He aha ʻo Valbenazine: Nā Hoʻohana, Dosage, Nā ʻaoʻao ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Valbenazine e kōkua ana i ka mālama ʻana i nā neʻe ʻana i makemake ʻole ʻia, e hana pinepine ʻia ana i kapa ʻia ʻo tardive dyskinesia. Inā ʻoe e hana nei me nā neʻe ʻana o nā ʻiʻo i kou maka, alelo, a i ʻole nā wahi ʻē aʻe o kou kino, hiki i kēia lāʻau lapaʻau ke hāʻawi i ke kōkua āu e ʻimi nei.

Hana pinepine kēia mau neʻe ʻana ma ke ʻano he hopena ʻaoʻao mai kekahi mau lāʻau lapaʻau psychiatric, a hana ʻo valbenazine ma ka hoʻoponopono hou ʻana i nā kemika lolo e mālama ana i ka neʻe ʻana o nā ʻiʻo. Ua hoʻolālā ʻia ia e kōkua i nā kānaka e hoʻihoʻi i ka mana ma luna o ko lākou kino a e ʻoluʻolu i ko lākou ola i kēlā me kēia lā.

He aha ʻo Valbenazine?

He lāʻau lapaʻau ʻo Valbenazine e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo VMAT2 inhibitors. Hana ia ma ka ālai ʻana i kahi protein kikoʻī i kou lolo e hoʻopili ana i ka dopamine, he kemika ʻelele e mālama ana i ka neʻe ʻana.

E noʻonoʻo iā ia he ʻōnaehana paʻa mālie no nā hōʻailona neʻe nui i kou lolo. Ma ka hoʻemi ʻana i ka nui o ka dopamine i loaʻa i kekahi mau wahi lolo, kōkua ʻo valbenazine i ka hoʻomaha ʻana i ka hana ʻana o ke aʻalolo nui e hoʻoulu ai i nā neʻe ʻana.

Hele mai ka lāʻau lapaʻau i ke ʻano capsule a lawe ʻia e ka waha i hoʻokahi manawa i ka lā. Ua ʻae ʻia ʻo FDA no ka mālama ʻana i ka tardive dyskinesia i nā pākeke, e lilo ia i koho lapaʻau i manaʻo ʻia no kēia kūlana paʻakikī.

No ke aha e hoʻohana ʻia ai ʻo Valbenazine?

Hoʻohana nui ʻia ʻo Valbenazine e mālama i ka tardive dyskinesia, kahi maʻi e hoʻoulu ai i nā neʻe ʻana i makemake ʻole ʻia, e hana pinepine ʻia. Hoʻopilikia pinepine kēia mau neʻe ʻana i kou maka, alelo, lehelehe, a i kekahi manawa i kou mau lima, wāwae, a i ʻole ke kino.

Hana maʻamau ʻo Tardive dyskinesia ma hope o ka lawe ʻana i kekahi mau lāʻau lapaʻau psychiatric no nā mahina a i ʻole nā makahiki. Hiki i nā neʻe ʻana ke komo i ka lehelehe, ka alelo, ka helehelena, a i ʻole nā neʻe ʻana o nā manamana lima āu e hiki ʻole ai ke kāohi.

Hiki i kēia maʻi ke hōʻoluʻolu ʻole i ke kino a me ka naʻau, e pili ana i kou hilinaʻi i nā kūlana pili kanaka. Kōkua ʻo Valbenazine i ka hōʻemi ʻana i kēia mau neʻe ʻana, e ʻae ana iā ʻoe e manaʻo hou i ka mana o kou kino a ʻoi aku ka ʻoluʻolu i kāu mau hana i kēlā me kēia lā.

Pehea e hana ai ʻo Valbenazine?

Hana ʻo Valbenazine ma ka ʻimi ʻana i kahi protein kikoʻī i kapa ʻia ʻo VMAT2 i kou lolo. Na kēia protein e hoʻopili i ka dopamine i loko o nā vesicles waihona, he mau pahu liʻiliʻi e paʻa ana i nā kemika lolo.

Ke ālai ʻo valbenazine iā VMAT2, hoʻemi ia i ka nui o ka dopamine i loaʻa i kekahi mau wahi lolo. Kōkua kēia i ka hoʻoponopono hou ʻana i ka kemika lolo i hoʻopilikia ʻia e nā lāʻau lapaʻau ma mua, e hōʻoluʻolu ana i nā hōʻailona hana nui e hoʻoulu ai i nā neʻe ʻole.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika iki a hana mālie i ka manawa. ʻAʻole paha ʻoe e ʻike i nā loli koke, akā hoʻomaka ka hapa nui o nā kānaka e ʻike i ka hoʻomaikaʻi ʻana i kā lākou neʻe ʻana i loko o kekahi mau pule o ka hoʻomaka ʻana i ka lāʻau.

Pehea wau e lawe ai iā Valbenazine?

E lawe iā valbenazine e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā me ka ʻole o ka meaʻai. Hiki iā ʻoe ke lawe me ka wai, ka waiū, a i ʻole ka wai - ʻo nā mea a pau e ʻoluʻolu ai iā ʻoe.

E ale i nā capsules holoʻokoʻa me ka wehe ʻole ʻana, ka ʻoki ʻana, a i ʻole ka nau ʻana iā lākou. Ua hoʻolālā ʻia ka lāʻau lapaʻau e hoʻokuʻu mālie i loko o kāu ʻōnaehana, no laila hiki i ka wāwahi ʻana i ka capsule ke keakea i ke ʻano o kāna hana.

ʻAʻole pono ʻoe e hoʻonohonoho i kāu mahele i nā meaʻai, akā ʻo ka lawe ʻana iā ia i ka manawa like i kēlā me kēia lā e kōkua i ka mālama ʻana i nā pae paʻa i kou kino. Nui ka poʻe i ʻike he maʻalahi ke hoʻomanaʻo i ka wā e hoʻopili ai lākou i kahi hana i kēlā me kēia lā e like me ka ʻaina kakahiaka a i ʻole ka manawa moe.

Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu kauka e pili ana i nā koho. Hiki iā lākou ke hōʻike i nā ʻenehana a i ʻole nā ​​mea ʻē aʻe e hana maikaʻi ai iā ʻoe.

Pehea ka lōʻihi e lawe ai au iā Valbenazine?

He ʻokoʻa ka lōʻihi o ka mālama ʻana me ka valbenazine mai kēlā kanaka i kēia kanaka a pili i ka maikaʻi o kou pane ʻana i ka lāʻau. Pono kekahi poʻe i ka lāʻau no nā mahina he nui, a ʻo nā mea ʻē aʻe e lawe paha ia no nā makahiki.

E hoʻomaka maʻamau kāu kauka iā ʻoe me ka lāʻau haʻahaʻa a e hoʻonui mālie ia i nā pule he nui. Kōkua kēia i kou kino e hoʻoponopono i ka lāʻau a hiki i kāu kauka ke loaʻa i ka lāʻau maikaʻi loa me nā hopena ʻaoʻao liʻiliʻi.

Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā hoʻomaikaʻi ʻana i kā lākou neʻe ʻana i loko o 4 a 6 pule o ka hoʻomaka ʻana i ka lāʻau. Eia naʻe, hiki ke lawe i 3 mau mahina e ʻike i nā pōmaikaʻi piha o ka lāʻau.

Mai hooki i ka lawe ʻana i ka valbenazine me ka ʻole e kamaʻilio mua me kāu kauka. Hiki i ka hooki ʻana i ka lāʻau ke hoʻi mai a ʻoi aku paha kou mau hōʻailona, no laila e ʻōlelo paha kāu kauka e hoʻemi mālie i kāu lāʻau i ka wā e pono ai e hooki i ka lāʻau.

He aha nā hopena ʻaoʻao o Valbenazine?

E like me nā lāʻau lapaʻau a pau, hiki i ka valbenazine ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. ʻO ka hapa nui o nā hopena ʻaoʻao he maʻalahi a i ka waena a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Ka hiamoe a i ʻole ka luhi
• Ka maʻi a i ʻole ka ʻōpū
• Ke poʻo
• Ka wili
• Waha maloʻo
• Paʻa
• ʻIke pōʻeleʻele

Hiki ke hana pinepine kēia mau hopena i nā pule mua o ka mālama ʻana a pinepine e lilo i mea ʻike ʻole i ka wā e hoʻoponopono ai kou kino. Hiki i ka lawe ʻana i ka lāʻau me ka meaʻai ke kōkua i ka hōʻemi ʻana i ka ʻōpū.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka hopohopo e pono ai ka lāʻau lapaʻau:

• Ka hiamoe nui e keakea ana i nā hana o kēlā me kēia lā
• Nā loli o ke ʻano a i ʻole ke kaumaha
• Paʻakikī i ka noʻonoʻo
• Nā pilikia kaulike a i ʻole ka piʻi ʻana o ka pilikia hāʻule
• ʻOkoʻa ka ʻoʻoleʻo o nā ʻiʻo a i ʻole nā haʻalulu

E kelepona i kāu kauka inā loaʻa iā ʻoe kekahi o kēia mau hopena, ʻoiai inā mau a ʻoi aku paha i ka manawa.

Hiki i nā hopena ʻaoʻao laha akā koʻikoʻi ke komo i ka manawa QT lōʻihi (nā loli o ka puʻuwai), nā hopena maʻi maʻi koʻikoʻi, a i ʻole ka ʻoi ʻana o nā maʻi neʻe e kū nei. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike iā lākou a e ʻimi koke i ka lāʻau lapaʻau inā loaʻa iā ʻoe ka ʻeha o ka umauma, ka pilikia o ka hanu ʻana, a i ʻole nā hopena ʻili koʻikoʻi.

ʻO wai ka mea ʻaʻole pono e lawe iā Valbenazine?

ʻAʻole kūpono ʻo Valbenazine no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia nāu. Pono kekahi poʻe e pale i kēia lāʻau lapaʻau ma muli o nā pilikia olakino.

ʻAʻole pono ʻoe e lawe iā valbenazine inā he maʻi ʻoe i ka lāʻau lapaʻau a i ʻole kekahi o kāna mau meaʻai. ʻO nā hōʻailona o ka hopena maʻi e komo pū ana me ka ʻōpala, ka ʻūlū, ka pehu, ka ʻūlū nui, a i ʻole ka pilikia o ka hanu.

Pono paha ka poʻe me kekahi mau maʻi puʻuwai e pale i ka valbenazine a i ʻole e pono i ka nānā ʻana:

• ʻO ka maʻi QT lōʻihi a i ʻole nā maʻi puʻuwai ʻē aʻe
• ʻO ka puʻuwai puʻuwai hou a i ʻole ka maʻi puʻuwai paʻa ʻole
• ʻO ka puʻuwai puʻuwai nui
• ʻO ka mōʻaukala ʻohana o ka make puʻuwai koke

E kauoha paha kāu kauka i ka electrocardiogram (ECG) ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau e nānā i kāu puʻuwai.

ʻAʻole kūpono paha ʻo Valbenazine inā loaʻa iā ʻoe ka maʻi ate a i ʻole ka maʻi kīkī, no ka mea, kōkua kēia mau ʻōpū i ka hana ʻana i ka lāʻau lapaʻau. Pono paha kāu kauka e hoʻoponopono i kāu mahele a i ʻole e koho i kahi koho lapaʻau ʻē aʻe.

Inā hāpai ʻoe, e hoʻolālā ana e hāpai, a i ʻole e hānai ana i ka waiū, e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kāu kauka. ʻAʻole i hoʻokumu piha ʻia ka palekana o ka valbenazine i ka wā hāpai a me ka hānai ʻana.

ʻO ka inoa inoa inoa o Valbenazine

Loaʻa ʻo Valbenazine ma lalo o ka inoa inoa ʻo Ingrezza. ʻO kēia wale nō ka mana inoa inoa i loaʻa i kēia manawa ma ʻAmelika Hui Pū ʻIa.

Loaʻa ʻo Ingrezza i nā capsules o nā ikaika like ʻole: 40 mg, 60 mg, a me 80 mg. He ʻokoʻa nā kala o nā capsules e kōkua iā ʻoe e ʻike i ka mahele kūpono i kauoha ʻia e kāu kauka.

I kēia manawa, ʻaʻohe mau mana generic o valbenazine i loaʻa, ʻo ia hoʻi ʻo Ingrezza wale nō ke ʻano o kēia lāʻau lapaʻau hiki iā ʻoe ke loaʻa. Hiki i kēia ke hoʻopilikia i ke kumukūʻai a me ka uhi ʻinikua, no laila he mea pono e kūkākūkā i nā koho kōkua kālā me kāu kauka a i ʻole ka mea kūʻai lāʻau.

Nā Koho ʻē aʻe o Valbenazine

Inā ʻaʻole kūpono ʻo valbenazine iā ʻoe, aia kekahi mau lāʻau lapaʻau ʻē aʻe no ka tardive dyskinesia. Hiki i kāu kauka ke kōkua iā ʻoe e ʻimi i kēia mau koho e pili ana i kāu kūlana.

ʻO Deutetrabenazine (Austedo) kekahi mea pale VMAT2 e hana like me valbenazine. Ua ʻae ʻia nō hoʻi e ka FDA no ka tardive dyskinesia a he koho maikaʻi paha inā ʻaʻole hiki iā ʻoe ke ʻae iā valbenazine a i ʻole pono ʻoe i ka lāʻau ʻelua i ka lā.

Hiki i kekahi mau kauka ke noʻonoʻo i nā lāʻau lapaʻau off-label no ka tardive dyskinesia, me:

• Clonazepam (he benzodiazepine hiki ke kōkua i nā neʻe ʻana o nā ʻiʻo)
• Amantadine (ʻo ia ka lāʻau lapaʻau Parkinson)
• Nā injections botulinum toxin no nā neʻe kūloko
• Vitamin E (ʻoiai ua kaupalena ʻia nā hōʻike)

I kekahi mau hihia, hiki i ka hoʻoponopono ʻana a i ʻole ka hoʻololi ʻana i ka lāʻau lapaʻau i kumu mua i ka tardive dyskinesia ke kōkua, akā pono e hana ʻia me ka mālama nui ʻana me ke alakaʻi ʻana a kāu psychiatrist.

Aia ke koho maikaʻi loa i kāu mau hōʻailona pilikino, ka mōʻaukala olakino, a me ka maikaʻi o kāu pane ʻana i nā lāʻau lapaʻau i hala. E hana pū kāu kauka me ʻoe e ʻimi i ke koho kūpono loa.

Ua ʻoi aku ka maikaʻi o Valbenazine ma mua o Deutetrabenazine?

He mau lāʻau lapaʻau maikaʻi ʻo Valbenazine a me deutetrabenazine no ka tardive dyskinesia, akā he mau ʻokoʻa ko lākou e hiki ai ke kūpono kekahi iā ʻoe ma mua o kekahi.

Hāʻawi ʻo Valbenazine i ka maʻalahi o ka hoʻohana ʻana i hoʻokahi manawa i ka lā, kahi mea e maʻalahi ai ka poʻe e hoʻomanaʻo a pili pū. Pono ʻo Deutetrabenazine i ka hoʻohana ʻana i ʻelua manawa i ka lā, kahi mea e paʻakikī ai ke mālama mau.

Ma ke ʻano o ka pono, hōʻike nā lāʻau lapaʻau ʻelua i nā hopena like i ka hōʻemi ʻana i nā neʻe ʻole. Hōʻike nā haʻawina lapaʻau e hiki i nā mea ʻelua ke hoʻomaikaʻi nui i nā hōʻailona tardive dyskinesia, me ka hapa nui o nā kānaka e ʻike ana i ka hoʻomaikaʻi ʻana i loko o 4 a 6 mau pule.

Ua like loa nā ʻaoʻao hopena, me nā lāʻau lapaʻau ʻelua e hiki ke hoʻoulu i ka hiamoe, ka nausea, a me ka luhi. Eia naʻe, hiki i kekahi poʻe ke ʻae i kekahi ma mua o kekahi ma muli o nā ʻokoʻa pilikino i ke ʻano o ko lākou kino e hana ai i kēia mau lāʻau lapaʻau.

E noʻonoʻo kāu kauka i nā mea e like me kāu hana maʻamau i kēlā me kēia lā, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, ka hana o ka puʻupaʻa, a me nā makemake pilikino i ka wā e hoʻoholo ai i ka lāʻau lapaʻau e hana maikaʻi loa iā ʻoe. ʻAʻohe koho

Inā ua lawe ʻoe i ka valbenazine ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana o ka lāʻau make. ʻO ka lawe ʻana i ka nui loa hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao e like me ka hiamoe nui, ka wili, a i ʻole nā pilikia o ka puʻuwai.

Mai hoʻāʻo e hoʻokō iā ʻoe iho e luaʻi a i ʻole e lawe i nā lāʻau lapaʻau home. Akā, e kelepona i kāu kauka, e hele i ka lumi pilikia kokoke loa, a i ʻole e kelepona i ka Poison Help Line ma 1-800-222-1222. E lawe mai i ka hue lāʻau me ʻoe i ʻike nā mea mālama ola i ka mea a me ka nui āu i lawe ai.

Q3. He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Valbenazine?

Inā ua hala ʻoe i kahi mahele o ka valbenazine, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele aʻe. I kēlā hihia, e lele i ka mahele i hala a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻopiha ai i kahi mahele i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i kahi alarm i kēlā me kēia lā a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Valbenazine?

Pono ʻoe e hooki i ka lawe ʻana i ka valbenazine ma lalo o ke alakaʻi a kāu kauka. ʻO ka hooki ʻana i ka hikiwawe hiki ke hoʻihoʻi i kāu mau hōʻailona tardive dyskinesia a i ʻole e hoʻonui paha, i kekahi manawa i loko o nā lā a i ʻole nā pule.

E ʻōlelo maʻamau kāu kauka e hōʻemi mālie i kāu mahele i nā pule he nui ma mua o ka hooki ʻana i ka hikiwawe. Kōkua kēia i ka hōʻemi ʻana i ka pilikia o ka hoʻihoʻi ʻana i nā hōʻailona a hiki i kou kino ke hoʻoponopono mālie i ka loli lāʻau.

Q5. Hiki iaʻu ke kalaiwa i ka wā e lawe ana i ka Valbenazine?

Hiki i ka Valbenazine ke hoʻoulu i ka hiamoe, ka wili, a i ʻole ka ʻike pohihihi, ʻoiai ke hoʻomaka mua ʻoe e lawe. Pono ʻoe e pale i ke kalaiwa a i ʻole ka hana ʻana i nā mīkini a hiki i kou ʻike ʻana i ke ʻano o ka lāʻau e pili ana iā ʻoe.

Hiki i ka hapa nui o nā kānaka ke hoʻokele palekana ma hope o ka hoʻoponopono ʻana i ka lāʻau lapaʻau a ʻaʻole e ʻike i nā hopena ʻaoʻao nui. Eia naʻe, e hoʻohana mau i kou manaʻo a pale i ka hoʻokele inā ʻoe e hiamoe ana, e wili ana, a i ʻole e emi ana ka makaʻala ma mua o ka maʻamau, ʻoiai inā ua lawe ʻoe i ka lāʻau lapaʻau no kekahi manawa.