He aha te Crisaborole: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā ā-rohe a Crisaborole e āwhina ana ki te rongoā i te eczema ngawari ki te āhua (atopic dermatitis) mā te whakaiti i te mumura me te mānukanuka. Ko tēnei kirīmi ngawari, kāore i te steroid, e mahi rerekē ana i ngā rongoā steroid tuku iho, he kōwhiringa whai hua mō te hunga e hiahia ana ki te whakahaere eczema wā-roa me te kore ētahi o ngā āwangawanga e pā ana ki te whakamahi steroid roa.

He aha te Crisaborole?

He aukati phosphodiesterase-4 (PDE-4) a Crisaborole e puta mai ana hei hinu ā-rohe. I hangaia motuhake hei rongoā i te eczema mā te whai i te tukanga mumura e pā ana ki ngā pānga kiri whero, mānukanuka, me te riri e kitea ana i tēnei āhuatanga.

Kāore i rite ki ngā steroid ā-rohe, kāore a Crisaborole e pēhi whānui i tō pūnaha ārai mate. Engari, e mahi ana i te kōwhiri mā te aukati i ngā enzyme motuhake e whai wāhi ana ki te mumura i tō kiri. Ko tēnei huarahi whai i te whāinga e tino whai hua ana mō ngā wāhi tairongo pēnei i te mata me te kaki, i te wā e pāngia ai te whakamahi steroid wā-roa e te kikokore, ētahi atu rānei huringa kiri.

I whakaaetia te rongoā e te FDA i te tau 2016, ā, kua noho hei kōwhiringa rongoā nui mō ngā tamariki me ngā pakeke e pā ana ki te eczema. E wātea ana anake mā te rēhitatanga, ā, e tohutohutia ana i te nuinga o te wā i te wā kāore anō ētahi atu rongoā i whai hua, i te wā rānei e hiahia ana koe ki tētahi kōwhiringa kāore i te steroid mō te whakahaere tonu.

He aha te Crisaborole e whakamahia ana mō?

Ko te Crisaborole te mea nui e whakamahia ana ki te rongoā i te atopic dermatitis ngawari ki te āhua, e mōhiotia ana ko te eczema. Ko tēnei āhuatanga kiri roa e pā ana ki ngā pānga o te kiri kia mumura, mānukanuka, whero, ā, i ētahi wā ka pakaru, ka pākē rānei.

Ka tohutohu pea tō tākuta i te crisaborole mēnā ka pā ki a koe ngā tohumate eczema noa pēnei i te mōmona tonu, ngā pāti whero, parauri rānei o te kiri, ngā pūpū iti e piki ana ka waiho pea he wai ka rakurakuhia, te kiri matotoru, pakaru, rānei, te kiri unahi rānei. He tino whai hua mō te rongoā i te eczema i ngā wāhi tairongo o tō tinana, tae atu ki tō mata, ngā kamo, te kaki, me ngā kōpaki kiri.

He whai hua hoki te rongoā mō te rongoā tiaki wā roa. Nā te mea kāore i te mau i ngā tūponotanga rite ki te whakamahi steroid wā roa, he maha ngā tākuta e tohutohu ana mō ngā tāngata e hiahia ana ki te rongoā tonu hei ārai i ngā pānga o te eczema. Ka taea te whakamahi haumaru mō ngā wā roa me te kore e māharahara ki te kikokore o te kiri, ki ētahi atu pānga taha e pā ana ki te steroid.

Me pēhea te mahi a Crisaborole?

Ka mahi a Crisaborole mā te aukati i tētahi enzyme e kīia ana ko te phosphodiesterase-4 (PDE-4) i roto i ō pūtau kiri. Ko tēnei enzyme te tikanga ka pakaru i tētahi matū e kīia ana ko te cyclic adenosine monophosphate (cAMP), e āwhina ana ki te whakahaere i te mumura.

Inā aukatia te PDE-4, ka piki ake ngā taumata cAMP i roto i ō pūtau kiri. Ko ngā taumata cAMP teitei ake ka āwhina i te whakaiti i te hanga o ngā matū mumura e pā ana ki te whero, te pūhi, me te mōmona e pā ana ki te eczema. Whakaarohia me te whakaiti i te rōrahi i runga i te urupare mumura o tō kiri, kaua ki te whakaweto katoa.

Nā tēnei tikanga ka waiho te crisaborole hei rongoā anti-mumura kaha. Kāore i te kaha tonu pēnei i ngā steroid ā-roto kaha, engari e whakarato ana i te āwhina pumau, rite tonu, me te kore e tūpono ki te kikokore o te kiri, ki ētahi atu raruraru e pā ana ki te steroid. Ko te tikanga ka tīmata te mahi a te rongoā i roto i ngā rā torutoru ki te wiki o te whakamahi auau, me ngā painga katoa e kitea ana i muri i te 2-4 wiki o te tono tonu.

Me pēhea taku tango i te Crisaborole?

Whakamahia te crisaborole kia rite ki te tohutohu a tō tākuta, te tikanga e rua ngā wā i te rā ki ngā wāhi kiri e pā ana. Ka taea e koe te whakamahi me te kore kai rānei, he rongoā ā-roto tēnei kāore e pā ana ki tāu e kai ana.

Me tīmata mā te horoi i ō ringaringa kia tino mā, i mua i te whakamahi. Horoi marie i te kiri e pā ana ki te hopi ngawari me te wai, ka whakamaroke. Whakamahia he paparanga angiangi o te hinu ki ngā wāhi e pā ana, ka mirimiri marie kia ngaro rawa. Me whakamahi te rongoā ki tō kiri, kaua ki ngā membrane mucous pēnei i roto i tō waha, i tō ihu rānei.

I muri i te whakamahi i te crisaborole, horoi anō ō ringaringa ki te kore koe e rongoā ana i ō ringaringa ake. Kāore koe e hiahia ki te hipoki i ngā wāhi kua rongoā ki ngā pātene, ki ngā kākahu rānei, ki te kore tō tākuta e tohutohu ana. Ka taea e koe te whakamahi i te whakamāori i runga i te rongoā ki te hiahiatia, engari tatari mō ētahi meneti kia mimiti tuatahi te crisaborole.

Kaua e tukua te rongoā kia uru ki ō kanohi, waha, ki roto rānei i tō ihu. Ki te pēnei tēnei i tūpono, horoia te wāhi ki te wai. Ka taea e koe te kaukau, te ua rānei i te wā e whakamahi ana i te crisaborole, engari ngana ki te whakamahi i te rongoā ki te kiri mā, maroke mō te mimiti pai.

Kia Pēhea Te Roa E Whakamahi Ai Au i te Crisaborole?

He rerekē te roa o te rongoā crisaborole i runga i tō urupare takitahi me te kaha o tō eczema. Te nuinga o te tangata ka tīmata ki te kite i te whakapai ake i roto i te wiki tuatahi o te whakamahi, me ngā painga nui e puta ana i muri i te 2-4 wiki o te whakamahi tonu.

Mō ngā pūhaehae koi, ka whakamahi pea koe i te crisaborole mō ētahi wiki kia pai te whakahaere i ō tohumate. Kia pai ake tō eczema, ka tohutohu pea tō tākuta kia haere tonu te rongoā hei rongoā tiaki kia kore ai e puta anō ngā pūhaehae. Koinei tētahi o ngā painga o te crisaborole - ka taea te whakamahi haumaru mō ngā wā roa, kāore he āwangawanga e pā ana ki te whakamahi steroid mō te wā roa.

E whakamahi ana ētahi tāngata i te crisaborole mō ngā marama, ētahi tau rānei, hei wāhanga o tā rātou mahere whakahaere eczema e haere tonu ana. Mā tō tākuta e aroturuki tō ahunga whakamua, ā, ka whakatika pea i tō mahere maimoatanga i runga i te pai o te urupare o tō kiri, me te pānga o ētahi pānga taha. Kaua e mutu te whakamahi i te rongoā me te kore e kōrero ki tō kaiwhakarato hauora, nā te mea ka hoki mai pea ō tohumate.

He aha ngā pānga taha o te Crisaborole?

He pai te whakawhitiwhiti a te nuinga o te tāngata i te crisaborole, engari pērā i ngā rongoā katoa, ka pānga taha pea. Ko te rongo pai, he mea noa ngā pānga taha nui, ā, he ngawari, he wā poto noa iho te nuinga o ngā urupare.

Ngā pānga taha noa e pā ana ki te 10% o te tāngata:

• Te wera, te ngau rānei i te wāhi e whakamahia ana (te nuinga he ngawari, he wā poto)
• Te riri kiri, te whero rānei i te wāhi e whakamahia ana te rongoā
• Te mānukanuka i te wāhi e whakamahia ana (he mea rerekē pea, nā te mea e rongoatia ana e te rongoā te mānukanuka)
• Te mamae kiri, te ngawari rānei
• Te dermatitis whakapā mate pāwera (urupare kiri ki te rongoā tonu)

Ko te tikanga, ka puta ēnei urupare noa i te wā tuatahi ka tīmata koe ki te whakamahi i te rongoā, ā, ka pai ake i te wā e urutau ana tō kiri ki te maimoatanga. Ko te wera, te ngau rānei te mea e tino kitea ana i ngā whakamahinga tuatahi, ā, ka heke i te wā e whakamahi tonu ana.

Ngā pānga taha kaore i te noa, engari he nui ake te māharahara:

• Ngā urupare mate pāwera nui (te pupuhi, te hives, te uaua ki te manawa, te pūhi o te mata, ngā ngutu, te korokoro rānei)
• Ngā tohu o te mate kiri (te whero nui, te mahana, te pūhi, te kirika rānei)
• Te kino haere o ō tohumate eczema
• Ngā huringa kiri rerekē, te huringa tae rānei

Mēnā ka pā ki a koe ētahi urupare nui, mēnā rānei kāore ngā pānga taha ngawari e pai ake i muri i te wiki e whakamahi ana, whakapā atu ki tō kaiwhakarato hauora. Ka taea e rātou te āwhina ki te whakatau mēnā me haere tonu koe i te rongoā, me whakamātau rānei i tētahi atu huarahi maimoatanga.

Ko wai e kore e tango Crisaborole?

Kāore a Crisaborole e tika ana mō te katoa, ā, me karo ētahi tāngata ki te whakamahi i tēnei rongoā. Ka arotakehia e tō tākuta tō hītori hauora me te āhua o tō hauora i tēnei wā i mua i te whakahau i tēnei rongoā.

Kaua koe e whakamahi i te crisaborole mēnā he pānga koe ki a ia, ki ōna kai rānei. Ko ngā tohu o te pānga mate ko te pūwha nui, te māngai, te uaua ki te hā, te pūhi rānei o tō mata, ngā ngutu, te arero, te korokoro rānei. Mēnā i pānga koe ki ngā rongoā ā-roto rite i mua, me mōhio ki tō tākuta.

Me whakamahi tūpato ngā tāngata e pā ana ki ētahi āhua kiri ki te crisaborole:

• Ngā mate kiri kaha (pūtaiao, huaketo, harore rānei) i te wāhi rongoā
• Ngā patunga tuwhera, te kiri rānei kua pakaru rawa
• Ētahi atu āhua kiri i tua atu i te eczema ka kino pea e te rongoā
• Hītori o ngā pānga mate nui ki ngā rongoā ā-roto

He mea whai whakaaro motuhake ki ngā wāhine hapū me te whāngai ū. Ahakoa kāore anō ngā rangahau i whakaatu i ngā pānga kino ki ngā pēpi kāore anō i whānau, me whakamahi anake te crisaborole i te wā e hapū ana mēnā ka nui ake ngā painga i ngā tūponotanga. Mēnā kei te whāngai ū koe, karo i te tono i te rongoā ki ngā wāhi ka pā atu pea tō pēpi ki a ia, pēnei i te uma, te wāhi ū rānei.

Kaua ngā tamariki i raro i te 2 tau te pakeke e whakamahi i te crisaborole ki te kore i tohutohutia e tētahi tākuta kiri tamariki. Kāore anō te haumaru me te whai huatanga i roto i ngā tamariki tino iti i whakatūria katoatia.

Ngā Ingoa Waitohu Crisaborole

Kei te wātea a Crisaborole i raro i te ingoa waitohu Eucrisa i te United States. Koinei te ingoa waitohu tuatahi e hokona ana, e whakahaua ana te rongoā.

I hangaia a Eucrisa e Pfizer, ā, ka tae mai hei hinu ā-roto 2%. Kei te wātea te rongoā i roto i ngā ngongo o ngā rahi rerekē, te tikanga 60 karamu, 100 karamu rānei, i runga i tō whakahau me ngā hiahia rongoā.

I tēnei wā, kāore he momo rongoā whānui o te crisaborole e wātea ana i Amerika. Ko te tikanga ko Eucrisa anake te kōwhiringa waitohu, ā, ka nui ake te utu o te rongoā i ngā rongoā whānui kē atu. Heoi anō, he maha ngā mahere inihua e hipoki ana i te crisaborole, ā, e tuku ana te kaihanga i ngā hōtaka āwhina tūroro hei āwhina i te whakaiti i ngā utu mō ngā tāngata e tika ana.

Ngā Kōwhiringa kē atu mō te Crisaborole

Mēnā kāore te crisaborole i te pai mōu, kāore rānei i te whai hua, he maha ngā rongoā kē atu e wātea ana mō te whakahaere i te eczema. Ka taea e tō tākuta te āwhina i a koe ki te tūhura i ēnei kōwhiringa i runga i ō hiahia me tō hītori hauora.

Ko ngā corticosteroids ā-rohe tonu te rongoā e tino whakahaua ana. Kei roto i ēnei ko ngā kōwhiringa ngawari pēnei i te hydrocortisone mō ngā wāhi tairongo, ngā steroids kaha-wawaenga pēnei i te triamcinolone mō ngā wāhi o te tinana, me ngā kōwhiringa kaha ake pēnei i te clobetasol mō ngā pūwhā nui. Ahakoa he whai hua, me mātakitaki ēnei rongoā mō te whakamahi wā-roa kia kore ai e pā ngā pānga taha pēnei i te kikokore o te kiri.

Ko ētahi atu kōwhiringa kore-steroidal ko:

• Ngā aukati calcineurin ā-rohe (tacrolimus, pimecrolimus) - he tino whai hua mō te rongoā i te kanohi me te kaki
• Ngā aukati JAK ā-rohe pēnei i te ruxolitinib - he kōwhiringa hou mō te eczema ngawari ki te wawaenga
• Ngā kirīmi whakatika arai me ngā whakamākū rongoā
• Ngā antihistamines mō te whakaiti i te mānukanuka

Mō te eczema nui kāore e aro ki ngā rongoā ā-rohe, ka whakaarohia ngā kōwhiringa pūnaha. Kei roto i ēnei ko ngā rongoā waha pēnei i ngā werohanga dupilumab, methotrexate, cyclosporine rānei, ahakoa e rāhui ana ēnei mō ngā take nui ake nā te mea ka nui ake ngā pānga taha.

He pai ake te Crisaborole i te Tacrolimus?

He rongoā whai hua a Crisaborole me te tacrolimus mō te eczema kāore i te steroid, engari he rerekē te mahi, ā, he rerekē ngā painga. Ko te whiriwhiri i waenga i a rāua e whakawhirinaki ana ki tō āhuatanga motuhake, te tairongo o te kiri, me ngā whāinga o te rongoā.

He ngawari ake te Crisaborole, ā, he iti ake te wera, te ngau rānei i te wā e whakamahia ana i te tacrolimus. Nō reira he pai ake mō te hunga he kiri tairongo rawa, mō te hunga rānei kāore i kaha ki te tacrolimus nā te riri i te tīmatanga. Kāore hoki a Crisaborole e mau ana i te whakatūpato pouaka pango a te FDA e pā ana ki te tacrolimus mō te tūponotanga o te mate pukupuku i te wā roa e whakamahia ana.

Heoi anō, e mōhiotia ana he kaha ake te tacrolimus, ā, he whai hua ake pea mō te eczema ngawari ki te kaha. Kua roa kē te wā e wātea ana, ā, he nui ake ngā rangahau e tautoko ana i tōna whakamahinga. He tere ake hoki te mahi a Tacrolimus i te crisaborole, ā, ka kite ētahi tāngata i te whakapai ake i roto i ngā rā, kaua i ngā wiki.

Mō te eczema o te kanohi, he pai ngā rongoā e rua nei i te mea kāore e angiangi te kiri pērā i te steroids. Ka tīmata pea tō tākuta ki te crisaborole mēnā he kiri tairongo tō, he āwangawanga rānei mō te kaha, katahi ka whakaaro ki te tacrolimus mēnā e hiahia ana koe i ngā pānga anti-inflammatory kaha ake. Ka whakamahi ētahi tāngata i ngā rongoā e rua i ngā wā rerekē, mō ngā wāhi rerekē rānei o te tinana hei wāhanga o tā rātou mahere rongoā.

Ngā Pātai Auau mō Crisaborole

He Haumaru a Crisaborole mō te Mate Huka?

Āe, he haumaru te crisaborole mō te hunga mate huka. I te mea he rongoā ā-rohe e mahi ana i te kiri, kāore e pā ana ki ngā taumata huka toto, e rānei e pokanoa ana ki ngā rongoā mate huka.

Heoi anō, me tino tūpato te hunga mate huka ki te tiaki kiri, nā te mea he nui ake te tūponotanga ki ngā mate kiri me te puhoi o te whakaora patunga. Ki te mate huka koe, ā, ka puta mai ētahi tohu o te mate kiri i te wā e whakamahi ana koe i te crisaborole, pēnei i te whero nui ake, te mahana, te pūhi, te kirika rānei, whakapā atu ki tō tākuta i te wā tonu. Ka hiahia pea tō kaiwhakarato hauora ki te aroturuki i tō kiri i te wā o te maimoatanga kia mōhio ai kei te ora tika.

Me Pēhea Taku Mahi Mēnā Ka Whakamahia E Au Te Nui Rawa O Crisaborole?

Ko te whakamahi i te nui rawa o te crisaborole i ētahi wā, kāore pea e puta he raruraru nui, nā te mea he rongoā ā-rohe tēnei. Heoi anō, ko te whakamahi i te nui rawa ka piki ake te tūponotanga o ngā pānga taha pēnei i te riri kiri, te wera, te pānga pāwera rānei.

Mēnā ka whakamahi koe i te nui rawa, horoia ngā mea nui ki te kakahu mā, mākū. Kaua e mirimiri, e hōmai rānei i te kaha, nā te mea ka nui ake te riri o tō kiri. Aroturukihia te wāhi kua rongoāhia mō te whero nui ake, te wera, ētahi atu tohu rānei o te riri i ngā hāora e whai ake nei.

Mēnā ka pā ki a koe te wera nui, te pāhau whānui, ētahi tohu rānei o te pānga pāwera i muri i te whakamahi i te nui rawa o te crisaborole, horoia te wāhi ki te hopi ngawari me te wai, whakapā atu ki tō kaiwhakarato hauora. Ā muri ake nei, kia mahara he mea nui te paparanga angiangi - kāore te nui ake o te rongoā e whai hua ake.

Me Pēhea Taku Mahi Mēnā Ka Ngaro I Au Tētahi Inenga Crisaborole?

Mēnā ka ngaro i a koe tētahi inenga crisaborole, whakamahia i te wā e mahara ana koe. Heoi anō, mēnā kua tata te wā mō tō inenga e whai ake nei, waiho te inenga i ngaro, ka haere tonu ki tō hōtaka whakamahi auau.

Kaua e whakamahi i te rongoā atu hei utu mō te inenga i ngaro, nā te mea ka piki ake te tūponotanga o ngā pānga taha. He mea nui te rite tonu ki te crisaborole, nā reira ngana ki te whakamahi i te wā kotahi i ia rā kia mau tonu ai ngā taumata i tō kiri.

Mēnā he maha ō wā e wareware ana ki ngā horopeta, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i te rongoā hei wāhanga o tō rātou rā, pēnei i muri i te parai i ō niho i te ata me te ahiahi. Kāore he kino o te ngaro i ngā horopeta i ētahi wā, engari ka taea e te whakamahi i ngā rongoā i ngā wā katoa te whakaiti i te whai huatanga o te rongoā ki te whakahaere i tō eczema.

Āhea Āhau e mutu ai te tango i te Crisaborole?

Ka taea e koe te whakamutu i te whakamahi i te crisaborole i te wā kua ngaro ō tohumate eczema, kua noho pūmau hoki mō tētahi wā i whakatauhia e tō tākuta. Heoi, kaua e whakamutu ohorere i te rongoā me te kore e kōrero tuatahi ki tō kaiwhakarato hauora.

He maha ngā tākuta e tūtohu ana kia whakaheke haere i te auau o te whakamahi, kaua e mutu ohorere. Hei tauira, ka huri pea koe mai i te rua wā i te rā ki te kotahi wā i te rā, kātahi ki ia rā kē, i mua i te whakamutu katoa. Mā tēnei huarahi e ārai ai i ngā mura o te ahi, me te tuku i a koe ki te aroturuki i te urupare o tō kiri.

Me haere tonu ētahi tāngata ki te crisaborole hei rongoā tiaki wā-roa hei ārai i ngā mura o te eczema. I te mea he haumaru mō te whakamahi whānui, ka tūtohu pea tō tākuta i te rongoā tonu mēnā he eczema mau tonu tōu e hoki mai ana i te wā e mutu ana te rongoā. Ko te whakatau ki te haere tonu, ki te mutu rānei me mahi tonu i te kōrero tahi me tō kaiwhakarato hauora i runga i tō urupare me ō hiahia.

Ka taea e au te whakamahi i te Crisaborole me ētahi atu rongoā eczema?

Āe, ka taea te whakamahi i te crisaborole me ētahi atu rongoā eczema, engari me tirotiro tonu koe ki tō tākuta i mua i te whakakotahi i ngā rongoā. Ka taea e tō kaiwhakarato hauora te āwhina ki te waihanga i tētahi mahere rongoā whānui e whakanui ana i ngā painga i te wā e whakaiti ana i ngā pānga tūturu.

He pai te mahi a Crisaborole me ngā whakamākū me ngā kirīmi whakatika arai, he wāhanga nui ēnei o te whakahaere eczema. Whakamahia te crisaborole i te tuatahi, tatari mō ētahi meneti kia mimiti, kātahi ka whakamahi i tō whakamākū. Ka taea hoki e koe te whakamahi me ngā antihistamines waha mō te whakawātea i te mānukanuka.

Mēnā kei te whakamahi koe i ētahi atu rongoā ā-rohe, tērā pea ka tūtohu tō tākuta kia whakamahia ēnei i ngā wā rerekē o te rā, kia whakawhiti rānei i ngā rongoā hei karo i ngā pānga pea. Ko ētahi huinga, pēnei i te whakamahi crisaborole me ngā steroid ā-rohe, tērā pea ka tohua mō ngā pūremu nui, engari me mātakitaki tēnei e te tākuta kia mōhio ai kei te haumaru, ā, e whai hua ana.