He aha te Bevacizumab: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu

He rongoā mate pukupuku whāinga a Bevacizumab e āwhina ana ki te whakaiti i te tipu o te puku mā te aukati i te hanganga o ngā oko toto. E mahi ana tēnei rongoā motuhake mā te tapahi i te tuku toto e hiahiatia ana e ngā puku kia tipu, kia horapa puta noa i tō tinana.

Hei paturopi monoclonal, he huarahi tika ake a bevacizumab ki te rongoā mate pukupuku i te chemotherapy tuku iho. Ka tūtohu pea tō tākuta mate pukupuku i tēnei rongoā hei wāhanga o tō mahere manaaki mate pukupuku whānui, i te nuinga o te wā me ētahi atu rongoā kia whai hua pai ai koe.

He aha te Bevacizumab?

He pūmua i hangaia i te taiwhanga a Bevacizumab e whai ana i ngā paturopi o tō tinana. E whāinga ana tēnei ki tētahi pūmua e kīia ana ko VEGF (vascular endothelial growth factor) e whakamahia ana e ngā puku ki te hanga oko toto hou.

Whakaarohia te VEGF hei tohu e kī ana ki tō tinana kia hanga huarahi nui mō te rere o te toto. He nui ngā tohu e tukuna ana e ngā pūtau mate pukupuku kia whiwhi i ngā matūkai e hiahiatia ana e rātou kia tipu. Ka aukati a Bevacizumab i ēnei tohu, e tapahi ana i te tuku kai o te puku.

No tētahi akomanga tēnei rongoā e kīia ana ko ngā aukati angiogenesis, ko te tikanga e ārai ana i te hanganga o ngā oko toto hou. Mā te mahi i tēnei, ka āwhina pea ki te whakaiti i te tipu o te mate pukupuku me te whai hua ake o ētahi atu rongoā mate pukupuku.

He aha te Bevacizumab e whakamahia ana?

E rongoā ana a Bevacizumab i ētahi momo mate pukupuku matatau, ina koa kua horapa, kua hoki mai rānei i muri i te rongoā tuatahi. Ka tohua e tō tākuta i te wā i hanga ai e ngā pūtau mate pukupuku ā rātou ake whatunga tuku toto.

Ko ngā mate pukupuku e rongoāhia ana e bevacizumab ko te mate pukupuku colorectal, te mate pukupuku pūkahukahu, te mate pukupuku whatukuhu, me ētahi puku roro e kīia ana ko glioblastomas. Ka whakamahia hoki mō ētahi mate pukupuku gynecologic pēnei i te mate pukupuku ovarian me te mate pukupuku cervical.

Ko te tikanga ka whakakotahi tō tākuta mate pukupuku i te bevacizumab me te rongoā matū, kaua ki te whakamahi anake. He pai ake te mahi tahi i tētahi anake, ka hoatu e tō tinana ngā huarahi maha ki te whawhai i te mate pukupuku.

I ētahi wā, ka whakamahi ngā tākuta i te bevacizumab mō ngā āhuatanga o te kanohi pēnei i te makular degeneration e pā ana ki te pakeke, ahakoa e hiahia ana tēnei i tētahi hanganga rerekē me te hōtaka inenga i te rongoā mate pukupuku.

Me pēhea te mahi a Bevacizumab?

Ka mahi a Bevacizumab mā te here ki ngā pūmua VEGF i roto i ō toto, e ārai ana i a rātou ki te piri ki ngā kaiwhiwhi i runga i ngā pūtau o ngā oko toto. Ka aukati tēnei i te tohu e kī ana i te nuinga o te wā ki tō tinana kia tipu ngā oko toto hou ki te puku.

Hei rongoā whāinga, ka whakaarohia te bevacizumab he rongoā kaha-waenga e mahi rerekē ana i te rongoā matū tuku iho. Kāore i te patu tika i ngā pūtau mate pukupuku, engari ka whakamate i a rātou mā te tapahi i ō rātou tūtohu toto.

Ka huri te rongoā i roto i ō toto mō ētahi wiki i muri i ia whakaurunga. I tēnei wā, ka aukati tonu i ngā tohu VEGF, e āwhina ana ki te whakatika i ngā whatunga oko toto raruraru e hangaia ana e ngā puku.

Ka taea e tēnei huarahi te whakaraerae i ngā puku ki ētahi atu rongoā pēnei i te rongoā matū, te iraruke rānei, koinei te take e whakamahi ana ngā tākuta i te bevacizumab hei wāhanga o te rongoā tahi, kaua ki te whakamahi anake.

Me pēhea taku tango i te Bevacizumab?

Ka hoatu te Bevacizumab mā te whakaurunga i roto i te uaua (IV) anake i te whare rongoā mate pukupuku, i te hōhipera rānei. Kāore e taea e koe te tango i tēnei rongoā mā te waha, te werohia rānei e koe i te kāinga.

Ko te tikanga ka roa te whakaurunga tuatahi mō te 90 meneti, e āhei ana i tō rōpū hauora ki te aroturuki i te urupare a tō tinana. Ki te pai tō urupare, ka taea te whakapoto i ngā whakaurunga i muri mai ki te 60 meneti, ā, i te mutunga ki te 30 meneti.

Kāore koe e hiahia kia nohopuku i mua i te rongoā, engari mā te kai i tētahi kai māmā i mua ka āwhina koe kia pai ake te noho i te wā o te whakaurunga. Mauria mai he wai me ngā paramanawa, nā te mea ka noho koe mō tētahi wā roa.

Ka tirohia e tō nēhi whakaurunga ō tohu nui i ngā wā katoa, ā, ka mātakitaki mō ngā urupare tonu. Ka konatunatua te rongoā ki te otinga tote me te hoatu pōturi mā tō rārangi IV kia iti ake ngā pānga taha.

Kia Pēhea te Roa e Tango ai au i te Bevacizumab?

He rerekē te roa o te rongoā bevacizumab i runga i te momo mate pukupuku motuhake, te wāhanga, me te pai o tō urupare ki te rongoā. Ko te nuinga o ngā tūroro ka whiwhi whakaurunga ia 2-3 wiki mō ētahi marama.

Ka aroturukihia e tō tākuta mate pukupuku tō mate pukupuku mā ngā karapa me ngā whakamātautau toto i ngā wā katoa hei whakatau mēnā kei te mahi te rongoā. Mēnā kei te pai te urupare o tō mate pukupuku, ā, kei te pai koe ki te rongoā, ka taea te haere tonu te rongoā mō te 6-12 marama, neke atu rānei.

Ka haere tonu ētahi tūroro i te bevacizumab hei rongoā tiaki ahakoa te ahua kua whakahaerea tō rātou mate pukupuku. Mā tēnei rongoā e haere tonu ana e āwhina ana ki te ārai i te mate pukupuku mai i te whakawhanake i ngā oko toto hou me te tupu anō.

Ka kōrerohia e tō tākuta te whakamutu i te rongoā mēnā ka piki ake tō mate pukupuku ahakoa te rongoā, mēnā ka whakawhanake koe i ngā pānga taha nui, mēnā rānei ka hiahia koe ki te pokanga e hiahia ana ki te wā whakaora.

He Aha ngā Pānga Taha o te Bevacizumab?

Mā te māramatanga ki ngā pānga taha ka āwhina koe ki te mōhio he aha te mea e tūmanakohia ana, ā, nō te wā e whakapā atu ai ki tō rōpū hauora. Ko te nuinga o ngā tāngata ka pā ki ētahi pānga taha, engari he maha ngā wā ka taea te whakahaere mā te tautoko tika me te aroturuki.

Ngā pānga taha noa e pā ana ki te nuinga o ngā tūroro ko te toto tiketike, te ngenge, me te ihu toto. Ka kite pea koe i ngā huringa i tō rongo o te reka, te whakapairuaki ngawari, te piki ake rānei o te pānga o te maru mai i ngā pūpū iti.

Koinei ngā pānga taha e pūrongohia ana i te nuinga o te wā:

• Te toto tiketike e hiahia ana ki te whakatikatika rongoā
• Te ngenge me te ngoikore ka kaha ake i te roanga o te wā
• Te ihu toto, ētahi atu wāhanga toto iti rānei
• Pūmua i roto i tō mimi i kitea mā te whakamātautau auau
• Ngā huringa reka e pā ana ki tō hiahia kai
• Te whakapairuaki ngawari ki te pōturi
• Te pōtae nui ake, te whakaora patunga rānei e puhoi ana

Ko ngā pānga taha nui ake e hiahia ana ki te āwhina hauora tonu, ahakoa he iti noa iho te auau. Ka mōrearea te ora ēnei raruraru ki te kore e whakatikahia e tō rōpū hauora.

Ko ngā pānga taha onge engari nui ko:

• Te toto nui i roto i tō puku, pūkahukahu, roro rānei
• Ngā toto toto i roto i ō waewae, pūkahukahu, ngākau rānei
• Ngā rua, ngā roimata rānei i roto i tō pakitara whekau (perforation)
• Te raruraru toto tiketike nui
• Ngā raruraru ngākau tae atu ki te ngoikore o te ngākau
• Te kino o te tākihi me te ngaro o te pūmua
• Ngā tauhohenga mate pāwera nui i te wā o te whakauru

Ka aroturukihia e tō rōpū hauora ēnei raruraru nui mā te whakamātautau toto auau, te tirotiro i te toto tiketike, me ngā whakamātautau tinana. Ko te kitenga wawe me te rongoā o ngā pānga taha ka ārai i te nuinga o ngā raruraru mai i te mōrearea.

Ko wai kāore e tika kia tango Bevacizumab?

Ko ētahi āhuatanga hauora me ngā āhuatanga ka kore e haumaru te bevacizumab, ka hiahia rānei ki ngā whakatūpato motuhake. Ka āta arotakehia e tō tākuta mate pukupuku tō hītori hauora i mua i te tūtohu i tēnei rongoā.

Kāore koe e tika kia whiwhi bevacizumab mēnā kei te hapū koe, kei te whakamahere rānei koe kia hapū, nā te mea ka pā mai ngā hē whānau nui. Me whakamahi ngā wāhine o te tau whānau i te aukati whānau whai hua i te wā o te rongoā me te ono marama i muri mai.

Ko ngā tāngata i te wā tata i te pokanga nui, i ngā tikanga pokanga rānei e whakamahere ana, kāore e taea te whiwhi bevacizumab. Ka pā te rongoā ki te whakaora patunga, nō reira me whakamutu e koe te rongoā i te iti rawa 28 rā i mua i te pokanga e whakamahere ana.

Ko ētahi atu āhuatanga ka ārai i te whakamahi i te bevacizumab ko:

• Te toto tiketike kāore i te whakahaeretia ahakoa te rongoā
• He hītori tata o ngā wāhanga toto nui
• Ngā mate toto e tū ana i tēnei wā
• Te mate ngākau nui, te pānga ngākau tata rānei
• Ngā mate kaha kāore e aro ana ki te rongoā
• Te mate tākihi nui me te ngaronga pūmua
• He whiu tata, he toto rānei i te roro

Ka whakataurite tō tākuta i ngā painga pea ki ēnei tūponotanga mō tō āhuatanga motuhake. I ētahi wā ka taea e ngā whakarerekētanga ki tō mahere rongoā, te aroturuki atu rānei te bevacizumab kia haumaru ake mō te hunga whai āhuatanga motuhake.

Ngā Ingoa Waitohu Bevacizumab

E wātea ana te Bevacizumab i raro i ētahi ingoa waitohu, ko Avastin te mea e mōhiotia whānuitia ana. Kua whakamahia tēnei putanga ingoa waitohu ki te rongoā mate pukupuku mō ngā tau maha, me te rangahau nui e tautoko ana i ōna whai huatanga.

Kei te wātea ināianei ngā putanga koiora o te bevacizumab, e tuku ana i ngā painga rongoā kotahi i ngā utu iti ake pea. Kei roto i ēnei ko Mvasi, Zirabev, me Alymsys, kua whakaaetia katoa hei ōrite ki te Avastin taketake.

Ka pā pea tō inihua ki te waitohu ka tohua e tō tākuta, engari kei roto i ngā putanga katoa kua whakaaetia te whakauru kaha kotahi, ā, ka mahi ōrite i tō tinana. Ko te kōwhiri i waenga i ngā waitohu ka whakawhirinaki ki te wātea me ngā whakaaro utu, kaua ki ngā rerekētanga rongoā.

Ngā Kōwhiringa Bevacizumab

He maha atu ngā rongoā e mahi ana i te ara kotahi ki te bevacizumab mā te aro ki te hanganga o ngā oko toto, ahakoa he āhuatanga motuhake me ngā whakamahinga kua whakaaetia. Ka whakaaro pea tō tākuta mate pukupuku ki ēnei kōwhiringa i runga i tō momo mate pukupuku motuhake me te hītori rongoā.

Ko te Ramucirumab (Cyramza) tētahi atu rongoā e whai ana i te VEGF e whakamahia ana mō te mate pukupuku o te puku me te pūkahukahu. E mahi ana mā tētahi tikanga rerekē engari ka whakatutuki i ngā hua rite ki te aukati i te tipu o ngā oko toto o te puku.

Ko ētahi atu aukati angiogenesis ko te aflibercept (Zaltrap) mō te mate pukupuku colorectal me te regorafenib (Stivarga) mō te mate pukupuku colorectal me te ate. E tuku ana ēnei rongoā i ngā kōwhiringa whakahaere waha, e pai ana ētahi tāngata i runga i ngā whakawhiwhinga IV.

Mō ētahi mate pukupuku, ko ngā rongoā immunotherapy pēnei i te pembrolizumab (Keytruda) rānei nivolumab (Opdivo) ka whakaarohia hei utu mō te bevacizumab, i te taha rānei, i runga i ngā āhuatanga motuhake me ngā tohu koiora o tō mate pukupuku.

He Pai Anei te Bevacizumab i Ētahi Atu Rongoā Rite?

Ko te Bevacizumab te aukati VEGF tuatahi i whakaaetia, ā, he nui rawa ngā raraunga rangahau e tautoko ana i tōna whakamahinga puta noa i ngā momo mate pukupuku maha. Mā tēnei rekoata roa e āwhina ana i ngā tākuta ki te matapae i te āhua o tō urupare ki te rongoā.

Ki te whakataurite ki ngā momo rongoā hou pēnei i te ramucirumab, he maha tonu ngā huinga rongoā e wātea ana ki te bevacizumab me te whānui ake o te whakaaetanga mō ngā momo mate pukupuku rerekē. Heoi, ko te kōwhiringa

Ka pā te Bevacizumab ki tō pūnaha cardiovascular, nō reira me nui ake te aroturuki me ngā whakatūpato mō te hunga e pā ana ki ngā mate o te ngākau. Ka mahi tahi tō tākuta ngākau me tō tākuta mate pukupuku ki te whakatau mēnā ka nui ake ngā painga i ngā tūponotanga.

Mēnā he mate ngākau ngawari tōna e pai ana te whakahaere, ka taea tonu pea e koe te whiwhi bevacizumab me te nui ake o te aroturuki i te ngākau. Kei roto i tēnei ko ngā ECG auau, ngā echocardiograms, me te whakahaere i te pēhanga toto i te wā o te maimoatanga.

Ko te hunga e pā ana ki te ngoikore o te ngākau nui, ngā whakaeke ngākau tata nei, te pēhanga toto tiketike rānei kāore i te whakahaerehia, kāore e taea te whiwhi bevacizumab. Ka taea e te rongoā te whakapōrearea i ēnei āhuatanga me te whakanui i te tūponotanga o ngā raruraru cardiovascular nui.

Me aha au mēnā ka whiwhi au i te nui rawa o te Bevacizumab?

He tino onge te nui rawa o te bevacizumab nā te mea ka whakahaerea e ngā tākuta whakangungu i roto i ngā wāhi hauora whakahaere. Ka āta tatau te rongoā i runga i tō taumaha tinana, ka hoatu mā te āta haere mā te whakauru IV e aroturukihia ana.

Mēnā kei te whakaaro koe kua whiwhi koe i te horopeta hē, whakamōhio atu ki tō nēhi whakauru, ki tō tākuta rānei i te wā tonu. Ka taea e rātou te arotake i ō rātou rekoata maimoatanga me te aroturuki i a koe kia tata ake mō ngā pānga taha rerekē.

Ko ngā tohu e tohu ana i ngā take horopeta ko te mamae nui o te upoko, te pēhanga toto tino tiketike, te toto rerekē, te whakapairuaki nui rānei. E mōhio ana tō rōpū hauora ki te whakahaere i ēnei āhuatanga, ā, ka whakarato i te manaaki tautoko e tika ana.

Me aha au mēnā ka ngaro au i te horopeta o te Bevacizumab?

Whakapā atu ki tō rōpū mate pukupuku i te wā tonu mēnā ka ngaro koe i te whakaurunga bevacizumab kua whakaritea. Ka whakarite anō rātou i a koe mō te wā e tika ana i te wā wawe ki te pupuri i tō whai huatanga maimoatanga.

Ka taea e tō tākuta te whakatika i tō hōtaka maimoatanga kia uru ki te horopeta i ngaro, engari kaua e ngana ki te "whakatika" mā te whiwhi horopeta tata atu. Ko te wā i waenga i ngā whakaurunga kua āta whakamaherehia hei taurite i te whai huatanga me te haumaru.

Ko te ngaro i tētahi horopeta i te nuinga o te wā kāore e nui te pānga ki te putanga o tō maimoatanga whānui, ina koa ka hoki wawe koe ki tō hōtaka auau. Ka aroturukihia e tō tākuta mate pukupuku tō urupare, ā, ka tūtohu pea i ētahi atu karapa hei whakarite kia mau tonu tō mate pukupuku.

Āhea ka taea e au te whakamutu i te tango Bevacizumab?

Ko te whakatau ki te whakamutu i te bevacizumab e whakawhirinaki ana ki ētahi mea, tae atu ki te urupare o tō mate pukupuku ki te maimoatanga, ngā pānga taha e pā ana ki a koe, me tō āhua hauora whānui. Mā tō tākuta mate pukupuku e ārahi tēnei whakatau i runga i te aroturuki auau.

Ka mutu pea te maimoatanga ki te piki ake tō mate pukupuku ahakoa te rongoā, ki te whakawhanake koe i ngā pānga taha nui atu i ngā painga, ki te hiahia koe ki te pokanga e hiahia ana ki te whakaora pai i te patunga.

Ka mutu pea ētahi tūroro i te bevacizumab i muri i te whakaoti i tētahi akoranga maimoatanga kua whakamaherehia, i te mea ka haere tonu ētahi atu i te wā e āwhina ana ki te whakahaere i tō rātou mate pukupuku me te pai o te whakawātea. Kāore he "rā mutunga" i mua i te whakatau mō te katoa.

Kaua rawa e whakamutu i te bevacizumab anake me te kore e kōrero tuatahi ki tō tākuta mate pukupuku. Kāore te whakamutu ohorere e pā ki ngā tohumate tangohanga mōrearea, engari ka taea e tō mate pukupuku te piki ake i te tere atu i te mea e tūmanakohia ana.

Ka taea e au te inu waipiro i te wā e tango ana i te Bevacizumab?

Ko te inu waipiro i te āhua pai te nuinga o te wā i te wā e whiwhi ana i te bevacizumab, engari me kōrero koe i ō tikanga inu waipiro ki tō tākuta mate pukupuku. Ka taea e te waipiro te pā ki ētahi atu rongoā e tango ana koe, ā, ka kino pea ētahi pānga taha.

I te mea ka pā te bevacizumab ki tō toto me te whakanui i te tūponotanga o te toto, ka taea e te waipiro te whakanui i ēnei pānga. Ki te whiriwhiri koe ki te inu, whakawhāitihia koe ki te kotahi inu i ia rā, ā, karo i te waipiro tata ki ō rā whakaurunga.

Kia tūpato ki te pānga o te waipiro ki a koe i te wā e rongoa ana koe, nā te mea ka taea e ngā rongoā mate pukupuku te whakarerekē i tō kaha ki te whakawhāiti. E kitea ana e ētahi tāngata tūroru ka kaha ake te pānga o te waipiro ki a rātou, ka nui ake rānei te ngenge i te wā e whakakotahi ana i te waipiro me te bevacizumab.