He aha te Atazanavir me te Cobicistat: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te Atazanavir me te cobicistat he rongoā whakakotahi e whakamahia ana hei rongoā i te mate HIV i roto i ngā pakeke me ngā tamariki. E mahi tahi ana tēnei tokorua kaha ki te āwhina i te pupuri i te huaketo i raro i te mana whakahaere me te tiaki i tō pūnaha ārai mate mai i te kino atu.

I te wā e noho ana koe me te HIV, ka taea e ngā kōwhiringa rongoā whai hua te kawe mai i te rangimārie nui. Ko tēnei huinga rongoā e tohu ana i tētahi taputapu nui i roto i te manaaki HIV hou, i hangaia hei whakamaama me te whai hua ake i tō rongoā.

He aha te Atazanavir me te Cobicistat?

E whakakotahi ana te Atazanavir me te cobicistat i ngā momo rongoā HIV e rua ki roto i tētahi pire pai. No te akomanga rongoā e kiia nei ko te aukati protease te Atazanavir, i te wā e mahi ana te cobicistat hei whakarei e āwhina ana i te atazanavir kia whai hua ake i roto i tō tinana.

Whakaarohia te cobicistat hei kaiawhina whai hua e whakarite ana kia noho kaha tonu te atazanavir i roto i tō pūnaha mō te roa ake. Ki te kore te cobicistat, ka pakaru tō tinana i te atazanavir i te tere rawa, ka iti ake te whai hua ki te whawhai i te HIV.

Ka whakamahia tonu tēnei huinga i te taha o ētahi atu rongoā HIV hei wāhanga o te mea e kiia ana e ngā tākuta ko te rongoā antiretroviral tino kaha (HAART). E kore koe e tango i tēnei rongoā anake nā te mea he pai rawa te mahi o te rongoā HIV i te wā e whakaeke ana ngā rongoā maha i te huaketo mai i ngā koki rerekē.

He aha te Atazanavir me te Cobicistat e whakamahia ana?

E rongoā ana tēnei huinga rongoā i te mate HIV-1, te momo tino noa o te HIV puta noa i te ao. I hangaia motuhake mō ngā tāngata e tīmata ana i te rongoā HIV mō te wā tuatahi, e huri ana rānei mai i ētahi atu rongoā HIV.

Ka tohutohu pea tō tākuta i tēnei huinga ki te hiahia koe i tētahi tikanga rongoā he kaha, he pai hoki. He maha ngā tāngata e maioha ana ki te iti ake o ngā pire hei tango i ia rā, ka taea e tēnei te māmā ake te piri ki tō hōtaka rongoā.

Me pēhea te mahi a Atazanavir me Cobicistat?

He pai rawa atu te rongoā nei mō te hunga kāore anō kia whai parenga te HIV ki ngā aukati protease. Ka whakamātau pea tō tākuta kia mōhio ai he pai tēnei huinga mō tō āhuatanga motuhake.

Me pēhea te mahi a Atazanavir me Cobicistat?

Ka aukati a Atazanavir i tētahi enzyme e kīia ana ko te HIV protease, e hiahiatia ana e te huaketo hei hanga i ngā kape hou o ia anō. Ki te aukatia tēnei enzyme, kāore e taea e te HIV te whakaputa anō, ā, ka tino heke te kawenga huaketo i roto i ō toto.

Kāore a Cobicistat e whawhai tika ana ki te HIV, engari e ārai ana i tō ate kia kore e pakaru wawe rawa te atazanavir. Ko tēnei pānga whakanui te tikanga ka taea e te atazanavir te noho kaha i roto i tō pūnaha mō te 24 haora katoa me te horopeta kotahi ia rā.

E kiia ana he huinga rongoā HIV kaha tēnei. He kaha ki te aukati i te huaketo i roto i te nuinga o te tangata, engari he pai te aro ki te taha ki ētahi rongoā HIV tawhito.

He pai rawa atu te mahi o te huinga ki te tangohia i ia rā i te wā kotahi. Ko te ngaro i ngā horopeta ka taea e te HIV te whakaputa anō, ā, ka whai parenga pea ki te rongoā.

Me pēhea taku tango i te Atazanavir me te Cobicistat?

Tangohia tēnei rongoā kotahi anō i ia rā me te kai, he pai ake i te wā kotahi i ia rā. Ka āwhina te kai i tō tinana ki te tango tika i te rongoā, ā, ka whakaiti i te tūponotanga o te puku.

Ka taea e koe te tango me tētahi kai, tētahi paramanawa nui rānei, engari karohia te tango i runga i te puku kau. He pai te mahi o te kai māmā me ētahi pūmua, ngako rānei, pēnei i te tōhi me te pata pīnati, te miraka pē me te granola.

Horomia te papa katoa ki te wai, ki tētahi inu rānei. Kaua e kuru, e ngaungau, e wāwāhi rānei i te papa, nā te mea ka pā tēnei ki te āhua e tangohia ana, e tukuna ana te rongoā i roto i tō tinana.

Mēnā kei te tango koe i ngā antacids, wehea mai i tēnei rongoā mō te 2 haora i mua, 1 haora rānei i muri i te tango i te atazanavir me te cobicistat. Ka taea e ngā antacids te whakararu i te pai o te tango a tō tinana i te rongoā.

E hia te roa e tango ai au i te Atazanavir me te Cobicistat?

Me tango e koe tenei rongoa mo te wa e tohutohu ana to taakuta, ko te tikanga mo te oranga. He herenga mo te wa roa te rongoa HIV, a, ko te whakamutu i te rongoa ka taea e te huaketo te whakanui tere ano.

Ko te nuinga o nga tangata e haere tonu ana ki te tango i a ratou rongoa HIV mo te wa roa kia mau tonu ai te kawenga viral kaore e kitea. Ina kore e kitea te HIV, e kore e taea te tuku atu ki etahi atu, a, ka noho hauora to punaha mate.

Ka aroturukihia e to taakuta to urupare ki te maimoatanga ma nga whakamatautau toto i nga wa katoa, i te nuinga o te wa i nga marama 3 ki te 6. Ka tirohia e enei whakamatautau to kawenga viral me te tatau CD4 kia mohio ai kei te pai te mahi o te rongoa.

Kaua rawa e mutu te tango i tenei rongoa me te kore e korero tuatahi ki to kaiwhakarato hauora. Ahakoa te pai o to ahua, kei te noho tonu te huaketo i roto i to tinana me te hiahia maimoatanga tonu kia noho whakahaerehia.

He aha nga paanga taha o te Atazanavir me te Cobicistat?

Pērā i ngā rongoā katoa, ka taea e te atazanavir me te cobicistat te pānga taha, ahakoa he maha ngā tāngata e pai ana ki te tango. Ko te nuinga o nga paanga taha he ngawari, ka pai ake i te wa e urutau ana to tinana ki te rongoa i roto i nga wiki tuatahi.

Anei nga paanga taha noa ka pa ki a koe:

• Te whakapairuaki me te kore e pai te puku
• Te ānini
• Te ngenge, te ngenge ranei i te nuinga o te wā
• Te korere, te kumete ranei
• Te kōwhai o te kiri, o ngā kanohi rānei (jaundice)
• Te pupuhi, te riri kiri ranei
• Te whanoke

Ka puta te kōwhai o te kiri, o ngā kanohi rānei nā te mea ka taea e te atazanavir te whakanui i ngā taumata bilirubin i roto i tō toto. He harakore tenei, he huri ano, engari he mea nui kia whakahuahia ki tō tākuta.

Ka pā ki ētahi tāngata ngā pānga taha nui engari he iti noa iho e hiahia ana ki te āwhina hauora:

• Te whakapairuaki nui, te ruaki rānei
• Te mamae uaua, te ngoikore rānei, he mea rerekē
• Te uaua ki te hā
• Te mamae puku nui
• Ngā tohu o ngā raruraru ate (te mimi pouri, te tino ngenge, te ngaro o te hiahia)
• Te pā o te ngākau rerekē
• Te pupuhi nui me te kirika

He mea rerekē engari he pānga kino pea ko ngā raruraru tākihi, ngā huringa i roto i te manawataki o te ngākau, me ngā tauhohenga mate pāwera nui. Ka aroturukihia koe e tō tākuta i ngā wā katoa kia kitea wawe ngā take ka puta.

Whakapā atu ki tō kaiwhakarato hauora mēnā ka pā ki a koe ētahi tohu e mōrearea ana, inā koa mēnā ka mau tonu, ka kaha ake rānei i te wā. Ko te nuinga o ngā pānga taha ka taea te whakahaere pai mā te ārahitanga hauora tika.

Ko wai kāore e tika kia tango Atazanavir me Cobicistat?

Kāore tēnei rongoā e tika ana mō te katoa, ā, ka āta arotakehia tō hītori hauora e tō tākuta i mua i te whakarite. Ko ētahi āhuatanga me ngā rongoā ka kore e haumaru, ka iti ake rānei te whai hua o tēnei huinga.

Kāore koe e tika kia tango i tēnei rongoā mēnā kei a koe:

• Te mate ate nui, te cirrhosis rānei
• Ētahi raruraru manawataki o te ngākau
• Te mate tākihi nui
• Te mate pāwera mō atazanavir, cobicistat, ētahi rānei o ngā kai o te rongoā

He maha ngā rongoā ka taea te tauhohe kino ki a atazanavir me cobicistat, nō reira me mōhio tō tākuta ki ngā mea katoa e tango ana koe, tae atu ki:

• Ētahi rongoā hopu
• Ētahi paturopi me ngā rongoā anti-harore
• Ētahi rongoā ngākau
• Ngā aukati papu porotoni mō te waikawa rerenga
• Ētahi rongoā whakaheke cholesterol
• Ētahi rongoā hinengaro

Me whakamahi tēnei rongoā e te hunga mate huka mā te tūpato, nā te mea ka pā ki ngā taumata huka toto. Akene me whakatika e tō tākuta āu rongoā mate huka, me aroturuki rānei i tō huka toto i ngā wā katoa.

Ka taea e ngā wahine hapū te tango i tēnei rongoā, engari me mātakitaki motuhake. Ka taea e te rongoā te uru ki te waiu u, nā reira kōrerohia ngā kōwhiringa whāngai ki tō tākuta.

Ngā Ingoa Waitohu o Atazanavir me Cobicistat

Ko te ingoa waitohu mō te huinga atazanavir me cobicistat ko Evotaz. Koinei te momo rongoā huinga e tohua ana i te United States.

Ka kitea pea e koe ngā wāhanga takitahi e hokona ana motuhake. Ko Atazanavir anake e hokona ana i raro i te ingoa waitohu Reyataz, i te wā e wātea ana a cobicistat hei Tybost.

Ka wātea pea ngā momo rongoā whānui o te huinga i te roanga o te wā, engari i tēnei wā, ko Evotaz te kōwhiringa tuatahi. Ko te tikanga ka tukuna e tō whare rongoā te ingoa waitohu ki te kore koe me tō tākuta e tono motuhake.

Ngā Kōwhiringa kē mō Atazanavir me Cobicistat

He maha atu ngā huinga rongoā HIV ka taea te whakamahi hei kōwhiringa kē mēnā kāore a atazanavir me cobicistat e pai ana mōu. Ka tohutohu pea tō tākuta ki te huri mēnā ka pā mai ngā pānga taha, ki te kore rānei tō uta viral e aro tika ana.

Ko ētahi atu huinga aukati protease ko:

\n
• Darunavir me cobicistat, ritonavir rānei
\n
• Lopinavir me ritonavir
\n
• Tipranavir me ritonavir
\n

Ko ngā kōwhiringa kē-kore aukati protease ko ngā aukati integrase pēnei i te dolutegravir, bictegravir rānei, e honoa ana ki ētahi atu momo rongoā HIV. Koinei pea ngā kōwhiringa mēnā me karo katoa e koe ngā aukati protease.

Ka whakaaro tō tākuta ki tō hītori hauora motuhake, ētahi atu rongoā, me ngā tauira aukati rongoā i te wā e whiriwhiri ana i te kōwhiringa kē pai mōu.

He Pai Anei a Atazanavir me Cobicistat i te Darunavir?

He rongoā HIV whai hua a Atazanavir me cobicistat me darunavir (e honoa ana ki te cobicistat, ritonavir rānei), engari he rerekē ō rātou painga. Ko te kōwhiringa

He pai pea te atazanavir me te cobicistat ki te hiahia koe kia kotahi te horopeta i ia ra me te iti ake o nga taunekeneke rongoa. He iti ake ano te paanga ki nga taumata cholesterol i etahi atu aukati protease.

Ka taea te whiriwhiri i nga huinga Darunavir mena he HIV to koe e atete ana ki etahi atu aukati protease, na te mea he arai nui te darunavir ki te aukati. He pai hoki mo te hunga kua tango rongoa HIV i mua.

Ka whakaarohia e to taakuta nga mea penei i to hitori maimoatanga, nga taunekeneke rongoa pea, nga tohu o te taha, me nga hiahia whaiaro i te wa e awhina ana koe ki te whiriwhiri i waenga i enei whiringa.

Nga Pātai e Pātai pinepine ana mo Atazanavir me Cobicistat

He Haumaru te Atazanavir me te Cobicistat mo te hunga mate huka?

Ae, ka taea e te hunga mate huka te tango atazanavir me te cobicistat, engari me ata tirotiro. Ka taea e tenei rongoa te pa ki nga taumata huka toto, ka piki ake pea i te tikanga.

Tera pea ka hiahia to taakuta ki te tirotiro i to huka toto i nga wa maha ka timata koe i tenei rongoa. Akene ka hiahia koe ki te whakatika i o rongoa mate huka, i nga horopeta insulin ranei kia pai ai te whakahaere i to huka toto.

Ko te rongo pai ko te nuinga o te hunga mate huka ka taea te tango i tenei rongoa HIV me te tirotiro hauora tika. Kaua e waiho nga awangawanga mate huka e aukati i a koe ki te whiwhi maimoatanga HIV whai hua.

Me aha ahau ki te tango pohehe au i te nui rawa o te Atazanavir me te Cobicistat?

Mena ka tango pohehe koe i te nui atu i to horopeta kua tohua, whakapā atu ki to taakuta, ki te pokapū whakahaere paihana ranei i te wa tonu. Ko te tango i te nui rawa o tenei rongoa ka kino pea, ka puta pea nga paanga kino.

Ko nga tohu o te nui rawa o te horopeta ka uru pea ki te nausea nui, te ruaki, te whanoke, te raruraru ranei o te manawataki o te ngakau. Kaua e tatari kia kite mena ka puta nga tohu, rapua tonu te rongoa.

Hei ārai i te horomanga nui ohorere, whakamahia he kaiwhakarite pire, ā, tangohia o rongoā i te wā kotahi i ia rā. Ki te kāore koe i te mōhio kua tangohia e koe tō horopeta, he pai ake te karo i te horopeta, kaua e tūpono ki te tango i te rua.

Me pēhea te mahi ki te ngaro i te horopeta o Atazanavir me Cobicistat?

Ki te ngaro i te horopeta, ā, kua iti iho i te 12 hāora mai i tō wā horopeta, tangohia te horopeta i ngaro me te kai i te wā e mahara ana koe. Ki te nui ake i te 12 hāora, karo i te horopeta i ngaro, ā, tangohia tō horopeta e whai ake nei i te wā tika.

Kaua rawa e tango i ngā horopeta e rua i te wā kotahi hei utu mō te horopeta i ngaro. Ka piki ake tēnei i tō tūponotanga ki ngā pānga taha, kāore he painga atu.

Whakamātau ki te whakaiti i ngā horopeta i ngaro mā te whakatakoto pūoho waea, te whakamahi i ngā kaiwhakarite pire, te hono rānei i tō wā rongoā ki tētahi rāpoi rā, pēnei i te parakuihi, te hākari rānei.

Āhea e taea ai e au te whakamutu i te tango i te Atazanavir me Cobicistat?

Me haere tonu koe ki te tango i te atazanavir me te cobicistat mō te wā e tūtohu ana tō tākuta, ko te tikanga mō te ora. He āhuatanga mau tonu te HIV e hiahia ana ki te rongoā tonu kia noho whakahaere.

Ka whakaaro pea tō tākuta ki te huri i tō rongoā ki te pā ana koe ki ngā pānga taha e kore e taea te whakawhāiti, ki te whakawhanake rānei tō HIV i te ātete ki te rongoā o nāianei. Heoi, ka huri koe ki tētahi rongoā HIV rerekē, kaua e whakamutu i te rongoā katoa.

Ahakoa ka kore e kitea tō uta viral, me haere tonu koe ki te tango i ngā rongoā HIV kia mau tonu ai tērā tūnga. Ko te whakamutu i te rongoā ka taea e te huaketo te whakanui tere, ā, ka puta pea te haere whakamua o te AIDS.

Ka taea e au te inu waipiro i te wā e tango ana i te Atazanavir me Cobicistat?

Ka taea e koe te inu waipiro i te āhua tika i te wā e tango ana i te atazanavir me te cobicistat, engari he mea nui kia tūpato. Ka taea e te waipiro te whakanui i te tūponotanga ki ngā raruraru ate, ā, mai i te mea ka pā tēnei rongoā ki te mahi ate, me whakaaro nui te whakakotahi i a rāua.

Mēnā ka whiriwhiri koe ki te inu, piri ki ngā rahinga āhua noa, ā, karo i te inu waipiro nui. Kōrero ki tō tākuta mō te aha te inu waipiro haumaru mō tō āhuatanga motuhake.

Kia mahara hoki, ka taea e te waipiro te whakararu i tō kaha ki te tango rongoā i ngā wā katoa, ā, ka kino ake pea ētahi pānga taha pēnei i te whakapairuaki, te whanoke rānei.