He aha ka Ustekinumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Ustekinumab e kōkua ana i ka hoʻomaha ʻana i kāu ʻōnaehana pale ke hana nui. Ua hoʻolālā ʻia e mālama i kekahi mau maʻi autoimmune kahi e hoʻouka hewa ai ka ʻōnaehana pale o kou kino i nā ʻiʻo olakino, e hoʻoulu ana i ka mumū a me nā hōʻailona hōʻoluʻolu ʻole.

No ka papa o nā biologics kēia lāʻau lapaʻau, i hana ʻia mai nā cell ola ma mua o nā kemika. E noʻonoʻo i ka ustekinumab ma ke ʻano he lāʻau lapaʻau i manaʻo ʻia e ālai i nā protein kikoʻī i loko o kāu ʻōnaehana pale e hoʻoulu ai i ka mumū, e kōkua ana i ka hoʻihoʻi ʻana i ke kaulike i nā hana maoli o kou kino.

No ke aha e hoʻohana ʻia ai ka Ustekinumab?

Hoʻomaʻamaʻa ʻo Ustekinumab i kekahi mau maʻi autoimmune kahi e hoʻoulu ai kāu ʻōnaehana pale i ka mumū i nā ʻāpana like ʻole o kou kino. Hiki i kāu kauka ke kuhikuhi iā ia ke hāʻawi ʻole nā lāʻau lapaʻau ʻē aʻe i ka hōʻoluʻolu lawa a i ʻole ke pono ʻoe i ka lāʻau lapaʻau i manaʻo ʻia.

Ua ʻae ʻia ka lāʻau lapaʻau e ka FDA no ka mālama ʻana i ka psoriasis plaque maʻalahi a koʻikoʻi, kahi maʻi ʻili e hoʻoulu ai i nā pā mānoanoa a me ka unahi. Hoʻohana ʻia nō hoʻi no ka psoriatic arthritis, e pili ana i kou ʻili a me nā hono, e hoʻoulu ana i ka ʻeha a me ka ʻoʻoleʻo.

Eia kekahi, kōkua ʻo ustekinumab i ka mālama ʻana i ka maʻi o Crohn a me ka ulcerative colitis, ʻelua ʻano o ka maʻi ʻāʻī ʻōpū e hoʻoulu ai i ka mumū o ka ʻōpū. Hiki i kēia mau maʻi ke hoʻopilikia nui i kou ola i kēlā me kēia lā, a hāʻawi ʻo ustekinumab i ka manaʻolana no ka mālama ʻana i nā hōʻailona maikaʻi.

I kekahi mau hihia, kuhikuhi nā kauka i ka ustekinumab no nā maʻi ʻāʻī ʻē aʻe ke hana ʻole nā lāʻau lapaʻau maʻamau. E hoʻoholo kāu mea mālama ola inā kūpono kēia lāʻau lapaʻau no kāu kūlana.

Pehea e hana ai ka Ustekinumab?

Hana ʻo Ustekinumab ma ka ālai ʻana i ʻelua protein kikoʻī i loko o kāu ʻōnaehana pale i kapa ʻia ʻo interleukin-12 a me interleukin-23. Kōkua maʻamau kēia mau protein i ka hoʻonohonoho ʻana i kāu pane pale, akā i nā maʻi autoimmune, hiki iā lākou ke hoʻoulu i ka mumū nui.

Ma ka pale ʻana i kēia mau protein, kōkua ka ustekinumab i ka hōʻemi ʻana i nā hōʻailona mumū e hoʻoulu ai i kou mau hōʻailona. Hāʻawi kēia hana i kāu ʻōnaehana pale e hana maʻamau a pale nō hoʻi iā ʻoe mai nā maʻi a me nā mea hoʻoweliweli ʻē aʻe.

Ua manaʻo ʻia ka lāʻau lapaʻau he lāʻau ikaika, i manaʻo ʻia, ʻoi aku ka pololei ma mua o nā lāʻau immunosuppressive kahiko. Hoʻopā pololei ia i nā ala e pili ana i kou maʻi ma mua o ka hoʻopau ʻana i kāu ʻōnaehana pale.

ʻAʻole maʻamau ka hopena i ka pō. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā hoʻomaikaʻi ʻana i loko o 4 a 12 mau pule o ka hoʻomaka ʻana i ka lāʻau lapaʻau, me ka hoʻomau ʻana o ka hoʻomaikaʻi ʻana i nā mahina he nui i ka wā e kūkulu ai ka lāʻau lapaʻau i loko o kou ʻōnaehana.

Pehea e lawe ai au i ka Ustekinumab?

Hāʻawi ʻia ka Ustekinumab ma ke ʻano he injection ma lalo o kou ʻili, e like me ke ʻano o ka poʻe me ka maʻi diabetes e hāʻawi iā lākou iho i nā pana insulin. E aʻo kāu mea mālama ola iā ʻoe i ke ʻano o ka injection kūpono a i ʻole e hoʻonohonoho i kahi loea mālama ola e lawelawe ai.

Hele mai ka lāʻau lapaʻau i nā syringes i hoʻopiha mua ʻia a i ʻole nā mea hoʻopili auto e maʻalahi ai ke kaʻina hana. E hoʻokomo maʻamau ʻoe iā ia i loko o kou ʻūhā, lima luna, a i ʻole ka ʻōpū, e hoʻololi ana i nā wahi injection e pale ai i ka huhū o ka ʻili.

ʻAʻole pono ʻoe e lawe i ka ustekinumab me ka meaʻai a i ʻole e pale i ka ʻai ʻana ma mua o kāu injection. Eia naʻe, e hōʻoia e mālama i ka lāʻau lapaʻau i loko o kāu pahu hau a e ʻae iā ia e hiki i ka mahana o ka lumi ma mua o ka hoʻokomo ʻana, e lawe ana ma kahi o 15 a 30 mau minuke.

E mālama i ka papa hana injection a kaha iā ia ma ka kalena. Hiki i nā mea i hala ke hoʻopilikia i ka maikaʻi o ka lāʻau lapaʻau, no laila he mea nui ka kūlike no nā hopena maikaʻi loa.

Pehea ka lōʻihi e lawe ai au i ka Ustekinumab?

ʻO ka Ustekinumab ka mea maʻamau he lāʻau lapaʻau lōʻihi e hoʻomau ai ʻoe i ka wā e kōkua ana i kou maʻi a ke ʻae maikaʻi nei ʻoe. Pono ka hapa nui o nā kānaka i ka lāʻau lapaʻau e mālama i kā lākou hoʻomaikaʻi a pale i nā hōʻailona mai ka hoʻi ʻana.

E nānā mau kāu kauka i kāu pane, maʻamau i kēlā me kēia mau mahina i ka wā mua, a laila ʻaʻole pinepine ke paʻa kou maʻi. E loiloi lākou inā e hana pono ana ka lāʻau a inā e ʻike ana ʻoe i nā hopena ʻaoʻao e hopohopo ai.

Hiki i kekahi poʻe ke hōʻemi i kā lākou alapine ʻana i ka lāʻau a i ʻole e hoʻomaha mai ka lāʻau inā e loaʻa iā lākou ka hoʻōki mau. Eia naʻe, ʻo ka hoʻōki ʻana i ka lāʻau e alakaʻi pinepine i ka hoʻi ʻana mai o nā hōʻailona, no laila pono e kūkākūkā pono ʻia nā loli me kāu mea mālama ola.

Aia ka hoʻoholo e pili ana i ka lōʻihi o ka lāʻau i kāu maʻi kikoʻī, pehea ka maikaʻi o kāu pane ʻana, a me kou kūlana olakino holoʻokoʻa. E hana pū kāu kauka me ʻoe e ʻimi i ke kaulike kūpono ma waena o ka mālama ʻana i nā hōʻailona a me ka hōʻemi ʻana i nā pilikia lōʻihi.

He aha nā hopena ʻaoʻao o Ustekinumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka ustekinumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia nā hopena maʻalahi ma ke kahua injection, e like me ka ʻulaʻula, ka pehu, a i ʻole ke aloha. Hoʻoponopono maʻamau kēia mau mea i loko o hoʻokahi a ʻelua paha lā a ʻaʻole ʻike ʻia i ka wā e hoʻoponopono ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e pili ana i kou kino holoʻokoʻa:

• Nā maʻi o ka ʻōnaehana hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā poʻo e maʻamau ka maʻalahi a i ka waena
• ʻO ka luhi a i ʻole ka manaʻo e luhi pinepine ma mua o ka maʻamau
• ʻO ka nausea maʻalahi a i ʻole ka ʻoluʻolu o ka ʻōpū
• ʻO nā ʻeha ʻiʻo a i ʻole nā hui
• Ka maʻi maʻi a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao maʻamau a hoʻomaikaʻi pinepine i ka wā e hoʻoponopono ai kou kino i ka lāʻau. ʻIke ka hapa nui o ka poʻe hiki iā lākou ke hoʻomau i kā lākou hana maʻamau i ka wā e lawe ana i ka ustekinumab.

Akā, aia kekahi mau hopena ʻaoʻao koʻikoʻi e pono ai ke kōkua lapaʻau koke, ʻoiai ʻaʻole maʻamau. No ka mea e pili ana ka ustekinumab i kāu ʻōnaehana pale, e ʻoi aku paha ʻoe i nā maʻi.

Eia nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi e nānā ai:

• Nā maʻi koʻikoʻi ʻaʻole e pane i ka mālama maʻamau
• Nā hōʻailona o ka maʻi tuberculosis e like me ka ʻū mau, ke kuni, a i ʻole nā ​​sweats pō
• Nā loli ʻili ʻokoʻa a i ʻole nā ​​ulu hou
• Nā hopena maʻi koʻikoʻi me ka pilikia o ka hanu a i ʻole ka pehu
• Ke kuni mau a i ʻole nā ​​hōʻailona e like me ka maʻi flu
• Ke kahe koko ʻokoʻa a i ʻole ka ʻeha

Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona koʻikoʻi, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole e ʻimi i ka mālama ulia pōpilikia. Hiki i ka ʻike mua a me ka mālama ʻana i kēia mau pilikia kakaʻikahi ke pale i nā pilikia koʻikoʻi.

ʻO wai ka mea ʻaʻole pono e lawe i ka Ustekinumab?

ʻAʻole kūpono ka Ustekinumab no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻO kekahi mau kūlana a i ʻole nā ​​kūlana e lilo ai kēia lāʻau lapaʻau i mea pilikia a i ʻole ka liʻiliʻi.

ʻAʻole pono ʻoe e lawe i ka ustekinumab inā loaʻa iā ʻoe kahi maʻi koʻikoʻi ʻaʻole i mālama pono ʻia. Aia kēia i nā maʻi bacteria, viral, a i ʻole fungal e hiki ke lilo i mea koʻikoʻi ke hoʻololi ʻia kāu ʻōnaehana pale.

Pono ka poʻe me ka mōʻaukala o ka maʻi tuberculosis i ka loiloi kūikawā ma mua o ka hoʻomaka ʻana i ka ustekinumab. E hoʻāʻo kāu kauka no ka tuberculosis ikaika a me ka latent, no ka mea, hiki i kēia lāʻau lapaʻau ke hoʻonui i ka pilikia o ka hoʻāla hou ʻana o ka tuberculosis.

Eia nā kūlana ʻē aʻe e hiki ai i ka ustekinumab ke kūpono ʻole iā ʻoe:

• Ka mālama ʻana i ka maʻi maʻi i kēia manawa a i ʻole i ka wā i hala (i loko o nā makahiki 5 i hala)
• Nā lāʻau lapaʻau ola i loaʻa i loko o ka mahina i hala
• ʻIke ʻia ka maʻi maʻi i ka ustekinumab a i ʻole kona mau mea
• Maʻi hepatitis B a i ʻole C ikaika
• Maʻi kīkī a i ʻole ate nui
• Hāpai a i ʻole ka hānai ʻana i ka waiū (e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kāu kauka)

E noʻonoʻo pū ana kāu mea mālama ola i kou makahiki, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me kou kūlana olakino holoʻokoʻa. Hiki iā lākou ke ʻōlelo aku i ka nānā ʻana hou a i ʻole nā lāʻau lapaʻau ʻē aʻe inā he nui loa nā pilikia o ka ustekinumab no kou kūlana.

Nā inoa inoa o Ustekinumab

Kūʻai ʻia ʻo Ustekinumab ma lalo o ka inoa inoa ʻo Stelara ma ʻAmelika Hui Pū ʻIa a me ka hapa nui o nā ʻāina ʻē aʻe. ʻO kēia ka inoa inoa mua i hoʻomohala ʻia e Janssen Pharmaceuticals a ʻo ia wale nō ka mana i loaʻa i kēia manawa.

ʻAʻole like me kekahi mau lāʻau lapaʻau i loaʻa nā inoa inoa he nui a i ʻole nā mana generic, loaʻa wale nō ka ustekinumab ma ke ʻano he Stelara. He paʻakikī ka hana ʻana i kēia lāʻau lapaʻau biologic, no laila ʻaʻole i loaʻa nā mana generic.

Ke loaʻa iā ʻoe kāu kauoha, e ʻike ʻoe iā "Stelara" ma ka ʻeke a me nā palapala. Loaʻa ka lāʻau lapaʻau i nā ikaika like ʻole e pili ana i kou kūlana a me ka nui i kauoha ʻia.

E hōʻoia mau me kāu lāʻau lapaʻau e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono a me ka ikaika. Pono e hōʻike maopopo ka ʻeke i ka "Stelara" a me ka "ustekinumab" e hōʻoia i ka loaʻa ʻana o ka huahana kūpono.

Nā koho ʻē aʻe o Ustekinumab

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i nā kūlana like me ka ustekinumab, ʻoiai ʻo ke koho maikaʻi loa e pili ana i kāu maʻi kikoʻī a me nā kūlana pilikino. Hiki i kāu kauka ke noʻonoʻo i nā koho ʻē aʻe inā ʻaʻole kūpono a maikaʻi paha ka ustekinumab iā ʻoe.

No ka psoriasis a me ka psoriatic arthritis, nā lāʻau lapaʻau biologic ʻē aʻe e komo pū ana me adalimumab (Humira), etanercept (Enbrel), a me secukinumab (Cosentyx). Hana kēia mau mea ma nā ʻano hana like ʻole akā hiki ke like ka maikaʻi no nā kānaka he nui.

Inā loaʻa iā ʻoe ka maʻi ʻōpū mumū, hiki i nā koho ʻē aʻe ke komo i ka infliximab (Remicade), adalimumab (Humira), a i ʻole vedolizumab (Entyvio). Hoʻopā kēlā me kēia i nā ʻano like ʻole o ke kaʻina mumū.

Loaʻa nō hoʻi nā koho non-biologic, me nā lāʻau immunosuppressive kuʻuna e like me methotrexate, azathioprine, a i ʻole corticosteroids. Hiki ke noʻonoʻo ʻia kēia mau mea inā ʻaʻole kūpono nā biologics a i ʻole ma ke ʻano he lāʻau hui.

E kōkua kāu mea mālama ola iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia o nā koho lapaʻau like ʻole e pili ana i ke koʻikoʻi o kou maʻi, ka mōʻaukala olakino, a me nā makemake pilikino.

Ua ʻoi aku ka maikaʻi o Ustekinumab ma mua o Humira?

He mau lāʻau biologic maikaʻi ʻo Ustekinumab (Stelara) a me adalimumab (Humira), akā hana lākou ma o nā ʻano hana like ʻole a ʻoi aku ka maikaʻi no nā kānaka like ʻole. Hōʻike nā hoʻohālikelike pololei e hiki ke maikaʻi loa nā mea ʻelua no ka mālama ʻana i nā maʻi autoimmune.

Hoʻopā ʻo Ustekinumab i nā protein kikoʻī (IL-12 a me IL-23) i pili i ka mumū, ʻoiai ʻo Humira e ālai i ka tumor necrosis factor (TNF), kahi protein mumū ʻē aʻe. ʻO kēia ʻokoʻa ke manaʻo e hana maikaʻi lākou no nā kānaka like ʻole e pili ana i kā lākou mau ala mumū kikoʻī.

ʻO kekahi mea maikaʻi o ustekinumab ʻo kāna papa hana dosing. Lawe ka hapa nui o nā kānaka i kēlā me kēia 8 a 12 pule ma hope o nā doses mua, ʻoiai ʻo Humira e koi pinepine i nā injections i kēlā me kēia pule ʻelua. Hiki i kēia dosing liʻiliʻi ke ʻoluʻolu no nā maʻi he nui.

Eia naʻe, ua loaʻa ʻo Humira no ka lōʻihi a loaʻa nā ʻikepili noiʻi nui. Hiki i kekahi poʻe ke pane maikaʻi i kekahi lāʻau ma luna o kekahi, a pono kekahi manawa e hoʻololi ma waena o lākou e ʻimi i ka lāʻau lapaʻau maikaʻi loa.

E noʻonoʻo kāu kauka i kāu maʻi kikoʻī, ka mōʻaukala lapaʻau, a me nā mea pilikino i ka wā e ʻōlelo ai i ka lāʻau lapaʻau e hana maikaʻi loa iā ʻoe. ʻAʻole ʻoi aku ka maikaʻi o kekahi ma mua o kekahi.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Ustekinumab

He Palekana ʻo Ustekinumab no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana palekana ʻia ʻo Ustekinumab i ka poʻe me ka maʻi diabetes, akā e nānā pono kāu kauka iā ʻoe. ʻAʻole e pale ʻakomi ka maʻi diabetes iā ʻoe mai ka lawe ʻana i kēia lāʻau, akā pono ia i ka nānā hou ʻana e pale i nā pilikia.

Hiki i ka poʻe me ka maʻi diabetes ke loaʻa i kahi pilikia liʻiliʻi o nā maʻi, a no ka mea hiki i ka ustekinumab ke hoʻonui i ka pilikia o ka maʻi, e makaʻala loa kāu mea mālama ola e nānā i nā hōʻailona o ka maʻi. Hiki iā lākou ke ʻōlelo aku i nā loiloi pinepine a i ʻole nā hoʻokolohua koko.

He mea nui ka mālama ʻana i ke kō koko i ka wā e lawe ana i ka ustekinumab. ʻO ka maʻi diabetes i mālama maikaʻi ʻia e hōʻike ana i nā pilikia liʻiliʻi ma mua o ka maʻi diabetes i mālama ʻole ʻia, no laila e hana pū kāu kauka me ʻoe e hoʻomaikaʻi i kāu pae kō koko ma mua o ka hoʻomaka ʻana i ka lāʻau.

Inā loaʻa iā ʻoe ka maʻi diabetes, e hōʻoia e haʻi i kāu mea mālama ola e pili ana i kāu pae kō koko, nā maʻi i hala koke aku nei, a me ka maikaʻi o ka mālama ʻia ʻana o kāu maʻi diabetes. Kōkua kēia ʻike iā lākou e hana i nā hoʻoholo lapaʻau maikaʻi loa no kou kūlana.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Ustekinumab?

Inā ʻoe e hoʻokomo hewa i ka nui o ka ustekinumab ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola, ʻoiai inā maikaʻi ʻoe. ʻOiai he kakaikahi nā hopena nui o ka overdose, pono nā poʻe loea lapaʻau e nānā iā ʻoe no nā pilikia hiki ke loaʻa.

Mai hoʻāʻo e

I ka hapanui o nā hihia, ʻaʻole i hana nā overdoses ulia i nā pilikia koʻikoʻi koke, akā hiki ke ʻōlelo ʻia ka nānā ʻana i nā hopena ʻaoʻao a i ʻole nā maʻi. Na kāu mea mālama ola e alakaʻi iā ʻoe ma nā hana e pono ai.

He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Ustekinumab?

Inā ua hala ʻoe i kahi mahele i hoʻonohonoho ʻia o ustekinumab, e lawe koke iā ia ke hoʻomanaʻo ʻoe, a laila e hoʻi i kāu papa hana maʻamau. Mai kali a hiki i kāu mahele i hoʻonohonoho ʻia e hiki mai ana inā he mau lā wale nō ʻoe i hala.

E hoʻokaʻaʻike i ke keʻena o kāu mea mālama ola e kūkākūkā i ka mahele i hala a loaʻa ke alakaʻi i ka manawa e lawe ai i kāu injection e hiki mai ana. Hiki iā lākou ke hoʻoponopono iki i kāu papa hana e mālama i ka manawa kūpono ma waena o nā mahele.

Mai pāpālua i nā mahele a i ʻole e lawe i ʻelua injections kokoke i kekahi i kekahi e

Pono e hoʻoholo ʻia ka hoʻōki ʻana i ka ustekinumab ma muli o ka loiloi pono ʻana i kou kūlana i kēia manawa, ka pane ʻana i ka lāʻau lapaʻau, a me ke olakino holoʻokoʻa. E kōkua kāu mea mālama ola iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia o ka hoʻomau ʻana i ka lāʻau lapaʻau.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana i ka Ustekinumab?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana i ka ustekinumab, akā pono ʻoe e pale i nā lāʻau lapaʻau ola i ka wā o ka lāʻau lapaʻau. E kōkua kāu mea mālama ola iā ʻoe e hoʻolālā i nā lāʻau lapaʻau kūpono e pale ai i kou olakino.

ʻO nā lāʻau lapaʻau ʻole e like me ka pana flu, ka lāʻau lapaʻau pneumonia, a me nā lāʻau lapaʻau COVID-19 he palekana a paipai ʻia i ka wā e lawe ana i ka ustekinumab. ʻAʻole paha e hana iki kēia mau lāʻau lapaʻau ma mua o ka poʻe me nā ʻōnaehana pale maʻamau, akā hāʻawi lākou i ka pale nui.

Pono e pale ʻia nā lāʻau lapaʻau ola e like me ka lāʻau lapaʻau measles-mumps-rubella (MMR), ka lāʻau lapaʻau varicella (chickenpox), a me ka lāʻau lapaʻau flu ola i ka wā e lawe ana i ka ustekinumab. Hiki i kēia mau mea ke hoʻoulu i nā maʻi i ka poʻe me nā ʻōnaehana pale i hoʻopaʻa ʻia.

ʻO ka mea kūpono, pono ʻoe e loaʻa i nā lāʻau lapaʻau e pono ai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau ustekinumab. Inā pono ʻoe i nā lāʻau lapaʻau i ka wā o ka lāʻau lapaʻau, e kūkākūkā i ka manawa a me ke ʻano me kāu mea mālama ola e hōʻoia i kou palekana.