He aha ka Ustekinumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ka Ustekinumab e kōkua ana i ka hoʻomaha ʻana i kahi ʻōnaehana pale i hana nui ʻia. No ka papa o nā lāʻau i kapa ʻia ʻo biologics, i hana ʻia mai nā cell ola a hana ma ka hoʻopaʻa ʻana i nā protein kikoʻī e hoʻoulu ai i ka mumū i loko o kou kino.

He mea maikaʻi loa kēia lāʻau lapaʻau no ka poʻe me nā maʻi autoimmune kahi e hoʻouka hewa ai ka ʻōnaehana pale i nā ʻiʻo olakino. E noʻonoʻo iā ia he lāʻau i manaʻo ʻia e kōkua ana i ka hoʻihoʻi ʻana i ke kaulike i kāu pane pale ma mua o ka hoʻopaʻa ʻana i kāu ʻōnaehana pale holoʻokoʻa.

No ke aha e hoʻohana ʻia ai ka Ustekinumab?

Hoʻomaʻamaʻa ka Ustekinumab i kekahi mau maʻi autoimmune kahi e pāʻani ai ka mumū i kahi hana nui. Hiki i kāu kauka ke kauoha iā ia i ka wā i hāʻawi ʻole ai nā lāʻau lapaʻau ʻē aʻe i ka hoʻomaha lawa a i ʻole ke pono ʻoe i kahi ala i manaʻo ʻia e mālama i kou maʻi.

Ua ʻae ʻia ka lāʻau lapaʻau e ka FDA no ka mālama ʻana i ka psoriasis plaque maʻalahi a koʻikoʻi, kahi maʻi ʻili e hoʻoulu ai i nā pā i hāpai ʻia a me ka unahi. Hoʻohana ʻia nō hoʻi no ka psoriatic arthritis, e pili ana i kou ʻili a me nā hono, e hoʻoulu ana i ka ʻeha a me ka ʻoʻoleʻo.

Eia kekahi, kōkua ka ustekinumab i ka mālama ʻana i ka maʻi o Crohn a me ka ulcerative colitis, ʻelua ʻano o ka maʻi ʻōpū inflammatory e hoʻoulu ai i ka mumū mau i loko o kāu ʻōpū digestive. Hiki i kēia mau maʻi ke hoʻopilikia nui i kou maikaʻi o ke ola, a hāʻawi ka ustekinumab i ka manaʻolana no ka mālama ʻana i nā hōʻailona maikaʻi.

Pehea ka hana ʻana o ka Ustekinumab?

Hana ka Ustekinumab ma ka pale ʻana i nā protein kikoʻī i kapa ʻia ʻo interleukin-12 a me interleukin-23, he mau mea nui i ka hoʻoulu ʻana i ka mumū. Kōkua maʻamau kēia mau protein i kāu ʻōnaehana pale e hakakā i nā maʻi, akā i nā maʻi autoimmune, lilo lākou i mea hana nui a hoʻoulu i ka mumū ʻino.

Ma ka pale ʻana i kēia mau protein, kōkua ʻo ustekinumab i ka hōʻemi ʻana i ka pane mumū e alakaʻi ana i nā hōʻailona e like me nā pā ʻili, ka ʻeha hui, a me ka mumū o ka ʻōpū. ʻO kēia ala i manaʻo ʻia he lāʻau ikaika ia e hiki ke hāʻawi i ke kōkua nui no nā poʻe he nui.

ʻAʻole hoʻōla ka lāʻau i kēia mau maʻi, akā hiki iā ia ke kōkua i ka mālama ʻana i nā hōʻailona a me ka hoʻolohi ʻana i ka holomua o ka maʻi. Nui ka poʻe e ʻike i ka hoʻomaikaʻi ʻana i kā lākou mau hōʻailona i loko o 12 a 16 mau pule o ka hoʻomaka ʻana i ka lāʻau.

Pehea wau e lawe ai iā Ustekinumab?

Hāʻawi ʻia ʻo Ustekinumab ma ke ʻano he injection, ma lalo o kou ʻili (subcutaneous) a i ʻole i loko o ke aʻa (intravenous). E hoʻoholo kāu kauka i ke ʻano maikaʻi loa no ʻoe e pili ana i kou kūlana kikoʻī a me nā pahuhopu lapaʻau.

No nā injections subcutaneous, e loaʻa iā ʻoe ka lāʻau i kēlā me kēia 8 a 12 pule ma hope o ka hoʻomaka ʻana. E aʻo kāu mea mālama ola iā ʻoe pehea e hāʻawi ai iā ʻoe iho i kēia mau injections ma ka home, a i ʻole e lawelawe ʻia lākou i kahi hoʻonohonoho lapaʻau.

Hāʻawi ʻia nā infusions intravenous i loko o kahi hale mālama ola a lawe ma kahi o hoʻokahi hola e hoʻopau ai. Aia ke alapine i kou kūlana, akā maʻamau ia i kēlā me kēia 8 pule ma hope o nā lāʻau mua.

Hiki iā ʻoe ke lawe iā ustekinumab me ka ʻole o ka meaʻai, no ka mea, ʻaʻole ia e pili i ka maikaʻi o ka hana ʻana o ka lāʻau. Eia naʻe, he mea nui e mālama i nā wahi injection maʻemaʻe a hoʻololi iā lākou e pale i ka huhū.

Pehea ka lōʻihi e lawe ai au iā Ustekinumab?

ʻO Ustekinumab ka mea maʻamau he lāʻau lōʻihi, a pono ka hapa nui o ka poʻe e hoʻomau i ka lawe ʻana iā ia no ka manawa pau ʻole e mālama i ka mana hōʻailona. E nānā kāu kauka i kāu pane ʻana i ka lāʻau a hiki ke hoʻololi i kāu hoʻolālā lapaʻau i ka manawa.

Hiki iā ʻoe ke hoʻomaka e ʻike i nā hoʻomaikaʻi i loko o 4 a 6 mau pule, akā ʻo nā pōmaikaʻi piha e lawe pinepine i 12 a 16 mau pule e lilo i mea maopopo. ʻIke kekahi poʻe i ka hoʻomaikaʻi hou ʻana ma hope o kekahi mau mahina o ka lāʻau.

E loiloi mau kāu kauka inā e hana pono ana ka lāʻau lapaʻau iā ʻoe. Inā ʻaʻole ʻoe e ʻike i ka hoʻomaikaʻi kūpono ma hope o 16 mau pule, hiki iā lākou ke noʻonoʻo e hoʻoponopono i kāu mahele lāʻau a i ʻole e ʻimi i nā lāʻau lapaʻau ʻē aʻe.

He aha nā hopena ʻaoʻao o Ustekinumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka ustekinumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e manaʻoʻiʻo e pili ana i kāu lapaʻau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia:

• Nā maʻi o ka ʻōnaehana hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā ʻeha poʻo i ka maʻamau he maʻalahi a i ʻole kaulike
• Luhi a i ʻole ka manaʻo e luhi pinepine ana ma mua o ka maʻamau
• Nā hopena ma ka pūnaewele injection e like me ka ʻulaʻula, ka pehu, a i ʻole ka ʻeha maʻalahi
• Nausea a i ʻole ka ʻōpū maʻalahi
• ʻEha hope a i ʻole nā ʻeha ʻiʻo

ʻO kēia mau hopena ʻaoʻao maʻamau ka mea hiki ke mālama ʻia a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

Hiki ke hana ʻia nā hopena ʻaoʻao koʻikoʻi, ʻoiai ʻaʻole maʻamau lākou. Pono kēia i ka lāʻau lapaʻau koke a komo pū:

• Nā hōʻailona o nā maʻi koʻikoʻi e like me ke kuni, ke anu, a i ʻole ka ʻūlū mau
• Nā loli maʻamau i kou ʻili, e like me nā ulu hou a i ʻole nā loli i nā mole e kū nei
• Nā hopena maʻi maʻi koʻikoʻi me ka pilikia o ka hanu a i ʻole ka pehu ʻana o kou maka
• Nā hōʻailona o ka mumū o ka maʻi ʻōpū inā loaʻa iā ʻoe ka maʻi o Crohn
• Nā hōʻailona neurological e like me ka huikau, nā loli ʻike, a i ʻole nā ʻeha poʻo koʻikoʻi

ʻO nā hopena ʻaoʻao laha akā koʻikoʻi e komo pū ana me ka piʻi ʻana o ka pilikia o kekahi mau maʻi maʻi a me nā maʻi koʻikoʻi. E nānā pono kāu kauka iā ʻoe no kēia mau pilikia hiki ke hana ma o nā loiloi maʻamau a me nā hoʻokolohua koko.

ʻO wai ka mea pono ʻole e lawe i ka Ustekinumab?

ʻAʻole kūpono ʻo Ustekinumab no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. ʻO kekahi mau maʻi a me nā kūlana olakino e hana i kēia lāʻau lapaʻau kūpono ʻole a i ʻole e koi i ka nānā kūikawā.

ʻAʻole pono ʻoe e lawe i ka ustekinumab inā loaʻa iā ʻoe kahi maʻi maʻi, ʻoiai nā maʻi koʻikoʻi e like me ka maʻi tuberculosis a i ʻole hepatitis B. E hoʻāʻo kāu kauka i kēia mau maʻi ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Pono ka poʻe me ka mōʻaukala o ka maʻi kanesa, ʻo ia hoʻi ka lymphoma a i ʻole ka maʻi ʻili, i ka loiloi pono ʻana ma mua o ka hoʻohana ʻana i ka ustekinumab. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hiki o kāu ʻōnaehana pale e ʻike a hakakā i nā cell cancer.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kāu kauka. ʻOiai hiki ke hoʻohana ʻia ka ustekinumab i ka wā hāpai i kekahi mau kūlana, pono ia i ka nānā pono ʻana.

ʻO ka poʻe me ka maʻi ate a i ʻole ka maʻi kīkī koʻikoʻi e pono paha i nā hoʻoponopono ʻana i ka lāʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe. E noʻonoʻo kāu kauka i kou kūlana olakino holoʻokoʻa i ka wā e hoʻoholo ai inā kūpono ka ustekinumab iā ʻoe.

Nā inoa inoa o Ustekinumab

Loaʻa ka Ustekinumab ma lalo o ka inoa inoa Stelara, i hana ʻia e Janssen Biotech. ʻO kēia ke ʻano i kauoha pinepine ʻia o ka lāʻau lapaʻau.

ʻO ka mana biosimilar, ustekinumab-auub, ua kūʻai ʻia ma lalo o ka inoa inoa Wezlana. Ua like loa nā Biosimilars me ka lāʻau lapaʻau kumu akā loaʻa paha nā ʻokoʻa liʻiliʻi i nā mea hana ʻole.

Hana like nā mana ʻelua a loaʻa nā ʻano like a me nā palekana. E kōkua kāu kauka a me ka mea hoʻolako ʻinikua e hoʻoholo i ke koho maikaʻi loa no kāu kūlana.

Nā koho ʻē aʻe o Ustekinumab

Loaʻa kekahi mau lāʻau lapaʻau ʻē aʻe inā ʻaʻole kūpono ka ustekinumab iā ʻoe a i ʻole ʻaʻole e hāʻawi i ka mana o nā hōʻailona. Hana kēia mau koho ʻē aʻe ma o nā ʻano hana like ʻole akā e kuhikuhi i nā ala inflammatory like.

ʻO nā lāʻau lapaʻau olaola ʻē aʻe e komo pū ana me adalimumab (Humira), infliximab (Remicade), a me secukinumab (Cosentyx). He mau pōmaikaʻi a me nā hopena ʻaoʻao paha ko kēlā me kēia, a e kōkua kāu kauka iā ʻoe e koho i ke koho kūpono loa.

ʻO nā koho ʻē aʻe ʻaʻole olaola e komo pū ana me methotrexate, sulfasalazine, a me nā lāʻau lapaʻau topical like ʻole no nā maʻi ʻili. Hana ʻokoʻa kēia mau lāʻau lapaʻau a hiki ke hui pū ʻia me nā lāʻau olaola no ka hoʻomaikaʻi ʻana i ka pono.

E noʻonoʻo kāu kauka i nā mea e like me kou maʻi kikoʻī, nā pane lapaʻau mua, a me ke olakino holoʻokoʻa i ka wā e ʻōlelo ai i nā koho ʻē aʻe. I kekahi manawa, ʻo ka hoʻāʻo ʻana i nā lāʻau lapaʻau like ʻole e kōkua i ka loaʻa ʻana o ka lāʻau lapaʻau maikaʻi loa no kāu mau pono pilikino.

Ua ʻoi aku ka maikaʻi o Ustekinumab ma mua o Adalimumab?

He mau lāʻau lapaʻau olaola maikaʻi ʻo Ustekinumab a me adalimumab, akā hana lākou ma nā ʻano hana like ʻole a ʻoi aku paha ka maikaʻi no nā kānaka like ʻole. ʻAʻole ʻoi aku kekahi ma mua o kekahi.

Pale ʻo Ustekinumab i ka interleukin-12 a me ka interleukin-23, ʻoiai ʻo adalimumab e kuhikuhi ana i ka tumor necrosis factor-alpha. ʻO kēia ʻokoʻa ke manaʻo e hana maikaʻi lākou no nā ʻano mumū like ʻole a i ʻole i nā kānaka i pane ʻole i kekahi a i ʻole kekahi.

Hāʻawi pinepine ʻia ʻo Ustekinumab ma mua o adalimumab, a he mea maʻalahi kekahi poʻe. Eia naʻe, ua loaʻa ʻo adalimumab no ka lōʻihi a he nui nā ʻikepili palekana lōʻihi.

E noʻonoʻo kāu kauka i kou maʻi kikoʻī, nā pane lapaʻau mua, a me nā makemake pilikino i ke koho ʻana ma waena o kēia mau lāʻau lapaʻau. I kekahi manawa, hoʻololi ka poʻe mai kekahi i kekahi inā ʻaʻole lākou e loaʻa ka mana o nā hōʻailona.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Ustekinumab

He palekana anei ʻo Ustekinumab no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana maʻamau ʻia ʻo Ustekinumab i ka poʻe me ka maʻi diabetes, akā pono e nānā pono. ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kō koko, akā hiki i nā maʻi ke paʻakikī i ka mālama ʻana i ka maʻi diabetes.

Mai ka mea e pili ana ʻo ustekinumab i kou ʻōnaehana pale, aia paha ʻoe i ka pilikia nui no nā maʻi, hiki ke hoʻopilikia i ka mālama ʻana i ka maʻi diabetes. E nānā pono kāu kauka iā ʻoe a e ʻōlelo paha i nā nānā ʻana i ke kō koko.

He mea nui e mālama i ka mālama maikaʻi ʻana i ka maʻi diabetes i ka wā e lawe ana i ka ustekinumab, no ka mea, kōkua kēia i ka hōʻemi ʻana i kou pilikia maʻi. E mālama i kāu mālama maʻi diabetes maʻamau a e hoʻomaopopo i kāu kauka i nā hōʻailona e pili ana.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Ustekinumab?

Inā hoʻokomo hewa ʻoe i ka nui o ka ustekinumab, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole e kelepona i kahi kikowaena mana ʻawa. ʻOiai he kakaikahi nā overdoses me kēia lāʻau lapaʻau, he mea nui e kiʻi i ka ʻōlelo aʻo lapaʻau ʻoihana.

Mai ho'āʻo e

Pono ʻoe e hooki i ka lawe ʻana i ka ustekinumab ma lalo o ke alakaʻi a kāu kauka, no ka mea, ʻo ka hooki ʻana i ka lāʻau lapaʻau hiki ke alakaʻi i ka piʻi ʻana o nā hōʻailona. Pono ka hapa nui o nā kānaka e hoʻomau i ka lāʻau lapaʻau no ka wā lōʻihi e mālama i ka mana o nā hōʻailona.

Hiki i kāu kauka ke noʻonoʻo e hooki i ka lāʻau lapaʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, inā ʻaʻole ia e hana hou, a i ʻole inā komo kou maʻi i ka remission lōʻihi. Pono e hana mau ʻia kēia hoʻoholo me kāu hui mālama ola.

Inā hooki ʻoe i ka lawe ʻana i ka ustekinumab, e nānā pono kāu kauka iā ʻoe no ka hoʻi ʻana mai o nā hōʻailona a hiki ke ʻōlelo aku i nā lāʻau lapaʻau ʻē aʻe e mālama i kou olakino a me ka maikaʻi o ke ola.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana i ka Ustekinumab?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana i ka ustekinumab, akā he mea nui ka manawa a me ke ʻano o ka lāʻau lapaʻau. E hana kāu kauka i kahi hoʻolālā lāʻau lapaʻau e hana pū me kāu papa hana lapaʻau.

Pono e pale ʻia nā lāʻau lapaʻau ola e like me ka MMR a i ʻole nā lāʻau lapaʻau varicella i ka wā e lawe ana i ka ustekinumab, no ka mea, hiki iā lākou ke hoʻoulu i nā maʻi. He palekana a paipai ʻia nā lāʻau lapaʻau ʻole e like me ka pana flu.

ʻOi aku ka maikaʻi e hoʻopau i nā lāʻau lapaʻau pono ma mua o ka hoʻomaka ʻana i ka ustekinumab ke hiki. Inā pono ʻoe i nā lāʻau lapaʻau i ka wā o ka lāʻau lapaʻau, e kūkākūkā i ka manawa me kāu kauka e hōʻoia i ka pale a me ka palekana.