He aha ʻo Umbralisib: Nā Hoʻohana, Ka Leki, Nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Umbralisib e kōkua ana i ka mālama ʻana i kekahi mau ʻano maʻi koko ma ka pale ʻana i nā protein kikoʻī e kōkua ana i nā sela maʻi e ulu a ola. No ka papa o nā lāʻau i kapa ʻia ʻo kinase inhibitors kēia lāʻau lapaʻau waha, e hana ana e like me nā kuapo molekala e hoʻopau i nā hōʻailona e hoʻoulu ai i ka ulu ʻana o ka maʻi.

Hiki i kāu kauka ke kuhikuhi iā umbralisib ke kū nei ʻoe i nā maʻi koko kikoʻī ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe. Ua hoʻolālā ʻia e ʻoluʻolu i kou kino ma mua o ka chemotherapy kuʻuna ʻoiai e hakakā pono ana i nā sela maʻi.

No ke aha e hoʻohana ʻia ai ʻo Umbralisib?

Hoʻomaʻamaʻa ʻo Umbralisib i ʻelua ʻano nui o nā maʻi koko: marginal zone lymphoma a me follicular lymphoma. ʻO kēia nā ʻano o ka non-Hodgkin's lymphoma, kahi maʻi e pili ana i kāu ʻōnaehana lymphatic, he ʻāpana ia o kāu pūnaewele hakakā maʻi o ke kino.

E ʻōlelo maʻamau kāu kauka iā umbralisib inā ua hoʻāʻo mua ʻoe i ʻelua mau lāʻau lapaʻau maʻi ʻē aʻe me ka holomua ʻole. Ua ʻae ʻia ia no ka poʻe i hoʻi mai kā lākou maʻi a i ʻole ʻaʻole i pane i nā lāʻau lapaʻau mua.

Hana maikaʻi ka lāʻau lapaʻau no kekahi mau ʻano genetic o kēia mau maʻi. E hana kāu hui mālama ola i nā hoʻokolohua kikoʻī e hōʻoia i ka koho kūpono ʻo umbralisib no kāu kūlana.

Pehea e hana ai ʻo Umbralisib?

Hoʻopaʻa ʻo Umbralisib i ʻelua mau protein kikoʻī i kapa ʻia ʻo PI3K-delta a me CK1-epsilon e pono ai nā sela maʻi e ulu a hoʻonui. E noʻonoʻo i kēia mau protein e like me nā pauma wahie e mālama ana i nā sela maʻi e holo ana - hoʻopau maoli ʻo umbralisib i kēia mau pauma.

ʻO kēia ka mea e lilo ai ʻo umbralisib i lāʻau lapaʻau i manaʻo ʻia. ʻOi aku ka pololei ma mua o ka chemotherapy kuʻuna no ka mea e kālele ana i nā sela maʻi ʻoiai e waiho ana i ka hapa nui o nā sela olakino wale nō. Eia naʻe, hiki nō ke hoʻopilikia i kekahi mau sela maʻamau e hoʻohana ana i kēia mau protein like.

Hiki i ka lāʻau lapaʻau ke komo i loko o kou kahe koko a hele a puni kou kino e hōʻea i nā pūnaewele maʻi maʻi ma nā wahi a lākou e hūnā ai. Kōkua kēia hana holoʻokoʻa i ka mālama ʻana i ka maʻi maʻi i laha i nā wahi he nui.

Pehea e lawe ai au i ka Umbralisib?

E lawe i ka umbralisib e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā me ka meaʻai. ʻO ka loaʻa ʻana o ka meaʻai i loko o kou ʻōpū e kōkua i kou kino e komo maikaʻi i ka lāʻau lapaʻau a hiki ke hōʻemi i ka ʻōpū.

E ale i nā papa holoʻokoʻa me ke aniani wai piha - mai ʻoki, wāwahi, a nau paha iā lākou. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai.

E hoʻāʻo e lawe i kāu mahele i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i loko o kou kahe koko. Hiki iā ʻoe ke lawe me kekahi meaʻai, akā nui ka poʻe i ʻike he maʻalahi ke hoʻomanaʻo me ka ʻaina kakahiaka a i ʻole ka ʻaina ahiahi.

E pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana i ka umbralisib, no ka mea, hiki i kēia mau mea ke keakea i ke ʻano o ka hana ʻana o kou kino i ka lāʻau lapaʻau. E hāʻawi kāu kauka iā ʻoe i kahi papa inoa piha o nā meaʻai a me nā lāʻau lapaʻau e pale ai.

Pehea ka lōʻihi e lawe ai au i ka Umbralisib?

E hoʻomau ʻoe i ka lawe ʻana i ka umbralisib i ka wā e hana ana ia e kāohi i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe iā ia. Hiki i kēia ke mau mahina a i ʻole mau makahiki, ma muli o ke ʻano o ka pane ʻana o kou kino.

E nānā kāu kauka i kāu holomua ma o nā hoʻokolohua koko maʻamau a me nā kiʻi kiʻi. Kōkua kēia mau mea e hoʻoholo inā e hakakā pono ana ka lāʻau lapaʻau i kāu maʻi maʻi a pehea e mālama ai kou kino i ka lāʻau.

Mai hooki i ka lawe ʻana i ka umbralisib me ka ʻole e kamaʻilio mua me kāu hui mālama ola. Pono paha lākou e hoʻoponopono i kāu mahele i ka liʻiliʻi a i ʻole e hoʻololi iā ʻoe i kahi lāʻau lapaʻau ʻē aʻe inā lilo nā hopena ʻaoʻao i mea paʻakikī loa.

He aha nā hopena ʻaoʻao o Umbralisib?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka umbralisib ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama kūpono a me ka nānā ʻana mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e ʻike ʻia:

• Pāpaʻa, hiki ke maʻalahi a paʻakikī paha
• Nausea a me ka luaʻi i kekahi manawa
• Luhi a i ʻole ka luhi ma mua o ka maʻamau
• Hoʻemi ʻia ka ʻai
• ʻEha ʻiʻo a me nā hui
• Poʻo
• Pāpaʻa ʻili a i ʻole ka ʻūlū

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu kauka ke hōʻike i nā ala e mālama pono ai iā lākou.

ʻO kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e koi i ka lāʻau lapaʻau koke:

• Pāpaʻa nui ʻaʻole e hoʻomaikaʻi me ka lāʻau lapaʻau
• Nā hōʻailona o ka maʻi e like me ke kuni, nā anu, a i ʻole ka ʻūlū mau
• ʻO ka ʻeha a i ʻole ke kahe ʻana
• Nā hopena ʻili koʻikoʻi a i ʻole ka pāpaʻa ākea
• Paʻakikī ka hanu ʻana a i ʻole ka ʻeha o ka umauma
• Melemele o ka ʻili a i ʻole nā maka

E hoʻokaʻaʻike koke i kāu hui mālama ola inā ʻike ʻoe i kekahi o kēia mau hōʻailona koʻikoʻi. Hiki iā lākou ke hoʻoponopono i kāu lāʻau lapaʻau a i ʻole e hāʻawi i ke kākoʻo hou e kōkua iā ʻoe e ʻoi aku ka maikaʻi.

ʻO wai ka mea pono ʻole e lawe iā Umbralisib?

ʻAʻole kūpono ʻo Umbralisib no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. Pono paha ka poʻe me kekahi mau maʻi olakino i nā koho lapaʻau like ʻole.

ʻAʻole pono ʻoe e lawe iā umbralisib inā he maʻi ʻoe i ka lāʻau a i ʻole kekahi o kāna meaʻai. E nānā kāu kauka i ka papa inoa meaʻai piha me ʻoe inā he maʻi ʻoe.

E haʻi i kāu kauka e pili ana i kāu mau maʻi olakino a pau, ʻoiai inā loaʻa iā ʻoe:

• Nā maʻi hana a i ʻole ka mōʻaukala o nā maʻi hou
• Nā pilikia o ke ake a i ʻole ka hepatitis
• He mōʻaukala o nā hopena ʻili koʻikoʻi i nā lāʻau lapaʻau
• Nā lāʻau lapaʻau hou a i ʻole i hoʻolālā ʻia
• ʻO nā maʻi autoimmune

ʻAʻole pono nā wāhine hāpai e lawe i ka umbralisib no ka mea hiki iā ia ke hōʻeha i ka pēpē e ulu ana. Inā he makahiki hānau keiki kāu, e kūkākūkā kāu kauka i nā ʻano hana hoʻomalu hānau ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Pono nō hoʻi nā makuahine e hānai ana i ka waiū e pale i ka umbralisib, no ka mea, hiki ke hele i loko o ka waiū umauma a hiki ke hōʻeha i ka pēpē e hānai ana.

Nā inoa inoa Umbralisib

Kūʻai ʻia ʻo Umbralisib ma lalo o ka inoa inoa Ukoniq ma ʻAmelika Hui Pū ʻIa. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau.

E nānā mau me kāu lāʻau lapaʻau e hōʻoia e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono. Pono e hōʻailona maopopo ʻia nā papa me ka inoa inoa a me ka ʻike kauoha a kāu kauka.

Inā he mau nīnau ʻinikua kāu e pili ana i ka uhi ʻana no Ukoniq, hiki i kāu hui mālama ola a i ʻole ka lāʻau lapaʻau ke kōkua iā ʻoe e ʻimi i nā papahana kōkua maʻi e loaʻa ana.

Nā koho ʻē aʻe o Umbralisib

Hiki i kekahi mau lāʻau lapaʻau i manaʻo ʻia ke mālama i nā maʻi koko like inā ʻaʻole kūpono ka umbralisib iā ʻoe. E koho kāu kauka i ke koho maikaʻi loa e pili ana i kāu ʻano maʻi maʻi a me ka mōʻaukala olakino.

Hana nā mea pale kinase ʻē aʻe e like me idelalisib, copanlisib, a me duvelisib ma o nā ʻano hana like akā loaʻa paha nā hopena ʻaoʻao like ʻole. Hiki i kāu oncologist ke wehewehe pehea e hoʻohālikelike ai kēia mau koho.

Loaʻa nō hoʻi nā ʻano chemotherapy kuʻuna a me nā lāʻau lapaʻau immunotherapy hou. ʻO ke koho maikaʻi loa e pili ana i nā mea e like me kou olakino holoʻokoʻa, nā lāʻau lapaʻau mua, a me ke ʻano o ka pane ʻana o kāu maʻi maʻi.

E hana pū kāu hui mālama ola me ʻoe e ʻimi i ka lāʻau lapaʻau maikaʻi loa me nā hopena ʻaoʻao liʻiliʻi loa no kāu kūlana.

ʻOi aku ka maikaʻi o Umbralisib ma mua o nā lāʻau lapaʻau like ʻē aʻe?

Hāʻawi ʻo Umbralisib i kekahi mau mea maikaʻi ma luna o nā mea pale kinase ʻē aʻe, ʻoi aku hoʻi e pili ana i ka hiki ke ʻae. He nui nā maʻi i maʻalahi ke lawe ma mua o kekahi mau lāʻau lapaʻau kahiko i kēia papa.

I ka hoʻohālikelike ʻana me idelalisib, hiki i ka umbralisib ke hana i nā pilikia ate liʻiliʻi a me nā maʻi koʻikoʻi. Eia naʻe, hiki i nā lāʻau ʻelua ke hana pono i ka mālama ʻana i nā maʻi maʻi koko, a ʻo ke koho maikaʻi loa e hilinaʻi ana i kou kūlana pilikino.

ʻO ka lāʻau

Mai lawe i nā lāʻau ʻelua i ka manawa hoʻokahi e pani ai i ka lāʻau i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole e hāʻawi i ka pōmaikaʻi hou.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Umbralisib?

E hooki wale i ka lawe ʻana iā umbralisib ke haʻi aku kāu kauka iā ʻoe. ʻOiai inā ʻoe e manaʻo maikaʻi ana, e hana ana paha ka lāʻau lapaʻau e kāohi i kāu maʻi maʻi ma nā ala ʻaʻole hiki iā ʻoe ke manaʻo.

E hoʻohana kāu kauka i nā hoʻokolohua koko a me nā scans e hoʻoholo ai i ka wā e palekana ai ke hooki i ka lāʻau. Hoʻokumu ʻia kēia hoʻoholo i ka maikaʻi o ka pane ʻana o ka maʻi maʻi a inā paha e ʻike nei ʻoe i nā hopena ʻaoʻao hiki ke mālama ʻia.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Umbralisib?

ʻOi aku ka maikaʻi e pale i ka waiʻona a i ʻole e kaupalena nui iā ia i ka wā e lawe ana iā umbralisib. Hiki i ka waiʻona ke hoʻonui i kou pilikia o nā pilikia o ke ake a hiki ke hoʻonui i nā hopena ʻaoʻao e like me ka nausea a me ka luhi.

Inā koho ʻoe e inu i kekahi manawa, e kamaʻilio me kāu kauka e pili ana i nā palena palekana no kou kūlana. Hiki iā lākou ke aʻo iā ʻoe e pili ana i kou olakino holoʻokoʻa a pehea ʻoe e pane nei i ka lāʻau.