He aha te Entacapone: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

He rongoā a Entacapone e āwhina ana i ngā tāngata e mate ana i te mate o Parkinson kia nui ake te painga mai i tā rātou rongoā matua. E mahi tahi ana me te levodopa, te rongoā paerewa koura mō te mate o Parkinson, kia roa ake te noho i roto i tō tinana, kia whai hua ake.

Whakaarohia te entacapone hei hoa whai hua, kaua hei rongoā motuhake. No roto ia i tētahi rōpū rongoā e kīia ana ko ngā COMT inhibitors, e aukati ana i tētahi enzyme e wawahi ana i te levodopa i te tere rawa. Kua āwhina tēnei huarahi mahi tahi i te tini o ngā tāngata e mate ana i te mate o Parkinson ki te wheako i te whakahaere ngawari ake i ngā tohumate puta noa i te rā.

He aha te Entacapone?

He rongoā whakahau a Entacapone i hangaia hei whakanui i te whai huatanga o te rongoā levodopa i roto i te mate o Parkinson. Ehara i te rongoā e tango ana koe anake, engari he rongoā tautoko e mahi ana i ngā wāhi o muri.

Ka tae mai te rongoā hei papa karaka, āhua ōwao e horomia ana e koe. Koinei te mea e kīia ana e ngā tākuta he COMT inhibitor, ko te tikanga e aukati ana i tētahi enzyme e kīia ana ko catechol-O-methyltransferase. Ko tēnei enzyme te tikanga e wawahi ana i te levodopa i mua i tōna tae ki tō roro, nō reira mā te aukati i tēnei, ka āwhina te entacapone i te nui ake o te levodopa kia tae ki te wāhi e tino hiahiatia ana.

Me tango tonu e koe te entacapone me tō huinga levodopa me te carbidopa. Ko tēnei mahi tahi toru-ara e hanga ana i tētahi pānga tūmau me te roa ake i te mea ka taea e te levodopa anake te whakarato.

He aha te Entacapone e whakamahia ana mō?

E rongoā ana a Entacapone i ngā tohumate motika o te mate o Parkinson mā te whakawhānui i ngā painga o te rongoā levodopa. He tino whai hua mō ngā tāngata e wheako ana i ngā wāhanga

Ka tohutohu pea tō tākuta i te entacapone mēnā kei te tango kē koe i te levodopa me te carbidopa engari e kite ana kei te poto haere ō wā pai. He tokomaha ngā tāngata e pā ana ki te mate Parkinson e mōhio ana, i te roanga o te wā, ka tere ake te pau o ā rātou rongoā, ka waiho rātou me te mārō, te pōturi, te wiri rānei i waenga i ngā horopeta.

Ka āwhina hoki te rongoā ki te whakaiti i ngā rereketanga "on-off" e kore e taea te matapae e pā ana ki ētahi tāngata. I ngā wā "off", ka pērā pea te āhua kei te kore e mahi ana tō rongoā, i te wā "on" ka kawea mai te whakamaungia mai i ngā tohumate. Ka āwhina te Entacapone ki te whakatikatika i ēnei rereketanga mā te pupuri i ngā taumata levodopa kia rite tonu i roto i tō pūnaha.

Me pēhea te mahi a te Entacapone?

Ka mahi te Entacapone mā te aukati i tētahi enzyme motuhake e wawahi ana i te levodopa i tō tinana i mua i te tae ki tō roro. Koinei te rongoā whai hua, e whakanui ana i te kaha o te levodopa, kaua ki te whakarato i ngā pānga kaha anake.

I te wā e tango ana koe i te levodopa, ka whakaputa noa tō tinana i tētahi enzyme e kīia ana ko COMT e tīmata ana ki te wawahi tonu. Ka mahi tēnei enzyme i roto i ō toto me tō roro, e whakataetae ana ki te kaupapa o te rongoā. Ka uru mai te Entacapone ki te aukati i tēnei enzyme, e whai wāhi ana te levodopa ki te tae ki tō roro me te huri ki te dopamine.

Ko te hua ko te nui ake o tō horopeta levodopa ka mahi i te wāhi e hiahiatia ana. Ka kite pea koe ka roa ake te levodopa me te whakarato i te whakamaungia o ngā tohumate puta noa i te rā. Kāore tēnei e waiho i te entacapone hei rongoā kaha anake, engari ka whai hua ake tō rongoā levodopa.

Me pēhea taku tango i te Entacapone?

Me tango e koe te entacapone i te mea i tohutohutia e tō tākuta, me te tahi tonu me tō huinga levodopa me te carbidopa. Ko te horopeta noa he 200 mg me ia horopeta levodopa, ā, ka taea e koe te tango me te kore rānei he kai.

Ka āwhina pea te tango entacapone me te kai ki te whakaiti i te pōpō i te puku mēnā ka pā ki a koe ētahi pānga taha ki te kūnatu. E kitea ana e ētahi tāngata he māmā ake ki tō rātou puku te tango me te paramanawa māmā, te kai rānei, engari ko ētahi atu e pai ana te tango i te puku kau.

Me horomia katoatia te papa me te karaihe wai. Kaua e kuru, e ngaungau, e whati rānei i te papa, nā te mea ka pā tēnei ki te āhua o te rongoā e uru ana ki tō tinana. Mēnā he uaua ki a koe te horomia i ngā papa, kōrero ki tō tākuta mō ētahi atu kōwhiringa.

He mea nui anō te wā. I te mea e mahi tahi ana te entacapone me te levodopa, ka tango koe i te wā kotahi me tō horopeta levodopa. Mā tēnei e whakarite kia mahi tahi ana ngā rongoā e rua i roto i tō pūnaha i te wā e tino hiahia ana koe ki a rātou.

Kia Pēhea Te Roa E Tango Ai Au i te Entacapone?

Ko te tikanga ka tango koe i te entacapone i te wā e tango ana koe i te levodopa, me te kite he pai mō ō tohumate Parkinson. Ko te tikanga he rongoā wā-roa tēnei ka noho hei wāhanga o tō rāpoi rongoā ia rā.

Kei te haere tonu te nuinga o te tangata ki te tango entacapone mō te wā mutunga kore, nā te mea he āhuatanga haere tonu te mate Parkinson e hiahia ana ki te whakahaere tonu. Ka aroturuki tō tākuta i te pai o te mahi o te rongoā mōu, ā, ka whakatika pea i tō mahere rongoā i te wā e huri ana ō hiahia.

He mea nui kia kaua rawa e mutu te tango entacapone ohorere me te kore e kōrero tuatahi ki tō tākuta. Ko te mutu ohorere ka puta te hokinga tere mai o ō tohumate Parkinson, ā, ka arahi pea ki tētahi āhuatanga nui e kīia ana ko te neuroleptic malignant syndrome, ahakoa he onge tēnei.

Ka tono pea tō tākuta kia whakaiti, kia mutu rānei te entacapone mēnā ka pā ki a koe ētahi pānga taha nui e nui ake ana i ngā painga, mēnā rānei ka huri te mahere rongoā whānui. Ko ngā huringa katoa ki tō rāpoi rongoā me mahi tonu i te āta haere, i raro i te tirotiro hauora.

He Aha Ngā Pānga Taha o te Entacapone?

Ko ngā pānga taha tino noa o te entacapone he ngawari noa, ā, he māmā te whakahaere, ahakoa ka mōrearea pea ki te kore koe e tatari ana. Ko te nuinga o te tangata ka pā ki ētahi pānga taha i te tīmatanga, engari he maha ngā tāngata ka kite i te pai ake i te wā e urutau ana tō rātou tinana ki te rongoā.

Me haere tahi tāua i ngā mea ka pā ki a koe, ka tīmata mai i ngā pānga tino noa ka tūtaki pea koe:

• Mimi tae karaka: Kāore he kino o tēnei, ā, ka pā ki te nuinga o te tangata e tango ana i te entacapone. Ka huri pea tō mimi i te karaka mārama, i te karaka whero rānei, he mea ohorere pea tēnei, engari kāore he mōrearea.
• Korere: Ka pā tēnei ki te maha o te tangata, ina koa i te tīmatanga o te rongoā. He ngawari noa iho, ā, ka pai ake pea i te wā.
• Ngāwari: Ka pōuri pea koe, ina koa i ngā wiki tuatahi o te rongoā.
• Te piki ake o ngā nekehanga kore: Ka kite ētahi tāngata i te nui ake o te dyskinesia (ngā nekehanga e kore e hiahiatia) nā te mea ka whai hua ake te levodopa i te entacapone.
• Māuiui: Ka pā tēnei i te wā e tū ana koe i te wawe, i ngā mahi o ia rā rānei.
• Ngenge: Ka ngenge pea koe i te tikanga, ina koa i te wā e urutau ana tō tinana ki te rongoā.

Ko ēnei pānga taha noa he wā poto noa iho, ā, he māmā te whakahaere. Ka āwhina pea tō tākuta i a koe ki te kimi i ngā huarahi hei whakaiti i a rātou ki te pōuri rātou.

Ināianei, me whakamārama e au ētahi pānga taha kāore i te noa, engari he nui ake te mōrearea e hiahia ana kia aro. Ahakoa kāore ēnei e pā ki te nuinga o te tangata, he mea nui kia mōhio koe ki ngā mea hei mātakitaki:

• Te korere nui: Ki te mea he korere wai tō, e kore e pai ake, tērā pea ka matewai koe.
• Ngā pōhewa: Ētahi tāngata ka kite, ka rongo rānei i ngā mea kāore i reira, inā koa ki te mea he kaumātua rātou, e tango ana rānei i ngā horopeta nui ake.
• Pōraruraru, whakatūpātai rānei: Ka puta ngā huringa i te āhua o te hinengaro, inā koa ki ngā tūroro kaumātua.
• Te whanoke nui, te ngaro rānei: Tērā pea tēnei e tohu ana i te hekenga nui o te pēhanga toto.
• Te mārō o ngā uaua me te kirika: Tērā pea tēnei he tohu o tētahi āhuatanga onge, engari he nui te kino.

He wāhi anō hoki o ngā pānga taha onge, engari he nui te kino, me whai wawe te āwhina hauora. He mea kore noa ēnei raruraru, engari mā te mōhio ki a rātou ka āwhina i a koe ki te rapu wawe i te āwhina ki te hiahiatia:

• Te mate kino o te neuroleptic: Ko tēnei āhuatanga onge e pā ana ki te kirika nui, te mārō o ngā uaua, te pōraruraru, me ngā huringa i te tere o te ngākau, i te pēhanga toto rānei.
• Ngā raruraru ate: I te wā onge, ka pā te entacapone ki te mahi ate, ka puta ngā tohumate pērā i te kōwhai o te kiri, o ngā kanohi rānei, te mimi pouri, te mamae nui rānei o te puku.
• Ngā tauhohenga mate pāwera nui: Ahakoa te tino onge, ka puta pea te ponana, te pūhi, te uaua rānei ki te hā ki ētahi tāngata.
• Rhabdomyolysis: Ko tēnei āhuatanga onge e pā ana ki te pakaru o ngā uaua, ā, ka puta te mimi pouri, te mamae o ngā uaua, me te ngoikore.

Kia mahara ko te nuinga o ngā tāngata e pai ana ki te entacapone, ā, he mea kore noa ngā pānga taha nui. Kua tohua tēnei rongoā e tō tākuta nā te mea e whakapono ana rātou he nui ake ngā painga i ngā tūponotanga mō tō āhuatanga motuhake.

Ko wai e kore e tango i te Entacapone?

Kaua ētahi tāngata e tango i te entacapone nā te āwangawanga haumaru, i ngā pānga rānei ki ētahi atu āhuatanga. Ka arotake tō tākuta i tō hītori hauora i mua i te tohutohu i tēnei rongoā.

Kaua koe e tango entacapone mēnā he mōhiotia tō mate pāwera ki te rongoā, ki ētahi o ōna whakauru rānei. Ko ngā tohu o te tauhohenga pāwera pea ko te pūwha, te mōmiti, te pūpū, te uaua rānei ki te hā.

Me whai whakaaro motuhake te hunga e mate ate ana, nā te mea ka pā te entacapone ki te mahi ate i ētahi wā onge. Ka hiahia pea tō tākuta ki te aroturuki i ō whākōrere ate mēnā he hītori tō mate ate.

Mēnā kei te tango koe i ētahi rongoā, kāore pea te entacapone e tika ana māu. Kei roto i ēnei ko ētahi paturopi, rongoā whakapōuri, me ngā rongoā mō ngā raruraru o te manawataki. Me kōrero tonu ki tō tākuta mō ngā rongoā katoa, ngā tāpiringa, me ngā rongoā otaota e tango ana koe.

Me kōrero tahi ngā wāhine hapū me te whāngai i ngā pēpi i ngā tūponotanga me ngā painga ki tō rātou tākuta. Ahakoa he iti noa ngā raraunga mō te haumaru o te entacapone i te wā e hapū ana, ka nui ake pea ngā painga i ngā tūponotanga i ētahi wā.

Ngā Ingoa Waitohu o Entacapone

Kei te wātea te Entacapone i raro i ētahi ingoa waitohu, ko Comtan te mea e mōhiotia ana i te United States. Kei roto i tēnei putanga ingoa waitohu te whakauru kaha kotahi i ngā hanganga entacapone whānui.

Ka tūtaki pea koe ki te entacapone hei wāhanga o ngā papa whakakotahi. Ka whakakotahi a Stalevo i te entacapone me te levodopa me te carbidopa i roto i te pire kotahi, he pai ake pea i te tango i ngā rongoā motuhake.

Kei te wātea whānuitia ngā putanga whānui o te entacapone, ā, kei roto i a rātou te whakauru kaha kotahi i ngā kōwhiringa ingoa waitohu. Ka whakakapi pea tō whare rongoā i tētahi putanga whānui mēnā kāore tō tākuta e tono motuhake i te ingoa waitohu.

Ngā Kōwhiringa kē o Entacapone

Mēnā kāore te entacapone e tika ana māu, he maha ngā kōwhiringa kē ka āwhina i te whakarei ake i tō rongoā levodopa. Ka whakawhirinaki te kōwhiri ki ō tohu motuhake, ētahi atu rongoā, me te pai o tō tū ki ngā rongoā rerekē.

Ko te Tolcapone tētahi atu aukati COMT e mahi ana i te rite ki te entacapone engari he kaha ake. Heoi, me mātakitaki tonu te ate nā te mōrearea nui ake o ngā raruraru ate, nō reira ka rāhui kē mō te hunga kāore e pai ki te entacapone.

Ko te Rasagiline me te selegiline he aukati MAO-B ka taea hoki te whakawhānui i ngā pānga o te levodopa. E mahi ana ēnei rongoā mā te aukati i tētahi enzyme rerekē e wawahi ana i te dopamine i roto i te roro. He maha ngā wā ka whakamahia hei rongoā kē atu i te wā kāore e tika ana ngā aukati COMT.

Ka whakaaro pea tō tākuta ki te whakatika i tō hōtaka inenga levodopa, ki te tāpiri i ngā agonist dopamine pēnei i te pramipexole, ropinirole rānei, ki te tūhura rānei i ētahi atu rongoā Parkinson. Ko te rongoā kē pai rawa atu ka whakawhirinaki ki tō āhuatanga takitahi me ngā whāinga maimoatanga.

He Pai Ake Te Entacapone I Te Tolcapone?

He whai hua ngā entacapone me te tolcapone hei aukati COMT, engari he rerekētanga nui ō rāua e tika ai tētahi i tētahi mō ngā tāngata rerekē. Kāore tētahi e tino

Ka taea te whakamahi tūpato i te entacapone ki te hunga e mate ngākau ana, engari me tino mātakitaki. I ētahi wā ka pā te rongoā nei ki te pēhanga toto, ki ngā raruraru rānei o te manawa, nō reira me arotake tō hauora ngākau e tō tākuta i mua i te tīmatanga o te rongoā.

Mēnā he mate ngākau tōu, ka tīmata pea tō tākuta i tētahi horopeta iti ake, ka mātakitaki rānei i a koe i te tīmatanga o te entacapone. Me mōhio hoki rātou ki ngā rongoā ngākau e tango ana koe, nā te mea ka pāhekoheko ētahi ki te entacapone.

Me pēhea taku mahi mēnā ka nui rawa taku tango i te Entacapone?

Mēnā ka nui rawa tō tango i te entacapone, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei i te wā tonu. Ka pā te nui rawa o te rongoā ki te whakapairuaki nui, te ruaki, te pāhau, me ngā huringa pea e mōrearea ana i te pēhanga toto, i te manawa rānei.

Kaua e ngana ki te ruaki i a koe anō mēnā kāore i tohutohutia e tētahi kaiwhakarato hauora. Engari, rapua he āwhina hauora i te wā tonu, ka mau mai i te pounamu rongoā kia kite ai ngā kaimahi hauora i te aha me te nui i tango koe.

Me pēhea taku mahi mēnā ka ngaro i ahau tētahi horopeta o te Entacapone?

Mēnā ka ngaro i a koe tētahi horopeta o te entacapone, tangohia i te wā e mahara ana koe, me tō horopeta levodopa. Heoi, mēnā kua tata te wā mō tō horopeta e whai ake nei, waiho te horopeta i ngaro, ka haere tonu ki tō hōtaka auau.

Kaua rawa e tango i te horopeta rua hei utu mō tētahi i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga taha. Mēnā he maha ngā wā e wareware ana koe ki ngā horopeta, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i a koe kia noho i runga i te ara.

Āhea taku whakamutu i te tango i te Entacapone?

Kaua rawa koe e whakamutu i te tango i te entacapone ohorere me te kore e kōrero tuatahi ki tō tākuta. Ko te whakamutu ohorere ka puta te hokinga tere mai o ngā tohumate o Parkinson, ā, i ngā wā onge, ka puta he āhuatanga nui e kīia ana ko te neuroleptic malignant syndrome.

Mēnā ka whakatau koe me tō tākuta ki te whakamutu i te entacapone, me mahi haere. Ka hangaia e tō tākuta tētahi hōtaka whakaheke e whakaheke haere ana i tō horopeta i roto i te wā, i te wā e aroturukihia ana te āhua o tō urupare ki ngā huringa.

Ka taea e au te inu waipiro i te wā e tango ana i te Entacapone?

He pai ake te whakaiti i te inu waipiro i te wā e tango ana i te entacapone, nā te mea ka taea e te waipiro te whakapōrearea i ētahi pānga taha pēnei i te whanoke me te hōhā. I tua atu, ka taea e te waipiro te whakararu i te whai huatanga o tō rongoā Parkinson.

Mēnā ka whiriwhiria e koe te inu waipiro, me mahi i runga i te āhua tika, me te aro ki te āhua o tō tū. E kite ana ētahi tāngata ahakoa te iti o te waipiro ka nui ake te kore tū me te rangirua i te wā e honoa ana ki ā rātou rongoā Parkinson.