He aha ka Trioxsalen: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Trioxsalen e hoʻonui ai i ka ʻili i ka mālamalama ultraviolet, e kōkua ana i ka mālama ʻana i kekahi mau maʻi ʻili e like me ka vitiligo a me ka psoriasis. No ka pūʻulu o nā lāʻau lapaʻau i kapa ʻia ʻo psoralens, e hana pū ana me ka lāʻau lapaʻau UV kūikawā e kōkua i ka hoʻihoʻi ʻana i ka pigmentation ʻili maʻamau a i ʻole e hōʻemi i nā ʻāpana mānoanoa a me ka unahi.

Ua kōkua kēia ʻano hana, i ʻike ʻia ʻo PUVA therapy, i ka poʻe me nā maʻi ʻili paʻakikī no nā makahiki he nui. ʻOiai e koi ana i ka nānā pono ʻana a ʻaʻole kūpono i nā mea a pau, ʻike ka nui o nā maʻi he mea pono ia i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe.

He aha ka Trioxsalen?

ʻO Trioxsalen kahi lāʻau lapaʻau e hoʻonui ai i ka mālamalama e hoʻomākaukau ai i kou ʻili e pane maikaʻi i ka mālamalama ultraviolet A (UVA) i mālama ʻia. E noʻonoʻo iā ia he mea kōkua e hoʻomaikaʻi ai i kou ʻili i nā hopena hoʻōla o nā nalu māmā.

Hele mai ka lāʻau lapaʻau mai kahi hui kūlohelohe i loaʻa i kekahi mau mea kanu a ua hana kūikawā ʻia no ka hoʻohana ʻana i ka lāʻau lapaʻau. Ke lawe ʻoe i ka trioxsalen a laila loaʻa ka lāʻau lapaʻau UVA, hiki i ka hui ke hoʻoulu i nā cell e hana ana i ka pigment i kou ʻili a i ʻole e kōkua i ka hōʻemi ʻana i ka mumū ma nā wahi i hoʻopilikia ʻia.

E nānā mau kāu kauka i kēia lāʻau lapaʻau no ka mea pono e hoʻonohonoho pono ʻia ka manawa a me ka hoʻohana ʻana me kāu mau kau lapaʻau māmā.

No ke aha e hoʻohana ʻia ai ka Trioxsalen?

Hoʻonohonoho mua ʻia ʻo Trioxsalen no ka vitiligo, kahi maʻi e nalowale ai nā ʻāpana o ka ʻili i ko lākou kala maʻamau, a no ka psoriasis koʻikoʻi i pane ʻole i nā lāʻau lapaʻau ʻē aʻe. ʻO kēia nā kūlana nui i hōʻike ai kēia lāʻau lapaʻau i ka pōmaikaʻi nui.

No ka vitiligo, kōkua ka lāʻau lapaʻau i ka hoʻoulu ʻana i nā cell e hana ana i ka melanin (ka pigment maoli o kou ʻili) e hoʻomaka hou i ka hana ma nā wahi i hoʻopilikia ʻia. Hiki i kēia ke kōkua mālie i ka hoʻihoʻi ʻana i kahi leo ʻili like, ʻoiai ʻokoʻa nā hopena mai kēlā me kēia kanaka.

I ka mālama ʻana i ka psoriasis, hiki i ka trioxsalen i hui pū ʻia me ka mālamalama UVA ke kōkua i ka hoʻolohi ʻana i ka ulu wikiwiki ʻana o nā cell skin e hana ai i kēlā mau ʻāpana mānoanoa a me ka unahi. Hoʻomaopopo ʻia kēia ala ke hāʻawi ʻole nā lāʻau lapaʻau topical a i ʻole nā lāʻau lapaʻau waha ʻē aʻe i ka hōʻoluʻolu lawa.

Hiki i kekahi mau kauka ke ʻōlelo aku i kēia lapaʻau no nā maʻi ʻili laha ʻē aʻe e pili ana i ka pigmentation abnormal, akā ʻaʻole maʻamau kēia mau hoʻohana a pono i ka loea kūikawā.

Pehea e Hana ai ʻo Trioxsalen?

Hana ʻo Trioxsalen ma ka hoʻonui ʻana i ka ʻike o kou mau cell skin i ka mālamalama UVA, a laila hoʻomaka i nā loli kōkua i ke ʻano o ka hana ʻana o kou ʻili. Ke lawe ʻoe i ka lāʻau lapaʻau, laha ia ma kou kino a hōʻiliʻili i loko o kou mau cell skin.

Ke hiki ka mālamalama UVA i kou ʻili i mālama ʻia, hoʻāla ʻia ka trioxsalen a hoʻomaka i kahi cascade o nā hana cellular. I ka vitiligo, hiki i kēia hoʻāla ke hoʻāla i nā cell hana pigment dormant a paipai iā lākou e hoʻomaka e hana hou i ka melanin.

No ka psoriasis, kōkua ka trioxsalen i hoʻāla ʻia e ka mālamalama i ka hoʻolohi ʻana i ka hana nui ʻana o nā cell skin e hana ai i nā ʻāpana mānoanoa a me ka unahi. Loaʻa nō hoʻi nā hopena anti-inflammatory e hiki ke hōʻemi i ka ʻulaʻula a me ka huhū i nā wahi i hoʻopilikia ʻia.

Ua manaʻo ʻia he ala lapaʻau ikaika i kaulike e pono ai ka mālama olakino akahele. Hoʻokumu mālie nā hopena ma luna o nā kau lapaʻau he nui, no laila pono ʻoe i ke ahonui i ka pane mālie ʻana o kou ʻili i ka lāʻau lapaʻau.

Pehea e Lawe ai au i ka Trioxsalen?

Pono ʻoe e lawe i ka trioxsalen e like me ke kau ʻana a kāu kauka, maʻamau 2 a 4 mau hola ma mua o kāu lapaʻau mālamalama UVA i hoʻonohonoho ʻia. He mea nui ka manawa no ka mea pono ka lāʻau lapaʻau i ka manawa e komo ai a hāʻawi ʻia ma kou ʻili.

E lawe i kāu mahele me ka meaʻai a i ʻole ka waiū e kōkua i ka hōʻemi ʻana i ka ʻōpū, i kekahi manawa hiki ke hana me kēia lāʻau lapaʻau. He meaʻai māmā a i ʻole ka ʻai ʻana ma kahi o 30 mau minuke ma mua o ka lawe ʻana i ka pila e hana maikaʻi.

E ale i ka papa holoʻokoʻa me ke aniani wai piha, a mai ʻoki a nau paha. Ua hoʻolālā ʻia ka lāʻau lapaʻau e komo mālie, no laila ʻo ka hoʻololi ʻana i ka papa hiki ke hoʻopilikia i kāna hana.

Ma hope o ka lawe ʻana i ka trioxsalen, pono ʻoe e pale i kou ʻili mai nā kukuna o ka lā a me nā kukui ʻālohilohi i loko a hiki i ka pau ʻana o kāu kau ʻana i ka UVA. ʻO ia hoʻi, e ʻaʻahu i nā lole pale, nā aniani, a noho i loko o ka hale ke hiki.

E hāʻawi kāu kauka iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka manawa e hōʻea ai no kāu mālama ʻana i ke kukui, no ka mea, pono ka manawa no ka palekana a me ka pono.

Pehea ka lōʻihi e lawe ai au i ka Trioxsalen?

He ʻokoʻa loa ka lōʻihi o ka mālama ʻana i ka trioxsalen ma muli o kou kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. ʻO ka hapa nui o nā papa lapaʻau e pili ana i nā kau ʻelua i ka pule no kekahi mau mahina, ʻoiai paha e pono kekahi poʻe i nā manawa lapaʻau lōʻihi.

No ka vitiligo, hiki iā ʻoe ke hoʻomaka e ʻike i kekahi hoʻomaikaʻi ma hope o 6 a 8 mau pule o nā lāʻau lapaʻau maʻamau, akā ʻo ka hoʻihoʻi ʻana i ke kala nui e lawe pinepine i 3 a 6 mau mahina a ʻoi aku paha. E nānā kāu kauka i kāu holomua a hoʻoponopono i ka papa hana lapaʻau e like me ka mea e pono ai.

Hiki ke pōkole nā manawa lapaʻau psoriasis, me kekahi hoʻomaikaʻi ʻana i ʻike pinepine ʻia ma hope o 4 a 6 mau pule o ka lāʻau lapaʻau mau. Eia naʻe, pono paha nā lāʻau lapaʻau mālama e mālama i kou kūlana ʻili.

E loiloi mau kāu mea mālama ola i ka pane o kou ʻili a me nā hopena ʻaoʻao āu e ʻike nei. E hoʻoholo lākou i ka manawa i loaʻa ai iā ʻoe nā hopena maikaʻi loa a i ʻole ka manawa e hoʻāʻo ai i kahi ala ʻokoʻa.

Mai hooki i ka lawe ʻana i ka trioxsalen i ka manawa koke a i ʻole e hoʻololi i kāu papa hana lapaʻau me ka ʻole e kūkākūkā mua i kāu kauka, no ka mea, hiki i kēia ke hoʻopilikia i ka pono o kāu lāʻau lapaʻau.

He aha nā hopena ʻaoʻao o Trioxsalen?

E like me nā lāʻau lapaʻau a pau, hiki i ka trioxsalen ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. ʻO nā hopena ʻaoʻao maʻamau ka mea maʻamau a pili i ka piʻi ʻana o ka ʻike i ka lā.

Eia nā hopena ʻaoʻao āu e ʻike ai, a he mea kōkua ke ʻike i ka mea e manaʻo ai i hiki iā ʻoe ke mālama pono iā lākou:

• ʻO ka nausea a i ʻole ka ʻōpū, ʻoi loa i ka hoʻomaka ʻana i ka lāʻau lapaʻau
• Hoʻonui i ka ʻike i ka lā a me nā kukui mālamalama a hiki i 24 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau
• Hoʻonāukiuki ʻili māmā a i ʻole ka ʻulaʻula ma nā wahi lapaʻau
• Ka ʻūlū ʻana i ka wā a i ʻole ma hope o nā kau ʻana i ka mālamalama
• ʻO nā poʻo, he mea maʻamau a he manawa pōkole
• ʻO ka ʻūlū a i ʻole ka manaʻo māmā

ʻO kēia mau hopena maʻamau e lilo i mea hiki ke mālama ʻia i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau, a hiki i kāu hui mālama ola ke hāʻawi i nā hoʻolālā e hōʻemi i ka hōʻoluʻolu.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke:

• Nā hopena e like me ka lā e ʻā ana me ka ʻōpū a i ʻole ka ʻili
• ʻO ka nausea mau a i ʻole ka luaʻi ʻana e pale iā ʻoe mai ka mālama ʻana i ka meaʻai
• Nā loli ʻili ʻokoʻa a i ʻole nā ​​ulu hou
• ʻO ka huhū o ka maka nui a i ʻole nā ​​pilikia ʻike
• Nā hōʻailona o ka hopena maʻi e like me ka pilikia o ka hanu ʻana a i ʻole ka pehu

ʻOiai ʻaʻole maʻamau kēia mau hopena koʻikoʻi, he mea nui e hoʻokaʻaʻike koke i kāu kauka inā ʻike ʻoe i kekahi o lākou. Loaʻa i kāu hui lapaʻau ka ʻike i ka mālama ʻana i kēia mau lāʻau lapaʻau a hiki ke kōkua iā ʻoe e hoʻokele i nā pilikia e kū mai.

ʻO wai ka mea pono ʻole e lawe i ka Trioxsalen?

ʻAʻole palekana ʻo Trioxsalen no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻO kekahi mau kūlana a me nā kūlana e hana i kēia lāʻau lapaʻau kūpono ʻole a i ʻole ka pilikia.

ʻAʻole pono ʻoe e lawe i ka trioxsalen inā loaʻa iā ʻoe kekahi o kēia mau maʻi, no ka mea, hiki iā lākou ke hoʻonui i kou pilikia o nā pilikia koʻikoʻi:

• Mōʻaukala o ka maʻi ʻaʻai ʻili a i ʻole nā maʻi ʻili ma mua o ka maʻi ʻaʻai
• Lupus a i ʻole nā maʻi autoimmune ʻē aʻe e hoʻolilo iā ʻoe i mea maʻalahi i ka lā
• Cataracts a i ʻole nā pilikia maka koʻikoʻi ʻē aʻe
• Maʻi ate a i ʻole ka hana ate i hoʻopilikia nui ʻia
• Maʻi kīkī e pili ana i ke ʻano o ka hana ʻana o kou kino i nā lāʻau
• Hāpai a i ʻole nā hoʻolālā e hāpai i ka wā o ka mālama ʻana
• Hānai ʻana i ka waiū

Eia kekahi, hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka trioxsalen, no laila pono i kāu kauka e ʻike e pili ana i nā mea a pau āu e lawe nei, me nā lāʻau lapaʻau a me nā mea hoʻohui.

Hiki i nā poʻe me ka ʻili maikaʻi loa e ʻā maʻalahi ke pono i nā hana kūikawā a i ʻole nā lāʻau lapaʻau ʻē aʻe. E loiloi kāu dermatologist i kou ʻano ʻili a e hoʻoholo inā kūpono ka trioxsalen no kou kūlana.

Nā inoa inoa o Trioxsalen

Loaʻa ka Trioxsalen ma lalo o nā inoa inoa like ʻole, ʻo Trisoralen ka mea i kauoha pinepine ʻia ma nā ʻāina he nui. Hiki i kāu hale kūʻai lāʻau lapaʻau ke hāʻawi i kēia lāʻau lapaʻau ma lalo o nā inoa like ʻole e pili ana i ka mea hana.

Hiki i kekahi mau hale kūʻai lāʻau lapaʻau ke lawe i nā mana generic o trioxsalen, aia ka mea hana like akā ʻokoʻa paha a i ʻole mai nā mea hana like ʻole. Pono e like ka pono me ka inoa inoa.

E nānā mau me kāu pharmacist inā he nīnau kāu e pili ana i ka hoʻomākaukau kikoʻī āu e loaʻa nei, ʻoiai inā ʻokoʻa ia mai ka mea āu i lawe ai ma mua. Hiki iā lākou ke hōʻoia e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono a me ka ikaika.

Nā koho ʻē aʻe o Trioxsalen

Inā ʻaʻole kūpono ka trioxsalen iā ʻoe a i ʻole ʻaʻole e hāʻawi i nā hopena āu e pono ai, hiki i kekahi mau lāʻau lapaʻau ʻē aʻe ke kūpono ke kūkākūkā me kāu kauka. ʻO ke koho maikaʻi loa e pili ana i kou kūlana a me nā kūlana pilikino.

No ka vitiligo, nā koho ʻē aʻe e komo pū ana me nā corticosteroids topical, nā mea pale calcineurin e like me tacrolimus, a i ʻole nā lāʻau lapaʻau hou e like me nā mea pale JAK. ʻO ka lāʻau lapaʻau māmā UVB narrowband me ka ʻole o ka lāʻau lapaʻau he mea hiki nō hoʻi i kekahi poʻe e ʻike he pono.

He nui nā koho ʻē aʻe o nā maʻi psoriasis, e like me nā lāʻau lapaʻau topical e like me corticosteroids a i ʻole nā analog vitamin D, nā lāʻau lapaʻau waha e like me methotrexate, a i ʻole nā lāʻau lapaʻau biologic hou e kuhikuhi ana i nā ʻāpana kikoʻī o ka ʻōnaehana pale.

Loaʻa i kekahi poʻe ka pōmaikaʻi mai ka phototherapy me ka hoʻohana ʻana i nā ʻano māmā like ʻole ʻaʻole pono i ka lāʻau lapaʻau, ʻoiai e lōʻihi ana kēia mau lāʻau lapaʻau e hōʻike i nā hopena. Hiki i kāu dermatologist ke kōkua iā ʻoe e kaupaona i nā mea maikaʻi a me nā mea maikaʻi ʻole o kēlā me kēia koho.

Ua ʻoi aku ka maikaʻi o Trioxsalen ma mua o Methoxsalen?

ʻO Trioxsalen a me methoxsalen nā psoralens i hoʻohana ʻia no nā kūlana like, akā he mau ʻokoʻa koʻikoʻi ko lākou e hiki ai ke kūpono i kekahi no kou kūlana. Manaʻo ʻia ʻo Trioxsalen he haʻahaʻa ka pilikia o kekahi mau hopena ʻaoʻao, ʻo ia hoʻi ka nausea a me nā pilikia o ke ake.

ʻOi aku ka ikaika o Methoxsalen a hiki ke hana wikiwiki no kekahi poʻe, akā hele pū me ka pilikia kiʻekiʻe o nā hopena ʻaoʻao a pono e nānā pono ʻia. Makemake pinepine ʻia ʻo Trioxsalen i ka wā e pono ai ke ala mālie a i ʻole i ka wā i loaʻa ai i nā maʻi ka pilikia o ka hoʻomanawanui ʻana i ka methoxsalen.

ʻO ke koho ma waena o kēia mau lāʻau lapaʻau e hilinaʻi pinepine ʻia i kou kūlana kikoʻī, ka mōʻaukala olakino, a me ke ʻano o kou pane ʻana i nā lāʻau lapaʻau ʻē aʻe. E noʻonoʻo kāu kauka i nā mea e like me kāu hana ate, ke ʻano o ka ʻili, a me nā ʻike lapaʻau mua.

Pono nā lāʻau lapaʻau ʻelua i ka pale māmā a me ka mālama ʻana i ka lāʻau lapaʻau, no laila ua like nā hana palekana me ka nānā ʻole i ka mea i kauoha ʻia.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Trioxsalen

He palekana anei ʻo Trioxsalen no ka maʻi puʻuwai?

Hiki ke hoʻohana palekana ʻia ʻo Trioxsalen i ka poʻe me ka maʻi puʻuwai, akā pono e hoʻopili kāu cardiologist a me dermatologist i kāu mālama. ʻAʻole pili pololei ka lāʻau lapaʻau i ka hana o ka puʻuwai, akā pono paha kekahi poʻe me nā maʻi puʻuwai e hoʻoponopono i nā papa hana lapaʻau.

ʻO ka mea nui e pono ai ʻoe e kaupalena i ka hana kino a me ka ʻike ʻana i ka lā no kekahi mau hola ma hope o ka lawe ʻana i ka trioxsalen, he mea hiki ke mālama ʻia no ka hapa nui o nā maʻi puʻuwai. E hōʻoia kāu mau kauka e hana ana kāu hoʻolālā lapaʻau me nā lāʻau lapaʻau puʻuwai āu e lawe nei.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Trioxsalen?

Inā lawe hewa ʻoe i ka nui o ka trioxsalen ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena mana ʻawaʻawa, ʻoiai inā maikaʻi ʻoe. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui iā ʻoe i ka mālamalama a hoʻonui i kou pilikia o ke ahi nui.

E noho i loko o kahi lumi pouli a pale i nā kumu kukui a pau, me nā kukui i loko o ka hale, a hiki i kou kamaʻilio ʻana me kahi ʻoihana mālama ola. Mai ho'āʻo e hana iā ʻoe iho e luaʻi ke ʻole i kuhikuhoʻo ʻia e nā limahana lapaʻau.

Makemake paha kāu kauka e nānā pono iā ʻoe a i ʻole e hoʻoponopono i kāu papa hana lapaʻau māmā e pale ai i nā pilikia mai ka overdose.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Trioxsalen?

Inā haʻalele ʻoe i kahi mahele o ka trioxsalen, mai lawe i ka lohi a i ʻole e hoʻāʻo e hana i luna me kāu mahele i hoʻonohonoho ʻia. E hoʻokaʻaʻike i ke keʻena o kāu kauka e kūkākūkā i ka hoʻonohonoho hou ʻana i kāu manawa lapaʻau māmā, no ka mea, he mea nui ka hoʻonohonoho manawa no ka palekana.

ʻO ka lawe ʻana i ka trioxsalen me ka ʻole o ka lapaʻau māmā i hoʻonohonoho pono ʻia ʻaʻole e hāʻawi i kekahi pōmaikaʻi a hiki ke hoʻoulu i nā hopena ʻaoʻao pono ʻole. Pono paha e hoʻoponopono ʻia kāu papa hana lapaʻau e mālama i nā manawa kūpono ma waena o nā kau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Trioxsalen?

Hiki iā ʻoe ke hooki i ka lawe ʻana i ka trioxsalen ke hoʻoholo kāu kauka ua loaʻa iā ʻoe nā hopena maikaʻi loa a i ʻole ke hāʻawi hou ʻole ka mālama ʻana i nā pōmaikaʻi. Hana mau ʻia kēia hoʻoholo ma waena o ʻoe a me kāu hui mālama ola.

Pono paha kekahi poʻe i nā mālama mālama manawa e mālama i ko lākou ʻili, a hiki i nā poʻe ʻē aʻe ke hooki loa ma hope o ka hoʻokō ʻana i kā lākou pahuhopu lapaʻau. E nānā kāu kauka i ka pane ʻana o kou ʻili a kōkua iā ʻoe e hoʻomohala i kahi hoʻolālā hoʻokele lōʻihi.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Trioxsalen?

ʻOi aku ka maikaʻi o ka pale ʻana i ka waiʻona i ka wā e lawe ana i ka trioxsalen, no ka mea, hiki iā ia ke hoʻonui i kou pilikia o ka nausea a me ka ʻōpū. Hiki nō hoʻi i ka waiʻona ke hoʻopilikia i ke ʻano o ka hana ʻana o kou ate i ka lāʻau lapaʻau, e hoʻonui ana i nā hopena ʻaoʻao.

Inā koho ʻoe e inu i kekahi manawa, e hana pēlā me ka maʻalahi a ʻaʻole loa i ka lā hoʻokahi me kāu trioxsalen dose a me ka mālama māmā. E kūkākūkā mau i ka hoʻohana ʻana i ka waiʻona me kāu kauka, no ka mea, hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kou olakino holoʻokoʻa a me ka hoʻolālā lapaʻau.