He aha te Alendronate: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu

Ko te Alendronate he rongoā whakakaha i te wheua e āwhina ana ki te ārai i ngā whati i roto i ngā tāngata e mate ana i te osteoporosis, i te ngaronga wheua rānei. No roto i te rōpū rongoā e kīia ana ko te bisphosphonates, e mahi ana mā te whakaroa i te tukanga tūturu e wawahi ana i te kiko wheua. Mā tēnei ka nui ake te wā o tō tinana ki te hanga wheua hou, kaha ake, e āwhina ana ki te whakaiti i tō tūponotanga ki ngā whati i a koe e pakeke ana.

He aha te Alendronate?

Ko te Alendronate he rongoā i runga i te whakahaunga i hangaia hei rongoā me te ārai i te osteoporosis, he āhuatanga ka ngoikore, ka ngawari hoki ngā wheua. Whakaarohia he whakangungu rakau mō ō wheua - e āwhina ana ki te pupuri i te kiato wheua mā te whakararu i ngā pūtau e wawahi ana i te kiko wheua.

Ka tae mai te rongoā i roto i te ahua papa, ka tangohia mā te waha, te nuinga kotahi i te wiki, kotahi rā rānei i te rā, i runga i te tohutohu a tō tākuta. Kua whakamahia marie mō ngā tekau tau ki te āwhina i te miriona tāngata ki te pupuri i ngā wheua kaha ake me te whakaiti i tō rātou tūponotanga whati.

E kiia ana ko te Alendronate he rongoā tuatahi mō te osteoporosis, ko te tikanga he maha ngā tākuta e kōwhiri ana i tēnei hei tō rātou tohutohu tuatahi nā te mea kua whakamatauria tōna whai huatanga me tōna haumaru.

He aha te Alendronate e whakamahia ana mō?

Ka rongoā te Alendronate i te osteoporosis i roto i ngā tāne me ngā wāhine, ina koa ko te hunga e tūpono ana ki ngā whati wheua. He tino whai hua mō ngā wāhine i muri i te menopause, nā te mea ka taea e ngā huringa homoni i te wā o te menopause te whakatere i te ngaronga wheua.

Ka tohutohu pea tō tākuta i te alendronate mēnā he maha ō āhuatanga e pā ana ki te wheua e hiahia ana kia aro:

• Osteoporosis me te hītori o ngā whati
• Te kiato wheua iti (osteopenia) e anga whakamua ana ki te osteoporosis
• Osteoporosis i whakaohoohohia e te steroid mai i te whakamahi corticosteroid wā roa
• Te mate o Paget, kei te tipu ke te rahi me te ngoikore o ngā wheua
• Te ārai i te ngaronga wheua i roto i ngā tāngata e tango ana i ngā rongoā e whakangoikore ana i ngā wheua

He mea nui te rongoā nei mō te hunga kua pā ki te whati kotahi, nā te mea ka tino whakaiti i te tūponotanga o ngā whati i te wā e haere ake nei. Ka whakamahia hoki hei ārai i te hunga he maha ngā āhuatanga mō te osteoporosis.

Me pēhea te mahi a Alendronate?

Ka mahi a Alendronate mā te aukati i ngā pūtau motuhake e kīia ana ko te osteoclasts e pakaru ana i te kiko o te wheua tawhito. He rongoā kaha tēnei e huri nui ana i te tukanga whakahou o tō wheua.

Kei te whakahou tonu ō wheua i a rātou anō mā te taurite o te pakaru me te hanga. Ki te hē tēnei taurite ki te nui rawa o te pakaru, ka ngoikore ngā wheua, ka māmā te whati. Ka whakatika a Alendronate i te taurite mā te whakaiti i te taha pakaru o te whārite.

Ka uru te rongoā ki roto i tō kiko wheua, ka noho ki reira mō ngā marama, tau rānei, e whakarato ana i te whakamarumaru roa. Koinei te take e mau tonu ana ngā pānga ahakoa kua mutu te tango, ahakoa ka heke haere te whakamarumaru i te wā.

Ka kite koe i te pai ake o te kiato o te wheua i roto i te 6 ki te 12 marama i muri i te tīmatanga o te rongoā, me te whai hua nui i muri i te 2 ki te 3 tau o te whakamahi tonu.

Me pēhea taku tango i te Alendronate?

He wā motuhake me te whakarite e hiahiatia ana e Alendronate kia pai te mahi me te karo i te riri o te puku. Me tango e koe i te ata i te wa e ara ana koe, i runga i te puku kau, me te karaihe wai māori.

Koinei te tukanga taahiraa-i-taahiraa ka tūtohu pea tō tākuta:

1. Tangohia te papa i te wā tonu e ara ana koe, i mua i te kai, te inu rānei i tētahi mea
2. Horomia katoatia ki te 6 ki te 8 hekere wai māori (kāore he wai kohuke, kawhe, wai rānei)
3. Kia tū tika (e noho ana, e tū ana rānei) mō te 30 meneti i muri i te tango
4. Taria mō te 30 meneti i mua i te kai, te inu, te tango rānei i ētahi atu rongoā
5. Kaua e takoto, e piko, e whakakori tinana kaha rānei i tēnei wā tatari

Ehara nga tohutohu nei i te mea he whakaaro noa iho - he mea nui kia kore ai e puta nga paanga kino, me te whakarite kia whai hua te rongoa. Ko te tūnga tika ka ārai i te rongoa kia kore e riri i tō kōiwi.

Mēnā kei te tango koe i ngā tāpiringa konupūmā, i ngā antacids rānei, tatari kia 2 hāora i muri i tō horopeta alendronate, nā te mea ka raru pea ēnei i te ngongo.

Kia Pēhea te Roa e Tango Ana ahau i te Alendronate?

Ko te nuinga o te tangata e tango ana i te alendronate mō te 3 ki te 5 tau i te tīmatanga, ahakoa me nui ake te rongoa i ētahi tāngata i runga i te tūponotanga o te whati. Ka arotakehia e tō tākuta i ngā wā katoa mēnā me haere tonu koe, me okioki, me huri rānei ki tētahi rongoa rerekē.

I muri i te 5 tau o te rongoa, he maha ngā tāngata ka taea te tango i te mea e kiia ana he "hararei rongoa" - he okiokinga kua whakamaherehia mai i te rongoa. Ka pēnei tēnei nā te mea ka noho te alendronate i roto i ō kōiwi mō ngā tau, e haere tonu ana te whakarato i ētahi whakamarumaru ahakoa kua mutu te tango.

Ka whakaarohia e tō tākuta ētahi mea i te wā e whakatau ana i te roa o te rongoa. Kei roto i ēnei ko ō pūwāhi ki te kōiwi i te tīmatanga, te pai o tō urupare ki te rongoa, tō tau, me tō tūponotanga whati.

Ko ētahi tāngata he tino nui te tūponotanga whati ka hiahia pea ki te haere tonu i te rongoa mō ngā wā roa ake, ki te huri rānei ki tētahi momo rongoa kōiwi rerekē. Ko ngā karapa kōiwi i ngā wā katoa me ngā arotake ka āwhina i ēnei whakatau.

He Aha ngā Pānga Kino o te Alendronate?

He pai te whakamanawanui a te nuinga o te tangata ki te alendronate, engari pērā i ngā rongoa katoa, ka puta pea ngā pānga kino mai i te ngawari ki te kino. Ko te rongo pai he mea kāore i te noa ngā pānga kino i te wā e tika ana te tango i te rongoa.

Ko ngā pānga kino e tino kitea ana ka ngawari noa iho, ā, ka pai ake i te wā e urutau ana tō tinana ki te rongoa:

• Te pōpō i te puku, te whakapairuaki rānei
• Te ngākau pāwera, te waikawa rānei
• Te mamae puku ngawari
• Te korere, te pāpā rānei
• Te ānini
• Te mamae uaua, te mamae tahi rānei

Ko ēnei tohumate ka puta i ngā wiki tuatahi o te rongoā, ā, he maha ngā wā ka ngaro noa iho. Mā te tango i te rongoā i runga i ngā tohutohu ka tino whakaiti i te tūponotanga o ngā pānga taha e pā ana ki te puku.

He torutoru ngā pānga taha onge engari he nui te kino e hiahia ana kia tere te rongoā, ahakoa he iti iho i te 1 i roto i te 1,000 ngā tāngata e pā ana:

• Te mamae nui o te kauae, te uaua rānei ki te whakatuwhera i tō waha (osteonecrosis o te kauae)
• Te mamae o te huha, te mamae rānei e kore e ngaro
• Te ngākau nui, te uaua rānei ki te horo
• Te mamae o te uma hou, te kino rānei
• Te mamae nui o te uaua, te wheua, te hononga rānei e rerekē ana i tō mamae noa

I te wā onge, ka pā pea te whati atypical o te wheua huha ki ētahi tāngata i muri i te whakamahi wā roa. Ko ēnei whati rerekē ka puta i ētahi wā me te iti o te whara, ā, ka mua pea i te mamae huha mō ngā wiki, mō ngā marama rānei.

Ko wai kāore e tika kia tango Alendronate?

Kāore a Alendronate e tika ana mō te katoa, ā, ko ētahi āhuatanga hauora ka kore e haumaru, ka iti rānei te whai hua. Ka āta arotake tō tākuta i tō hītori hauora i mua i te whakahau i tēnei rongoā.

Kāore koe e tango alendronate mēnā he āhuatanga tōu e whai ake nei e tūpono ana ka kino te rongoā:

• Ngā raruraru ki tō esophagus, tae atu ki te whāiti, te uaua rānei ki te horo
• Te kore e taea te noho, te tū tika rānei mō te 30 meneti neke atu
• Ngā taumata konupūmā toto tino iti (hypocalcemia)
• Te mate tākihi nui
• Ngā mate pāwera e mōhiotia ana ki te alendronate, ki ngā rongoā rite rānei

Ko ētahi āhuatanga hauora e hiahia ana kia nui te tūpato me te aroturuki, ahakoa kāore e aukati i a koe ki te tango alendronate. Ka whakatau tō tākuta i ngā painga ki ngā tūponotanga ka pā mēnā he raruraru tōu ki te puku, ngā raruraru niho, te ngoikore rānei o te huaora D.

Kāore e tika ana kia tango a alendronate e ngā wāhine hapū me te whāngai u, nā te mea ka pā kino pea ki te pēpi e tipu ana. Ka noho pea te rongoā ki roto i te kiko o te wheua mō ngā tau, nō reira me kōrero ngā wāhine e whakamahere ana kia hapū ki tō rātou kaiwhakarato hauora mō te wā.

Ngā Ingoa Waitohu o Alendronate

Kei te wātea a Alendronate i raro i ētahi ingoa waitohu, ko Fosamax te mea e mōhiotia ana. Kei roto i te putanga whānui te mea kaha kotahi, ā, he rite tonu te whai hua ki ngā putanga waitohu.

Ngā ingoa waitohu noa ko Fosamax, Fosamax Plus D (kei roto te huaora D), me Binosto (he papa e rewa ana i roto i te wai). Ka mau pea tō whare rongoā i ētahi waitohu rerekē, engari kei roto katoa i a rātou te rongoā kotahi.

Ko te whiriwhiri i waenga i ngā putanga whānui me ngā putanga waitohu ka heke iho ki te utu me te inihua. Ko te alendronate whānui te nuinga o te wā he iti ake te utu, ā, he rite tonu te mahi ki ngā putanga waitohu.

Ngā Kōwhiringa kē mō Alendronate

Mēnā kāore i te pai te mahi a alendronate mōu, ka pā rānei ngā pānga taha e raruraru ana, he maha ngā rongoā kē ka āwhina i te whakakaha i ō wheua. Ka āwhina tō tākuta i a koe ki te kimi i te kōwhiringa pai rawa atu i runga i ō hiahia me ō āhuatanga hauora.

Ko ētahi atu rongoā bisphosphonate he rite tonu te mahi ki a alendronate engari he māmā ake pea te aro:

• Risedronate (Actonel) - ka tangohia ia wiki, ia marama rānei
• Ibandronate (Boniva) - e wātea ana hei pire ia marama, hei werohanga ia hauwhā rānei
• Zoledronic acid (Reclast) - ka hoatu hei whakauru i roto i te uaua ia tau

Ko ngā kōwhiringa kē kore-bisphosphonate ko te denosumab (Prolia), ka hoatu hei werohanga ia 6 marama, me te teriparatide (Forteo), e whakahihiri ana i te hanganga wheua hou, kaua ki te aukati i te ngaronga wheua.

Mō ētahi tāngata, ko te rongoā whakakapi homoni, ngā kaiwhakawhāiti kaiwhakawhiwhi estrogen whiriwhiri, te calcitonin rānei, he kōwhiringa kē pea. Ko te kōwhiringa pai rawa atu ka whakawhirinaki ki tō tau, tō ira tangata, te tūponotanga o te whati, me ētahi atu āhuatanga hauora.

He pai ake te Alendronate i te Risedronate?

He rongoā bisphosphonate whai hua a Alendronate me Risedronate e mahi ana i te ara kotahi hei aukati i nga whati me te whakakaha i nga wheua. E whakaatu ana nga rangahau he rite tonu te whai huatanga, e rua ana te whakaiti i te tupono o te whati i te 30-50%.

Ko nga rerekētanga nui kei roto i nga mahinga inenga me te pai o te tangata ki ia rongoā. Ko te tikanga ka tangohia te Alendronate kotahi i te wiki, engari ka taea te tango i te risedronate i ia wiki, i ia marama ranei. E kitea ana e etahi tangata he ngawari ake tetahi ki te whakamanawanui i tetahi atu mo nga paanga o te puku.

He ngawari ake pea te Risedronate ki te puku mo etahi tangata, ahakoa e hiahia ana nga rongoā e rua i te whakahaere tupato i runga i te puku kau me te nui o te wai. Ko te whiriwhiri i te nuinga o te wa ka whakawhirinaki ki to urupare takitahi me o hiahia.

Ka whakaarohia e to taakuta to ahuatanga hauora motuhake, etahi atu rongoā e tango ana koe, me nga wheako o mua me nga bisphosphonates i te wa e whakatau ana i waenga i enei whiringa.

Nga Pātai e Pātai pinepine ana mo Alendronate

He Haumaru te Alendronate mo te hunga e mate ana i te mate whatukuhu?

Ka taea te whakamahi i te Alendronate i roto i te hunga e raru ana i te whatukuhu ngawari, engari kaore i te taunakitia mo te hunga e mate ana i te mate whatukuhu nui. Ka tirohia e to taakuta to mahi whatukuhu me nga whakamatautau toto i mua i te whakahau i te alendronate, a ka aroturukihia i ia wa i te wa o te maimoatanga.

Mena he mate whatukuhu koe, ka kowhiria e to taakuta tetahi rongoā wheua rereke, ka whakatika ranei i to mahere maimoatanga. Kaua te hunga e mate ana i te mate whatukuhu nui e tango i te alendronate na te mea ka hanga i roto i te tinana, ka raru pea.

Me aha ahau ki te whakamahi pohehe au i te nui rawa o te Alendronate?

Mena ka tango pohehe koe i te nui atu i to horopeta i whakaritea, kaua e mataku, engari whakapā atu ki to taakuta, ki te mana whakahaere paitini ranei. Kaua e ngana ki te ruaki, na te mea ka riri te rongoā i to korokoro me te esophagus i te ara ki runga.

Inumia he nui miraka, wai rānei hei āwhina i te whakaiti i te rongoā i roto i tō puku. Kia tū tika, kaua e takoto. Ko te nuinga o te hunga e inu ana i ngā horopeta taapiri i tūpono noa, kāore e pā ki ngā raruraru nui, engari he mea nui te tohutohu hauora hei whakarite i tō haumaru.

Me pēhea taku mahi mēnā ka ngaro i ahau tētahi horopeta o Alendronate?

Mēnā ka ngaro i a koe tō horopeta ia wiki, ka mahara i roto i te rā, e rua rānei, tangohia i te wā ka mahara koe, me te whai i ngā tohutohu katoa. Katahi ka hoki ki tō hōtaka auau i te wiki e whai ake nei.

Mēnā kua maha ngā rā mai i tō horopeta i ngaro, waiho katoa, ka tango i tō horopeta e whai ake nei i tō rā kua whakaritea. Kaua e tango i ngā horopeta e rua i te wiki kotahi hei utu mō te horopeta i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga taha.

Āhea taku mutu i te tango Alendronate?

Kaua rawa e mutu te tango alendronate ohorere, me te kore e kōrero ki tō tākuta i te tuatahi. Ka taea e te nuinga o te hunga te tango i ngā okiokinga kua whakamaherehia mai i te rongoā i muri i te 3 ki te 5 tau o te maimoatanga, engari me mahi tonu tēnei whakatau me te tohutohu hauora.

Ka arotakehia e tō tākuta tō kiato wheua o nāianei, te tūponotanga whati, me te hauora whānui i mua i te whakatū i te tūtohu mēnā me haere tonu te maimoatanga, te okioki, te huri rānei ki tētahi rongoā rerekē. Akene pea me haere tonu te maimoatanga o ētahi tāngata i runga i ō rātou āhuatanga tūpono takitahi.

Ka taea e au te tango Alendronate me ētahi atu rongoā?

Ka taea e Alendronate te pā ki ētahi rongoā, nō reira he mea nui ki te kōrero ki tō tākuta mō ngā mea katoa e tango ana koe. Ka taea e ngā taapiringa konupūmā, ngā antacids, me ngā taapiringa rino te whakararu i te urunga o te alendronate mēnā ka tangohia tata tahi.

Me tatari koe kia 2 haora i muri i te tango alendronate i mua i te tango konupūmā, antacids, ētahi atu rongoā rānei. Akene pea ka piki ake te tūponotanga o te riri puku i te wā e honoa ana ki te alendronate ētahi rongoā pēnei i ētahi paturopi, rongoā anti-inflammatory rānei.