʻau ʻē aʻe i ka wā e lawe ana iā Trastuzumab?

He palekana ka hapa nui o nā lāʻau lapaʻau e lawe me trastuzumab, akā e nānā mau me kāu hui mālama ola ma mua o ka hoʻomaka ʻana i kekahi mea hou. Aia kēia me nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ka pāʻani, a me nā mea hoʻohui.

Pono paha kekahi mau lāʻau lapaʻau e pili ana i ka hana o ka naʻau i ka nānā kūikawā ke hoʻohana ʻia me trastuzumab. E nānā kāu kauka i kāu mau lāʻau lapaʻau a pau e hōʻoia i ka hana palekana.