He aha te Werohanga Edrophonium: Ngā Whakamahinga, Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te werohanga Edrophonium he rongoā e aukati ana i te pakarutanga o te acetylcholine, he karere matū i roto i tō pūnaha io. Na tēnei ka puta he whakapai ake i te kaha me te mahi o te uaua, he poto noa nei engari ka kitea. Ko te hunga hauora te whakamahi i tēnei rongoā werohia hei taputapu tātaritanga hei āwhina i te tautuhi i ētahi āhuatanga uaua me te io, ina koa ko te myasthenia gravis.

He aha te Edrophonium?

Ko te Edrophonium he rongoā poto te mahi, nō te rōpū rongoā e kiia nei ko te cholinesterase inhibitors. E mahi ana mā te aukati i te pakarutanga o te acetylcholine, he mea nui mō te whakawhitiwhiti kōrero i waenga i ō io me ō uaua. Ka piki ake te taumata o te acetylcholine mō tētahi wā, ka kaha ake te kirimoko o ō uaua.

Ka tae mai te rongoā hei otinga mārama, kāore he tae, ka hoatu e te hunga hauora mā te werohanga ki roto i tō uaua. Kāore i rite ki ētahi atu rongoā, he tere te mahi a te edrophonium engari he torutoru meneti noa iho te roa. Ko tēnei wā motuhake te mea e tino whai hua ana mō te whakamātautau tātaritanga, kaua mō te rongoā tonu.

Ka kitea te edrophonium i roto i te hōhipera, i te whare haumanu rānei, i reira ka āta aroturukihia tō urupare e ngā tākuta. E mōhiotia ana te rongoā i raro i tōna ingoa waitohu Tensilon, ahakoa te momo generic te nuinga o te wā e whakamahia ana i tēnei rā.

He aha te Edrophonium e Whakamahia Ana?

Ko te Edrophonium te mea nui hei taputapu tātaritanga hei āwhina i ngā tākuta ki te tautuhi i te myasthenia gravis, he āhuatanga e whakaeke ana tō pūnaha ārai mate i ngā hononga i waenga i ngā io me ngā uaua. I te wā o te whakamātautau, ka werohia e tō tākuta te edrophonium, ka mātakitaki mō te whakapai ake i te ngoikoretanga o te uaua, i te kamo rānei e tarewa ana.

Ka whakamahia hoki te rongoa hei wehewehe i waenga i te raruraru myasthenic me te raruraru cholinergic i roto i nga turoro kua kitea he myasthenia gravis. Ka puta te raruraru myasthenic i te wa e kino ana to ahuatanga, me nui ake te rongoa, i te wa e puta ana te raruraru cholinergic i te wa i whiwhi koe i te nui rawa o te rongoa.

I etahi wa, ka whakamahi nga taakuta i te edrophonium hei whakahoki i nga paanga o etahi kaiwhakangungu uaua e whakamahia ana i te wa o te pokanga. Ma tenei ka awhina i o uaua kia hoki ki te mahi noa i muri i nga tikanga rongoa. Heoi, he iti ake te whakamahi i tenei i nga tono tātaritanga.

I nga wa onge, ka whakamahi pea nga kaiwhakarato hauora i te edrophonium hei whakamatautau mo etahi atu mate neuromuscular, hei arotake ranei i te whai huatanga o etahi atu maimoatanga myasthenia gravis. Ko enei whakamahinga motuhake e hiahia ana kia tupato te tirotiro hauora me te tohunga.

Me pehea te mahi a Edrophonium?

Ka mahi a Edrophonium ma te aukati i te enzyme e kiia nei ko te acetylcholinesterase, e pakaru ana te acetylcholine i roto i to tinana. I te wa e aukatia ana tenei enzyme, ka kohia te acetylcholine i te hononga i waenga i ou io me ou uaua, ka hanga i nga tohu kaha ake mo te kirimana uaua.

Whakaarohia te acetylcholine hei ki e iriti ana i te nekehanga uaua. I roto i nga ahuatanga penei i te myasthenia gravis, kaore he raka e mahi ana mo enei ki. Kaore a Edrophonium e hanga raka ake, engari ka mau tonu nga ki kia roa ake kia nui ake ai te tupono ki te mahi.

E kiia ana he kaha te rongoa engari he poto rawa te mahi. Ko ona paanga ka timata i roto i te 30 ki te 60 hēkona o te werohanga, ka 5 ki te 10 meneti noa iho. Ko tenei wa poto ka pai mo nga kaupapa whakamatautau engari kaore e tika ana mo te maimoatanga mo te wa roa.

Ko te timatanga tere me te wa poto te tikanga ka wa poto nga paanga taha ka pa ki a koe. Ko tenei ahuatanga ka noho haumaru ake a edrophonium mo te whakamahi tātaritanga i te whakataurite ki nga rongoa roa ake i roto i te karaehe kotahi.

Me pehea taku tango i te Edrophonium?

E kore koe e tango i te edrophonium i a koe anō – e hoatu ana e ngā tākuta hauora i roto i te wāhi rongoā. Ka tae mai te rongoā hei werohanga e haere tika ana ki roto i tō uaua mā te raina IV, i ētahi wā rānei ki roto i tō uaua. Mā tō tākuta e whakatau te horopeta tika i runga i tō taumaha, tō tau, me te whakamātautau motuhake e mahia ana.

I mua i te whiwhinga i te edrophonium, kāore koe e hiahia ki te karo i te kai, te inu rānei, ki te kore te tākuta e tohutohu motuhake ana ki a koe. Heoi anō, me whakamōhio koe i tō rōpū hauora mō ngā rongoā katoa e tango ana koe, tae atu ki ngā rongoā kore-whakahaere me ngā tāpiringa.

He hēkona noa iho te werohanga, engari ka mātakitaki tata koe mō ētahi meneti i muri mai. Ka mātakitaki tō rōpū hauora mō ngā huringa i tō kaha uaua, te manawa, me te āhua whānui i tēnei wā.

Ka whiwhi koe i te edrophonium i te wā e takoto ana koe, e noho ana rānei i te pai. Mā tēnei tūnga e āwhina i tō haumaru, ā, ka taea e ngā kaiwhakarato hauora te mātakitaki pai i ngā huringa i tō mahi uaua.

Kia Pēhea Te Roa E Tango Ai Au i te Edrophonium?

Ehara te Edrophonium i te rongoā e tango ana koe mō te wā roa. I hangaia mō te whakamātautau tātaritanga kotahi-whakamahi, ā, ka ngaro noa iho ōna pānga i roto i te 5 ki te 10 meneti. E kore koe e whai whakahaere hei tango ki te kāinga, he mahere rānei hei whai.

Mēnā kei te whai koe i ngā whakamātautau maha, ka hoatu pea e tō tākuta te edrophonium ki a koe i ngā wā rerekē, engari he kotahi tonu te whakamahi, he wā poto. E kore te rongoā e hanga i roto i tō pūnaha, e hiahia rānei i te pikinga, i te whakahekenga rānei o te horopeta.

Mō ngā tūroro e mate ana i te myasthenia gravis e hiahia ana ki te rongoā tonu, ka tohutohu ngā tākuta i ngā rongoā roa-mahi pēnei i te pyridostigmine, kaua ki ngā werohanga edrophonium e tukurua ana. Ko te mahi a te Edrophonium te tuatahi he tātaritanga, kaua ki te rongoā.

He Aha Ngā Pānga Taha o te Edrophonium?

He pai te manawanui o te nuinga o te tangata ki te edrophonium, engari pērā i ngā rongoā katoa, ka pānga ngā pānga taha. Ko te rongo pai ko ngā pānga taha ka pā ki a koe he wā poto noa iho, nā te poto o te mahi o te rongoā.

Anei ngā pānga taha e mōhiotia ana ka pā ki a koe, me te mōhio ka ngaro noa iho ēnei i roto i ngā meneti:

• Te whakapairuaki, te hāneanea rānei o te puku
• Te nui ake o te waiwai
• Te nui ake o te werawera i te tikanga
• Te wiri o te uaua, te fasciculations rānei
• Ngā kōpiko o te puku
• Te korere
• Te nui ake o te mimi
• Te mōhio ki te whanoke, te māmā rānei o te mahunga

Ka puta ēnei tohumate nā te mea ka whakanui te edrophonium i te acetylcholine puta noa i tō tinana, ehara i te hononga uaua-uaua e whakamātauhia ana. E mōhio ana te nuinga o te tangata he pai ēnei pānga nā te mea e mōhio ana rātou ka tere te ngaro.

He pānga taha kino engari he onge hoki e hiahia ana kia tere te rongoā. Ka titiro tō rōpū hauora ki ēnei, engari he pai ki te mōhio he aha:

• Te uaua nui ki te hā, te raruraru rānei o te manawa
• Te ngākau pōrearea, te mamae rānei o te uma
• Te ngoikore nui o te uaua (te urupare paradox)
• Ngā pōrearea
• Te ngaro o te mōhiotanga
• Ngā urupare mate pāwera nui me te pupuhi, te rānei

He onge ēnei urupare kino, ā, ka noho koe i roto i te taiao rongoā e wātea ana te rongoā tonu ki te hiahiatia. Kua whakangungua ō kaiwhakarato hauora ki te mōhio me te whakahaere i ēnei āhuatanga i te tere.

Ko wai kāore e tika kia tango i te Edrophonium?

Kāore ētahi tāngata e tika kia whiwhi edrophonium nā te nui ake o te mōrea o ngā raruraru kino. Ka arotake tō tākuta i tō hītori hauora i mua i te whakatau mēnā he haumaru tēnei rongoā mō koe.

Kāore koe e tika kia whiwhi edrophonium mēnā he mate ngākau ōna, nā te mea ka pānga te rongoā ki tō manawataki me te tere. Anei ngā āhuatanga matua e kore ai e tika te edrophonium:

\n
• Ngā raruraru manawa nui (arrhythmias)
\n
• Te whakaeke manawa i tēnei wā, te mate manawa rānei kāore i te pūmau
\n
• Te mate huangō nui, te mate rānei e pā ana ki te pūkahukahu (COPD)
\n
• Te aukati i te whekau, i te pūngāwerewere rānei
\n
• Te mōhiotanga he pānga ki te edrophonium, ki ngā rongoā rite rānei
\n
• Te mate tākihi nui
\n
• Te mate whewhe puku e kaha ana
\n

Ka tūpato anō tō tākuta ki te whakamahi i te edrophonium mēnā kei te hapū koe, kei te whāngai ū rānei, ahakoa he wā ka tika pea mō ngā take tātaritanga. Ka taea e te rongoā te whiti i te pūrewa, ā, ka pā pea ki tō pēpi.

Mēnā he hītori tō koe mō ngā pākia, ka āta whiriwhiria e tō rōpū hauora ngā tūponotanga me ngā painga. Ahakoa ka taea e te edrophonium te whakaoho i ngā pākia i ngā wā onge, he mea nui pea ngā kōrero tātaritanga e whakaratohia ana mō tō atawhai.

Kāore te pakeke anake e whakakore i a koe ki te whiwhi edrophonium, engari ka nui ake pea te tairongo o ngā pakeke ki ōna pānga. Ka whakatika tō tākuta i te horopeta kia rite, ā, ka āta mātakitaki i a koe i te wā o te whakamātautau.

Ngā Ingoa Waitohu o Edrophonium

I te tuatahi i hokohoko te edrophonium i raro i te ingoa waitohu Tensilon e Valeant Pharmaceuticals. Heoi, kāore te putanga ingoa waitohu e wātea whānuitia ana i roto i te maha o ngā whenua, tae atu ki te United States.

I tēnei rā, ka kitea e koe te edrophonium hei rongoā whānui. E mahi ana ngā putanga whānui i te ara kotahi tonu me te hua waitohu, ā, e tutuki ana i ngā paerewa haumaru me te whai hua. Ka kī noa tō kaiwhakarato hauora ko

Ahakoa kei te noho tonu te edrophonium hei paerewa koura mo etahi whakamātautau tātaritanga, he huarahi kē pea ka whakaarohia e tō tākuta. Kei te whakawhirinaki te whiriwhiri ki te āhua e tirotirohia ana me tō āhuatanga hauora motuhake.

Mō te tātaritanga o te myasthenia gravis, ka whakamahi pea tō tākuta i ētahi atu tikanga hei whakakapi, hei tāpiri rānei ki te whakamātautau edrophonium. Ka taea e ngā whakamātautau toto te kite i ngā paturopi motuhake e pā ana ki te myasthenia gravis, e whakarato ana i ngā mōhiohio tātaritanga me te kore e hiahia ki te werohanga.

Ka taea hoki e ngā rangahau whakahaere io me te electromyography (EMG) te āwhina i te tātaritanga o ngā mate neuromuscular. E ine ana ēnei whakamātautau i te mahi hiko i roto i ō io me ō uaua, e tuku ana i ngā mōhiohio taipitopito mō te pai o te mahi o tō pūnaha io.

Mō ngā tūroro e kore e taea te whiwhi edrophonium, ka whakamahi pea ngā tākuta i ngā whakamātautau pōkai huka mō ētahi tohumate pēnei i te kamo e tarewa ana. Ko te whakamahi i te huka ka whakapai ake i te mahi uaua i roto i te myasthenia gravis, e whakarato ana i ngā tohu tātaritanga me te kore rongoā.

I ētahi wā, ka tohutohu pea tō tākuta i te whakamātau o te pyridostigmine waha, he rongoā roa ake i te akomanga kotahi me te edrophonium. Mēnā ka tino pai ake ō tohumate i tēnei maimoatanga, ka taea e ia te tautoko i te tātaritanga o te myasthenia gravis.

He Pai Ake Te Edrophonium I Te Pyridostigmine?

He rerekē ngā kaupapa o te Edrophonium me te pyridostigmine, nō reira kāore i te rite te whakataurite i a rāua. He pai te Edrophonium hei taputapu tātaritanga nā te tere o tōna tīmatanga me te poto o tōna roa, i te wā e pai ake ana te pyridostigmine mō te maimoatanga tonu.

Mō te whakamātautau tātaritanga, nā te mahi tere o te edrophonium i pai ake ai i te pyridostigmine. Ka kite koe i ngā hua i roto i te meneti, ā, mēnā ka pā ki a koe ngā pānga taha, ka tere te ngaro. E 30 ki te 60 meneti te roa o te pyridostigmine ki te mahi, ā, ka roa mō ētahi haora, nā reira kāore i te whai hua mō ngā kaupapa whakamātautau.

Heoi anō, mō te rongoā i te myasthenia gravis i te wā roa, he pai ake te pyridostigmine i te edrophonium. Ka taea e koe te tango pyridostigmine mā te waha i te maha o ngā wā i te rā kia mau tonu ai te whakahaere tohu, engari me whai uru IV tonu me te aroturuki i te hōhipera mō te edrophonium.

He rite te kaha o ēnei rongoā, engari nā te roa o te mahi ka pai mō ngā āhuatanga rerekē. Whakaarohia te edrophonium hei whakaahua tātaritanga tere, engari ka whai hua rongoā tonu te pyridostigmine.

Ka whiriwhiria e tō tākuta te rongoā tika i runga i te hiahia ki te tātaritanga, ki te rongoā tonu rānei. He maha ngā tūroro ka whiwhi tuatahi i te edrophonium mō te whakamātautau, ā, ki te tātaritia he myasthenia gravis, ka huri ki te pyridostigmine mō te whakahaere i ia rā.

Ngā Pātai Auau mō Edrophonium

He Haumaru te Edrophonium mō te Mate Ngākau?

Ka pā te edrophonium ki tō reiti ngākau me te manawataki, nō reira me tino whakaaro mēnā he mate ngākau tōu. Ka arotakehia e tō tākuta tō āhuatanga ngākau motuhake, ā, ka whakatau pea ka nui ake ngā painga tātaritanga i ngā tūponotanga, ina koa he poto noa ngā pānga o te rongoā.

Mēnā he ngawari, he pūmau te mate ngākau, ka taea tonu e koe te whiwhi edrophonium me te aroturuki tata. Heoi anō, mēnā he nui ngā raruraru manawataki ngākau, he pānga ngākau tata nei, he mate ngākau kore pūmau rānei, ka whiriwhiria e tō tākuta ētahi atu tikanga tātaritanga.

Ka aroturukihia e tō rōpū hauora tō manawataki ngākau i te wā o te whakamātautau mēnā he āwangawanga ngākau tōu. Ka whai rongoā anō rātou hei whakakore i ngā pānga o te edrophonium mēnā e tika ana, ahakoa he onge ngā raruraru ngākau nui.

Me Pēhea Taku Mahi Mēnā Ka Whiwhi Au i te Nui Rawa o te Edrophonium?

He ohorere hauora te nui rawa o te edrophonium, engari ka whiwhi koe i tenei rongoa i roto i te waahi hauora kei reira te maimoatanga tonu. Ka mohio wawe to roopu hauora ki nga tohu o te nui rawa, ka whakautu tika.

Ko nga tohu o te nui rawa o te edrophonium ko te ngoikore o te uaua, te uaua ki te manawa, te nui o te waiwai, te nui o te nausea me te ruaki, me nga huringa morearea i roto i te manawataki o te ngakau. Ka tere te puta mai o enei tohu engari ka taea te rongoa me te manaaki hauora tika.

He rongoa patu ta nga kaiwhakarato hauora e kiia nei ko te atropine ka taea te whakakore i nga paanga o te edrophonium. Ka mahi tenei rongoa ma te aukati i te nui o te mahi acetylcholine e puta ai nga tohu o te nui rawa. Kua whakangungua to roopu hauora ki te tatau i te horopeta tika me te whakahaere tere mena e tika ana.

Ko te pai o te korero he onge te nui rawa o te edrophonium na te mea ka tatau nga kaiwhakarato hauora i nga horopeta i te tupato, a he poto te mahi o te rongoa. Ahakoa ka nui rawa te whiwhi, ka timata nga paanga ki te ngaro noa i roto i nga meneti.

Me aha ahau ki te kore e mahi te whakamatautau Edrophonium?

Ko te whakamatautau edrophonium kino ehara i te mea karekau koe i te myasthenia gravis, i etahi atu ahuatanga neuromuscular ranei. I etahi wa me whakahoki ano te whakamatautau, me whakamahi ranei to taakuta i nga huarahi tātaritanga rereke kia marama ai te whakautu.

He maha nga mea ka pa ki nga hua whakamatautau, tae atu ki te wa o o tohu, etahi atu rongoa e tango ana koe, me nga uaua motuhake e whakamatauria ana. Ka kii pea to taakuta kia whakahoki ano i te whakamatautau i tetahi wa rereke, i te wa e kaha ake ana o tohu.

Mena kaore ano kia whakatauhia te whakamatautau edrophonium, ka tono pea to taakuta i etahi atu whakamatautau penei i te mahi toto ki te tirotiro i nga paturopi myasthenia gravis, nga rangahau whakahaere io, nga karapa whakaahua ranei. Ka taea e enei whakamatautau te whakarato i etahi atu korero hei awhina i te tātaritanga.

I ētahi wā, ka tūtohu pea tō tākuta kia whakamātau koe i te rongoā e roa ana te mahi, pēnei i te pyridostigmine. Mēnā ka pai ake ō tohumate i te rongoā, ka taea e tēnei te tautoko i te tātaritanga ahakoa i kino te whakamātautau edrophonium.

Āhea ka taea e au te hoki ki ngā mahi noa i muri i te edrophonium?

Ka taea e koe te hoki ki ngā mahi noa i muri tonu i te whiwhinga edrophonium, nā te mea ka ngaro ōna pānga i roto i te 5 ki te 10 meneti. Heoi, ka tūtohu pea tō tākuta kia tatari koe kia roa ake kia mōhio ai koe kua hoki katoa koe ki te noa i mua i te wehenga atu i te whare hauora.

Mēnā i pā ki a koe ētahi pānga taha i te wā o te whakamātautau, tatari kia ngaro katoa ēnei i mua i te taraiwa, i te whakahaere rānei i ngā mīhini. Ko te nuinga o te tangata e pai ana i roto i te 15 ki te 20 meneti i muri i te whiwhinga i te werohanga, engari whakarongo ki tō tinana, kaua hoki e tere ki te kore koe e tino pai.

Kāore he here kai, he here mahi rānei i muri i te whakamātautau edrophonium. Ka taea e koe te kai, te inu, me te tango i ō rongoā noa i te tikanga, ki te kore tō tākuta e hoatu ki a koe ētahi tohutohu motuhake.

Mēnā kei te whai koe i ētahi atu whakamātautau, i ētahi atu tikanga rānei i te rā kotahi, whakamōhio atu ki tō rōpū hauora kua whiwhi koe i te edrophonium. Ahakoa te mea kāore e pā ana ki ētahi atu whakamātautau, he pai tonu te whakamōhio i tō rōpū hauora mō ngā rongoā katoa i whiwhi koe.

Ka taea e au te tango i aku rongoā noa i muri i te edrophonium?

Āe, ka taea e koe te tango i ō rongoā noa i muri i te whiwhinga edrophonium. Kāore te rongoā e pā ana ki te nuinga o ngā rongoā noa, ā, ko tōna wā poto te tikanga kāore e noho roa ana i roto i tō pūnaha kia puta ai ngā pānga tonu.

Mēnā kei te tango kē koe i ngā rongoā mō te myasthenia gravis, ka hoatu pea e tō tākuta ki a koe ētahi tohutohu motuhake mō te wā. I ētahi wā, ka tono rātou ki a koe kia pupuri i ēnei rongoā i mua i te whakamātautau kia tika ake ngā hua, katahi ka hoki anō ki a rātou i muri mai.

Me whakamōhio tonu ki tō rōpū hauora mō ngā rongoā katoa e tango ana koe, tae atu ki ngā rongoā ka taea te hoko me ngā tāpiringa. Ahakoa he iti noa ngā pānga ki te edrophonium, me mōhio tō rōpū hauora ki ngā kōrero katoa hei whakarite i tō haumaru.

Mēnā he pātai āu mō ngā rongoā motuhake, pātai atu ki tō tākuta i mua i te wehenga atu i te whare hauora. Ka taea e rātou te tuku tohutohu whaiaro ki a koe i runga i tō hītori hauora katoa me ngā rongoā e tango ana koe i tēnei wā.