Gịnị Bụ Iloprost: Ojiji, Ọgwụ, Mmetụta Akụkụ na Ihe Ọzọ

Iloprost bụ ọgwụ pụrụ iche nke na-enyere aka imeziwanye ọbara site n'imepe arịa ọbara ndị dị warara. Ọ bụ ụdị ihe e ji eme ihe nke ihe sitere n'okike ahụ gị na-emepụta nke a na-akpọ prostacyclin, nke na-eme dị ka onye ozi dị nro na-agwa arịa ọbara gị ka ha zuru ike ma gbasaa. A na-enyekarị ọgwụ a site na IV n'ụlọ ọgwụ ma ọ bụ ụlọ ọgwụ, ebe ndị ọkachamara ahụike nwere ike ileba anya nke ọma ka ị na-esi emeghachi omume na ọgwụgwọ.

Gịnị Bụ Iloprost?

Iloprost bụ nke ezinụlọ ọgwụ a na-akpọ prostacyclin analogs. Chee echiche banyere ya dị ka onye inyeaka nke na-eṅomi ihe ahụ gị na-eme n'ụzọ nkịtị iji mee ka ọbara na-asọpụta nke ọma. Mgbe arịa ọbara gị na-aghọ nke dị warara ma ọ bụ nke siri ike, iloprost na-abanye iji gbaa ha ume ka ha megharịa ọzọ.

Ọgwụ a na-arụ ọrụ na ọkwa cellular, na-eziga mgbaàmà na-enyere arịa ọbara aka izu ike ma belata nrapado nke platelets ọbara. Nsonaazụ ya bụ mgbasa ọbara ka mma, nke nwere ike iweta enyemaka dị mkpa na mpaghara ahụ gị nke na-enwetaghị ọbara zuru oke na mbụ.

Gịnị Ka A Na-eji Iloprost?

A na-ejikarị Iloprost agwọ ọrịa pulmonary arterial hypertension (PAH), ọnọdụ dị njọ ebe nrụgide ọbara n'ime ngụgụ na-abawanye nke ukwuu. Ọ na-enyere aka imeghe obere arịa ọbara dị n'ime ngụgụ gị, na-eme ka obi gị dịkwuo mfe ịgbanye ọbara site na ha.

E wezụga PAH, dọkịta na-edekarị iloprost maka nnukwu ọrịa akwara akwara, ọkachasị mgbe ọgwụgwọ ndị ọzọ anaghị arụ ọrụ nke ọma. N'ọnọdụ ndị a, ọ nwere ike inye aka imeziwanye ọbara na ogwe aka na ụkwụ gị, na-ebelata mgbu ma na-enyere aka igbochi mmebi anụ ahụ.

N'ọnọdụ ụfọdụ pụrụ iche, enwere ike iji iloprost maka ischemia akụkụ ahụ dị oke egwu, ọnọdụ ebe a na-ebelata ọbara na-aga na akụkụ ahụ gị nke ukwuu. A na-atụlekwa ya mgbe ụfọdụ maka ụdị Raynaud's phenomenon ụfọdụ mgbe ọnọdụ ahụ dị oke njọ na ọgwụgwọ ndị ọzọ enyeghị enyemaka zuru oke.

Kedu ka Iloprost si arụ ọrụ?

A na-ewere Iloprost dị ka vasodilator dị nro, nke pụtara na o nwere ike imeghe arịa ọbara mana ọ chọrọ ịṅụ ọgwụ nke ọma. Ọ na-arụ ọrụ site na ijikọ na ndị nnata akọwapụtara na mgbidi arịa ọbara gị, na-akpata usoro ihe omume na-eduga na izu ike na ịgbasa.

Ọgwụ ahụ nwekwara ihe mgbochi mkpụkọ, nke pụtara na ọ na-enyere aka igbochi ọbara gị ịghọ nke na-arapara nke ukwuu ma ọ bụ na-emepụta mkpụkọ na-achọghị. Ihe omume abụọ a nke imeghe arịa ọbara na imeziwanye njirimara ọbara na-eme ka ọ dị irè maka nsogbu mgbasa ọbara.

N'adịghị ka ụfọdụ ọgwụ na-arụ ọrụ ozugbo, mmetụta iloprost na-ebili n'ime oge site na ọgwụgwọ ugboro ugboro. Ị nwere ike ịmalite ịhụ mmelite na mgbaàmà gị mgbe ọtụtụ oge ọgwụgwọ gasịrị, n'agbanyeghị na ụfọdụ ndị na-enweta uru ngwa ngwa.

Kedu ka m ga-esi ewere Iloprost?

A na-enye Iloprost mgbe niile site na intravenously (site na IV) na ntọala ahụike, ọ dịghị mgbe n'ụlọ. Ndị otu ahụike gị ga-etinye obere tube n'ime otu n'ime akwara gị, na-emekarị n'aka gị, a ga-enyekwa ọgwụ ahụ nwayọọ nwayọọ n'ime awa ole na ole.

Ntinye ahụ na-ewe ihe dịka awa 6 ruo 9, ị ga-anọrịrị na mpaghara ọgwụgwọ n'oge a. Ndị otu ahụike gị ga-enyocha ọbara mgbali gị, ọnụọgụ obi gị, na otú ị na-eche n'oge usoro niile.

Ị chọghị ịgba ọsọ tupu ọgwụgwọ, mana ọ na-enyekarị aka iri nri dị mfe tupu oge eruo ebe usoro ahụ na-ewe ọtụtụ awa. Ịnọgide na-enwe mmiri dị mkpa, yabụ ṅụọ mmiri dị ukwuu tupu na n'oge ọgwụgwọ ma ọ bụrụ na dọkịta gị adịghị enye ndụmọdụ ọzọ.

Ụfọdụ ndị na-ahụ na ọ na-enyere aka iwebata ihe iji mee ka ha nọrọ n'oge ogologo oge infusion, dị ka akwụkwọ, mbadamba, ma ọ bụ egwu. Ebe a na-agwọ ọrịa na-adịkarị mma, mana ị ga-anọgide na-anọ jụụ iji zere ịkwụsị ahịrị IV.

Ogologo Oge Ka M Kwesịrị Iji Iloprost?

Ogologo oge ọgwụgwọ iloprost na-adịgasị iche nke ukwuu dabere na ọnọdụ gị na otú i si azaghachi ọgwụ ahụ. Maka ọbara mgbali elu nke akwara akpa ume, usoro ọgwụgwọ na-agụnyekarị infusions kwa ụbọchị maka ọtụtụ ụbọchị na-esochi, na-esochi oge ezumike.

Ọtụtụ ndị na-enweta usoro ọgwụgwọ nke na-adịru ụbọchị 3 ruo 5, na-emegharị kwa izu 6 ruo 12. Otú ọ dị, dọkịta gị ga-emepụta usoro onwe onye dabere na mgbaàmà gị, nsonaazụ ule, na ọnọdụ ahụike gị.

Maka ọrịa akwara akwara ma ọ bụ ischemia akụkụ ahụ dị oke egwu, usoro ọgwụgwọ nwere ike ịdị iche, mgbe ụfọdụ na-agụnye usoro ogologo oge ma ọ bụ ọgwụgwọ ugboro ugboro na mbụ. Ndị otu ahụike gị ga-enyocha mgbe niile ma ọgwụ ahụ na-enyere aka ma gbanwee atụmatụ ọgwụgwọ ahụ.

Atụmatụ ọgwụgwọ ogologo oge dabere na ọnọdụ gị dị n'okpuru na ma iloprost na-aga n'ihu na-enye uru. Ụfọdụ ndị nwere ike ịgbanwe gaa na ọgwụ ndị ọzọ, ebe ndị ọzọ nwere ike ịga n'ihu na iloprost dị ka akụkụ nke atụmatụ nlekọta ha na-aga n'ihu.

Kedu Ihe Bụ Mmetụta Ọjọọ nke Iloprost?

Dị ka ọgwụ niile, iloprost nwere ike ịkpata mmetụta, n'agbanyeghị na ọtụtụ ndị na-anabata ya nke ọma mgbe a na-enyocha ya nke ọma. Ịghọta ihe ị ga-atụ anya ya nwere ike inyere gị aka inwekwu nkwadebe na obi ike n'oge ọgwụgwọ.

Mmetụta ndị na-emekarị ị nwere ike ịnweta gụnyere isi ọwụwa, ihu uhie (ịnụ ọkụ ma na-acha uhie n'ihu), na ahụ erughị ala. Ndị a na-emekarị n'oge ma ọ bụ obere oge ka a gbasasịrị ya ma na-adịkarị mma ka ahụ gị na-emegharị na ọgwụ ahụ.

Nke a bụ mmetụta ndị na-emekarị ndị mmadụ na-enweta:

• Isi ọwụwa, nke nwere ike ịdị site na nwayọọ ruo na ọkara
• Ihu uhie na inwe mmetụta ọkụ
• Ahụ erughị ala ma ọ bụ afọ na-afụ ụfụ
• Ọgbụgbọ ma ọ bụ isi na-agba
• Mgbu agba ma ọ bụ mgbu akwara
• Afọ ọsịsa ma ọ bụ afọ na-agbapụta mmiri
• Ọgwụgwụ ma ọ bụ ike ọgwụgwụ

Mmetụta ndị a na-adịkarị mfe ijikwa ma na-ebelata ike ha ka ị na-enweta ọgwụgwọ ndị ọzọ. Ndị otu ahụike gị nwere ike inye atụmatụ iji nyere aka belata ahụ erughị ala.

Ụfọdụ ndị nwere ike ịnweta mmetụta dị mkpa karị nke chọrọ nlekota anya:

• Obere ọbara mgbali, nke nwere ike ịkpata ọgbụgbọ ma ọ bụ ịda mbà n'obi
• Ọnụego obi dị ngwa ma ọ bụ palpitations
• Nsogbu iku ume ma ọ bụ ike n'obi
• Isi ọwụwa siri ike nke na-adịghị mma na enyemaka mgbu na-enweghị ọgwụ
• Ihe ịrịba ama nke ọbara ọgbụgba, dị ka mmerụ ahụ ma ọ bụ imi ọbara

Mmetụta ndị a adịkarịghị, ma ọ dị mkpa ịgwa ndị otu ahụike gị ozugbo ma ọ bụrụ na ha mere.

Obere oge, ụfọdụ ndị nwere ike ịnweta nnukwu mmeghachi omume nke chọrọ nlebara anya ahụike ozugbo:

• Nnukwu mmeghachi omume nfụkasị ahụ nwere ọkụ, afụ, ma ọ bụ nsogbu iku ume
• Nnukwu mbelata nke ọbara mgbali chọrọ ntinye aka
• Ihe na-adịghị mma nke obi
• Pulmonary edema (mmiri n'ime ngụgụ)
• Nsogbu ọbara ọgbụgba siri ike

Ọ bụ ezie na mmetụta ndị a dị njọ adịghị ahụkebe, ebe ahụike ebe a na-achịkwa iloprost na-eme ka enyemaka dị ozugbo ma ọ dị mkpa.

Ònye kwesịrị ịghara iji Iloprost?

Iloprost adabaghị maka onye ọ bụla, dọkịta gị ga-eleba anya nke ọma na akụkọ ahụike gị tupu ịkwado ọgwụgwọ a. Ụfọdụ ọnọdụ ma ọ bụ ọnọdụ na-eme ka iloprost nwee ike ịdịghị mma ma ọ bụ dịkwuo irè.

Ịkwesighi ịnata iloprost ma ọ bụrụ na ị nwere nnukwu ọrịa obi, karịsịa ụdị ọdịda obi ma ọ bụ nnukwu nkụchi obi na nso nso a. Mmetụta ọgwụ ahụ na nrụgide ọbara na ọnụego obi nwere ike ịbụ nsogbu na ọnọdụ ndị a.

Ndị nwere nsogbu ọbara na-arụ ọrụ ma ọ bụ ndị na-aṅụ ọgwụ na-eme ka ọbara dị gịrịgịrị nwere ike ọ gaghị abụ ezigbo ndị na-aga iloprost. Ebe ọ bụ na ọgwụ ahụ na-emetụta ọbara, ọ nwere ike ịbawanye ihe ize ndụ nke ọbara na-agba n'ime ndị na-adịghị ike.

Ụdị ọnọdụ ndị ọzọ na-egbochi iji iloprost gụnyere:

• Nnukwu ọrịa imeju ma ọ bụ ọdịda imeju
• Nnukwu ọrịa akụrụ chọrọ dialysis
• Nnukwu nrụgide ọbara na-achịkwaghị achịkwa
• Ọrịa strok ma ọ bụ ọbara ọgbụgba ụbụrụ na nso nso a
• Ọrịa peptic ulcer na-arụ ọrụ
• Nnukwu anaemia ma ọ bụ ọnụọgụ platelet dị ala

Afọ ime na inye nwa ara chọrọ nlebara anya pụrụ iche, ebe a naghị aghọta nke ọma mmetụta iloprost na ụmụaka na-etolite. Dọkịta gị ga-atụle uru nwere ike inwe megide ihe ize ndụ nwere ike ime ma ọ bụrụ na ị dị ime ma ọ bụ na-eme atụmatụ ịmụ nwa.

Afọ naanị abụghị ihe mgbochi maka ọgwụgwọ, mana ndị okenye nwere ike ịchọ nlekota anya karịa n'ihi mmụba mmetụta na mmetụta ọgwụ ahụ.

Aha Ụdị Iloprost

Iloprost dị n'okpuru ọtụtụ aha ụdị, ebe Ventavis bụ nke a na-amata nke ọma na United States. A na-emepụta ụdị a kpọmkwem maka ọgwụgwọ iku ume, n'agbanyeghị na ụdị intravenous dịkwa n'okpuru aha dị iche iche.

Ụdị aha ndị ọzọ gụnyere Ilomedin, nke a na-eji na mba dị iche iche maka nlekọta intravenous. Ụdị aha na usoro dọkịta gị họọrọ ga-adabere n'ọnọdụ gị na ụzọ ọgwụgwọ ha kwenyere na ọ ga-arụrụ gị ọrụ kacha mma.

N'agbanyeghị aha ụdị, ọgwụ iloprost niile nwere otu ihe na-arụ ọrụ. Ihe dị iche bụ na mkpokọta, ụzọ nnyefe, na ụkpụrụ mmepụta ihe.

Ụzọ Ọzọ Maka Iloprost

Ọtụtụ ọgwụ ndị ọzọ nwere ike ịrụ ọrụ dị ka ụzọ ọzọ maka iloprost, dabere n'ọnọdụ gị na ebumnuche ọgwụgwọ gị. Ụzọ ndị a na-arụ ọrụ site na usoro yiri ya ma ọ bụ dị iche iche iji melite mgbasa ọbara ma belata mgbaàmà.

Maka ọbara mgbali elu pulmonary arterial, ụzọ ndị ọzọ gụnyere epoprostenol (Flolan), treprostinil (Remodulin), na selexipag (Uptravi). Onye ọ bụla nwere uru na nlebara anya nke ya gbasara usoro, mmetụta dị n'akụkụ, na ụzọ nlekọta.

Ụzọ ọgwụgwọ ndị ọzọ nwere ike ịgụnye ndị na-emegide endothelin receptor dị ka bosentan (Tracleer) ma ọ bụ ambrisentan (Letairis), nke na-arụ ọrụ site na igbochi ihe ndị na-akpata mgbawa arịa ọbara. Phosphodiesterase-5 inhibitors dị ka sildenafil (Revatio) na-enye ụzọ ọzọ iji melite mgbasa ọbara.

Maka ọrịa arịa ọbara dị n'akụkụ, ụzọ ndị ọzọ nwere ike ịgụnye ndị ọzọ vasodilators, ọgwụ antiplatelet, ma ọ bụ ọgwụgwọ ọhụrụ emebere iji kwalite uto arịa ọbara. Dọkịta gị ga-atụle ọnọdụ gị mgbe ị na-atụ aro ụzọ ndị ọzọ.

Iloprost Ọ Ka Mma Karịa Epoprostenol?

Ma iloprost na epoprostenol bụ prostacyclin analogs, mana ha nwere ihe dị iche iche dị mkpa nke na-eme ka otu nwere ike ịka mma maka ụfọdụ mmadụ. Nhọrọ n'etiti ha dabere na mkpa gị, ụdị ndụ gị, na otú i si anabata ọgwụ ọ bụla.

Iloprost nwere ndụ ndụ dị ogologo karịa epoprostenol, nke pụtara na ọ na-anọgide na-arụ ọrụ n'ime sistemụ gị ogologo oge. Nke a nwere ike ịba uru n'ihi na ọ na-enye ohere maka obere ọgwụ na-enye ma nwee ike inye mmetụta kwụsiri ike n'ụbọchị niile.

Epoprostenol chọrọ ntinye na-aga n'ihu site na ahịrị etiti na-adịgide adịgide, nke pụtara na ị ga-achọ iburu obere mgbapụta gị mgbe niile. Iloprost, n'aka nke ọzọ, nwere ike inye ya dị ka ntinye oge, nke ọtụtụ mmadụ na-ahụ dị ka ihe dị mma maka ndụ ha kwa ụbọchị.

Profaili mmetụta dị n'akụkụ yiri ya, mana ụfọdụ ndị na-anabata otu ọgwụ karịa nke ọzọ. Dọkịta gị ga-atụle ọnọdụ gị, gụnyere ikike gị ijikwa usoro nnyefe dị iche iche na nzaghachi gị na ọgwụgwọ.

Ajụjụ A Na-ajụkarị Gbasara Iloprost

Iloprost Ọ Dị Mma Maka Ọrịa Obi?

Iloprost chọrọ nyocha nke ọma ma ọ bụrụ na ị nwere ọrịa obi, n'ihi na ọ nwere ike imetụta ọnụọgụ obi gị na ọbara mgbali elu. Maka ndị nwere ọnọdụ obi dị nro ruo nke dị nro, ọ nwere ike ịdị mma n'okpuru nlekọta ahụike chiri anya, mana ndị nwere nnukwu ọrịa obi ma ọ bụ nkụchi obi na-adịbeghị anya anaghị enwekarị ike ịnata ọgwụ a.

Onye na-ahụ maka obi gị na ndị otu na-ejikwa ọgwụgwọ iloprost gị ga-arụkọ ọrụ ọnụ iji chọpụta ma ọ kwesịrị ekwesị maka ọnọdụ obi gị. Ha ga-atụle ihe dị ka ọrụ obi gị, ọgwụ ugbu a, na ahụike obi na akwara gị.

Ọ bụrụ na ị na-anata iloprost nwere ọrịa obi, ị ga-achọkarị nlekota ugboro ugboro n'oge ọgwụgwọ, gụnyere ọnụọgụ obi na nyocha ọbara mgbali elu n'oge usoro ntinye.

Gịnị Ka M Ga-eme Ọ Bụrụ na M Na-anata Iloprost Ọtụtụ?

Ebe ọ bụ na a na-enye iloprost n'ime akwara n'ime ụlọ ọgwụ, overdoses na-eme na mberede adịkarịghị n'ihi na ndị ọkachamara ahụike na-achịkwa ọgwụ ahụ nke ọma. Agbanyeghị, ọ bụrụ na ị nwere ahụmahụ siri ike n'oge ọgwụgwọ, ọ dị mkpa ikwu okwu ozugbo.

Ihe ịrịba ama nke iloprost gabigara ókè nwere ike ịgụnye isi ọwụwa siri ike, isi ọwụwa dị egwu, ọbara mgbali dị ala, ma ọ bụ nsogbu iku ume. Ndị otu ahụike na-elekọta ọgwụgwọ gị nwere ọzụzụ iji mata ma zaghachi ọnọdụ ndị a ngwa ngwa.

Ọ bụrụ na ọnọdụ oke ọgwụ na-eme, a ga-akwụsị infusion ozugbo, a ga-enyekwa nlekọta nkwado iji nyere ahụ gị aka ịgbake. Ọtụtụ mmetụta oke ọgwụ na-agbanwe agbanwe ozugbo a kwụsịrị ọgwụ ahụ.

Gịnị Ka M Kwesịrị Ime Ọ Bụrụ Na M Na-efu Ọgwụgwọ Iloprost Edebanyere Aha?

Ọ bụrụ na ị na-efu ọgwụgwọ iloprost edepụtara, kpọtụrụ onye na-ahụ maka ahụike gị ozugbo enwere ike iji hazie ya. Anwala ime ka ọgwụgwọ ndị furu efu site n'inweta ọgwụ ndị ọzọ ma ọ bụ ịgbatị oge infusion gị na-esote.

Dabere na ogologo oge ọ bụla kemgbe ọgwụgwọ gị furu efu na ọnọdụ gị, dọkịta gị nwere ike ịgbanwe usoro ọgwụgwọ gị ma ọ bụ tụọ aro nlekota ọzọ mgbe ị maliteghachi ọgwụgwọ.

Ịfụ ọgwụgwọ mgbe ụfọdụ anaghị adị ize ndụ, mana ịdịgide adịgide dị mkpa maka idobe uru ọgwụ ahụ. Sorokwa ndị otu ahụike gị rụọ ọrụ iji chọta usoro ị nwere ike idobe n'ezie.

Kedu Mgbe M Ga-akwụsị Iwere Iloprost?

Mkpebi ịkwụsị iloprost kwesịrị ka a na-eme ya mgbe niile na ndụmọdụ onye na-ahụ maka ahụike gị, ọ dịghị mgbe onwe gị. Ụfọdụ ndị nwere ike ịkwụsị ọgwụgwọ ma ọ bụrụ na ọnọdụ ha na-akawanye mma nke ukwuu ma ọ bụrụ na ha agbanwe gaa ọgwụ ndị ọzọ dị irè.

Maka ọnọdụ dị ka pulmonary arterial hypertension, ịkwụsị ọgwụgwọ na mberede nwere ike ịdị ize ndụ ma nwee ike ibute ngwa ngwa nke mgbaàmà. Dọkịta gị ga-ebelata ugboro ole a na-eme ọgwụgwọ nwayọọ nwayọọ ma ọ bụrụ na nkwụsị kwesịrị ekwesị.

Nlekota mgbe niile na ule dị ka echocardiograms, ọbara ọrụ, na nyocha mgbaàmà na-enyere ndị otu ahụike gị aka ikpebi ma ọ dị mkpa ọgwụgwọ na-aga n'ihu ma baara gị uru n'ọnọdụ gị.

\u1ee4m\u1ecb m ga-anya \u1ee5gb\u1ecdala mgbe m nwetara \u1ecbgw\u1ecd \u1eccl\u1ecd\u1ecbst?

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