Romiplostim (subcutaneous route)
利用可能なブランド
Nplate
この薬について
Romiplostim injection is used to treat low blood platelet counts (thrombocytopenia) and help prevent bleeding in patients with a blood disorder called immune thrombocytopenia (ITP). This medicine is used after a splenectomy (surgery to remove the spleen) or when other medicines (eg, steroids or immunoglobulins) have not worked well enough in patients with ITP for at least 6 months. Platelets help clot the blood. Romiplostim works by stimulating the bone marrow to produce more platelets. Romiplostim injection is also used to treat acute radiation syndrome in patients who have been exposed to high levels (myelosuppressive doses) of radiation. Myelosuppression is a bone marrow problem that can lead to a decrease in blood cell counts. This medicine is to be given only by or under the direct supervision of your doctor. This product is available in the following dosage forms:
この薬を使用する前に
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of romiplostim injection in children 1 year of age and older with ITP for at least 6 months. However, safety and efficacy have not been established in children younger than 1 year of age with ITP. Appropriate studies on the relationship of age to the effects of romiplostim injection have not been performed in newborns with acute radiation syndrome. However, pediatric-specific problems that would limit the usefulness of this medicine are not expected. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of romiplostim injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving romiplostim injection. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
この薬の使用方法
A doctor or other trained health professional will give you this medicine in a medical facility. It is given as a shot under your skin once a week for patients with ITP or once for every exposure to high levels of radiation. This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Call your doctor or pharmacist for instructions.