He aha te Bedaquiline: Ngā Whakamahinga, te Inenga, Ngā Pānga taha me ētahi atu

He paturopi motuhake a Bedaquiline i hangaia hei whawhai i ngā huakita kohi (TB) kāore e aro ki ngā rongoā paerewa. He rerekē te mahi o tēnei rongoā i ngā rongoā TB tawhito mā te aro ki te pūnaha whakaputa pūngao i roto i ngā huakita TB, e whakamate ana i a rātou.

Ka tūtaki pea koe ki te bedaquiline mēnā kei te raru koe i te mate kohi atawhai-maha (MDR-TB) rānei, te mate kohi atawhai-nui (XDR-TB) rānei. He momo TB tēnei e tino mōrearea ana kua pūngao ki ngā rongoā TB tino noa, e uaua ai te rongoā me te hiahia ki ngā huarahi kaha ake, e whāia ana.

He aha te Bedaquiline e whakamahia ana?

Ka rongoā a Bedaquiline i te mate kohi pūkahukahu atawhai-maha i roto i ngā pakeke me ngā tamariki 5 tau, neke atu rānei. Ko te tikanga tēnei e whāia ana e ia ngā mate TB i roto i ō pūkahukahu kāore i aro ki te iti rawa o ngā rongoā TB tuatahi e rua tino whai hua pēnei i te isoniazid me te rifampin.

Ka tohutohu anake tō tākuta i te bedaquiline hei wāhanga o te rongoā whakakotahi, kaua rawa ko ia anake. He mōhiotia ngā huakita TB, ā, ka tere te pūngao, nō reira ko te whakamahi i ngā rongoā maha i te taha kotahi ka ārai i ngā huakita mai i te tinihanga i tētahi rongoā kotahi. Ko tēnei huarahi whakakotahi ka whai wāhi pai tō tinana ki te whakakore rawa i te mate.

Kei te rāhui motuhake te rongoā mō ngā take i rahua ai ētahi atu kōwhiringa rongoā, kāore rānei i te tika. Ka whakamātau tō rōpū hauora i ō huakita TB i roto i te taiwhanga hei whakaū i te kore mahi o ngā rongoā paerewa i mua i te tūtohu i te bedaquiline.

Me pēhea te mahi a Bedaquiline?

Ka mahi a Bedaquiline mā te aukati i te ATP synthase, he enzyme e hiahia ana ngā huakita TB ki te whakaputa pūngao. Whakaarohia me te tapahi i te tuku pūngao ki tētahi wheketere - kāore he pūngao, kāore e ora, e whakaputa anō rānei ngā huakita.

He kaha rawa tenei i te bedaquiline ki te patu i te huakita TB, engari ehara i te rongoa e mahi ana i te po kotahi. Ka noho te rongoa ki roto i to punaha mo te wa roa, e haere tonu ana ki te whawhai i te mate ahakoa i waenga i nga horopeta. He awhina tenei noho roa i roto i to tinana mo te rongoa i te mate, me tetahi mea ka ata tirohia e to taakuta.

Kaore i rite ki etahi rongoa TB e patu ana i te huakita i te wa poto, ka mahi te bedaquiline i te wa roa me te pumau. He pai ake tenei huarahi haere mo nga momo TB e kaha ana, e atete ana kua ako ki te ora i etahi atu maimoatanga.

Me pehea taku tango i te Bedaquiline?

Tangohia te bedaquiline i runga i nga tohutohu a to taakuta, i te nuinga o te wa kotahi i te ra me te kai. Ka pai ake te ngongo o te rongoa ina tangohia me te kai, no reira kaua e peke i te kai i mua i to horopeta. Ka awhina tetahi kai i nga wa katoa - kaore koe e hiahia ki tetahi mea motuhake.

Horomia nga papa katoa me te wai. Kaua e kuru, e ngaungau, e wawahi ranei, na te mea ka pa tenei ki te tukunga o te rongoa i roto i to tinana. Mena he raruraru koe ki te horomia i nga papa, korero ki to kaiwhakarato hauora mo etahi atu whiringa.

Whakamātauria ki te tango i to horopeta i te wa kotahi i ia ra kia mau tonu nga taumata i roto i to punaha. Ko te whakarite i te whakamaharatanga o ia ra ka awhina i a koe kia rite tonu, he mea nui tenei mo te whawhai i te TB atete.

Tera pea ka tohua e to taakuta etahi atu rongoa TB me te bedaquiline. Tangohia katoa i runga i nga tohutohu, ahakoa ka timata koe ki te pai ake. Ko te whakamutu wawe i te maimoatanga ka taea e te huakita TB te hoki mai me te kaha ake te atete.

Kia pehea te roa e tango ai ahau i te Bedaquiline?

Ka tangohia e te nuinga o nga tangata te bedaquiline mo te 24 wiki (mo te 6 marama), engari ko te roa o to maimoatanga ka whakawhirinaki ki to ahuatanga. Ka whakaarohia e to taakuta nga mea penei i te pai o to urupare ki te maimoatanga me etahi atu rongoa e tango ana koe.

He mea nui ngā wiki e rua tuatahi – ka tango koe i te bedaquiline ia rā i tēnei wā ki te hanga tere i ngā taumata whai hua i roto i tō pūnaha. I muri i tērā, ka whakatika pea tō tākuta i te auau i runga i tō ahunga.

Kaua e mutu te tango i te bedaquiline ahakoa kei te pai koe. Ka taea e ngā huakita TB te huna i roto i tō tinana, ka hoki mai anō te kaha ki te mutu wawe te rongoā. Ka whakamahi tō rōpū hauora i ngā whakamātautau pēnei i ngā ahurea huware me ngā hihi-X o te uma ki te whakatau i te wā e haumaru ana te mutu.

E hiahia ana ētahi tāngata ki ngā akoranga rongoā roa ake, ina koa ki te tino kaha te TB, ki te whai rānei i ētahi atu āhuatanga hauora e pā ana ki te whakaora. Ka aroturuki tō tākuta i tō ahunga whakamua, ka whakatika i tō mahere rongoā i te mea e tika ana.

He aha ngā pānga taha o te Bedaquiline?

Pērā i ngā rongoā katoa, ka taea e te bedaquiline te pānga taha, ahakoa kāore te katoa e pā ana. Mā te māramatanga ki te aha e tūmanakohia ana ka āwhina koe ki te pai ake te whakarite, me te mōhio ki te wā ki te whakapā atu ki tō kaiwhakarato hauora.

Ko ngā pānga taha tino noa ka kitea pea ko te whakapairuaki, te mamae tahi, te ānini, me ngā huringa i tō rongo reka, i te kakara rānei. Ko te nuinga o ēnei pānga he ngawari, ā, ka pai ake i te wā e whakatika ana tō tinana ki te rongoā i ngā wiki tuatahi.

Koinei ngā pānga taha e pā ana ki te nuinga o ngā tāngata i te wā o te rongoā:

• Te whakapairuaki me te puku pōuri
• Te mamae tahi, te mamae uaua rānei
• Ngā ānini
• Te whanoke
• Ngā huringa i te reka, i te kakara rānei
• Te ngenge, te pōuri rānei
• Te pānga kiri

Ko ēnei pānga taha noa e taea ana te whakahaere, ā, kāore e hiahiatia te whakamutu i te rongoā. Heoi, me whakamōhio tonu ki tō rōpū hauora mō ngā tohumate e pā ana ki a koe kia taea ai e rātou te āwhina i a koe kia pai ake te noho.

Ko ngā pānga taha nui ake he iti noa iho, engari e hiahia ana ki te āwhina hauora tonu. Kei roto i ēnei ko ngā raruraru o te manawataki o te ngākau, ngā raruraru ate nui, ngā tohu rānei o te pānga mate pāwera nui.

Whakapā atu ki tō tākuta tonu mēnā ka pā ki a koe ētahi o ēnei tohumate e pā ana:

• Te ngākau pōrearea, te mamae rānei o te uma
• Te whakapairuaki nui, te ruaki, te ngaro rānei o te hiahia
• Te kōwhai o te kiri, o ngā kanohi rānei (jaundice)
• Te mimi pouri, te tūtae koma rānei
• Te ngenge nui, te ngoikore rānei
• Te uaua ki te manawa, ki te horomia rānei
• Te pūwha nui o te kiri, te māngai rānei

Ka aroturukihia koe e tō rōpū hauora i te wā o te maimoatanga mā te whakamātautau toto i ngā wā katoa me te aroturuki i te ngākau. Mā tēnei e āwhina ki te kite wawe i ngā raruraru ka puta, me te whakarite kia noho haumaru, kia whai hua hoki tō maimoatanga.

Ko wai kāore e tika kia tango Bedaquiline?

Kāore a Bedaquiline e tika ana mō te katoa, ā, ka āta arotake tō tākuta mēnā he tika tēnei mōu. Ko ngā tāngata e pā ana ki ētahi mate ngākau, ki te hunga rānei e tango ana i ētahi rongoā motuhake, tērā pea ka hiahia ki ētahi atu maimoatanga.

Kāore koe e tika kia tango bedaquiline mēnā he mōhiotia tō mate pāwera ki te rongoā, ki ētahi o ōna kai rānei. Ka tūpato anō tō tākuta ki te whakahau i tēnei rongoā mēnā he raruraru tō ngākau, kei te tango rongoā rānei e pā ana ki te mahi hiko o tō ngākau.

Ka hiahia tō kaiwhakarato hauora ki te mōhio mō ēnei āhuatanga i mua i te whakahau i te bedaquiline:

• Ngā raruraru o te manawataki o te ngākau (arrhythmias)
• Te mate ate, te pikinga rānei o ngā enzyme ate
• Ngā raruraru tākihi
• Te iti o te pāhare pāporo, te konupūmā, te konukura rānei
• Te hītori o ngā whakaeke ngākau, te ngoikore rānei o te ngākau
• Te hītori whānau o te mate ohorere o te ngākau

Ka taea e ētahi rongoā te pā tōtika ki te bedaquiline, ina koa ko ērā e pā ana ki te manawataki o te ngākau, ki te mahi ate rānei. Ka arotake tō tākuta i ō rongoā katoa o nāianei, tae atu ki ngā rongoā e hokona ana i te tākuta, me ngā taapiri, i mua i te tīmatanga o te maimoatanga.

Mēnā kei te hapū koe, kei te whāngai u rānei koe, ka āta whakatau tō tākuta i ngā painga me ngā tūponotanga. Ahakoa he mea nui te rongoā i te TB mō kōrua ko tō pēpi, ko te whakamahi i te bedaquiline i te wā e hapū ana me āta aroturuki, me te whakaaro ki ētahi atu rongoā.

Ngā Ingoa Waitohu o Bedaquiline

Kei te wātea te Bedaquiline i raro i te ingoa waitohu Sirturo i te nuinga o ngā whenua, tae atu ki te United States. Koinei te huarahi tino noa e kite ai koe i te rongoā e tohua ana, e tapaina ana i te whare rongoā.

Tērā pea ētahi whenua he rerekē ngā ingoa waitohu, ngā momo rongoā rānei. Ka taea e tō kaipūtaiao te āwhina i a koe ki te tautuhi i tō rongoā motuhake, me te whakarite kei te whiwhi koe i te hanganga tika.

Me kōrero tonu ki tō kaiwhakarato hauora, ki tō kaipūtaiao rānei mēnā he pātai āu mō te āhua, te tapanga rānei o tō rongoā. He mea nui kia mōhio kei te tango koe i te mea i tohua.

Ētahi Atu Rongoā hei Whakamahi hei Rīwhi mō Bedaquiline

Mēnā kāore te bedaquiline e tika ana mōu, tērā ētahi atu rongoā ka taea te rongoā i te TB e ātete ana ki ngā rongoā maha. Ka whakaaro pea tō tākuta ki ngā rongoā pēnei i te linezolid, clofazimine, ētahi atu rongoā hou rānei pēnei i te pretomanid, i runga i tō momo TB motuhake me tō āhua hauora.

Ko te whiriwhiri i ētahi atu rongoā e whakawhirinaki ana ki ētahi mea, tae atu ki ngā rongoā e ātete ana ō huakita TB, ō ētahi atu āhua hauora, me ngā pānga rongoā pea. Ka mahi tō rōpū hauora me ngā tohunga TB ki te kimi i te huinga pai mō tō āhuatanga.

Ka whakamahi pea ētahi tāngata i te bedaquiline i te taha o ēnei rongoā hei rīwhi. Ko te whāinga tonu ko te waihanga i tētahi mahere rongoā e tino whai hua ana ki te rongoā i tō TB, me te whakaiti i ngā pānga taha me ngā raruraru.

He uaua, he takitahi hoki ngā whakatau rongoā mō te TB e ātete ana ki ngā rongoā. Ka whakaaro tō tākuta ki ngā hua taiwhanga e whakaatu ana i ngā rongoā e whai hua ana ki tō momo TB motuhake, tō hītori hauora, me te pai o tō whakawātea i ngā rongoā rerekē.

He Pai Anei te Bedaquiline i Ētahi Atu Rongoā TB?

Kāore pea a Bedaquiline i te pai ake i ētahi atu rongoā TB – he rerekē tōna whāinga. Ahakoa e pai ana ngā rongoā TB tuatahi pērā i te isoniazid me te rifampin mō te nuinga o ngā tūponotanga TB, ka whāia e Bedaquiline ngā momo whakapakeke e kore e aro ki ngā rongoā paerewa.

Mō te TB whakapakeke ki ngā rongoā maha, kua whakaatu a Bedaquiline i ngā painga nui i roto i ngā rangahau haumanu. Ka taea e ia te āwhina ki te whakatutuki i ngā reiti rongoā teitei ake, ā, ka taea pea te whakaiti i ngā akoranga rongoā ina whakamahia hei wāhanga o te rongoā whakakotahi.

Ko te tikanga mahi ahurei o te rongoā nei ka whai hua ki ngā huakita TB kua whakapakeke ki ētahi atu rongoā. Heoi, e wātea ana mō ngā tūponotanga whakapakeke nā te utu, ngā pānga taha pea, me te hiahia ki te aroturuki tupato.

Ka whiriwhiria e tō tākuta ngā rongoā e tika ana i runga i tō momo TB motuhake, te hītori hauora, me ngā āhuatanga takitahi. Ko te rongoā

Mēnā i tūpono koe ki te tango i te bedaquiline nui atu i te mea i tohua, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei i te wā tonu. Kaua e tatari kia kite mena ka pūremu koe i ngā tohumate, nā te mea ka raru te nui o te bedaquiline i te manawataki o te ngākau.

Haere ki te ruma ohorere mēnā ka pūremu koe i te mamae o te uma, te manawataki koretake, te whanoke nui, te ngaro rānei i muri i te tango i te rongoā nui rawa atu. Mauria mai tō pounamu rongoā kia mōhio ai ngā kaiwhakarato hauora ki te aha me te nui i tango koe.

Hei aukati i te nui o te horopeta tūpono, waiho te bedaquiline ki roto i tōna ipu taketake me te tapanga mārama. Whakaarohia te whakamahi i te kaiwhakarite pire, te whakatakoto rānei i ngā whakamaharatanga hei āwhina i a koe ki te mahara kua tango kē koe i tō horopeta o ia rā.

Me aha au mēnā ka ngaro i ahau tētahi horopeta o te Bedaquiline?

Mēnā ka ngaro i a koe tētahi horopeta o te bedaquiline, tangohia i te wā tonu ka mahara koe, engari mēnā kei roto i te 6 hāora o tō wā kua whakaritea. Mēnā kua pahure i te 6 hāora, pekehia te horopeta i ngaro, ka tango i tō horopeta e whai ake nei i te wā tika.

Kaua rawa e tango i ngā horopeta e rua i te wā kotahi hei utu mō te horopeta i ngaro. Ka piki ake pea tēnei i tō tūponotanga ki ngā pānga taha, ina koa ko ngā raruraru o te manawataki o te ngākau. Engari, haere tonu ki tō hōtaka horopeta auau.

Mēnā ka wareware koe i ngā horopeta, kōrero ki tō kaiwhakarato hauora mō ngā rautaki hei āwhina i a koe ki te mahara. He mea nui te horopeta rite tonu mō te whawhai i te TB ātete i runga i te whai hua me te aukati i te huakita kia kaha ake te ātete.

Āhea ka taea e au te whakamutu i te tango i te Bedaquiline?

Ka taea e koe te whakamutu i te tango i te bedaquiline i te wā anake ka kī mai tō tākuta he haumaru ki te mahi pera. E whakatakoto ana tēnei whakatau i runga i ngā whakamātautau taiwhanga, ngā rangahau whakaahua, me tō urupare haumanu ki te rongoā, ehara i te mea i runga i te āhua o tō pūremu.

Ka aroturukihia e tō rōpū hauora ō ahurea huware, ngā hihi-X o te uma, me ētahi atu whakamātautau hei whakatau i te wā ka rongoā katoa tō mate TB. Ko te whakamutu wawe rawa ka taea e te huakita te hoki mai, ka kaha ake te ātete ki te rongoā.

Ahakoa ka mutu te tango i te bedaquiline, ka haere tonu pea koe i etahi atu rongoa TB me nga wa whakarite whai-a-roto. Ka hiahia to taakuta ki te whakarite kia kore te mate e hoki mai, me te mea kua ora katoa koe.

Ka taea e au te inu waipiro i te wa e tango ana i te Bedaquiline?

He pai ake te karo i te waipiro i te wa e tango ana i te bedaquiline, na te mea ka pa te rua ki to ate me te mahi o te ngakau. Ka taea e te waipiro te whakanui i to tupono ki nga raruraru ate, a tera pea ka raruraru i te ahua o te tukatuka o to tinana i te rongoa.

Mena ka whiriwhiria e koe te inu i etahi wa, korerohia tenei ki to kaiwhakarato hauora i te tuatahi. Ka taea e ratou te tohutohu i a koe i runga i to ahuatanga hauora me etahi atu rongoa e tango ana koe.

Kia mahara kei te kaha te mahi a to ate ki te tukatuka i te bedaquiline me etahi atu rongoa TB. Ko te taapiri i te waipiro ki te ranunga ka nui ake te taumahatanga ki tenei okana nui, a tera pea ka raruraru i te whai huatanga o to maimoatanga.