He aha te MGUS? Ngā Tohutohu, Ngā Take, me te Maimoatanga

Ko te MGUS te kupu poto mō te Monoclonal Gammopathy o te Kaupapa Kore i Teitei. He āhuatanga tēnei e nui rawa ana te hua o tetahi momo pūmua e kiia nei he pūmua monoclonal, he pūmua M rānei, i roto i tōu wheua wheua. Whakaarohia he mea hanga e tō tinana ngā kape tāpiri o te pūmua kotahi, ahakoa kāore e hiahiatia e ia.

Ko te nuinga o ngā tāngata e pangia ana e te MGUS ka tino pai te ahua me te kore o ngā tohu. Ko te āhuatanga te nuinga o te wā ka kitea mā te aituā i ngā whakamātautau toto noa mō ētahi take. Ahakoa ko te MGUS anō te tino koretake e pā ana ki ngā raruraru, ka tiaki tonu ngā tākua i te mea ka taea e ia te haere tonu ki ngā āhuatanga nui ake i roto i ngā tau maha.

He aha ngā tohu o te MGUS?

Koinei tetahi mea ka miharo pea koe: Kāore te MGUS e tino puta he tohu. Ko te nuinga o ngā tāngata e pangia ana e ia ka tino pai te ahua, ka haere tonu ki o rātou mahi o ia rā, me te kore e mōhio kei a rātou tēnei āhuatanga. Ko te nuinga o te wā ka kiia he āhuatanga ‘ngāwari’ nā te mea ka tino koretake te whakaatu i a ia i roto i tōu ahua.

Ina puta mai ngā tohu, he ngawari rawa te nuinga o te wā, ā, ka uru atu ki te ngenge, ki te ngoikore rānei. Ka kite pea etahi i te ngāwari o te whēnu atu i te noa. He tino onge enei tohu ki te MGUS, ā, he maha ngā whakamārama anō.

I roto i ngā take tino onge, ka taea e te pūmua nui te raruraru ki te mātotorutanga o te toto, ki te mahi o ngā io rānei. Ka āhei pea tenei ki te puta mai ngā tohu pēnei i te wiri i ngā ringa, i ngā waewae rānei, engari ka puta tenei i raro i te 5% o ngā tāngata e pangia ana e te MGUS.

He aha ngā take o te MGUS?

Kāore i tino mōhiotia te take tika o te MGUS, engari ka tīmata i roto i tōu wheua wheua, te wāhi e hangaia ai ngā pūtau toto. I etahi wā, ka tīmata ngā pūtau ārai mate e kiia nei ko ngā pūtau plasma ki te whakaputa nui rawa o tetahi pūmua motuhake, kahore he take mārama.

He mea nui te pakeke ki te whanake i te MGUS. Ka noho hei mea noa ake i te wā e pakeke ana te tangata, ka pā ki te 3% o ngā tāngata neke atu i te 50 tau, tae atu ki te 5% o ngā tāngata neke atu i te 70 tau. Ka rereke te pūnaha ārai mate i te wā e pakeke ana koe, ā, ka āhei pea tenei ki tēnei āhuatanga.

Ka āhei pea te ira ki te whai wāhi. E kite ana te MGUS ki ētahi whānau, e whakaatu ana pea ko ētahi ira ka āhei ake te tangata ki te whanake i a ia. Heoi, ki te mea he mema o tō whānau e pangia ana e te MGUS, kāore tēnā e tikanga ka whiwhi koe i a ia.

E whakaatu ana etahi rangahau ko ngā mate pukupuku roa, ko te whakaohooho tonu rānei o te pūnaha ārai mate ka āhei pea ki te whanake i te MGUS. Heoi, ko te nuinga o ngā tāngata e pangia ana e te MGUS kāore e taea te tohu i tetahi take, i te whakaohooho rānei mō tō rātou āhuatanga.

He aha ngā momo MGUS?

Ka whakarōpūhia te MGUS i runga i te momo pūmua rerekē e whakaputa ana tō wheua wheua. Ko te momo tino noa ko te IgG MGUS, e 70% te nui o ngā take katoa, ā, ko te momo tino pumau.

Ko te IgA MGUS e 10-15% te nui o ngā take, ā, he rite tonu te mahi ki te IgG MGUS. Ko te IgM MGUS e 15-20% te nui o ngā take, ā, he iti ake te tupono ki te haere tonu ki ētahi atu āhuatanga i te IgG me te IgA.

He iti ake te noa o te Light chain MGUS, engari he mea nui kia mōhiotia. I roto i tēnei momo, ko ngā wāhanga anake o ngā pūmua antibody ka whakaputahia i te nui rawa. Me tiaki tata tēnei momo nā te mea ka taea e ia te pā ki te mahi o te whatukuhu.

He momo onge anō e kiia nei ko te heavy chain MGUS, e pā ana ki ngā wāhanga pūmua rerekē. He tino onge tēnei momo, ā, te nuinga o te wā ka hiahiatia ngā whakamātautau motuhake hei whakatau tika.

Nōhea te haere ki te tākua mō te MGUS?

Mēnā kua whakatauhia koe ki te MGUS, me haere koe ki tō tākua mō ngā whakamātautau tirotiro kia rite ki te tūtohu. Ko ēnei te nuinga o te wā ka whakaritea i ia 6 ki te 12 marama, i runga i tō āhuatanga motuhake me ngā take morearea.

Me whakapiri atu koe ki tō tākua kia tere ake mēnā ka whanake koe i ngā tohu hou e awangawanga ana koe. Ka āhei pea enei ki te ngenge kahore e pai ake ki te okioki, ki te mamae o ngā wheua e mau tonu ana, ki ngā mate pukupuku e tino noa ana ki a koe.

Waea atu ki tō kaiwhakarato hauora mēnā ka kite koe i te ngāwari o te whēnu, i te toto rānei e tino nui ana. Ahakoa he maha ngā take o ēnei tohu, he mea tika kia kōrerohia ina pangia koe e te MGUS.

Ko ētahi rerekētanga nui i tō ahua, ina koa mēnā ka whanake haere i roto i ngā wiki, i ngā marama rānei, e tika ana kia whakarongohia. Ka taea e tō tākua te awhina ki te whakatau mēnā ko ēnei rerekētanga e pā ana ki te MGUS, ki tetahi atu mea rānei.

He aha ngā take morearea mō te MGUS?

Ko te mōhiotanga ki ō take morearea ka taea te awhina i a koe me tō tākua ki te whakatau whakamārama mō te tirotiro me te tiaki. Ko te take morearea tino kaha mō te MGUS ko te pakeke, ka noho hei mea noa ake te āhuatanga i muri i te 50 tau.

Koinei ngā take morearea matua ka taea te whakanui ake i tō tupono ki te whanake i te MGUS:

• Pakeke neke atu i te 50 tau, ka nui haere te morearea i muri i te 70
• Ira tane - he iti ake te tupono o ngā tāne ki te whanake i te MGUS i ngā wāhine
• Iwi African American - ko te āhuatanga e rua te nui i roto i ngā African American
• Hītori whānau o te MGUS, o ngā mate toto e pā ana rānei
• Hītori o ētahi āhuatanga autoimmune, o ngā mate pukupuku roa rānei
• Te whakamahinga o mua i ētahi matū, i te radiation rānei, ahakoa he iti ake tēnei

Ko te whai i ēnei take morearea kāore e tikanga ka whanake koe i te MGUS. Ko te nuinga o ngā tāngata e maha ana ngā take morearea kāore e whanake i te āhuatanga, ka mahi ētahi atu kahore he take morearea mārama. Ko ēnei take anake te awhina i ngā tākua ki te mōhio ko wai pea ka nui ake te tupono ki te whanake i te MGUS.

He aha ngā raruraru pea o te MGUS?

Ahakoa ko te MGUS anō te tino koretake e pā ana ki ngā raruraru, ko te take matua ko te taea e ia te haere tonu ki ngā mate toto nui ake i te wā. Ka puta haere tenei haere tonu, te nuinga o te wā i roto i ngā tau maha, ā, ko te iti noa o te ōrau o ngā tāngata e pangia ana e te MGUS.

Ko te raruraru pea tino nui ko te haere tonu ki te multiple myeloma, he momo mate pukupuku toto. Ka puta tenei i te 1% o ngā tāngata e pangia ana e te MGUS i ia tau. Ko te tikanga, i muri i te 10 tau, ko te 10% pea o ngā tāngata e pangia ana e te MGUS kua whanake i te multiple myeloma.

Ka taea e ētahi tāngata e pangia ana e te MGUS te whanake i ētahi atu mate toto pēnei i te lymphoma, i te āhuatanga e kiia nei ko te amyloidosis rānei. He iti ake te noa o ēnei raruraru i te multiple myeloma, engari he mea tika tonu te tiaki me te maimoatanga mēnā ka puta.

I roto i ngā take onge, ka taea e te pūmua nui i roto i te MGUS te raruraru ki te mātotorutanga o te toto, ki te whakakāo toto noa rānei. Ka āhei pea tenei ki ngā raruraru rere, ki te toto rerekē rānei, engari ko ēnei raruraru e pā ana ki te iti iho i te 5% o ngā tāngata e pangia ana e te MGUS.

He mea nui kia mahara ko te nuinga o ngā tāngata e pangia ana e te MGUS kāore e whanake i ētahi o ēnei raruraru. Ko te kaupapa o te tiaki noa ko te hopu i ngā rerekētanga i te tīmatanga mēnā ka puta.

Me pēhea te whakatau i te MGUS?

Ko te nuinga o te wā ka kitea te MGUS mā ngā whakamātautau toto kāore i te rapu motuhake mō ia. Ka taea e tō tākua te tono i ēnei whakamātautau mō te tirotiro hauora noa, ki te rangahau rānei i ētahi atu tohu e pā ana ki a koe.

Ko te whakamātautau matua e kiia nei ko te serum protein electrophoresis, e wehewehe ana i ngā pūmua rerekē i roto i tō toto. Mēnā ka whakaatu tēnei whakamātautau i te pūmua rerekē, ka tono atu tō tākua ngā whakamātautau motuhake ake hei whakatau tika i te momo pūmua e nui ake ana.

Ka awhina ngā whakamātautau toto tāpiri ki te whakatau i te nui o te pūmua rerekē, ki te tirotiro rānei mō ētahi atu rerekētanga pūtau toto. Ka uru atu ēnei whakamātautau ki te immunofixation electrophoresis me ngā whakamātautau mekameka marama koreutu, e whakarato ana i ngā mōhiohio taipitopito ake mō ngā pūmua motuhake e pā ana.

Ka taea pea e tō tākua te tūtohu i te biopsy wheua wheua hei titiro ki ngā pūtau e whakaputa ana i ēnei pūmua. Ka uru atu tenei ki te tango i te tauira iti o te wheua wheua, te nuinga o te wā mai i tō wheua huha, hei tirotiro i raro i te microscope. Ahakoa ka rongo tenei he awangawanga, ko te nuinga o te wā ka mahihia hei mahi manawanui me te anesthetic kūiti.

Ka taea pea te tono i ngā whakamātautau whakaahua pēnei i ngā X-rays, i ngā karaiti nui ake rānei hei tirotiro mō ētahi rerekētanga wheua. Ka awhina ēnei whakamātautau ki te wehewehe i te MGUS mai i ngā āhuatanga nui ake ka taea te pā ki ngā wheua.

He aha te maimoatanga mō te MGUS?

Koinei etahi karere whakamarie: Kāore te MGUS anō e tino hiahia ki tetahi maimoatanga. Nā te mea ko te nuinga o ngā tāngata e pangia ana e te MGUS ka pai te ahua, ā, kāore te āhuatanga e tino puta he raruraru, ko te nuinga o ngā tākua ka tūtohu i te huarahi ‘matakitaki me te tatari’.

Ko te ‘maimoatanga’ matua mō te MGUS ko te tiaki noa mā ngā whakamātautau toto. Ka whakaritea e tō tākua ngā hui whakamātautau i ia 6 ki te 12 marama hei tirotiro mēnā he pumau ngā taumata pūmua, hei tiaki rānei mō ētahi tohu o te haere tonu.

Mēnā ka whanake koe i ngā tohu ka pā pea ki te MGUS, ka taea e tō tākua te whakautu motuhake ki aua mea. Hei tauira, mēnā ka pā te pūmua nui ki tō mātotorutanga toto, he maimoatanga kei reira hei awhina ki te rere.

Ka taea pea e ētahi tākua te tūtohu i ngā mahi hauora whānui e tautoko ana i tō pūnaha ārai mate me tō oranga whānui. Ka uru atu ēnei ki te pupuri i te kai hauora, ki te whakahaere i te whakakori tinana, ki te noho rānei ki runga i ngā whakakōhatu.

Ka noho hei mea tika te maimoatanga mēnā ka haere tonu te MGUS ki te āhuatanga nui ake pēnei i te multiple myeloma. I taua wā, ka kōrero tō tākua i ngā kōwhiringa maimoatanga motuhake i runga i te whakatau hou.

Me pēhea te whakahaere i te MGUS i te kāinga?

Ko te noho tahi me te MGUS te nuinga o te wā e pā ana ki te pupuri i tō hauora whānui i te wā e mōhio ana koe ki tō āhuatanga. Nā te mea kāore te MGUS e tino puta he tohu, ka taea te haere tonu tō oranga o ia rā kia rite ki te wā i mua i tō whakatau.

Arotake ki te pupuri i te oranga hauora me te whakakori tinana noa, te kai rite, me te moe tika. Ka tautoko ēnei tikanga i tō pūnaha ārai mate me tō oranga whānui, he mea whai hua ahakoa kei a koe te MGUS, kāore rānei.

Pupuri i te tuhi o ō whakamātautau tiaki, ā, kaua e ngaro. Ko ngā whakamātautau toto noa tō taputapu pai rawa atu hei hopu i ngā rerekētanga i te tīmatanga. Whakaarohia te whakarite i ngā whakamahara i tō waea, i tō kārena rānei hei awhina i a koe ki te mahara ki ēnei tirotiro nui.

Noho mōhio ki tō āhuatanga, engari kaua e nui rawa te manukanuka, te rapu i te ipurangi rānei e āhei pea te whakanui i te awangawanga. Ko tō tākua tō puna pai rawa atu mō ngā mōhiohio tika, motuhake mō tō āhuatanga motuhake.

Whakarongo ki tō ahua, engari kaua e tino aro ki ia tohu iti. Ko te nuinga o ngā mamae o ia rā, o ngā mamae rānei kāore e pā ana ki te MGUS. Whakapiri atu ki tō tākua mēnā ka kite koe i ngā rerekētanga nui i tō kaha, i te mamae rerekē, i ētahi atu tohu awangawanga rānei.

Me pēhea te whakarite mō tō hui tākua?

Ko te whakarite mō ō whakamātautau whai muri o te MGUS ka taea te awhina i a koe ki te whakamahi pai i tō wā ki tō tākua. I mua i tō haerenga, tuhituhia ētahi pātai, ētahi awangawanga rānei e hiahia ana koe ki te kōrero, ahakoa he iti pea.

Pupuri i te tuhi ngāwari o ētahi tohu kua kitea e koe mai i tō whakamātautau whakamutunga. Tāpirihia te wā i tīmata ai, te roa o te wā, me te aha i āhei ai te awhina, i te whakaiti rānei i aua mea. Ka awhina ēnei mōhiohio i tō tākua ki te mōhio ki ngā rerekētanga i tō āhuatanga.

Mau mai he rārangi o ngā rongoā me ngā taapiri katoa e inu ana koe, tae atu ki ngā rāpoi me te wā e inu ana koe. Ka taea e ētahi rongoā te pā ki ngā hua whakamātautau toto, no reira me mōhio tō tākua ki ngā mea katoa e inu ana koe.

Whakaarohia te mau mai i te mema whānau, i te hoa rānei ki tō whakamātautau, ina koa mēnā kei te awangawanga koe mō tō whakatau. Ka taea e rātou te awhina i a koe ki te mahara ki ngā mōhiohio nui, ki te whakarato rānei i te tautoko ngākau.

Tuhituhia ō pātai tino nui i mua, ā, ui atu i te tīmatanga o te whakamātautau. Ka whakarite tēnei ka whiwhi koe i ngā whakautu ki ngā mea nui rawa atu ki a koe, ahakoa ka poto te whakamātautau.

He aha te mea nui mō te MGUS?

Ko te mea nui rawa atu hei mōhio mō te MGUS ko te nuinga o te wā he āhuatanga whakahaere e kore e tino pā ki tō oranga o ia rā. Ahakoa ko te ingoa pea ka rongo he whakawehi, ko te nuinga o ngā tāngata e pangia ana e te MGUS ka noho oranga noa, hauora, kahore he tohu, he raruraru rānei.

Ko te tiaki noa tō rautaki pai rawa atu hei pupuri i te hauora me te MGUS. Ka taea e ēnei tirotiro noa te awhina i tō tākua ki te aroturuki i ngā rerekētanga, ki te mahi rānei mēnā e hiahiatia ana.

Kia mahara ka haere tonu te MGUS ki ngā āhuatanga nui ake i roto i te iti noa o te ōrau o ngā tāngata, ā, ka puta haere tenei haere tonu i te wā roa i roto i ngā tau maha. Ko te nuinga o ngā tāngata e pangia ana e te MGUS kāore e whanake i ētahi raruraru mai i tō rātou āhuatanga.

Noho hono atu ki tō rōpū hauora, ā, kaua e whakaroa ki te ui i ngā pātai, ki te kōrero rānei i ngā awangawanga. Ko te mōhiotanga ki tō āhuatanga me te ngākau nui mai i tō rōpū hauora ka taea te awhina i te whakaiti i te awangawanga, me te whakapai ake i tō kounga oranga whānui.

Ngā pātai e ui pinepinetia ana mō te MGUS

He momo mate pukupuku te MGUS?

Kāore te MGUS he mate pukupuku, engari e kiia ana he āhuatanga precancerous. Ka uru atu ki te whakaputa pūmua rerekē e ngā pūtau ārai mate, engari kāore ēnei pūtau kua riro hei mate pukupuku. Ko te nuinga o ngā tāngata e pangia ana e te MGUS kāore e whanake i te mate pukupuku, ahakoa he iti te morearea o te haere tonu ki ngā mate pukupuku toto pēnei i te multiple myeloma i roto i ngā tau maha.

Ka taea te whakaora i te MGUS?

Kāore he rongoā mō te MGUS, engari kāore tēnā e tino raruraru nā te mea kāore te nuinga o ngā tāngata e hiahia ana ki te maimoatanga. Ko te MGUS te nuinga o te wā he āhuatanga pumau e kore e hiahia ki te whakauru. Ko te arotahi ki te tiaki, kāore ki te whakaora, nā te mea kāore te maimoatanga e tino hiahiatia kia kore rawa e puta ngā raruraru.

Ka pā te MGUS ki taku roa ora?

Mō te nuinga o ngā tāngata, kāore te MGUS e tino pā ki te roa ora. Ka whakaatu ngā rangahau ko ngā tāngata e pangia ana e te MGUS pumau he rite tonu te roa ora ki ngā tāngata kahore he āhuatanga. Ko te iti o te ōrau e whanake ana i ngā raruraru ka āhei pea ki ngā hua rerekē, engari ko te kite i te tīmatanga mā te tiaki noa te awhina i te whakarite i te maimoatanga tere ina hiahiatia.

Ka taea e au te whakakori tinana noa me te MGUS?

Ae, ka taea e koe te whakakori tinana noa me te MGUS. Ko te tikanga, ka whakaohoohohia te mahi tinana noa hei wāhanga o te pupuri i te hauora whānui. Kāore te nuinga o te wā he herenga whakakori tinana kia kore rawa e whanake koe i ngā raruraru motuhake. Kōrero atu ki tō tākua mō ētahi awangawanga, engari ko te nuinga o ngā tāngata e pangia ana e te MGUS ka taea te haere tonu ki o rātou mahi noa kahore he herenga.

Me kōrero atu rānei ahau ki tōku whānau mō taku whakatau MGUS?

Ko te kōrero atu rānei i tō whakatau he kōwhiringa whaiaro, engari ka taea te whai hua ki te kōrero atu ki ngā mema whānau tata. Ka taea e te MGUS te whai wāhi ira, no reira ka hiahia pea ngā mema whānau ki te kōrero mō te tirotiro ki ō rātou tākua. I tua atu, ko te whai tautoko whānau ka taea te awhina ngākau i te wā e haere ana koe i ngā whakamātautau tiaki noa.