He aha te Aflibercept: Ngā Whakamahinga, te Inenga, Ngā Pānga taha me ētahi atu

He rongoā motuhake a Aflibercept e werohia ana e ngā tākuta ki roto i tō kanohi hei rongoā i ngā raruraru tirohanga nui. E mahi ana tēnei rongoā kaha mā te aukati i ētahi pūmua e whakatupu ana i ngā oko toto kōaro me te kohikohi wai i roto i tō retina, e āwhina ana i te tiaki me te whakapai ake i tō tirohanga i ētahi wā.

Mēnā kua tūtohu tō tākuta i te aflibercept, kei te raru pea koe i tētahi āhuatanga e pā ana ki ngā oko toto ngawari i roto i tō kanohi. Ahakoa te whakaaro o te werohanga kanohi ka pōuri pea, kua āwhina tēnei rongoā i miriona tāngata ki te pupuri i ō rātou tirohanga me te kounga o te oranga.

He aha te Aflibercept?

E hāngai ana a Aflibercept ki tētahi momo rongoā e kīia ana ko ngā rongoā anti-VEGF, e tū ana mō ngā aukati i te tupu o te endothelial vascular. Whakaarohia te VEGF hei tohu e kī ana ki tō tinana kia whakatupu i ngā oko toto hou, e āwhina ana i te whakaora me te tupu.

Heoi, ka nui rawa te VEGF e whakaputaina ana e tō kanohi, ka taea e ia te whakatupu i ngā oko toto raruraru ki ngā wāhi kāore e tika ana. He maha ngā wā ka turuturu te wai, te toto rānei i ēnei oko kōaro, ka pōrearea tō retina me te whakatuma i tō tirohanga. Ka uru mai a Aflibercept ki te aukati i ēnei tohu VEGF kino.

Ka tae mai te rongoā hei otinga mārama e werohia ana e tō tākuta kanohi ki roto i te vitreous, te mea rite ki te hēra i roto i tō kanohi. E whakatutuki ana tēnei huarahi whāinga i te rongoā ki te wāhi e tino hiahiatia ana.

He aha te Aflibercept e whakamahia ana mō?

E rongoā ana a Aflibercept i ētahi āhuatanga kanohi nui ka taea te arahi ki te ngaronga tirohanga ki te kore e rongoā. Ka tūtohu pea tō tākuta i tēnei rongoā mēnā he mate pāpā i te macular e pā ana ki te pakeke, te edema macular diabetic, te retinopathy diabetic rānei.

Ko te āhua tino noa e rongoatia ana ki te aflibercept ko te mate kōpiko macular e pā ana ki te pakeke (AMD). Ka pā tēnei ina tipu ngā oko toto kōaro i raro i tō macula, te wāhi o tō retina e kawenga ana mō te tirohanga koi, pokapū. Ka turuturu ēnei oko i te wai me te toto, e pā ana ki te rerekē o te tirohanga me te matapō.

Ko te mate kanohi huka tētahi atu take nui e tohutohu ana ngā tākuta i te aflibercept. Ka taea e ngā taumata huka toto tiketike te whakangaro i ngā oko toto iti i roto i tō retina i te roanga o te wā. Ka arahina tēnei ki te edema macular huka, kei reira te wai e kohikohi ana i roto i tō macula, i te retinopathy huka rānei, kei reira ngā oko kua whakangaro ka toto, ka tipu kōaro rānei.

I te nuinga o te wā, ka whakamahia pea te aflibercept mō te aukati i te uaua retinal, he āhua ka aukatia ngā oko toto i roto i tō retina. Ka pā tēnei aukati i te pūhi me ngā raruraru tirohanga ka taea e te rongoā te āwhina.

Me pēhea te mahi a Aflibercept?

E kiia ana ko Aflibercept he rongoā kaha, e whāia ana, e mahi ana mā te mahi rite ki te mōkai mō ngā mea tipu kino i roto i tō kanohi. Ka herea te rongoā ki te VEGF-A, VEGF-B, me te mea tipu placental, e ārai ana i ēnei pūmua mai i te whakaoho i te tipu oko toto kōaro.

Inā kore ēnei mea tipu e mahi i tā rātou mahi, ka mutu te tipu o ngā oko toto raruraru, ā, ka iti pea. Ko ngā oko turuturu e noho ana ka noho pūmau ake, e whakaiti ana i te kohikohi wai i roto i tō retina. Ka āwhina tēnei tukanga ki te tiaki i tō tirohanga e noho ana, ā, ka pai ake pea i ētahi wā.

Ka noho kaha te rongoā i roto i tō kanohi mō ētahi wiki ki ētahi marama, koinei te take kāore koe e hiahia ana i ngā rongoā ia rā. Ka pakaru haere tō tinana, ka whakakore i te rongoā, koinei te take e tika ana ngā werohanga tukurua hei pupuri i ōna painga.

Me pēhea taku tango i te Aflibercept?

Ka hoatu anake te Aflibercept e tō tākuta kanohi, e tētahi tohunga rongoā whakangungu rānei i roto i te wāhi haumanu horoi. Kāore e taea e koe te tango i tēnei rongoā i te kāinga, me te mea e hiahia ana i te tikanga werohanga tika me ngā āhuatanga horoi hei ārai i te mate.

I mua i tō werohanga, ka whakamāhukia e tō tākuta tō kanohi ki ngā pata rongoā hei whakaiti i te mamae. Ka horoia hoki e rātou te wāhi huri noa i tō kanohi, ā, ka whakamahi pea i ngā pata paturopi hei whakaiti i te tūponotanga o te mate. He hēkona noa te roa o te werohanga, ahakoa te 15-30 meneti te roa o te hui katoa.

Kāore koe e hiahia ki te nohopuku, ki te karo rānei i te kai i mua i tō maimoatanga. Heoi, me whakarite e koe tētahi hei taraiwa i a koe ki te kāinga, nā te mea ka pōkaehe pea tō tirohanga i muri i te werohanga. Ka hoatu e tō tākuta ngā tohutohu motuhake mō ngā pata kanohi hei whakamahi i muri i te maimoatanga.

He mea nui kia haere tonu koe ki ngā whakaritenga whai muri, ahakoa te ahua o te pūmau o tō tirohanga. Mā te aroturuki auau e āwhina tō tākuta ki te whai i tō ahunga whakamua me te whakatika i tō hōtaka maimoatanga ki te hiahiatia.

Kia Pēhea te Roa e Tango Ana ahau i te Aflibercept?

Ko te nuinga o te tangata e hiahia ana ki ngā werohanga aflibercept mō ngā marama ki ngā tau, ā, ko ētahi ka hiahia pea ki te maimoatanga tonu mō ake tonu atu. Kei runga i tō āhuatanga motuhake te roa, te pai o tō urupare ki te maimoatanga, me te ahunga whakamua o tō mate i raro.

I te tīmatanga, ka whiwhi pea koe i ngā werohanga ia 4-8 wiki mō ngā marama tuatahi. Mā tēnei wāhanga uta e āwhina ki te whakatū i ngā pānga o te rongoā i roto i tō kanohi. Kia pūmau tō āhuatanga, ka taea e tō tākuta te whakawhānui i te wā i waenga i ngā werohanga ki ia 8-12 wiki.

Ka aroturukihia e tō tākuta kanohi tō ahunga whakamua mā ngā whakamātautau kanohi auau me ngā whakamātautau whakaahua. Ki te pūmau tonu tō tirohanga, ā, he hauora te ahua o tō retina, ka taea e rātou te whakanui i ngā maimoatanga. Heoi, ko te whakamutu i te maimoatanga ka arahi pinepine ki te ahunga whakamua o te mate me te ngaronga o te tirohanga.

Ka pā ki ētahi tāngata te murunga roa e taea ai te okioki i ngā maimoatanga. Ko ētahi e hiahia ana ki ngā werohanga tonu, tonu hei pupuri i tō rātou tirohanga. Ka hangaia tō mahere maimoatanga ki tō āhuatanga motuhake, ā, ka huri pea i te wā.

He Aha ngā Pānga Taha o te Aflibercept?

Pērā i ngā rongoā katoa, ka pānga ngā pānga taha ki te aflibercept, ahakoa te nuinga o te tangata e pai ana ki te tango. Mā te māramatanga ki ngā mea e tūmanakohia ana ka āwhina koe ki te pūmau ake, me te mōhio ki te wā ki te whakapā atu ki tō tākuta.

Ngā pānga taha noa e pā ana ki te nuinga o te tangata ko te raru o te kanohi mō te wā poto, te whero, me te āhua o te mea kei roto i tō kanohi. Ko te tikanga ka ngaro ēnei i roto i te rā, e rua rānei i muri i te werohanga.

Ko ēnei ngā pānga taha e pūrongotia ana:

• Te mamae, te raru rānei o te kanohi (te tikanga he ngawari, he wā poto)
• Te piki o te pēhanga o te kanohi
• Ngā ira iti, ngā mea rānei e mānu ana i tō tirohanga
• Te whakaheke toto o te kanohi (he ira whero iti i te mā o tō kanohi)
• Ngā kanohi maroke
• Te ānini
• Te ihu e rere ana, e pōti ana rānei

Ko ēnei pānga noa te tikanga ka taea te whakahaere, kāore hoki e hiahiatia te whakamutu i te rongoā. Ka taea e tō tākuta te whakarato rautaki hei whakaiti i te raru, me te āwhina i a koe ki te wehewehe i waenga i ngā pānga taha e tūmanakohia ana, me ngā tohu e pā ana ki te māharahara.

Ko ngā pānga taha nui ake, engari he iti noa iho, e hiahia ana kia aro mai te rongoā tonu. Ko ēnei ko te mamae nui o te kanohi, ngā huringa ohorere o te tirohanga, ngā tohu o te mate, te ānini tonu rānei me ngā raruraru o te tirohanga.

Ko ngā raruraru onge, engari he nui, ko:

• Endophthalmitis (te mate kanohi nui)
• Te wehenga o te retina
• Te roimata o te epithelium pigment retinal
• Te piki o te tūponotanga o te whiu, te whakaeke ngākau rānei (he onge rawa)
• Ngā tauhohenga pāwera nui

Ahakoa he onge ēnei pānga taha nui, e puta ana i roto i te iti iho i te 1% o ngā tūroro, he mea nui kia rapu rongoā tonu mēnā ka pā ki a koe te mamae nui o te kanohi, te ngaronga ohorere o te tirohanga, ngā tohu rānei o te mate pērā i te rerenga, te kirika rānei.

Ko wai kāore e tika kia tango Aflibercept?

Kāore te Aflibercept i te pai mō te katoa, ā, ka āta arotake tō tākuta mēnā he haumaru mō koe. Ko te mea nui rawa atu ko te mōhio mēnā he mate kaha tō kanohi, kei te taha rānei o tō kanohi, nā te mea ka taea e te werohanga te whakapōrearea i te mate.

Kāore koe e whiwhi aflibercept mēnā he pānga tō ki te rongoā, ki ētahi o ōna wāhanga rānei. Ko ngā tohu o ngā pānga pānga ko te mamae nui o te kanohi, te pūpū, te uaua ki te hā, te pānga kiri rānei e horapa ana. Kōrero atu ki tō tākuta mō ngā pānga pānga o mua ki ngā rongoā.

Ko ētahi āhuatanga hauora e hiahia ana kia tūpato atu i te wā e whakaaro ana ki te maimoatanga aflibercept. Ka whakataurite tō tākuta i ngā painga ki ngā tūponotanga mēnā he āhuatanga tō:

• Te whiu, te whakaeke ngākau rānei i tērā wā (i roto i ngā marama 3)
• Te toto tiketike kāore i te whakahaerehia
• Ngā mate toto e kaha ana te rere
• Te hapū, te mahere rānei kia hapū
• Te whāngai ū
• Te mate tākihi, te ate rānei e kaha ana

Mēnā kei te hapū koe, kei te whakamahere rānei koe kia hapū, kōrerohia tēnei ki tō tākuta tonu. Ka pā kino pea te aflibercept ki ngā pēpi e whanake ana, ā, e taunaki ana te whakamahi i te aukati hapū whai hua i te wā o te maimoatanga, ā, mō te 3 marama i muri i tō werohanga whakamutunga.

Ka whakaaro hoki tō tākuta ki tō āhua hauora whānui, ētahi atu rongoā e tango ana koe, me tō kaha ki te tae atu ki ngā whakaritenga wā katoa i te wā e whakatau ana mēnā he pai te aflibercept mōu.

Ngā Ingoa Waitohu Aflibercept

Kei te wātea te Aflibercept i raro i te ingoa waitohu Eylea i te nuinga o ngā whenua, tae atu ki te United States. Koinei te hanganga e tohua ana mō ngā werohanga kanohi, ā, kei roto ko te 2 mg o te aflibercept mō ia werohanga 0.05 mL.

Nō nā tata nei, kua wātea mai i ētahi rohe tētahi hanganga horopeta teitei ake e kiia nei ko Eylea HD (8 mg mō ia 0.07 mL). Mā tēnei putanga kaha ake e taea ai te werohanga iti ake i ētahi tūroro, ka whakaiti pea i te pōkai maimoatanga i te wā e mau tonu ana te whai huatanga.

Ka whakatau tō tākuta ko tēhea hanganga me te hōtaka horopeta e pai ana mō tō āhuatanga motuhake. Kei roto i ngā putanga e rua te wāhanga kaha kotahi, engari he rerekē te kukū me te auau werohanga.

Ngā Kōwhiringa Aflibercept

He maha atu ano nga rongoa anti-VEGF e wātea ana mēnā kāore a aflibercept e tika ana mōu, kāore rānei e whai hua. Ko ngā whiringa kē e tino kitea ana ko te ranibizumab (Lucentis) me te bevacizumab (Avastin).

He rite te mahi a Ranibizumab ki a aflibercept engari me nui ake te werohanga. Ko ētahi tāngata e pai ake ana ki tētahi rongoa i tētahi atu, nō reira ka tohutohu pea tō tākuta ki te huri mēnā kāore te rongoa e whai hua ana.

He maha ngā wā e whakamahia ana a Bevacizumab mō ngā āhuatanga o te kanohi, ā, he iti ake te utu i ētahi atu whiringa. Heoi, kāore i te whakaaetia mō ngā werohanga kanohi, ahakoa he maha ngā tākuta e whakamahi ana i te haumaru me te whai hua.

Mō ētahi āhuatanga, ka whakaarohia ētahi atu whiringa rongoa, tae atu ki te rongoa laser, te rongoa photodynamic, te werohanga steroid rānei. Mā tō tākuta kanohi koe e āwhina ki te mārama ki ngā whiringa katoa e wātea ana, me te whiriwhiri i te huarahi pai mō tō āhuatanga.

He Pai Anei Aflibercept i te Ranibizumab?

He rongoa whai hua te aflibercept me te ranibizumab, ā, kāore tētahi i te pai ake i tētahi atu. Ko te whiringa pai rawa atu ka whakawhirinaki ki tō āhuatanga motuhake, ngā āhuatanga o te noho, me te pēhea te urupare ki te rongoa.

He iti nei te painga o Aflibercept mō te auau o te werohanga, i te mea ka taea te rongoa ia 8 wiki i muri i te wā uta tuatahi. Ko te tikanga me werohia a Ranibizumab i ia marama i te tuatahi, ahakoa ka taea e ētahi tāngata te toro atu ki ia 6-8 wiki.

E whakaatu ana ngā rangahau haumanu he rite tonu ngā hua o te tirohanga mō te nuinga o ngā tāngata. E ai ki ētahi rangahau, he pai ake pea a aflibercept mō ētahi momo mate kanohi huka, i te mea kua roa te whakamahi i te ranibizumab, ā, he nui ngā raraunga haumaru.

Ka whai whakaaro tō tākuta ki ngā āhuatanga pēnei i te urupare ki te rongoā, te wātea o te hōtaka inenga, te inihua, me ngā pānga taha e pā ana ki a koe i te whakatau ko tēhea rongoā te mea pai mōu. Ko ētahi tāngata ka huri i waenga i ngā rongoā ki te kore e whai hua te rongoā tuatahi i te roanga o te wā.

Ngā Pātai e Pānuia ana mō Aflibercept

Q1. He Haumaru Aflibercept mō te Hunga Mate Huka?

Āe, he haumaru te aflibercept mō te hunga mate huka, ā, e whakamahia ana hei rongoā i ngā raruraru o te kanohi e pā ana ki te mate huka. Inā, kua whakaaetia mō te edema macular diabetic me te retinopathy diabetic.

Heoi anō, tērā pea ētahi atu mea hei whakaaro mā te hunga mate huka, pēnei i te whakahaere huka toto me te hauora ngākau. Ka mātakitaki tō tākuta i a koe, ā, ka mahi tahi pea me tō rōpū tiaki mate huka kia mau tonu tō hauora whānui i te wā o te rongoā.

Q2. Me Pēhea Taku Mahi Mēnā Ka Whakamahia E Au te Aflibercept Nui Rawa?

I te mea ka tukuna te aflibercept e ngā tākuta anake i ngā wāhi haumanu whakahaere, he iti noa te tūponotanga o te horopeta nui. Ka ine tika te rongoā, ā, ka whakahaerehia e ngā kaiwhakarato hauora whakangungu.

Mēnā ka pā mai ētahi tohumate rerekē i muri i te werohanga, pēnei i te mamae nui, te huringa ohorere o te tirohanga, ngā tohu rānei o te mate, whakapā atu ki tō tākuta kanohi tonu. Ka taea e rātou te arotake mēnā e pā ana ō tohumate ki te werohanga, me te hiahia rānei ki ētahi atu rongoā.

Q3. Me Pēhea Taku Mahi Mēnā Kua Ngaro i a Au tētahi Inenga o Aflibercept?

Mēnā kua ngaro i a koe tētahi whakaritenga, whakarite anō i te wā e taea ai. Mā te whakaroa i te rongoā ka kaha ake tō āhuatanga, ā, ka ngaro pea te tirohanga.

Kaua e tatari kia tae ki tō whakaritenga e whai ake nei mēnā kua ngaro i a koe tētahi. Whakapā atu ki te tari o tō tākuta ki te whakarite i te werohanga i ngaro, ā, mā rātou koe e āwhina kia hoki ki te hōtaka rongoā.

Q4. Āhea Āhei Ai Au ki te Kati te Tango Aflibercept?

Kaua e whakamutua te rongoā aflibercept me te kore e kōrero tuatahi ki tō tākuta kanohi. Ko te whakamutu wawe rawa ka hua te piki haere o te mate me te ngaronga o te tirohanga, ahakoa te pai o ō kanohi.

Mā tō tākuta e whakatau mō te wā e pai ana ki te whakaiti i te auau o te rongoā, ki te whakamutu rānei i ngā werohanga i runga i ō whakamātautau kanohi, ngā hua whakaahua, me te pūmautanga o te mate. Ka taea pea e ētahi tāngata te okioki i te rongoā, engari me rongoā tonu ētahi atu.

Q5. Ka taea e au te taraiwa i muri i te whiwhinga aflibercept?

Kaua koe e taraiwa i muri tonu i te whiwhinga aflibercept, nā te mea ka pāpō te tirohanga i te wā poto mai i ngā topata rongoā me te werohanga tonu. Whakaritea kia whai tangata hei taraiwa i a koe ki te kāinga i muri i tō pōhiri.

Ka taea e te nuinga o te tāngata te hoki ki ngā mahi noa, tae atu ki te taraiwa, i roto i te 24 hāora i muri i te werohanga. Heoi, tatari kia hoki anō tō tirohanga ki tō taumata tūturu i mua i te eke ki te wīra. Ki te pōro tonu tō tirohanga, whakapā atu ki tō tākuta i mua i te hoki ki te taraiwa.