Nephritis Lupus

Ka tangohia e ngā whatukuhu te paru me te wai tāpiri mai i te toto mā ngā wāhanga kānana e kiia nei ko ngā nephron. Kei roto i ia nephron tētahi kānana, e kiia nei ko te glomerulus. Kei roto i ia kānana ngā oko toto iti e kiia nei ko ngā capillary. Ka rere te toto ki roto ki tētahi glomerulus, ka pā atu ngā pūngāwerewere iti, e kiia nei ko ngā molecules, o te wai, ngā kohuke me ngā kai, me ngā paru, mā ngā pakitara capillary. Kāore ngā pūngāwerewere nui, pēnei i ngā pūtau pūmua me ngā pūtau toto whero. Ko te wāhanga i kānana ka pā atu ki tētahi atu wāhanga o te nephron e kiia nei ko te tubule. Ka tukuna te wai, ngā kai me ngā kohuke e hiahiatia ana e te tinana ki te rerenga toto. Ko te wai tāpiri me te paru ka waiho hei mimi ka rere ki te pūngāwerewere.

Ko te nephritis lupus tētahi raruraru e puta pinepine ana ki ngā tāngata he mate lupus erythematosus pūnaha, e kiia ana hoki ko te lupus.

Ko te lupus tētahi mate e whakaeke ana te pūnaha ārai mate o te tinana i ōna ake pūtau me ngā whekau, e kiia nei ko te mate ārai mate whaiaro. Ka whakaeke te lupus i te pūnaha ārai mate kia hangaia ngā pūtau pūmua e kiia nei ko ngā autoantibodies. Ka whakaeke ēnei pūtau pūmua i ngā kiko me ngā whekau o te tinana, tae atu ki ngā whatukuhu.

Ngā tohu me ngā tohu o te nephritis lupus ko: Te toto i roto i te mimi. Te mimi e pupū ana i te nui o te pūmua. Te toto teitei. Te pupū o ngā waewae, ngā turi, ngā waewae, ā, i etahi wā i roto i ngā ringa me te mata. Teitei o te taonga paru e kiia nei ko te creatinine i roto i te toto.

Kaore he uauatanga

E tae ana te haurua o ngā tāngata pakeke e pangia ana e te lupus pūnaha ki te nephritis lupus. Ko te lupus pūnaha te take i ngā whakaeke a te pūnaha ārai mate o te tinana ki ngā whatukuhu. Kāti ka kore e taea e ngā whatukuhu te whakakore i ngā paru penei i te tikanga.

Ko tētahi o ngā mahi nui o ngā whatukuhu ko te horoi i te toto. I te nekehanga o te toto puta noa i te tinana, ka kohia e ia te wai, ngā matū me ngā paru. Ka wehea ēnei mea e ngā whatukuhu i te toto. Ka kawea atu ki waho o te tinana i roto i te mimi. Ki te kore e taea e ngā whatukuhu te mahi i tēnei, ā, ka kore te āhuatanga e rongoā, ka puta mai ngā raruraru hauora nui, ā, ka ngaro te ora i te mutunga.

Ko ngā take morearea anake e mohiotia ana mō te nephritis lupus ko:

• Ko te tane. He nui ake te tūponotanga o ngā wāhine ki te whiwhi lupus, engari ka whiwhi ngā tāne i te nephritis lupus nui atu i ngā wāhine.
• Iwi, momo rākau rānei. He nui ake te tūponotanga o te iwi Pango, te iwi Hispanic me ngā Amerikana Āhia ki te whiwhi nephritis lupus i te hunga Pākehā.

Ka taea e te nephritis lupus te whakaeke i te:

• Te toto teitei.
• Te korenga o te whatukuhu.
• Te tupono teitei ake o te whiwhi mate pukupuku, ina koa tetahi e timata ana i roto i nga pūtau o te pūnaha ārai mate, e kiia nei ko te lymphoma B-cell.
• Te tupono teitei ake o nga raruraru o te ngakau me nga oko toto.

Kaore he uauatanga

Ngā whakamātautau hei whakatau i te nephritis lupus e whai ake nei:

• Ngā whakamātautau toto me te mimi. Haunga ngā whakamātautau toto me te mimi noa, ka taea te whakamātautau i te mimi i kohia i roto i te 24 haora. Ka inehia e ēnei whakamātautau te pai o te mahi o ngā whatukuhu.
• Biopsy whatukuhu. Ka tangohia he wahi iti o te kiko whatukuhu ka tukuna ki te taiwhanga. Ka whakatauhia e tēnei whakamātautau te nephritis lupus. Ka āhei hoki te whakaatu i te kino o te mate. Ka neke atu i te kotahi te biopsy i te wa.

Kāore he rongoā mō te nephritis lupus. Ko te whāinga o te maimoatanga ko te:

• Whakaiti i ngā tohu, ā, me whakakore i ngā tohu, e kiia ana ko te remission.
• Ārai i te kino haere o te mate.
• Kia kaua ngā tohu e puta mai anō.
• Kia mau tonu te mahi pai o ngā whatukuhu kia kaua ai e hiahiatia he mīhini hei tārai i ngā paru mai i te toto, e kiia ana ko te dialysis, te whakawhiti whatukuhu rānei.

I te nuinga, ko ēnei maimoatanga pea ka āwhina i ngā tāngata e pangia ana e te mate whatukuhu:

• Huringa kai. Ko te whakaiti i te nui o te pūmua me te tote i roto i te kai ka āwhina i te mahi pai ake o ngā whatukuhu.

Ko te maimoatanga i te nephritis lupus kino pea ka hiahia ki ngā rongoā e whakaheke ana, e mutu ana rānei i te pūnaha ārai mate kei te whakaeke i ngā pūtau ora. Ko te nuinga o ngā rongoā ka whakamahia tahi. I etahi wā, ka whakawhitihia etahi rongoā i whakamahia tuatahi kia ārai ai i ngā pānga pokanoa.

Ko ngā rongoā hei whakaora i te nephritis lupus pea ka uru ki:

• Steroids, pēnei i te prednisone (Rayos).
• Cyclosporine (Gengraf, Neoral, Sandimmune).
• Voclosporin (Lupkynis).
• Tacrolimus (Astagraf, Envarsus, Prograf).
• Cyclophosphamide (Cytoxan).
• Azathioprine (Azasan, Imuran).
• Mycophenolate (CellCept).
• Rituximab (Rituxan).
• Belimumab (Benlysta).

Kei te whakamātautau ngā whakamātautau hauora e haere tonu ana i ngā maimoatanga hou mō te nephritis lupus.

Mō ngā tāngata e haere tonu ana ki te kore mahi o ngā whatukuhu, ko ngā whiringa maimoatanga ko:

• Whakawhiti whatukuhu. Ki te mutu te mahi o ngā whatukuhu, pea ka hiahiatia he whatukuhu mai i tētahi kai hoatu, e kiia ana ko te whakawhiti.

Kaore he uauatanga