He aha te Ecallantide: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā whakahau a Ecallantide i hangaia hei rongoā i ngā whakaekenga ohorere, kaha hoki o te pōhēhē i te hunga whai angioedema tuku iho (HAE). E mahi ana tēnei rongoā werohia motuhake mā te aukati i ētahi pūmua i tō tinana e whakaoho ana i ngā wāhanga pōhēhē mōrearea, ina koa i te taha o tō mata, korokoro, me ētahi atu wāhi nui.

Mēnā kua tātai koe, tētahi rānei e mōhio ana koe i te HAE, mā te māramatanga ki tēnei rongoā ka āwhina koe ki te pūmau me te māia ki te whakahaere i tēnei āhuatanga onge engari he nui te raru. Me haere tātou i ngā mea katoa e hiahia ana koe ki te mōhio mō te ecallantide i roto i ngā kupu māmā, mārama.

He aha te Ecallantide?

He rongoā koiora whāinga a Ecallantide e mahi ana rite ki te kī motuhake, e aukati ana i ngā pūmua motuhake e kiia nei ko te kallikreins e pā ana ki ngā whakaekenga pōhēhē i ngā tāngata HAE. Whakaarohia he taputapu tika e uru ana i te wā o te raruraru hei āwhina i te aukati i te tukanga pōhēhē i mua i te mōrearea ki te ora.

No tētahi akomanga tēnei rongoā e kiia nei ko te aukati kallikrein, ko te tikanga e whāinga ana ki te take o ngā whakaekenga HAE kaua ki te rongoā i ngā tohu noa. E whakaaro ana ngā kaiwhakarato hauora he rongoā whakaora nā te mea e whakamahia ana i te wā o ngā wāhanga pōhēhē kaha, kāore i te rongoā ārai ia rā.

Ka tae mai te rongoā hei otinga mārama, kāore he tae e tika ana kia werohia i raro i te kiri (werohanga subcutaneous). Ko ngā tohunga hauora whakangungu anake me whakahaere i tēnei rongoā, i te nuinga o te wā i te hōhipera, i te wāhi haumanu rānei ka taea e koe te aroturuki mō ētahi urupare.

He aha te Ecallantide e whakamahia ana mō?

Kua whakaaetia motuhake a Ecallantide ki te rongoā i ngā whakaekenga koi o te angioedema tuku iho i ngā pakeke me ngā taiohi 12 tau me te pakeke ake. He āhuatanga ira onge te HAE kāore e whakahaere tika ana tō tinana i ētahi pūmua e whakahaere ana i te pōhēhē me te mumura.

I te wā o te whakaekenga HAE, ka pāngia pea e koe te pūhihi ohorere, kaha i tō mata, ngutu, arero, korokoro, ringa, waewae, rānei i ō taihemahema. Kāore anake tēnei pūhihi e kore e pai, engari he mōrearea pea, ina koa ka pā ki tō manawa, ki te horomi rānei.

He tino whai hua te rongoā mō te rongoā i ngā whakaekenga e pā ana ki tō ara rererangi o runga, ki te wāhi korokoro rānei, i te wāhi ka aukati pea te pūhihi i tō manawa. Ka whakamahi pea ngā kaiwhakarato hauora i tēnei mō ētahi atu wāhanga pūhihi kaha i te wā e nui ake ana ngā painga i ngā tūponotanga.

Me pēhea te mahi a Ecallantide?

Ka mahi a Ecallantide mā te aukati i te plasma kallikrein, he pūmua he tūranga nui ki te whakaoho i te pūhihi i roto i ngā tūroro HAE. I te wā e pāngia ana e koe te whakaekenga HAE, ka whakaputa tō tinana i te nui rawa o te mea e kīia nei ko te bradykinin, e pā ana ki ngā oko toto ki te turuturu wai ki ngā kiko e tata ana.

E whakaarohia ana tēnei rongoā he rongoā kaha, tere hoki e āwhina ana ki te aukati i te whakaekenga e haere ana. Mā te aukati i te kallikrein, ka āwhina a ecallantide ki te whakaiti i te whakaputanga o te bradykinin, e āwhina ana ki te whakaiti i te pūhihi me te mumura e pāngia ana e koe.

Ko te tikanga ka tīmata ngā pānga i roto i ngā hāora i muri i te werohanga, ahakoa ka rerekē ngā wā urupare takitahi. He rerekē tēnei i ngā rongoā ārai ka tango pea koe i ia rā ki te whakaiti i te auau o ngā whakaekenga.

Me pēhea taku tango i te Ecallantide?

Me hoatu a Ecallantide hei werohanga i raro i tō kiri e tētahi tohunga hauora whakangungu i roto i tētahi whare hauora. Kāore e taea e koe te tango i tēnei rongoā i te kāinga, te hoatu rānei ki a koe anō, nā te mea e hiahia ana kia āta aroturukihia me te tikanga werohanga tika.

Ko te horopeta paerewa ko te 30 mg te tikanga ka hoatu hei werohanga motuhake e toru 10 mg i raro i te kiri, te tikanga i ngā wāhi rerekē pēnei i tō huha, puku, ringa o runga rānei. Mā tō kaiwhakarato hauora e whakatau ngā wāhi werohanga tika, ā, ka wehe pea i a rātou kia whakaiti i te kore pai.

Kāore koe e hiahia ki te māharahara mō te tango i tēnei rongoā me te kai, te karo rānei i ētahi kai, nā te mea he werohanga tēnei, kāore i te tango mā te waha. Heoi anō, he mea nui kia noho wai tonu koe, me te whai i ētahi atu tohutohu ka tukuna e tō rōpū hauora i te wā o tō maimoatanga.

Kia Pēhea te Roa e Tango Ai au i te Ecallantide?

Ko te tikanga ka tukuna te Ecallantide hei maimoatanga kotahi i te wā o te whakaeke HAE nui, kāore i te rongoā haere tonu. Ko te nuinga o te tangata ka whiwhi i te horopeta katoa i te wā o te haerenga kotahi ki te whare hauora, ā, ka taea e ngā pānga te roa mō te roanga o taua whakaeke.

Mēnā ka pā tētahi atu whakaeke HAE ki a koe i te wā e haere ake nei, tērā pea ka tūtohu tō tākuta i te ecallantide anō, engari ka whakaarohia he mea motuhake ia maimoatanga, ā, ka whakatakoto i runga i ō tohu motuhake me ō hiahia hauora i taua wā.

Ka aroturukihia koe e tō kaiwhakarato hauora mō ētahi haora i muri i te whiwhinga i te werohanga kia mōhio ai kei te pai tō urupare, me te mātakitaki i ngā tauhohenga kino. He wāhanga nui tēnei wā o te aroturuki i te tukanga maimoatanga.

He Aha ngā Pānga taha o te Ecallantide?

Pērā i ngā rongoā katoa, ka taea e te ecallantide te pānga taha, ahakoa kāore te katoa e pā ana ki a rātou. Ko te mea nui kia māramahia ko te tauhohenga mate pāwera nui, ahakoa he mea onge, ka pā, ā, me hiahia tonu te āwhina hauora.

Koinei ngā pānga taha noa ka pā ki a koe:

• Te mamae o te upoko, te whanoke rānei
• Te whakapairuaki, te puku rānei
• Te ngenge, te ngenge rānei
• Te mamae, te whero, te pūhi rānei i te wāhi werohanga
• Te kirika ngawari, te wiri rānei

Ko ēnei pānga taha noa he ngawari noa iho, he wā poto, ka ngaro i roto i te rā, e rua rānei i muri i te maimoatanga.

Ko ngā pānga taha nui engari he iti noa iho ko:

• Ngā tauhohenga mate pāwera nui (anaphylaxis)
• Te uaua ki te manawa, te pōrearea rānei o te uma
• Ngā tauhohenga kiri nui, te pūwha rānei e horapa ana
• Te toto rere, te pāpā rānei e kore nei e rite
• Ngā tohu o te mate i ngā wāhi werohanga

Ko te mōrearea o ngā tauhohenga mate pāwera nui te take e hoatu ana tēnei rongoā ki ngā whare hauora anake, kei reira tonu te rongoā ohorere. Kua whakangungua tō tima hauora ki te mōhio me te rongoā i ēnei tauhohenga i te wā tonu, ki te puta.

Ko wai kāore e tika kia tango Ecallantide?

Kāore a Ecallantide e tika mō te katoa, ā, ka āta aromatawai tō tākuta mēnā koinei te whiringa tika mō tō āhuatanga. Ko ngā tāngata e mōhiotia ana he mate pāwera ki a ecallantide, ki ētahi rānei o ōna whakauru, kāore e tika kia whiwhi i tēnei rongoā.

Ka tūpato rawa tō kaiwhakarato hauora mēnā kei a koe:

• He hītori o ngā tauhohenga mate pāwera nui ki ētahi atu rongoā
• Ngā mate e kaha ana, te pūnaha ārai mate rānei kua ngoikore
• Ngā mate toto, ngā raruraru rānei o te whakaheke toto
• Ngā raruraru o te pūkahukahu, te ate rānei
• Te hapū, te whāngai ū rānei

Kāore ngā tamariki kei raro i te 12 tau te pakeke e tika kia whiwhi ecallantide, nā te mea kāore anō kia whakatūria te haumaru me te whai huatanga i tēnei rōpū tau. Kāore anō kia tino whakatūria te haumaru o te rongoā i te wā o te hapū me te whāngai ū, nō reira ka whakatau tō tākuta i ngā painga pea ki ngā mōrearea.

Ingoa Waitohu Ecallantide

Ko te ingoa waitohu mō ecallantide ko Kalbitor. Koinei te ingoa arumoni ka kite koe i ngā tapanga rongoā me ngā rekoata hauora ina tohua tēnei rongoā mō tō rongoā HAE.

He mea hanga a Kalbitor e tētahi kamupene rongoā motuhake, ā, e wātea ana mā ngā whare hauora anake e rite ana ki te whakahaere i ngā rongoā ohorere. Ka pā pea tō inihua me te wāhi rongoā motuhake ki te wātea me te utu.

Ngā Kōwhiringa kē mō Ecallantide

He maha atu ano nga rongoa ka taea te rongoa i nga whakaeke HAE koi, a tera pea ka whakaaro to taakuta ki etahi atu rongoa i runga i to hitori rongoa me te urupare ki te rongoa. Ko enei rongoa ke atu e mahi ana i roto i nga tikanga rereke engari e whai ana ki te whakatutuki i nga hua rite.

Ko etahi atu rongoa whakaeke HAE ko:

• Icatibant (Firazyr) - he werohanga ano e aukati ana i nga kaiwhakawhiwhi bradykinin
• Ko te tangata C1 esterase aukati i nga kukume - whakakapi i te pūmua ngaro i HAE
• Plasma hou tio - whakamahia i roto i nga ahuatanga ohorere kaore i te waatea etahi atu rongoa
• Recombinant C1 esterase aukati - he putanga i hangaia i te ira o te pūmua ngaro

Ma to kaiwhakarato hauora e awhina ki te whakatau ko tehea te whiringa rongoa e tika ana mo to momo HAE me nga ahuatanga rongoa takitahi.

He pai ake te Ecallantide i te Icatibant?

He rongoa whai hua a Ecallantide me te icatibant mo nga whakaeke HAE, engari e mahi ana i roto i nga tikanga rereke me nga painga rereke. Ko te whiriwhiri i waenga i a raatau e pa ana ki to ahuatanga rongoa takitahi, te kaha o te whakaeke, me te pehea e urupare ai to tinana ki ia rongoa.

Ka aukati a Ecallantide i te hanga o te bradykinin, i te wa e aukati ana a icatibant i nga kaiwhakawhiwhi bradykinin i muri i te hanganga o te matū. Ko etahi o nga turoro ka pai ake te urupare ki tetahi huarahi i tetahi atu, a ka whakaaro to taakuta ki nga mea penei i o tauira whakaeke me te hitori rongoa.

Ko te rereketanga whaihua nui ko te icatibant i etahi wa ka taea te whakahaere i te kainga i muri i te whakangungu tika, i te wa e tika ana kia hoatu tonu a ecallantide i roto i te whare hauora. Ma tenei ka pai ake te icatibant mo etahi turoro, engari ka pai ake a ecallantide mo nga whakaeke kino e hiahia ana kia tino aro turuki.

Nga Pātai e Pātai pinepine ana mo Ecallantide

He haumaru te Ecallantide mo nga tangata e mate ana i te ngakau?

Ka taea te whakamahi i te Ecallantide i roto i te hunga e mate ana i te ngakau, engari me mahi tahi tō kaimātai ngakau me te tohunga HAE kia mōhio ai he haumaru mō tō āhuatanga motuhake. Kāore te rongoā e pā ana ki ngā raruraru ngakau, engari ko te pēhanga o te whakaeke HAE ka pā ki tō pūnaha cardiovascular.

Ka aroturukihia e tō rōpū hauora tō reiti ngakau me te pēhanga toto i te wā o te maimoatanga, ā, ka whakatika pea i tā rātou huarahi aroturuki mēnā he mate ngakau tōna. Me mōhio ki ō tākuta katoa mō tō hītori hauora katoa i mua i te whiwhinga i tētahi maimoatanga HAE.

Me aha au mēnā ka whiwhi au i te nui rawa o te Ecallantide?

I te mea ka tukuna anake te ecallantide e ngā tāngata ngaio hauora i roto i ngā whare hauora, he tino kore pea te horopeta nui. Heoi, ki te whakapono koe kua whiwhi koe i tētahi horopeta hē, whakamōhio atu ki tō rōpū hauora tonu kia taea ai e rātou te aroturuki i a koe.

Ka mātakitaki tō rōpū hauora mō ngā tohu o te pikinga o ngā pānga taha, ā, ka roa pea tō wā mātakitaki i muri i te maimoatanga. Kāore he rongoā motuhake mō te horopeta nui o te ecallantide, nō reira ka arotahi te maimoatanga ki te whakahaere i ngā tohu ka puta, me te whakarato i te manaaki tautoko.

Me aha au mēnā ka ngaro au i tētahi maimoatanga Ecallantide kua whakaritea?

Ko te tikanga ka tukuna te Ecallantide hei maimoatanga kotahi i te wā o te whakaeke HAE kaha, nō reira kāore he

Ehara te Ecallantide i te rongoa e haere tonu ana ka tīmata koe ka mutu pēnei i ngā pire o ia rā. He rongoa whakaora e hoatu ana i te wā o ngā whakaekenga HAE takitahi, nō reira ka oti ia maimoatanga i te wā i whiwhi koe i te horopeta katoa, ā, kua aroturukihia mō ētahi haora.

Kāore koe e hiahia ki te "mutu" i te ecallantide i te tikanga tuku iho, engari me te tākuta, ka haere tonu koe ki te arotake mēnā kei te noho tonu ko te whiringa maimoatanga pai rawa atu mō ngā whakaekenga ā muri ake nei. Mēnā ka whakawhanake koe i ngā mate pāwera, i ngā pānga taha rānei, ka tūtohu tō rōpū hauora i ētahi atu maimoatanga mō ngā wāhanga ā muri ake nei.

Ka taea e au te haereere me Ecallantide?

I te mea me penapena te ecallantide i raro i ngā tikanga motuhake, ā, me whakahaere e ngā tāngata ngaio hauora, kāore e taea e koe te kawe i te rongoa i a koe e haereere ana. Engari, me whakarite e koe te uru atu ki ngā whare rongoā e rite ana ki te rongoa i ngā whakaekenga HAE i ngā wāhi katoa e haereere ana koe.

I mua i te haereere, kōrerohia ō mahere ki tō tohunga HAE, ā, rangahaua ngā whare rongoā i tō ūnga e taea ai te whakarato i te maimoatanga HAE ohorere. Whakaarohia te kawe i tētahi kāri whakatūpato hauora, i te poroporo rānei e tohu ana i tō āhuatanga me ngā kōrero whakapā ohorere mō tō rōpū hauora.