He aha ka Ustekinumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO ka Ustekinumab he lāʻau lapaʻau i kauoha ʻia e kōkua i ka hoʻomaha ʻana i kāu ʻōnaehana pale ke hana nui. He lāʻau lapaʻau i manaʻo ʻia e ālai i nā protein kikoʻī i loko o kou kino e hoʻoulu ai i ka mumū, e hana ana i mea kōkua nui no ka poʻe me nā maʻi autoimmune e like me ka psoriasis, ka maʻi o Crohn, a me ka ulcerative colitis.

No ka papa o nā monoclonal antibodies kēia lāʻau lapaʻau, he mau protein i hana ʻia i loko o ka lab e manaʻo ʻia e kuhikuhi i nā ʻāpana kikoʻī loa o kāu ʻōnaehana pale. E noʻonoʻo iā ia ma ke ʻano he mea hana pololei ma mua o ka lāʻau lapaʻau ākea, e hana ana e hōʻemi i ka mumū me ka ʻole o ka pani ʻana i kāu pane pale holoʻokoʻa.

No ke aha e hoʻohana ʻia ai ka Ustekinumab?

Hoʻomaʻamaʻa ka Ustekinumab i kekahi mau maʻi autoimmune kahi e hoʻouka hewa ai kāu ʻōnaehana pale i nā ʻāpana olakino o kou kino. Hiki i kāu kauka ke kuhikuhi iā ia i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe a i ʻole ke pono ʻoe i kahi ala i manaʻo ʻia e mālama i kou maʻi.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau no ka psoriasis plaque mai ka maʻi a hiki i ke koʻikoʻi, kahi maʻi ʻili e hoʻoulu ai i nā pā mānoanoa a me ka unahi. Ua ʻae ʻia nō hoʻi no ka psoriatic arthritis, e pili ana i kou ʻili a me kou mau hono, e hoʻoulu ana i ka ʻeha a me ka pehu.

No nā maʻi digestive, kōkua ka ustekinumab i ka mālama ʻana i ka maʻi o Crohn mai ka maʻi a hiki i ke koʻikoʻi a me ka ulcerative colitis. He mau maʻi ʻōpū mumū kēia e hoʻoulu ai i ka mumū mau i loko o kāu ʻōpū digestive, e alakaʻi ana i nā hōʻailona e like me ka ʻeha o ka ʻōpū, ka maʻi maʻi, a me ka pohō kaumaha.

Pehea ka hana ʻana o ka Ustekinumab?

Hana ka Ustekinumab ma ka ālai ʻana i ʻelua mau protein kikoʻī i kapa ʻia ʻo interleukin-12 a me interleukin-23. Hana kēia mau protein e like me nā ʻelele i loko o kāu ʻōnaehana pale, e haʻi ana iā ia e hana i ka mumū ʻoiai ʻaʻole pono.

Ma ka pale ʻana i kēia mau ʻelele, kōkua ka ustekinumab i ka hōʻemi ʻana i ka mumū nui e hana ana i kāu mau hōʻailona. Ua manaʻo ʻia he lāʻau lapaʻau ikaika waena e hāʻawi ana i ke kōkua i manaʻo ʻia ma mua o ka hoʻopau ākea ʻana i kāu ʻōnaehana pale.

ʻAʻole hiki koke nā hopena no ka mea pono ka manawa o kou kino e hoʻomaʻemaʻe i nā hōʻailona mumū e kū nei. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā hoʻomaikaʻi ʻana i loko o kekahi mau pule, me nā pōmaikaʻi kiʻekiʻe e ʻike pinepine ʻia ma hope o kekahi mau mahina o ka mālama ʻana.

Pehea e lawe ai au i ka Ustekinumab?

Loaʻa ka Ustekinumab i ʻelua ʻano: nā injections subcutaneous e hele ana ma lalo o kou ʻili, a me nā infusions intravenous e hele pololei ana i loko o kou kahe koko. Aia ke ʻano i kāu kūlana kikoʻī a me ka mea a kāu kauka e hoʻoholo ai e hana maikaʻi loa iā ʻoe.

No nā injections subcutaneous, e loaʻa iā ʻoe ma ke keʻena o kāu kauka a i ʻole e aʻo e hāʻawi iā lākou iā ʻoe iho ma ka home. Hoʻololi pinepine nā wahi injection ma waena o kou ʻūhā, ʻōpū, a i ʻole ka lima luna e pale ai i ka huhū ma kekahi wahi.

Inā loaʻa iā ʻoe nā infusions intravenous, hana mau ʻia kēia mau mea i kahi hoʻonohonoho mālama ola. E noho ʻoluʻolu ʻoe i ka wā e kulu mālie ai ka lāʻau lapaʻau i loko o kahi vein, e lawe ana ma kahi o hoʻokahi hola. E nānā kāu hui mālama ola iā ʻoe i ka wā a ma hope o ka infusion.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau me ka meaʻai, akā ʻo ka noho ʻana i ka wai maikaʻi i nā lā lapaʻau hiki ke kōkua iā ʻoe e ʻoluʻolu. E hāʻawi kāu kauka iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka manawa a me ka hoʻomākaukau ʻana e pili ana i kāu hoʻolālā lapaʻau pilikino.

Pehea ka lōʻihi e lawe ai au i ka Ustekinumab?

ʻO ka lōʻihi o ka mālama ʻana me ka ustekinumab e ʻokoʻa nui ana ma muli o kou kūlana a me ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau. Pono ka nui o nā kānaka e hoʻomau i ka mālama ʻana i ka wā lōʻihi e mālama i kā lākou hoʻomaikaʻi ʻana, i kekahi manawa no nā makahiki.

E loiloi mau kāu kauka i ke ʻano o kou pane ʻana e hoʻoholo ai inā pono ʻoe e hoʻomau. No nā maʻi e like me ka psoriasis, ʻike paha ʻoe i nā hoʻomaikaʻi nui e pono ai ka mālama lōʻihi. No nā maʻi ʻāʻī o ka ʻōpū, lilo pinepine ka lāʻau lapaʻau i ʻāpana o ka mālama mau.

Hiki i kekahi poʻe ke hōʻemi i kā lākou alapine ʻana i ka lāʻau a i ʻole e hoʻomaha mai ka lāʻau lapaʻau, akā pono kēia hoʻoholo i ka mālama olakino kokoke. ʻO ka hooki ʻana i ka wā mua e alakaʻi pinepine ai i ka hoʻi ʻana mai o nā hōʻailona, ​​i kekahi manawa ʻoi aku ka nui ma mua o ka wā ma mua.

He aha nā hopena ʻaoʻao o Ustekinumab?

E like me nā lāʻau lapaʻau a pau e pili ana i kāu ʻōnaehana pale, hiki i ka ustekinumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike, ʻo ia nā hopena ma ke kahua injection e like me ka ʻulaʻula, ka pehu, a i ʻole ke aloha ma kahi āu i loaʻa ai ka pana. He maʻalahi kēia mau hopena a hoʻoponopono iā lākou iho i loko o kekahi mau lā.

Eia nā hopena ʻaoʻao maʻamau e hōʻike ai ka poʻe:

• Nā maʻi hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā poʻo e hiki ke hana ma hope o nā mea mua
• ʻO ka luhi a i ʻole ka piʻi ʻana o ka luhi ma mua o ka maʻamau
• Nausea a i ʻole ka ʻōpū maʻalahi
• ʻEha hope a i ʻole nā ʻeha ʻiʻo
• ʻO ka ʻūlū, ʻoi loa ma hope o nā injections

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā mahina mua o ka mālama ʻana.

Hiki ke hana i nā hopena ʻaoʻao koʻikoʻi, ʻoiai ʻaʻole maʻamau lākou. No ka mea, pili ka ustekinumab i kāu ʻōnaehana pale, hiki iā ʻoe ke maʻalahi i nā maʻi. E nānā pono kāu kauka iā ʻoe no nā hōʻailona o nā maʻi koʻikoʻi.

Eia nā hopena ʻaoʻao koʻikoʻi e pono ai ka lāʻau lapaʻau koke:

• Nā hōʻailona o ka maʻi nui e like me ke kuni, nā hōʻailona e like me ka maʻi flu, a i ʻole ka luhi ʻole
• Nā loli ʻili me nā ulu hou a i ʻole nā loli i nā mole i loaʻa
• ʻAha mau a i ʻole nā pilikia hanu
• ʻEha ʻōpū nui a i ʻole nā loli i nā hana ʻōpū
• Nā ʻeha a i ʻole ke kahe ʻana o ke koko
• Nā hopena maʻi āpau nui i ka wā a i ʻole ma hope o nā injections

ʻOiai he kakaikahi kēia mau hopena ʻino, ʻo ka ʻike ʻana iā lākou e kōkua iā ʻoe e ʻimi i ka mālama kūpono inā pono.

Ua hōʻike ʻia kekahi mau maʻi kakaikahi loa akā koʻikoʻi, me kekahi mau ʻano maʻi maʻi a me nā maʻi lolo nui. E ana kāu kauka i kēia mau pilikia kakaikahi i nā pōmaikaʻi o ka mālama ʻana i kou maʻi i ka wā e ʻōlelo ai i ka ustekinumab.

ʻO wai ka mea pono ʻole e lawe i ka Ustekinumab?

ʻAʻole kūpono ka Ustekinumab no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia no ʻoe. ʻO kekahi mau maʻi olakino a me nā kūlana e hana i kēia lāʻau lapaʻau kūpono ʻole a i ʻole e koi i nā hana kūikawā.

ʻAʻole pono ʻoe e lawe i ka ustekinumab inā loaʻa iā ʻoe kahi maʻi ikaika, ʻoi aku hoʻi nā maʻi koʻikoʻi e like me ka maʻi tuberculosis a i ʻole ka hepatitis B. E hoʻāʻo kāu kauka no kēia mau maʻi ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a pono paha e mālama mua iā lākou.

Pono ka poʻe me kekahi mau moʻolelo olakino e mālama hou aʻe a i ʻole ʻaʻole paha he moho no kēia lāʻau lapaʻau:

• ʻO ka maʻi maʻi i kēia manawa a i ʻole i hala koke nei, ʻo ia hoʻi nā maʻi maʻi ʻili
• Moʻolelo o ka maʻi tuberculosis a i ʻole ka ʻike ʻana i ka maʻi tuberculosis
• Nā maʻi maʻi mau a i ʻole e hana hou ana
• Nā lāʻau lapaʻau ola i loaʻa i kēia manawa a i ʻole i hoʻolālā ʻia i ka wā o ka lāʻau lapaʻau
• ʻO ke ake nui a i ʻole ka maʻi kīkī
• Hāpai a i ʻole ka hānai ʻana me ka nānā ʻole ʻana i ka lāʻau lapaʻau

E noʻonoʻo pū kāu kauka i kou makahiki, ke olakino holoʻokoʻa, a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei i ka wā e hoʻoholo ai inā kūpono ka ustekinumab iā ʻoe.

Nā inoa inoa o Ustekinumab

Loaʻa ʻo Ustekinumab ma lalo o ka inoa inoa ʻo Stelara ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa inoa kumu i hoʻomohala ʻia e ka mea hana a ʻo ia ka inoa i ʻike nui ʻia no kēia lāʻau.

Hiki nō hoʻi iā ʻoe ke hālāwai me ka inoa formulation kikoʻī "ustekinumab-ttwe" i kekahi mau ʻano lapaʻau, e pili ana i kahi mana kūikawā o ka lāʻau. Eia naʻe, i ke kamaʻilio ʻana me kāu mea mālama ola a i ʻole ka lāʻau lapaʻau, ʻo "Stelara" ka inoa i hoʻohana pinepine ʻia.

Nā Koho ʻē aʻe no Ustekinumab

Nui nā lāʻau ʻē aʻe e hana like me ustekinumab no ka mālama ʻana i nā maʻi autoimmune. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ʻo ustekinumab iā ʻoe a i ʻole inā ʻaʻole ʻoe e pane maikaʻi iā ia.

No ka psoriasis a me ka psoriatic arthritis, nā lāʻau olaola ʻē aʻe e komo pū ana me adalimumab (Humira), etanercept (Enbrel), a me nā koho hou e like me secukinumab (Cosentyx) a i ʻole guselkumab (Tremfya). Hoʻopā kēlā me kēia i nā ʻāpana like ʻole o ka ʻōnaehana pale.

No nā maʻi ʻōpū mumū, nā koho ʻē aʻe e komo pū ana me adalimumab, infliximab (Remicade), a me vedolizumab (Entyvio). E noʻonoʻo kāu kauka i kou kūlana kikoʻī, nā lāʻau i hala, a me nā mea pilikino i ke koho ʻana i ke koho maikaʻi loa.

Hiki nō hoʻi ke noʻonoʻo ʻia nā lāʻau lapaʻau non-biologic e like me methotrexate, sulfasalazine, a i ʻole corticosteroids, ma muli o kou kūlana a me ka mōʻaukala lapaʻau.

ʻOi aku ka maikaʻi o Ustekinumab ma mua o Adalimumab?

ʻAʻole maʻalahi ka hoʻohālikelike ʻana iā ustekinumab me adalimumab no ka mea he mau lāʻau lapaʻau maikaʻi ʻelua e hana ʻokoʻa i nā kānaka like ʻole. ʻO ke koho "ʻoi aku ka maikaʻi" e hilinaʻi ana i kou kūlana kikoʻī, ka mōʻaukala olakino, a me ke ʻano o kou pane ʻana i ka lapaʻau.

Pono pinepine ʻo Ustekinumab i ka liʻiliʻi o ka hoʻopaʻa ʻana, kahi mea e ʻoluʻolu ai kekahi poʻe. Hāʻawi ʻia maʻamau i kēlā me kēia 8-12 pule ma hope o nā mea mua, ʻoiai hāʻawi ʻia ʻo adalimumab i kēlā me kēia pule ʻelua.

No ka psoriasis, ua like ka maikaʻi o nā lāʻau ʻelua i nā haʻawina lapaʻau, me kekahi poʻe e pane maikaʻi ana i kekahi ma mua o kekahi. No nā maʻi ʻōpū mumū, pili pinepine ka koho i kāu ʻano maʻi kikoʻī a me nā lāʻau i hala.

E noʻonoʻo kāu kauka i nā mea e like me kou ola, nā makemake injection, ka uhi ʻinikua, a me nā kūlana olakino ʻē aʻe i ke kōkua ʻana iā ʻoe e koho ma waena o kēia mau koho.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Ustekinumab

He Palekana ʻo Ustekinumab no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana palekana ʻia ʻo Ustekinumab i ka poʻe me ka maʻi diabetes, akā pono ia i ka nānā pono ʻana. ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kōpaʻa koko, akā hiki i ka loaʻa ʻana o ka maʻi diabetes ke hoʻonui iā ʻoe i nā maʻi i ka wā e mālama ʻia ai ka immunosuppressive therapy.

E hana pū kāu kauka me ʻoe e hōʻoia i ka mālama pono ʻia ʻana o kāu maʻi diabetes ma mua o ka hoʻomaka ʻana i ka ustekinumab. ʻO ka mālama maikaʻi ʻana i ke kōpaʻa koko e kōkua i ka hōʻemi ʻana i kou pilikia o ka maʻi a kākoʻo i ka hoʻōla maikaʻi inā loaʻa iā ʻoe kekahi hopena ʻaoʻao.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Ustekinumab?

Inā loaʻa iā ʻoe ka nui o ka ustekinumab, e hoʻokaʻaʻike koke i kāu mea mālama ola, ʻoiai inā maikaʻi ʻoe. ʻOiai he kakaikahi nā overdoses me kēia lāʻau lapaʻau, pono i kāu kauka ke ʻike i hiki iā lākou ke nānā pono iā ʻoe.

Mai ho'āʻo e

Na kou kauka e hoʻoholo i ka manawa kūpono no kāu mahele i hala ma muli o ka lōʻihi o ka hala ʻana mai kāu injection hope loa a me kāu papa hana lapaʻau pilikino. Hiki iā lākou ke hoʻoponopono i kāu papa hana dosing e hiki mai ana e hoʻihoʻi iā ʻoe i ke ala.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Ustekinumab?

Pono e hana mau ʻia ka hoʻoholo e hooki i ka ustekinumab me ke alakaʻi a kāu kauka. Nui ka poʻe e pono e hoʻomau i ka lapaʻau no ka wā lōʻihi e mālama i kā lākou hoʻomaikaʻi ʻana, a ʻo ka hooki ʻana i ka wā mua e alakaʻi pinepine i ka hoʻihoʻi ʻana o nā hōʻailona.

E loiloi mau kāu kauka i kāu pane ʻana i ka lapaʻau a kūkākūkā inā kūpono ke hoʻomau, hoʻemi i ke alapine, a i ʻole e hooki i ka lāʻau. ʻO nā mea e like me ka maikaʻi o ka mālama ʻia ʻana o kou maʻi a me nā hopena ʻaoʻao āu e ʻike nei e pili i kēia hoʻoholo.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Ustekinumab?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana iā ustekinumab, akā pono ʻoe e pale i nā lāʻau lapaʻau ola. E ʻōlelo kāu kauka e kiʻi i nā lāʻau lapaʻau koʻikoʻi ma mua o ka hoʻomaka ʻana i ka lapaʻau inā hiki.

ʻO nā lāʻau lapaʻau maʻamau e like me ka pana flu, nā lāʻau lapaʻau COVID-19, a me nā lāʻau lapaʻau pneumonia i kaulike a paipai ʻia i ka wā e lawe ana iā ustekinumab. E hōʻike mau i kekahi mea mālama ola e hāʻawi ana iā ʻoe i nā lāʻau lapaʻau e lawe ana ʻoe i kēia lāʻau.