Nā ho'okolohua Cytochrome P450 (CYP450)
E pili ana i kēia hoʻāʻo
ʻO nā ho'okolohua Cytochrome P450, i kapaʻia hoʻi he mau ho'okolohua CYP450, he mau ho'okolohua genotyping ia. Hiki i kāu limahana mālama ola ke hoʻohana i nā ho'okolohua cytochrome P450 e kōkua i ka ʻike ʻana i ka wikiwiki o ka hoʻohana ʻana a me ka hoʻopau ʻana o kou kino i ka lāʻau lapaʻau. ʻO ke ʻano o ka hoʻohana ʻana a me ka hoʻopau ʻana o ke kino i ka lāʻau lapaʻau, ua kapa ʻia ʻo ka hana ʻana a i ʻole ka metabolizing. Kūkulu nā enzyme Cytochrome P450 i ke kino e hana i nā lāʻau lapaʻau. Hiki i nā ʻano gene i hoʻoili ʻia i loko o nā ʻohana ke hoʻololi i kēia mau enzyme, no laila, ʻokoʻa ka hopena o nā lāʻau lapaʻau i kēlā me kēia kanaka.
No ke aha i hana ʻia ai
ʻO nā lāʻau lapaʻau no ke kaumaha, i kapa ʻia he antidepressants, maʻamau i kuhikuhi ʻia ma muli o nā hōʻailona a me ka mōʻaukala lapaʻau. No kekahi poʻe, ʻo ka antidepressant mua i hoʻāʻo ʻia e hoʻomaha i nā hōʻailona kaumaha, a ʻaʻole i hana nā hopena ʻaoʻao i nā pilikia nui. No nā mea ʻē aʻe he nui, ʻo ka loaʻa ʻana o ka lāʻau kūpono e pono ai ka hoʻāʻo a me ka hewa. I kekahi manawa, hiki ke hala kekahi mau mahina a ʻoi aku paha ka lōʻihi e loaʻa ai ka antidepressant kūpono. Hiki i nā hoʻokolohua CYP450 ke ʻike i nā ʻokoʻa ma nā enzyme he nui, e like me nā enzyme CYP2D6 a me CYP2C19. Hoʻoponopono ka enzyme CYP2D6 i nā antidepressants a me nā lāʻau antipsychotic he nui. Hoʻoponopono pū kekahi mau enzyme e like me ka enzyme CYP2C19 i kekahi mau antidepressants. Ma ke nānā ʻana i kāu DNA no kekahi mau ʻokoʻa gene, hiki i nā hoʻokolohua CYP450 e komo pū ana i nā hoʻokolohua CYP2D6 a me CYP2C19 ke hāʻawi i nā ʻōlelo aʻoaʻo e pili ana i ke ʻano o ka pane ʻana o kou kino i kahi antidepressant kikoʻī. Hiki i nā hoʻokolohua genotyping, e like me nā hoʻokolohua cytochrome P450, ke wikiwiki i ka manawa e pono ai e loaʻa nā lāʻau lapaʻau i hiki i ke kino ke hoʻoponopono maikaʻi aku. ʻOi aku ka maikaʻi, ʻoi aku ka emi ʻana o nā hopena ʻaoʻao a hana maikaʻi aku e hoʻomaha i nā hōʻailona. Hoʻohana ʻia nā hoʻokolohua CYP450 no ke kaumaha maʻamau wale nō inā ʻaʻole holomua nā lāʻau lapaʻau antidepressant mua. Hoʻohana ʻia nā hoʻokolohua genotyping i nā wahi ʻē aʻe o ka lāʻau lapaʻau. No ka laʻana, hiki i ka hoʻokolohua CYP2D6 ke kōkua i ka ʻike ʻana inā paha e hana maikaʻi nā lāʻau kanesa, e like me ka tamoxifen no ka maʻi ʻaʻai umauma. ʻO kekahi hoʻokolohua CYP450, ʻo ka hoʻokolohua CYP2C9, hiki ke kōkua i ka loaʻa ʻana o ka nui kūpono o ka mea hoʻoemi koko warfarin e hoʻemi i nā pilikia o nā hopena ʻaoʻao. Akā hiki i kāu limahana mālama ola ke manaʻo i kekahi ʻano o ka mea hoʻoemi koko. Ke ulu nei ke kahua o ka pharmacogenomics, a nui nā hoʻokolohua genotyping i loaʻa. Ke lilo nei nā hoʻokolohua CYP450 i mea maʻamau e like me ka hoʻāʻo ʻana o nā limahana mālama ola e hoʻomaopopo i ke kumu e kōkua ai nā antidepressants i kekahi poʻe a ʻaʻole i nā poʻe ʻē aʻe. He ʻokoʻa loa nā hoʻokolohua ma nā ʻano o nā lāʻau lapaʻau a lākou e nānā ai a pehea e hana ʻia ai nā hoʻokolohua. ʻOiai ke piʻi nei ka hoʻohana ʻana i kēia mau hoʻokolohua, aia nā palena. Hiki iā ʻoe ke kūʻai i nā pūʻolo hoʻokolohua pharmacogenetic home. Loaʻa kēia mau hoʻokolohua pololei-i-ka-mea kūʻai aku me ka ʻole o ka kuhikuhi. He ʻokoʻa loa nā hoʻokolohua i nā gene a lākou e nānā ai a pehea e hāʻawi ʻia ai nā hopena. ʻAʻole maopopo mau ka pololei o kēia mau hoʻokolohua home, a ʻaʻole lākou maʻamau e kōkua i ka hoʻoholo ʻana i nā koho lāʻau lapaʻau. Inā koho ʻoe e hoʻohana i kahi pūʻolo hoʻokolohua home, ʻoi aku ka maikaʻi ke lawe i nā hopena i kahi limahana mālama ola a i ʻole lāʻau lapaʻau e kamaʻāina ana i kēia ʻano hoʻokolohua. Hui pū ʻoe e kamaʻilio e pili ana i nā hopena a me kā lākou manaʻo no ʻoe.
Nā pilikia a me nā pilikia
ʻAʻohe pilikia aneane o ka hānai papalina, ka waha, a me nā ho'okolohua koko. ʻO ka pilikia nui loa me nā ho'okolohua koko, ʻo ia ka ʻeha a i ʻole ka ʻūlū ma kahi i unuhi ʻia ai ke koko. ʻAʻohe nui o nā kānaka e loaʻa i nā hopena koʻikoʻi i ka unuhi ʻana i ke koko.
Pehea e hoʻomākaukau ai
Ma mua o ka ho'okolohua holoi papalina, hiki paha ke noi 'ia 'oe e kali no 30 mau minuke ma hope o ka 'ai 'ana, ka inu 'ana, ka pu'i 'ana, a i 'ole ka nahu 'ana i ka 'epo.
He aha ka mea e manaʻo ʻia
No nā ho'okolohua cytochrome P450, lawe ʻia kahi hāpana o kāu DNA me kekahi o kēia mau ʻano: ʻOpihiki papalina. Hānai ʻia kahi ʻopihiki pulupulu i loko o kou papalina e kiʻi i kahi hāpana kele. ʻOhi wai waha. Kulu ʻoe i ka wai waha i loko o kahi pahu ʻohi. Ho'okolohua koko. Lawe ʻia kahi hāpana koko mai kahi ʻiʻo koko ma kou lima.
Ke hoʻomaopopo nei i kāu mau hopena
Holoi pinepine he mau lā a hiki i hoʻokahi pule e loaʻa ai nā hopena o nā ho'okolohua cytochrome P450. Hiki iā ʻoe ke kamaʻilio me kāu kauka lapaʻau a i ʻole lāʻau lapaʻau e pili ana i nā hopena a pehea lā e hiki ai iā lākou ke hoʻopili i kāu mau koho mālama. Hāʻawi nā ho'okolohua CYP450 i nā ʻōlelo aʻoaʻo e pili ana i ka maikaʻi o kāu kino e hoʻohana a hoʻopau i ka lāʻau lapaʻau ma ka nānā ʻana i nā enzyme kikoʻī. ʻO ke ʻano o ke kino e hoʻohana a hoʻopau ai i ka lāʻau lapaʻau i kapa ʻia ʻo ka hana ʻana a i ʻole ka metabolizing. Hiki ke hoʻokaʻawale ʻia nā hopena e like me ka wikiwiki o kāu metabolizing ʻana i kahi lāʻau lapaʻau kikoʻī. No ka laʻana, hiki i nā hopena o kahi ho'okolohua CYP2D6 ke hōʻike i kekahi o kēia mau ʻano ʻehā e pili ana iā ʻoe: Metabolizer maikaʻi ʻole. Inā nele ʻoe i kahi enzyme a i ʻole he liʻiliʻi loa ia, hiki iā ʻoe ke hana i kahi lāʻau lapaʻau i kahi lohi ma mua o nā poʻe ʻē aʻe. Hiki ke kūkulu ʻia ka lāʻau lapaʻau i loko o kou kino. Hiki i kēia kūkulu ʻana ke hoʻonui i ka hiki ke loaʻa nā hopena ʻaoʻao o ka lāʻau lapaʻau. Hiki paha iā ʻoe ke pōmaikaʻi mai kēia lāʻau lapaʻau, akā ma nā nui haʻahaʻa. Metabolizer waena. Inā hōʻike ka ho'okolohua ʻaʻole hana maikaʻi loa ka enzyme e like me ka manaʻo, hiki paha iā ʻoe ke hana ʻole i kekahi mau lāʻau lapaʻau e like me nā poʻe i kapa ʻia he metabolizers ākea. Akā ʻo ka maikaʻi o ka hana ʻana o kahi lāʻau lapaʻau no nā metabolizers waena he like loa ia me nā metabolizers ākea. Metabolizer ākea. Inā hōʻike ka ho'okolohua e hana ʻoe i kekahi mau lāʻau lapaʻau e like me ka manaʻo a ma ke ʻano maʻamau loa, ʻoi aku ka nui o kou pōmaikaʻi mai ka mālama ʻana a loaʻa nā hopena ʻaoʻao liʻiliʻi ma mua o nā poʻe ʻaʻole hana maikaʻi i kēlā mau lāʻau lapaʻau kikoʻī. Metabolizer wikiwiki loa. I kēia hihia, haʻalele koke nā lāʻau lapaʻau i kou kino, pinepine ma mua o ka manawa e hana ai lākou e like me kā lākou hana. Pono paha ʻoe i nā nui kiʻekiʻe ma mua o ka maʻamau o kēia mau lāʻau lapaʻau. Hiki nō hoʻi i nā ho'okolohua CYP450 ke hāʻawi i ka ʻike e pili ana i nā lāʻau lapaʻau e pono ai ke hana ʻia i kā lākou mau ʻano hana e ka enzyme cytochrome P450 i hiki ai iā lākou ke hana. Kūpono kēia mau lāʻau lapaʻau i kapa ʻia he prodrugs. No ka laʻana, ʻo ka tamoxifen he prodrug. Pono ia e metabolize ʻia a i ʻole hoʻoulu ʻia ma mua o ka loaʻa ʻana o ka hopena i makemake ʻia. ʻAʻole hiki paha i kahi kanaka ʻaʻohe enzyme hana lawa a he metabolizer maikaʻi ʻole ke hoʻoulu i ka lawa o ka lāʻau lapaʻau no ka hana ʻana e like me kāna hana. Hiki i kahi kanaka he metabolizer wikiwiki loa ke hoʻoulu i ka nui loa o ka lāʻau lapaʻau, a hiki ke hoʻokumu i ka overdose. ʻAʻole pono nā ho'okolohua CYP450 no nā antidepressants a pau, akā hiki iā ia ke hāʻawi i ka ʻike e pili ana i ke ʻano o kāu hana ʻana i kekahi o lākou. No ka laʻana: Hoʻopili ʻia ka enzyme CYP2D6 i ka hana ʻana i nā antidepressants e like me ka fluoxetine (Prozac), paroxetine (Paxil), fluvoxamine (Luvox), venlafaxine (Effexor XR), duloxetine (Cymbalta, Drizalma Sprinkle) a me vortioxetine (Trintellix). Hoʻopili ʻia ka enzyme i ka hana ʻana i nā antidepressants tricyclic e like me ka nortriptyline (Pamelor), amitriptyline, clomipramine (Anafranil), desipramine (Norpramin) a me imipramine. Hiki i kekahi mau antidepressants, e like me ka fluoxetine a me ka paroxetine, ke hoʻolohi i ka enzyme CYP2D6. Hoʻopili ʻia ka enzyme CYP2C19 i ka hana ʻana i ka citalopram (Celexa), escitalopram (Lexapro) a me sertraline (Zoloft).
Hōʻole: He kahua ʻike olakino ʻo ʻAukake a ʻaʻole hōʻike kāna mau pane i ka ʻōlelo aʻoaʻo lapaʻau. E kūkākūkā mau me kahi ʻoihana lapaʻau laikini kokoke iā ʻoe ma mua o ka hana ʻana i nā hoʻololi.
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