He aha te Azacitidine: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu mea

He rongoā mate pukupuku te Azacitidine e āwhina ana ki te rongoā i ētahi momo mate pukupuku toto mā te mahi i te taumata ira hei whakahoki i te mahi pūtau noa. Koinei te mea e kīia ana e ngā tākuta he "rongoā hypomethylating," ko te tikanga e āwhina ana ki te whakakā anō i ngā ira kua wahangu i ngā pūtau mate pukupuku, e āhei ai tō tinana ki te whawhai i te mate i runga i te whai hua.

Kua kawea mai e tēnei rongoā te tūmanako ki te tini o ngā tūroro e mate ana i te mate pukupuku toto i mua i te iti o ngā kōwhiringa rongoā. Ahakoa e hiahia ana kia āta aroturukihia, ā, he pānga taha ōna, kua āwhina te azacitidine ki te whakaroa me te whakapai ake i te kounga o te oranga mō ngā mano o ngā tāngata puta noa i te ao.

He aha te Azacitidine?

He putanga waihanga te Azacitidine o tētahi poraka hanga tūturu o te DNA e kīia ana ko te cytidine. E mahi ana mā te whakauru ki tō DNA me te RNA, kātahi ka aukati i tētahi enzyme e kīia ana ko te DNA methyltransferase e whakamahia ana e ngā pūtau mate pukupuku ki te wahangu i ngā ira nui.

Whakaarohia he kī ngota e iriti ana i ngā ira e hiahia ana tō tinana ki te whawhai i te mate pukupuku. Ka nui haere ngā pūtau mate pukupuku, ka "whakaweto" rātou i ngā ira e aukati ana i tō rātou tipu, e whakaoho ana rānei i te mate pūtau. E āwhina ana te Azacitidine ki te whakakā anō i ēnei ira whakamarumaru, e whai wāhi pai ana tō pūnaha ārai mate ki te mōhio me te whakaeke i ngā pūtau mate pukupuku.

No tētahi akomanga tēnei rongoā e kīia ana ko ngā antimetabolites, ko te tikanga e pokanoa ana ki te pūngao pūtau mate pukupuku me te hanga DNA. Kāore i rite ki ngā rongoā chemotherapy e paitini ana i ngā pūtau mate pukupuku, e mahi ana te azacitidine i runga i te ara ngaro mā te hōtaka anō i te āhua o te mahi a ngā pūtau mate pukupuku.

He aha te Azacitidine e whakamahia ana mō?

Ko te Azacitidine te mea nui e whakamahia ana ki te rongoā i ngā mate myelodysplastic (MDS), he rōpū mate pukupuku toto kāore e whakaputa tika ana tō wheua wheua i ngā pūtau toto hauora. Kua whakaaetia hoki mō ētahi momo leukemia myeloid acute (AML) i roto i ngā tūroro kāore i te tika mō te chemotherapy kaha.

Ka tohutohu pea tō tākuta i te azacitidine mēnā he momo momo MDS ōna e uru ana ki te anemia aukati, te anemia aukati me ngā sideroblasts mowhiti, te anemia aukati rānei me te nui o ngā pupuhi. Ko ēnei āhuatanga ka whakaputa e tō wheua wheua ngā pūtau toto kōaro e kore e pai te mahi, e arahi ana ki te anemia, te piki o te tūponotanga o te mate, me ngā raruraru toto.

I ētahi wā ka whakamahia te rongoā mō te leukemia myelomonocytic mau tonu (CMML), tētahi atu momo mate pukupuku toto e pā ana ki ngā pūtau toto mā. I ētahi wā, ka whakaaro pea ngā tākuta mō ētahi atu mate pukupuku toto i te wā e kore e tika ana ngā rongoā paerewa, kāore rānei i whai hua.

I te nuinga o te wā, ka whakamahia pea te azacitidine i waho o te tapanga mō ētahi puku mārō i te wā i rahua ai ētahi atu rongoā, ahakoa me tino whakaaro tēnei e tō rōpū oncology.

Me pēhea te mahi a Azacitidine?

Ka mahi a Azacitidine mā te raru i te methylation DNA, tētahi tukanga e whakamahia ana e ngā pūtau mate pukupuku ki te wahangu i ngā ira e ārai ana i te tipu o te puku. I te wā e whiwhi ana koe i te werohanga, ka haere te rongoā mā tō toto ka uru ki roto i te DNA o ngā pūtau e wehe tere ana, tae atu ki ngā pūtau mate pukupuku.

Kia uru ki roto i te DNA, ka mau a azacitidine ka pau te enzyme DNA methyltransferase, e whakawhirinaki ana ngā pūtau mate pukupuku ki te pupuri i ngā ira ārai puku kia weto. Mā tēnei ka taea e ngā ira nui pēnei i te p16 me te p15 te hoki ki te kaha, e āwhina ana ki te whakahoki i te mana o te huringa pūtau noa me te whakaoho i te mate o te pūtau mate pukupuku.

Ka pā ano te rongoā ki te RNA, e raru ana i te hanga pūmua i roto i ngā pūtau mate pukupuku. Ko tēnei mahi rua i runga i te DNA me te RNA ka tino whai hua te azacitidine ki ngā mate pukupuku toto kua aukati ki ētahi atu rongoā.

E kiia ana ko Azacitidine he rongoā mate pukupuku kaha. Kāore i te kaha pērā i ngā rongoā chemotherapy horopeta nui, engari he kaha ake i ngā rongoā homoni, i ngā rongoā whāinga rānei. Ko te nuinga o ngā tūroro e pai ana ki a ia i te chemotherapy tuku iho i te wā e kite tonu ana i ngā hua whai tikanga.

Me pēhea taku tango i te Azacitidine?

Ka tukuna te Azacitidine hei werohanga i raro i tō kiri (subcutaneous) rānei, ki roto i te uaua (intravenous), i te nuinga o te wā i roto i te tari tākuta, i te pokapū mate pukupuku rānei. Kāore e taea e koe te tango i tēnei rongoā mā te waha, me whakahaere e ngā tāngata hauora whakangungu.

Ko te hōtaka paerewa ko te whiwhi werohanga mō ngā rā e whitu i te rarangi, ka whai muri i te wā okiokinga e toru wiki. Ka tūrua tēnei huringa 28-rā, ahakoa ka whakatika pea tō tākuta i te wā i runga i te urupare o tō tinana me ō tatauranga toto.

I mua i ia werohanga, ka tirohia e tō rōpū hauora ō tatauranga toto me te āhua o tō hauora. Kāore koe e hiahia ki te nohopuku i mua i te maimoatanga, engari ko te kai i te kai māmā i mua ka āwhina i te aukati i te whakapairuaki. Ko te inu i te wai nui i ngā rā maimoatanga ka āwhina i ō tākihi ki te tukatuka i te rongoā i te pai ake.

Ka huri ngā wāhi werohanga hei aukati i te riri, te nuinga o te wā ka huri i waenga i ō huha, puku, me ō ringa o runga. He meneti noa iho te werohanga, ahakoa me noho koe mō te aroturuki, ina koa i ngā maimoatanga tuatahi.

Kia Pēhea te Roa o taku tango i te Azacitidine?

Ka haere tonu te nuinga o ngā tūroro i te azacitidine mō te whā ki te ono huringa (tata ki te 4-6 marama) i mua i te arotake katoa a ngā tākuta mō te mahi. He maha ngā tāngata e pai ana ki te rongoā ka haere tonu te maimoatanga mō te wā roa, i ētahi wā mō ngā tau, i te mea e pai ana te whakawhitiwhiti, me te whakahaere i tā rātou mate pukupuku.

Ka aroturukihia e tō tākuta ō tatauranga toto me te āhua o tō hauora i ia wiki hei whakatau mēnā kei te āwhina te rongoā. Ka kite ētahi tūroro i te whakapai ake i roto i ngā huringa tuatahi, i ētahi atu rānei ka roa ake te wā ki te whakaatu i ngā painga. Ko te whāinga ko te kimi i te taurite tika i waenga i te whakahaere i tō mate pukupuku me te pupuri i tō kounga o te oranga.

Mēnā ka pā mai ngā pānga taha nui, ka piki rānei tō mate pukupuku ahakoa te rongoā, ka whakatika pea tō tākuta i tō horopeta, ka huri i te wā, ka huri rānei ki tētahi rongoā kē. Ko te whakatau mō te haere tonu, te whakamutu rānei i te azacitidine e whakawhirinaki ana ki tō urupare takitahi me te pai o tō whakahaere i ngā pānga taha.

Kāore i rite ki ētahi rongoā mate pukupuku e hoatu ana mō te wā kua whakaritea, ka haere tonu te azacitidine i te nuinga o te wā i te wā e whai hua ana, kāore hoki e pā mai ngā pānga taha e kore e whakaaetia. Ka mahi tō rōpū oncology ki a koe ki te whakatau i te huarahi pai mō tō āhuatanga motuhake.

He aha ngā pānga taha o te Azacitidine?

Ka taea e te Azacitidine te pā mai ngā pānga taha nā te mea e pā ana ki ngā pūtau mate pukupuku me ētahi pūtau hauora e wehe tere ana. Ko te nuinga o ngā pānga taha ka taea te whakahaere mā te aroturuki tika me te manaaki tautoko, ā, he maha ngā tūroro e kite ana ka taea e rātou te pupuri i te kounga o te oranga i te wā e whiwhi rongoā ana.

Ko ngā pānga taha tino noa ka pā mai pea ki a koe ko te ngenge, te whakapairuaki, me ngā tauhohenga i te wāhi werohanga pēnei i te whero, te pūhi rānei. Ko te tikanga ka puta ēnei i roto i ngā rā tuatahi o ia huringa, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā.

Koinei ngā pānga taha ka tūpono pea koe, kua whakarārangihia mai i te mea tino noa ki te mea iti:

• Te ngenge me te ngoikore, e pā ana ki te 80% o ngā tūroro
• Te whakapairuaki me te ruaki, te nuinga he ngawari ki te āhua
• Ngā tauhohenga i te wāhi werohanga pēnei i te whero, te pūhi, te pā rānei
• Ngā tatauranga toto iti (te anemia, ngā pūtau toto mā iti, ngā pereti iti)
• Te pāhau, te kōroke rānei
• Te iti o te hiahia
• Te kirika, ina koa i ngā huringa tuatahi
• Te mamae o te uaua, o te hononga rānei
• Te whanoke, te ānini rānei
• Te poto o te manawa

Ka mātakitaki pū te rōpū hauora i a koe mō ēnei pānga, ā, ka taea e rātou te whakarato rongoā, rautaki rānei hei āwhina i te whakahaere i a rātou. Ko te nuinga o ngā tūroro e kite ana he nui ake ngā pānga taha i ngā huringa tuatahi, ā, ka ngāwari ake te whakahaere i te roanga o te wā.

Ko ngā pānga taha nui ake, engari he iti noa iho te pā, me āta tirotiro tonu e te tākuta. Kei roto i ēnei ko ngā tohu o te mate kino (te kirika nui, te wiri, te ngenge nui), te toto rere ke, te pānga rānei, te whakapairuaki nui e kore ai e taea e koe te pupuri wai, te uaua rānei ki te manawa.

I ētahi wā, ka pā ki ētahi tūroro ētahi raruraru nui ake pēnei i te pūkahukahu, ngā pānga kiri kino, ngā raruraru tākihi rānei. Ka kōrero tō tākuta i ēnei mea ki a koe, ā, ka whakamārama i ngā tohu whakatūpato hei mātakitaki i waenga i ngā maimoatanga.

Ko wai e kore e tango Azacitidine?

Kāore a Azacitidine i te pai mō te katoa, ā, ka āta arotake tō tākuta mēnā he haumaru mōu i runga i tō hauora whānui me tō hītori rongoā. E hiahia ana te rongoā kia nui te rāhui o tō tinana ki te whakahaere i ōna pānga ki te hanga pūtau toto.

Kaua koe e tango azacitidine mēnā he pānga tōna ki a koe, ki te mannitol rānei (he wāhanga e whakamahia ana i roto i te werohanga). Ka tūpato rawa tō tākuta mēnā he mate ate nui tōna, nā te mea ka pā tēnei ki te āhua o te whakahaere a tō tinana i te rongoā.

E hiahia ana ētahi āhuatanga kia nui ake te tūpato me te mātakitaki tata, ahakoa kāore rātou e whakakore aunoa i a koe i te maimoatanga:

• Te mate tākihi nui, te whakawhirinaki rānei ki te dialysis
• Ngā mate kaha, kāore i te whakahaerehia
• Te mate ngākau nui, te whakaeke ngākau tata rānei
• Ngā tatauranga toto tino iti kāore e pai ake ana i te tiaki tautoko
• Te hapū, te whāngai ū rānei
• Te pokanga nui tata, ngā patunga rānei e ora ana
• Ētahi atu mate pukupuku kaha e hiahia ana ki te maimoatanga

Ka whakatauritehia e tō tākuta ēnei āhuatanga ki ngā painga ka puta mai i te rongoā. I ētahi wā, mā te whakatika i ēnei take i te tuatahi, mā te whakarato rānei i te manaaki tautoko anō, ka waiho te azacitidine hei kōwhiringa pai.

Mēnā kei te whakamahere koe kia hapū, kia whānau rānei he tamaiti, kōrerohia tēnei ki tō tākuta i mua i te tīmatanga o te rongoā. Ka taea e te Azacitidine te whara i ngā pēpi e whanake ana, ā, me whakamahi ngā tāne me ngā wāhine i ngā tikanga aukati hapū whai hua i te wā o te rongoā, me ngā marama maha i muri mai.

Ngā Ingoa Waitohu Azacitidine

E wātea ana te Azacitidine i raro i te ingoa waitohu Vidaza, koinei te momo rongoā e tino whakahauhia ana. Ka tae mai a Vidaza hei paura ka konatunatua ki te wai kano i mua i te werohanga, ā, e wātea ana i roto i ngā hanganga i raro i te kiri me te uaua.

He momo waha hou e kiia nei ko Onureg (ngā papa azacitidine) e wātea ana mō ētahi tūroro e tika ana mō te rongoā tiaki i muri i te rongoā tuatahi. Mā tēnei momo papa e taea ai e ētahi tūroro te haere tonu i te rongoā i te kāinga, kaua ki te haere ki te hōhipera mō ngā werohanga.

E wātea ana hoki ngā momo rongoā whānui o te azacitidine werohia, ā, he iti ake pea te utu i te wā e whakarato ana i ngā painga rongoā ōrite. Ka pā pea tō inihua me tō whare rongoā ki te waitohu motuhake, ki te momo rongoā whānui rānei ka whiwhi koe.

Ahakoa te waitohu ka whiwhi koe, ka noho ōrite te whakauru kaha me te whai huatanga. Ka whakarite tō rōpū hauora kia whiwhi koe i te hanganga e tika ana mō tō mahere rongoā motuhake.

Ngā Kōwhiringa Azacitidine

He maha atu ngā rongoā ka taea te rongoā i ngā mate pukupuku toto rite, ahakoa ka whakawhirinaki te kōwhiringa ki tō tātaritanga motuhake, te hauora whānui, me ngā rongoā o mua. Ka whakaarohia e tō tākuta ēnei kōwhiringa mēnā kāore te azacitidine e tika ana, ka mutu rānei te mahi mōu.

Ko te Decitabine (Dacogen) tētahi atu rongoā whakaiti i te methylation e mahi ana i te ara rite ki te azacitidine. Ko ētahi tūroro kāore e whakahoki kupu ki tētahi ka whai hua pea i tētahi atu, ahakoa he maha ngā pānga taha me ngā tikanga mahi e rite ana.

Ko ētahi atu kōwhiringa rongoā ka whakaarohia e tō tākuta ko:

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• Venetoclax, he maha ngā wā ka honoa ki te azacitidine mō ētahi momo AML
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• Lenalidomide (Revlimid) mō ngā momo MDS motuhake
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• Ngā hōtaka matū rongoā kaha mō ngā tūroro taitamariki, hauora ake
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• Te manaaki tautoko me ngā whakawhitinga toto me ngā mea whakatipu
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• Ngā whakamātau haumanu e tūhura ana i ngā rongoā whakamātau hou
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• Te whakawhiti wheua wheua mō ngā tūroro e tika ana
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Ko te kōwhiringa pai rawa atu e whakawhirinaki ana ki ngā mea pēnei i tō tau, te hauora whānui, ngā tohu ira i roto i ō pūtau mate pukupuku, me ō hiahia ake. Ka kōrero tō rōpū oncology i ēnei kōwhiringa ki a koe mēnā kāore te azacitidine i te kōwhiringa tika, kua mutu rānei te mahi.

Ka whiwhi pea ētahi tūroro i ngā rongoā whakakotahi e uru ana ki te azacitidine me ētahi atu rongoā, i ētahi wā ka whai hua ake i tētahi rongoā anake.

He Pai Ake Te Azacitidine I Te Decitabine?

Ko te azacitidine me te decitabine he rongoā whakaiti i te methylation e mahi ana i te ara rite, engari he rerekētanga ō rāua e pai ake ai tētahi mō koe i tētahi atu. Kāore tētahi e tino

E ai ki nga rangahau, he paku ake pea te whai hua o te azacitidine mo etahi momo MDS, ina koa ko nga mate morearea nui. Heoi, tera pea ka pai ake te decitabine mo nga turoro e uaua ana ki nga tauhohenga ki te waahi werohanga, e pai ana ranei ki te whakahaere i roto i te uaua.

He rite tonu nga ahua o nga paanga taha i waenga i nga rongoa e rua, ahakoa he pai ake te manawanui o etahi turoro ki tetahi i tetahi atu. Ka whakaarohia e to taakuta to momo mate pukupuku, nga maimoatanga o mua, me nga hiahia whaiaro i te wa e whiriwhiri ana i waenga i a raatau.

Nga Patai e Paatai ​​Ana mo Azacitidine

He Haumaru te Azacitidine mo nga Turoro e mate ana i te mate whatukuhu?

Ka taea te whakamahi i te Azacitidine i roto i nga turoro e mate ana i te mate whatukuhu ngawari ki te ngawari, engari me ata tirotiro, me te whakatikatika i te horopeta. Ka tirohia e to taakuta to mahi whatukuhu i nga wa katoa ma nga whakamatautau toto, a ka whakaiti pea i to horopeta mena kaore i te pai te mahi o ou whatukuhu.

Mena he mate whatukuhu nui koe, kei runga ranei koe i te dialysis, ka ata whakataurite to taakuta i nga painga me nga tupono. Ka taea te tango i te rongoa ma te dialysis, no reira me whakatau te wa o nga maimoatanga me to mahinga dialysis.

Me aha ahau ki te whakamahi pohehe ahau i te nui rawa o te Azacitidine?

I te mea ka tukuna te azacitidine e nga tohunga hauora i roto i nga waahi whakahaere, he tino onge te horopeta pohehe. Heoi, ki te whakapae koe kua nui rawa te rongoa i a koe, kei te pa ranei koe i nga paanga taha kino, whakapā atu ki to roopu hauora i tenei wa tonu, haere ranei ki te ruma ohorere tata.

Ko nga tohu o te horopeta pea ko te nausea me te ruaki kino, te tino ngenge, te kirika, te rere toto rereke, te uaua ranei ki te manawa. Karekau he rongoa motuhake mo te azacitidine, no reira ka aro te maimoatanga ki te whakahaere i nga tohu me te tautoko i te whakaora o to tinana.

Me aha ahau ki te ngaro ahau i te horopeta o Azacitidine?

Mēnā ka ngaro koe i tētahi werohanga azacitidine kua whakaritea, whakapā atu ki tō rōpū hauora tonu ki te whakarite anō. Kaua e ngana ki te utu i ngā horopeta kua ngaro mā te tango rongoā atu – he mōrearea tēnei, ā, kāore e pai ake ai ō hua maimoatanga.

Ka taea e tō tākuta te whakatika i tō hōtaka maimoatanga, te whakarerekē rānei i tō huringa i runga i te maha o ngā horopeta kua ngaro i a koe. He mea nui te rite mō te whai huatanga, nā reira ngana ki te pupuri i ō whakaritenga katoa kua whakaritea, me te kōrero i ngā tautohetohe whakarite i mua.

Āhea Āhau e Kati ai te Tango Azacitidine?

Me mutu anake te tango azacitidine i raro i te tohutohu a tō tākuta. Kāore i rite ki ētahi rongoā e tangohia ana mō tētahi wā kua whakaritea, ka haere tonu te tango azacitidine i te wā e āwhina ana ki te whakahaere i tō mate pukupuku, ā, e pai ana tō tinana ki te rongoā.

Ka arotakehia e tō tākuta i ngā wā katoa mēnā kei te whai hua tonu te rongoā mā ngā whakamātautau toto, ngā koiora wheua wheua, me te aroturuki i ō tohumate. Mēnā ka piki ake tō mate pukupuku, ka kore rānei e taea te whakahaere i ngā pānga taha, ka kōrero tō tākuta i ngā maimoatanga kē, i ngā kōwhiringa manaaki tautoko rānei.

Ka Taea e Āhau te Tango Kano ārai mate i te wā e Tango ana i te Azacitidine?

Me karo koe i ngā kano ārai mate ora i te wā e tango ana i te azacitidine nā te mea ka taea e te rongoā te whakaiti i tō pūnaha ārai mate. Kei roto i tēnei ngā kano ārai mate pēnei i te kano ārai mate rewharewha ora (te rehu ihu), MMR, me ngā kano ārai mate varicella (pāpaka heihei).

Heoi anō, ko ngā kano ārai mate kore e ora ana pēnei i te werohanga rewharewha, te kano ārai mate pneumonia, me ngā kano ārai mate COVID-19 he haumaru, ā, e taunakitia ana. Ka tohutohu tō tākuta ki a koe mō ngā kano ārai mate me tango e koe, me te wā ki te tiki i a rātou mō te whakamarumaru pai i te wā e whakaiti ana i ngā tūponotanga.