He aha te Waldenstrom Macroglobulinemia? Tohutohu, Take, me te Maimoatanga

Ko te Waldenstrom macroglobulinemia he momo mate toto onge, e pa ana ki te kaha o to pūnaha mate kia whawhai ki ngā mate. Ka puta mai i te tipu haere o ētahi pūtau toto ma, e kiia nei ko ngā B-lymphocytes, ka nui rawa te hanga i te pūmua e kiia nei ko te IgM antibody.

He puhoi te nekehanga o tēnei āhuatanga ki te whakataurite ki ētahi atu mate toto, ā, ko te tikanga ka taea e te tini o te iwi te noho tahi me ia mō ngā tau e whakahaere ana i ō rātou tohu. Ahakoa ka rangona he nui rawa i te tīmatanga, ka taea e te mārama ki te mea kei te puta i roto i tō tinana te awhina i a koe kia nui ake te manaaki i tō haerenga hauora.

He aha te Waldenstrom Macroglobulinemia?

Ko te Waldenstrom macroglobulinemia, e kiia ana ko te WM, he mate pūngāwerewere e tīmata ana i roto i ō wheua wheua, te wāhi e hangaia ai ngā pūtau toto. Ko ngā pūtau mate pūngāwerewere he momo pūtau toto ma motuhake e awhina ana i a koe i te tikanga ki te tiaki i a koe i ngā mate.

Ka hanga e ēnei pūtau koretake ngā nui o te pūmua e kiia nei ko te immunoglobulin M, ko te IgM rānei. Ki te nui rawa te IgM e hanga ana i roto i tō toto, ka mātotorotoru ake tō toto i te tikanga, pērā i te honi, ehara i te wai. Ka taea e tēnei mātotorotorutanga te whakaputa i ngā raruraru ki te rere o te toto puta noa i tō tinana.

E kiia ana te WM he momo lymphoma, he momo lymphoma kore-Hodgkin motuhake. Kei te whakarōpūhia hoki hei lymphoma lymphoplasmacytic, no te mea ko ngā pūtau mate pūngāwerewere e rite ana ki te whakaranu i waenga i ngā lymphocytes me ngā pūtau plasma i raro i te microscope.

He aha ngā Tohutohu o te Waldenstrom Macroglobulinemia?

He tokomaha ngā tāngata e whai WM ana kaore he tohu i te tīmatanga, ā, ka kitea te āhuatanga i ngā whakamātau toto noa. Ki te puta mai ngā tohu, ka tipu haere, ā, ka taea te whakaaro he ngenge whānui, he raruraru hauora iti rānei.

Ko ngā tohu tino noa ka pā atu ki a koe ko:

• Te ngenge tonu e kore e pai ake me te okioki
• Te ngoikore e āhei ai ngā mahi o ia rā
• Te mārōngaro ngāwari, te toto rānei, ahakoa mai i ngā pakaru iti
• Te toto ihu maha, te toto ngutu rānei
• Ngā ngutu lymph nui i tō kaki, ngutu, i tō pūtake rānei
• Ngā wera po e whakamakuku ana i ō kakahu, i ō papa rānei
• Te ngaro taimaha kore e hiahiatia ana i roto i ngā marama maha
• Ngā mate maha e roa ana te ora

Ka whanakehia hoki e ētahi tāngata ngā tohu e pā ana ki te toto mātotorotoru, e kiia ana e ngā tākuta ko te hyperviscosity syndrome. Ka puta ēnei tohu no te mea he uaua te rere o te toto mātotorotoru i ngā oko iti i roto i tō tinana.

Ko ngā tohu o te toto mātotorotoru ko:

• Te tirohanga māreikore, te huringa rānei o te tirohanga
• Ngā mamae o te mahunga e rerekē ana i ō mamae mahunga noa
• Te wiri, te mārama rānei
• Te whakawareware, te uaua rānei ki te aro
• Te poto o te manawa i ngā mahi noa

Kaore i te noa, ka taea e koe te kite i te wiri, te ngenge rānei i ō ringa me ō waewae. Ka puta mai tēnei ina pā te pūmua IgM atu ki ō ngāwari, he āhuatanga e kiia nei ko te peripheral neuropathy.

He aha ngā Take o te Waldenstrom Macroglobulinemia?

Kaore i te tino mārama te take pono o te WM, engari e whakapono ana ngā kairangahau ka tīmata ina puta mai ngā huringa DNA i roto i ngā B-lymphocytes. Ka korero ēnei huringa ira ki ngā pūtau kia tipu, kia wehewehea ina kore e tika, ā, ka āhei ai te hanga o ngā pūtau koretake.

Ko te nuinga o ngā take o te WM ka puta noa mai kaore he whakaohooho mārama. Ko ngā huringa DNA e puta ai te WM ka puta i te oranga o te tangata, ehara i te whakawhiwhia mai i ngā mātua.

Heoi, kua kitea e ngā kāre e whai hua etahi take ka nui ake te tūponotanga o te whanaketanga o te WM. Ko te 20% o ngā tāngata e whai WM ana he whānau kei a rātou te WM, he mate toto e rite ana rānei, e whakaatu ana pea he wāhi te ira i roto i ētahi take.

Ko te tau te take tūponotanga kaha e mohio ana tātou. Ko te WM e pā ana ki ngā pakeke pakeke, ko te nuinga o ngā tāngata i te tekau tau atu i te 60, 70 rānei. He nui ake te tūponotanga o ngā tāne ki te whanake WM i ngā wāhine.

Nōhea te Kite i te Tākuta mō te Waldenstrom Macroglobulinemia?

Me whakapiri atu koe ki tō tākuta ki te pā atu ki a koe ngā tohu tonu e kore e pai ake i muri i ngā wiki torutoru. Ahakoa he maha ngā take o ēnei tohu, he mea nui kia tirotirohia, inā koa ki te maha ngā tohu e noho tahi ana.

Whakahaere he hui ki te kite koe i te ngenge tonu e āhei ana ki tō oranga o ia rā, te ngaro taimaha kore e whakamaarama, te maha rānei o ngā mate. E tika ana ēnei tohu kia whakarongohia te rongoā ahakoa te take.

Rapua te tiaki hauora tonu ki te whanake koe i ngā huringa tirohanga ohorere, ngā mamae o te mahunga nui, te whakawareware, te poto nui rānei o te manawa. Ka taea e ēnei te tohu kei te pā te toto mātotorotoru ki ngā kōpū nui, ā, e hiahia ana ki te rongoā tere.

Kaua e manukanuka ki te ahua tino tupato. Ka pai ake te tākuta ki te aromatawai i ngā tohu e puta mai ana he mea iti, i te ngaro i te mea e hiahia ana ki te whakarongo.

He aha ngā Take Tūponotanga mō te Waldenstrom Macroglobulinemia?

He maha ngā take ka nui ake ai ō tūponotanga ki te whanake WM, ahakoa te whai i ngā take tūponotanga kaore e tikanga ka whiwhi koe i te āhuatanga. Ko te nuinga o ngā tāngata e whai take tūponotanga ana kaore e whanake WM, ā, ko ētahi tāngata kaore he take tūponotanga e mohiotia ana ka whai.

Ko ngā take tūponotanga matua ko:

• Te tau neke atu i te 60, me te nui haere o te tūponotanga i te pakeke
• Ko te tane, i te mea ka whanake ngā tāne WM i te iti ake i ngā wāhine
• Te whai i te hītori whānau o te WM, te mate toto rānei e rite ana
• Te whai i te āhuatanga e kiia nei ko te monoclonal gammopathy o te kore e whakatau (MGUS)
• Te whakamahinga o mua ki te huaketo hepatitis C
• Ētahi āhuatanga autoimmune

Ko te MGUS he āhuatanga e hanga ana e tō tinana ngā pūmua koretake e rite ana ki ngā mea kei roto i te WM, engari i roto i ngā nui iti. Ko te nuinga o ngā tāngata e whai MGUS ana kaore e whanake mate pūngāwerewere, engari ka nui ake te tūponotanga o te WM me ētahi atu mate toto.

Kua akohia ngā take taiao pērā i te whakamahinga ki ētahi matū, te radiation rānei, engari kaore he hononga mārama ki te WM i whakatūria. Ko te rongo pai ko te nuinga o ngā take tūponotanga mō te WM he mea kaore e taea e koe te whakahaere, ko te tikanga kaore he mea i mahi koe ki te whakaputa i te āhuatanga.

He aha ngā Raruraru Ka Taea o te Waldenstrom Macroglobulinemia?

Ka taea e te WM te whakaputa i ngā raruraru maha, no te mea o te toto mātotorotoru me ngā pānga o ngā pūtau mate pūngāwerewere ki tō pūnaha mate. Ka taea e te mārama ki ēnei wāhi te awhina i a koe ki te mohio ki te wa e rapu ai i te tiaki hauora.

Ko te raruraru tino nui ko te hyperviscosity syndrome, te mātotorotoru rawa o te toto ki te rere tika. Ka pā tēnei ki te 10-30% o ngā tāngata e whai WM ana, ā, ka taea te whakaputa i ngā raruraru tirohanga, te toto, ā, i roto i ngā take onge, te pōkaikaha, te mate ngakau rānei.

Ko ngā raruraru noa ko:

• Te nui haere o te tūponotanga o ngā mate nā te ngoikore o te pūnaha mate
• Te anemia, te whakaputa i te ngenge me te poto o te manawa
• Ngā raruraru toto nā te iti o ngā tau platelet
• Te nui o te kōpū e taea ai te mamae o te kopu
• Ngā raruraru whatukuhu mai i te hanga pūmua
• Te kino o ngā ngāwari e whakaputa ana i te ngenge, te wiri rānei

Ka whanakehia e ētahi tāngata te āhuatanga e kiia nei ko te cryoglobulinemia, te whakakotahitanga o ngā pūmua i roto i te toto i ngā pāmahana makariri. Ka taea e tēnei te whakaputa i te mamae o ngā hononga, ngā pupuhi kiri, te raruraru rere rānei i te rangi makariri.

Kaore i te noa, ka taea e te WM te huri ki te momo lymphoma kaha ake e kiia nei ko te diffuse large B-cell lymphoma. Ka puta mai tēnei i raro i te 10% o ngā take, ā, ka puta i ngā tau maha i muri i te whakatau WM tuatahi.

Ko te rongo pai ko ngā maimoatanga hou ka taea te aukati, te whakahaere rānei i te nuinga o ēnei raruraru. Ko te tirotiro noa te awhina i te hopu i ngā raruraru i te tīmatanga ina ngāwari ake te rongoā.

Me pēhea te Whakatau o te Waldenstrom Macroglobulinemia?

Ko te whakatau i te WM e whakauru ana i ngā whakamātau maha ki te whakau i te noho o ngā pūtau mate pūngāwerewere me te ine i ngā taumata pūmua IgM i roto i tō toto. Ka tīmata tō tākuta me ngā whakamātau toto, ā, ka hiahia pea ki ētahi atu mahi hei whiwhi i te pikitia katoa.

Ko te tukanga whakatau e tīmata ana i te mahi toto e whakaatu ana i ngā taumata pūmua koretake, te tau o ngā pūtau toto rānei. Ka tono tō tākuta i ngā whakamātau motuhake ki te ine i ngā taumata IgM me te rapu i te tauira pūmua tohu o te WM.

Ko ngā whakamātau whakatau matua ko:

1. Te tau toto katoa ki te tirotiro i ngā momo pūtau toto katoa
2. Te whakamātau metabolic whānui ki te aromatawai i te mahi kōpū
3. Te electrophoresis pūmua serum ki te tautuhi i ngā pūmua koretake
4. Te immunofixation ki te whakau i te momo pūmua koretake
5. Te biopsy wheua wheua ki te tirotiro tika i ngā pūtau mate pūngāwerewere
6. Te cytometry rere ki te tautuhi i ngā tohu pūtau motuhake

Ko te biopsy wheua wheua e mahia ana i te tikanga hei mahi manawanui me te anesthetic rohe. Ka tango tō tākuta i te tauira iti o te wheua wheua mai i tō wheua huha ki te tirotiro i raro i te microscope.

Ka taea e ngā whakamātau atu te whakauru i ngā CT scans ki te tirotiro i ngā ngutu lymph nui, ngā kōpū rānei, ā, i etahi wā te whakamātau ira o ngā pūtau mate pūngāwerewere hei arahi i ngā whakatau maimoatanga. Ka taea hoki e tō tākuta te whakamātau i te mātotorotoru o tō toto ki te whai koe i ngā tohu o te hyperviscosity syndrome.

He aha te Maimoatanga mō te Waldenstrom Macroglobulinemia?

Ko te maimoatanga mō te WM e whakawhirinaki ana ki ō tohu, ngā hua whakamātau toto, me te hauora whānui. He tokomaha ngā tāngata e whai WM ana kaore e hiahia ki te maimoatanga tere, ā, ka taea te tirotiro me ngā tirotiro noa, he huarahi e kiia nei ko te "matakitaki me te tatari."

Ka tūtohutia e tō tākuta te maimoatanga ki te whanake koe i ngā tohu, ki te heke nui ō tau toto, ki te nui rawa te taumata IgM. Ko te whāinga ko te whakahaere i te mate, te whakaiti i ngā tohu, me te pupuri i tō kounga ora.

Ko ngā kōwhiringa maimoatanga noa ko:

• Ngā rongoā chemotherapy pērā i te bendamustine, te fludarabine rānei
• Ngā rongoā whakaeke pērā i te ibrutinib, te rituximab rānei
• Ngā whakakotahitanga immunotherapy e mahi tahi ana me tō pūnaha mate
• Te plasmapheresis ki te tango i ngā pūmua nui atu i te toto
• Te whakawhiti pūtau pūtau i roto i ngā manawanui taitamariki

Ko te Rituximab e whakamahia ana i te nuinga no te mea e tautuhi ana i ngā momo pūtau kei roto i te WM. E hoatu ana i te tikanga hei whakauru i roto i te rūma, ā, e whakakotahitia ana i te nuinga me ngā rongoā chemotherapy mō ngā hua pai ake.

Ko te Plasmapheresis he tukanga e kānana ana i tō toto ki te tango i te pūmua IgM nui atu. E whakamahia ana i te nuinga hei huarahi tere ki te whakaiti i te mātotorotoru o te toto i te wa e pā ana ngā maimoatanga atu.

Ko te maimoatanga e hoatu ana i te tikanga i roto i ngā huringa me ngā wā okioki i waenganui kia taea ai e tō tinana te ora. Ko te nuinga o ngā tāngata ka taea te whakahaere i ō rātou mahi noa i te wa e maimoatia ana, ahakoa ka taea e koe te ngenge atu i te noa.

Me pēhea te Whakahaere i te Waldenstrom Macroglobulinemia i te Kāinga?

Ko te noho tahi me te WM e whakauru ana i te tiaki i tō hauora whānui i te wa e whakahaere ana i ngā tohu ka pā atu ki a koe. Ka taea e ngā whakarerekētanga noho ora ngāwari te awhina i a koe kia pai ake te ahua me te whakaiti i tō tūponotanga ki ngā raruraru.

Aro atu ki te pupuri i tō kaha mā te whiwhi i te okioki tika me te kai i ngā kai kai hauora. E hiahia ana tō tinana ki te kaha atu ki te whakahaere i te āhuatanga, na kaua e whakama ki te hiahia ki te moe atu i mua.

Ko ngā mahi tiaki whaiaro nui ko:

• Te kai i te kai rite e whai hua ana i ngā hua, ngā huawhenua, me te pūmua
• Te pupuri i te wai mā te inu i te wai nui
• Te whiwhi i te whakakori tinana ngawari, ngawari i te wa e taea ana e tō kaha
• Te karo i ngā mano i te wa o te takurua me te mate huaketo
• Te horoi i ngā ringa maha hei aukati i ngā mate
• Te tango i ngā rongoā kua tohua tika i te ara i tohua

Tirohia ō tohu me te pupuri i ngā huringa. Ka kitea e ētahi tāngata he awhina te pupuri i te puka ngāwari o te ahua o rātou, he korero whai hua tēnei mō tō rōpū hauora.

Pupurihia te whakahou me ngā whakakakahu, engari tirohia tō tākuta tuatahi no te mea kaore pea e tūtohutia ētahi whakakakahu i te wa e maimoatia ana. Kaore pea tō pūnaha mate e whakautu ki ngā whakakakahu pērā i te noa, engari he pai ake te tiaki i te kore.

Kaua e whakaroa ki te tono awhina ki ngā mahi o ia rā ina ngenge koe, ina kore rānei e pai.

Me pēhea te Whakamahere mō tō Hui Tākuta?

Ko te whakamahere mō ō hui ka taea te awhina i a koe ki te whakamahi pai i tō wā me tō rōpū hauora. Tuhia ō pātai me ō awangawanga i mua kia kaua e wareware ki te kōrero i ngā kaupapa nui.

Kawe mai he rārangi katoa o ngā rongoā, ngā huaora, me ngā tāpiri katoa e tangohia ana e koe, tae atu ki ngā horopeta me te maha o te tango. Ka awhina tēnei i tō tākuta ki te karo i ngā mahi kino pea.

I mua i tō hui, whakamahere:

• He rārangi o ō tohu katoa me te wa i tīmata ai rātou
• Tō hītori hauora, tae atu ki ētahi atu āhuatanga me ngā maimoatanga
• Te hītori whānau o ngā mate toto, mate pūngāwerewere rānei
• Ngā pātai mō tō whakatau, ngā kōwhiringa maimoatanga, me te whakatau
• He hoa whakawhirinaki, he mema whānau rānei ki te haere mai ki a koe

Whakaarohia te kawe mai i tetahi ki ō hui, inā koa ina kōrero ana i ngā kōwhiringa maimoatanga, ina whiwhi rānei i ngā hua whakamātau. Ka taea e rātou te awhina i a koe ki te mahara ki ngā korero nui me te whakarato i te tautoko ngākau.

Kaua e wehi ki te tono atu ki tō tākuta kia whakamaarama i tetahi mea kaore koe e mārama. He mea noa te hiahia ki ngā kupu hauora kia whakamaaramahia i roto i te reo ngāwari ake, ā, ka mihi ngā tākuta pai ki ngā manawanui e hiahia ana ki te mārama ki ō rātou āhuatanga.

He aha te Tango Matua mō te Waldenstrom Macroglobulinemia?

Ko te WM he āhuatanga e taea te whakahaere e puhoi ana te tipu, e hoatu ana ki a koe me tō rōpū hauora te wā ki te whakarite i te huarahi pai mō tō āhuatanga.

Ko te mea nui rawa ki te mahara ko te WM e pā ana ki te katoa i te rerekē. Ko ētahi tāngata e hiahia ana ki te maimoatanga tere, ko ētahi atu kaore e hiahia ki te maimoatanga i ngā tau.

Kua pai ake ngā hua mō ngā tāngata e whai WM ana. Kei te whanake tonu ngā rongoā hou, ā, he tokomaha ngā tāngata e whiwhi ana i ngā wā roa e whakahaeretia pai ana to rātou mate.

Aro atu ki te mea ka taea e koe te whakahaere: te noho hauora, te whai i tō mahere maimoatanga, te pupuri i ō hui, me te pupuri i te kōrero whakatuwhera me tō rōpū hauora. Me te tiaki tika me te tirotiro, ka taea e te nuinga o ngā tāngata e whai WM ana te whakahaere tonu i ō rātou oranga me ngā mahi e aroha ana rātou.

Ngā Pātai Nui e Uihia ana mō te Waldenstrom Macroglobulinemia

He whakawhiwhia te Waldenstrom macroglobulinemia?

Ahakoa ko te nuinga o ngā take o te WM ka puta noa mai, ko te 20% o ngā tāngata e whai WM ana he whānau kei a rātou te āhuatanga ano, he mate toto e rite ana rānei. E whakaatu ana tēnei pea he wāhi te ira i roto i ētahi whānau, engari te whai i te mema whānau e whai WM ana kaore e tikanga ka whanake koe.

Ki te whai koe i te hītori whānau o te WM, kōrerohia tēnei ki tō tākuta. Ka tūtohu pea rātou ki ngā whakamātau toto maha atu hei tirotiro i ngā tohu tīmatanga, engari kaore he whakamātau tirotiro motuhake mō te WM i roto i ngā tāngata kaore he tohu.

E hā roa te ora o te tangata e whai Waldenstrom macroglobulinemia ana?

Ko te WM i te nuinga he mate pūngāwerewere e puhoi ana te tipu, ā, he tokomaha ngā tāngata e ora ana mō ngā tau maha i muri i te whakatau. Ko te ora toharite e inetia ana i roto i ngā tekau tau, ehara i ngā tau, inā koa me ngā maimoatanga hou.

Ko tō tirohanga motuhake e whakawhirinaki ana ki ngā take pērā i tō tau, te hauora whānui, ngā tohu i te whakatau, me te pai o tō whakautu ki te maimoatanga. Ka taea e tō tākuta te hoatu i ngā korero motuhake atu e whakaū ana ki tō āhuatanga motuhake.

Ka taea te whakaora i te Waldenstrom macroglobulinemia?

I tēnei wā, kaore he rongoā mō te WM, engari e kiia ana he āhuatanga tino taea te rongoā. He tokomaha ngā tāngata e whiwhi ana i te remission roa e kore e kitea te mate, e whakahaeretia ana rānei mō ngā tau.

Ko te whāinga o te maimoatanga ko te whakahaere i ngā tohu, te aukati i ngā raruraru, me te pupuri i te kounga ora. Me te maimoatanga tika, ka taea e te tini o ngā tāngata e whai WM ana te ora i ngā oranga noa me te whakahaere tonu i ō rātou mahi noa.

He aha te rerekētanga i waenga i te WM me te multiple myeloma?

Ko te WM me te multiple myeloma ngā mate toto e pā ana ki ngā pūtau plasma, engari he mate rerekē rātou. Ko te WM e hanga ana i ngā antibodies IgM i te nuinga, ā, kaore i te pā ki ngā wheua, i te wa e hanga ana te multiple myeloma i ngā antibodies rerekē i te nuinga, ā, e pā ana ki te kino o ngā wheua.

He rerekē ngā maimoatanga mō ēnei āhuatanga, ko te take tenei he mea nui te whiwhi i te whakatau tika. Ka whakamahi tō tākuta i ngā whakamātau motuhake hei wehewehe i ēnei me ētahi atu āhuatanga e rite ana.

Ka taea e au te whakahaere tonu i te mahi me te Waldenstrom macroglobulinemia?

He tokomaha ngā tāngata e whai WM ana e whakahaere tonu ana i te mahi, inā koa ki te kore rātou e whai tohu, ki te whakahaeretia pai rānei ō rātou tohu me te maimoatanga. Ko te pānga ki tō oranga mahi e whakawhirinaki ana ki ō tohu motuhake, ngā pānga o te maimoatanga, me te momo mahi e mahi ana koe.

Ko ētahi tāngata e hiahia ana ki te whakarerekē, pērā i te mahi mai i te kāinga i te wa e maimoatia ana, te tango rānei i te wā haere mō ngā hui. Kōrero whakatuwhera ki tō tākuta mō tō āhuatanga mahi kia taea ai e rātou te awhina i a koe ki te whakarite i te huarahi pai mō te pupuri i tō mahi i te wa e whakahaere ana i tō hauora.