He aha te Fidaxomicin: Ngā Whakamahinga, te Inenga, Ngā Pānga taha me ētahi atu mea

Ko te Fidaxomicin he paturopi motuhake e aro ana ki tētahi mate whekau motuhake, tino nui hoki, e mōhiotia ana ko te C. difficile colitis. He rerekē te mahi a tēnei rongoā i te nuinga o ngā paturopi nā te mea ka noho tonu ki roto i ō whekau, e whawhai ana ki ngā huakita kino i te wāhi e puta ana te raruraru, kāore e pā nui ki ngā huakita whai hua puta noa i tō tinana.

He aha te Fidaxomicin?

Ko te Fidaxomicin he paturopi rongoā i hangaia hei rongoā i ngā mate Clostridioides difficile (C. diff) i roto i tō pūwāhi. Kāore i rite ki ngā paturopi whānui e mahi ana puta noa i tō tinana katoa, ko te fidaxomicin te mea e kīia ana e ngā tākuta he paturopi "whāiti" e arotahi ana ki tōna mahi i roto i tō pūnaha kūnatu.

Ko tēnei huarahi whāinga ka whai hua te fidaxomicin nā te mea ka puta ngā mate C. diff i te wā e nui rawa ana ngā huakita kino i roto i ō whekau, i muri i te raru o ō paturopi i te toenga o ngā huakita o ō whekau. Whakaarohia te fidaxomicin hei taputapu tika, kaua hei hama nui i te wā e whawhai ana ki tēnei mate motuhake.

No tētahi rōpū paturopi te rongoā e mōhiotia ana ko te macrocyclics, he hanganga mowhiti motuhake tōna e āwhina ana i a rātou ki te here me te aukati i te whakanui o ngā huakita C. diff. Mā tēnei hoahoa motuhake ka whai hua te fidaxomicin i te wā e ngawari ana ki ō huakita whai hua o ō whekau.

He aha te Fidaxomicin e whakamahia ana?

Ka rongoā te Fidaxomicin i te Clostridioides difficile-associated diarrhea (CDAD) i roto i ngā pakeke me ngā tamariki 6 marama, neke atu rānei. Ka puta tēnei mate i te pāhau nui me te mumura o te whekau ka taea te rerekē mai i te kore pārekareka ki te whakatuma i te ora mēnā kāore i rongoatia.

Me hiahia pea koe ki te fidaxomicin mēnā ka whakawhanake koe i te C. diff colitis i muri i te tango i ētahi atu paturopi mō tētahi atu mate. Ka pēnei tēnei nā te mea ka taea e ngā paturopi te patu i ō huakita puku e tiaki ana, ka waihanga i tētahi taiao ka taea e te C. diff te whakatipu me te whakaputa i ngā paitini e whakangaro ana i te uhi o tō kōpū.

Ka tohua e tō tākuta te fidaxomicin i te nuinga o te wā ina whakapumautia e koe te mate C. diff mā te whakamātau i te tūtae, inā koa kua pā koe i ngā mate hoki mai, kāore rānei i pai te urupare ki ētahi atu rongoā. He tino whai hua te rongoā mō te ārai i te hokinga mai o te mate, he wero noa tēnei ki te C. diff.

I ētahi wā, ka whiriwhiri pea ngā tākuta i te fidaxomicin hei rongoā tuatahi mō ngā mate C. diff kaha, mō ngā tūroro rānei e tūpono ana ka hoki mai te mate. Kei roto i tēnei ko ngā pakeke kaumātua, ngā tāngata he pūnaha ārai mate kua ngoikore, ko te hunga rānei i pā i te maha o ngā wāhanga o mua.

Me pēhea te mahi a te Fidaxomicin?

Ka mahi te Fidaxomicin mā te aukati i tētahi tukanga nui e hiahia ana te huakita C. diff ki te whakanui me te ora. E whāia ana e ia tētahi enzyme e kīia ana ko te RNA polymerase e whakamahia ana e te huakita ki te hanga pūmua e tika ana mō tō rātou tipu me te whakaputa uri.

Ina uru te fidaxomicin ki tō pūnaha kūnatu, ka noho tonu ki tō puku, kaua ki te uru ki tō toto. Ko te tikanga ka taea e ia te tuku i ngā kukume nui o te rongoā ki te wāhi e pōrearea ana te huakita C. diff, i te wā e whakaiti ana i ngā pānga ki ngā huakita i ētahi atu wāhi o tō tinana.

E whakaarohia ana he kaha ngawari te rongoā, he tino whai hua ki te C. diff. Ko te mea e tino whai hua ana ko tōna kōwhiri - e whāia ana e ia te huakita C. diff i te kaha ake i tōna pānga ki ō huakita puku whai hua, e āwhina ana i te pupuri i tō taurite kūnatu tūturu.

Ko te tikanga hoki o tēnei mahi whāinga, he iti ake te tūponotanga o te fidaxomicin ki te whakaputa i te aukati paturopi i te whakataurite ki ngā paturopi whānui. Ka mahi tonu te rongoā ahakoa kua oti i a koe te akoranga maimoatanga, nā te mea ka noho kaha tonu i roto i tō kōpū mō ētahi rā.

Me pēhea taku tango i te Fidaxomicin?

Tangohia te fidaxomicin kia rite ki te tohutohu a tō tākuta, te tikanga 200 mg e rua i te rā mō te 10 rā. Ka taea e koe te tango me te kore kai rānei, engari ko te tango me te kai māmā ka āwhina i te whakaiti i ngā raruraru puku ka pā ki a koe.

Horomia ngā papa katoa me te karaihe wai katoa - kaua e kuru, e ngaungau, e whati rānei i a rātou, nā te mea ka pā tēnei ki te mahi o te rongoā. Whakamātauria te tango i ō horopeta i ngā wā kotahi i ia rā, me te whakatakoto i a rātou tata ki te 12 haora te wehenga kia mau tonu ai ngā taumata i roto i tō pūnaha.

Kāore koe e hiahia ki te karo i ētahi kai motuhake i te wā e tango ana i te fidaxomicin, engari ko te kai i te kai ngawari ka āwhina i tō pūnaha kūnatu ki te ora mai i te mate C. diff. Ko ngā kai pēnei i te panana, te raihi, te aporo, me te tōhi he māmā ake te aro ki te wā e maimoatanga ana.

Mēnā kei te tango koe i ētahi atu rongoā, whakatakotoria kia 2 haora te wehenga mai i te fidaxomicin i te wā e taea ana. Ka āwhina tēnei ki te ārai i ngā pānga ka pā mai, me te whakarite kia pai te mahi o ia rongoā.

Kia Pēhea te Roa o taku Tango i te Fidaxomicin?

Ko te nuinga o te tāngata e tango ana i te fidaxomicin mō te 10 rā, koinei te roa o te akoranga paerewa i whakaaturia e ngā rangahau haumanu he tino whai hua. He mea nui kia whakaoti i te akoranga katoa ahakoa ka tīmata koe ki te pai ake i muri i ētahi rā.

Ka kite pea koe i te whakapai ake i ō tohumate i roto i te 2-3 rā i te tīmatanga o te maimoatanga, engari ka noho tonu te huakita, ā, ka kino pea mēnā ka whakamutua e koe te rongoā i mua. Ko te whakamutu wawe ka piki ake te tūponotanga o te hokinga mai o te mate, he uaua ake pea te rongoā.

I ngā wā onge, ka whakatika pea tō tākuta i te roa o te rongoā i runga i tō āhuatanga motuhake, pēnei i te kaha o tō mate, i tō hauora whānui rānei. Heoi anō, ka piri te nuinga o ngā tūroro ki te rongoā paerewa 10-rā mō ngā hua pai.

Kāore i rite ki ētahi atu rongoā C. diff, kāore te fidaxomicin e hiahia ana ki ngā akoranga roa, ki ngā hōtaka whakaiti rānei. Ko ngā āhuatanga ahurei o te rongoā ka taea e ia te mahi tonu mō ētahi rā i muri i tō tango i tō horopeta whakamutunga, e whakarato ana i te whakamarumaru tonu ki te hokinga mai.

He aha ngā pānga taha o te Fidaxomicin?

He pai te whakamanuhia o te Fidaxomicin, ā, he iti noa iho ngā pānga taha e pā ana ki te nuinga o te tangata. Ko ngā pānga taha tino noa he ngawari, ā, e pā ana ki tō pūnaha kūnatu i te wā e ora ana i te mate C. diff.

Koinei ngā pānga taha ka pā ki a koe, me te mahara he maha ngā tāngata e tango ana i te fidaxomicin kāore he raruraru:

• Te whakapairuaki, te mamae puku ngawari rānei
• Te mamae puku, te kōpū rānei
• Te ruaki (kāore i te noa)
• Te ānini
• Te whanoke
• Te pāpāpā i te wā e hāpai ana ō nekehanga whekau

Ka pai ake ēnei pānga ngawari i te wā e urutau ana tō tinana ki te rongoā, ā, ka ngaro tō mate. E kite ana te nuinga o te tangata he nui ake te whakahaere i ngā raruraru i ngā tohu C. diff taketake.

He onge ngā pānga taha kino, engari ka puta. Whakapā atu ki tō tākuta tonu mēnā ka pā ki a koe ngā tauhohenga mate pāwera kino pēnei i te uaua ki te manawa, te pūhi o tō mata, o tō korokoro rānei, i ngā tauhohenga kiri kino rānei. Me rapu hoki i te āwhina hauora mēnā ka whanake koe i te mamae puku kino, te toto i roto i tō tūtae, i ngā tohu rānei o te mate hou.

E māharahara ana ētahi tāngata mō te whanake i te pāpāpā e pā ana ki te paturopi mai i te fidaxomicin, engari he iti ake tēnei i ētahi atu paturopi nā te mea e whai ana i te mahi whāinga. Heoi anō, mēnā ka whanake koe i te pāpāpā hou, i te pāpāpā rānei e kino ana i te wā e rongoā ana, whakamōhio atu ki tō kaiwhakarato hauora.

Ko wai e kore e tango Fidaxomicin?

Kāore a Fidaxomicin e tika ana mō te katoa, ahakoa he poto te rārangi o te hunga e kore e taea te tango. Ko te āwangawanga nui ko te mea kua pā koe i te tauhohenga mate pāwera nui ki a fidaxomicin, ki ētahi rānei o ōna kai i mua.

Me āta whakaaro tō tākuta ki a fidaxomicin mēnā he mate tākihi, ate rānei tōu, nā te mea ka pā ēnei āhuatanga ki te āhua e tukatuka ana tō tinana i ngā rongoā. Ahakoa kāore a fidaxomicin e ngāwari te uru ki roto i ō toto, tērā pea ka hiahia tō tākuta ki te aroturuki i a koe.

Ko te hunga e pā ana ki ētahi āhuatanga ira onge e pā ana ki tō rātou kaha ki te tukatuka i ngā huka motuhake me kōrero tēnei ki tō rātou tākuta, nā te mea kei roto i ngā papa fidaxomicin te iti o te lactose. Heoi, he iti rawa te nui ki te pā i ngā raruraru mō te nuinga o te hunga e kore e aro ki te lactose.

Mēnā kei te hapū koe, kei te whāngai ū rānei koe, ka whakataurite tō tākuta i ngā painga ki ngā tūponotanga. Ahakoa kāore anō ngā rangahau i whakaatu i ngā āwangawanga nui, ka taea e ngā mate C. diff te kino i te wā o te hapū, nō reira he mea tika te rongoā. Ka āwhina tō kaiwhakarato hauora i a koe ki te whakatau i te whakatau pai mō tō āhuatanga motuhake.

Ngā Ingoa Waitohu Fidaxomicin

Kei te wātea te fidaxomicin i raro i te ingoa waitohu Dificid i te United States. Koinei te ingoa waitohu taketake ka mōhio te nuinga o ngā tākuta me ngā kai rongoā i te wā e whakarite ana, e tuku ana rānei i te rongoā.

I ētahi atu whenua, ka kitea pea e koe te fidaxomicin e hokona ana i raro i ngā ingoa waitohu rerekē, pēnei i te Dificlir i ētahi mākete Pākehā. Heoi, ko te whakauru kaha me te whai huatanga e noho rite ana ahakoa te ingoa waitohu kei runga i te pōkai.

Kei te wātea ake ngā putanga whānui o te fidaxomicin i ētahi mākete, ka taea te āwhina ki te whakaiti i te utu o te rongoā. Ka taea e tō kai rongoā te kōrero ki a koe mēnā kei te wātea tētahi putanga whānui i tō rohe, me te mea e tika ana mō tō rongoā.

Ahakoa te ingoa waitohu, me mōhio kei te whiwhi koe i te fidaxomicin mō te rongoā C. diff, he rerekē rawa atu i ētahi atu paturopi, ā, kāore e taea te whakawhitiwhiti ki ētahi atu rongoā.

Ētahi atu rongoā mō te Fidaxomicin

He maha atu ētahi paturopi ka taea te rongoā i ngā mate C. diff, ahakoa he painga te fidaxomicin mō te ārai i te hokinga mai. Ko te Vancomycin te mea e whakamahia nuitia ana, ā, kua noho hei rongoā paerewa mō ngā tau maha.

I mua i te wā i whakamahia ai te Metronidazole mō ngā mate C. diff ngawari, engari e kī ana ngā aratohu rongoā o nāianei kia whakamahia te vancomycin, te fidaxomicin rānei hei kōwhiringa tuatahi pai ake. Ka whakaaro pea tō tākuta ki te metronidazole i ētahi wā, ina koa he nui te utu.

Mō ngā take nui, uaua rānei, ka tūtohu pea tō tākuta i ngā rongoā whakakotahi, i ngā rongoā hou rānei pēnei i te bezlotoxumab, he rongoā paturopi tēnei e āwhina ana ki te ārai i te hokinga mai. I ngā take tino nui, ka hiahiatia pea te pokanga, ahakoa he mea onge tēnei.

Ko te kōwhiringa i waenga i ngā rongoā kē e whakawhirinaki ana ki ngā mea pēnei i te kaha o tō mate, tō hītori rongoā, ngā wāhanga C. diff o mua, me tō hauora whānui. Ka whakaaro tō tākuta ki ēnei mea katoa i te whakatau i te huarahi rongoā pai mō tō āhuatanga motuhake.

He pai ake te Fidaxomicin i te Vancomycin?

Kua whakaatu te Fidaxomicin i ētahi painga ki runga i te vancomycin, ina koa ki te ārai i te hokinga mai o ngā mate C. diff. Kua kitea e ngā rangahau haumanu he iti ake te tūponotanga o te hunga e rongoatia ana ki te fidaxomicin ki te whai i ngā mate hoki mai i te hunga e rongoatia ana ki te vancomycin.

He tino whai hua ngā rongoā e rua ki te whakawātea i te mate C. diff tuatahi, me ngā reiti angitu e rite ana. Heoi, ko te kaha o te fidaxomicin ki te tiaki i te nuinga o ō huakita pai i roto i te puku i te wā e whawhai ana ki te C. diff te mea e whakarato ana i te whakamarumaru pai ake i te wā roa.

Ko te mea nui e whakaarohia ana e te tini o ngā tūroro ko te utu, nā te mea he nui ake te utu o te fidaxomicin i te vancomycin. Heoi, ki te whai whakaaro koe ki te iti o te tūponotanga o te hokinga mai me te hiahia pea ki ētahi atu rongoā, ka whai hua pea te fidaxomicin i te wā roa.

Ka whakaarohia e tō tākuta ō āhuatanga tūpono mō te hokinga mai, te kaha o tō mate, me tō hauora whānui i te wā e whiriwhiri ana i waenga i ēnei kōwhiringa. He rongoā pai ngā mea e rua, ā, ko te kōwhiringa pai rawa atu ka whakawhirinaki ki ō āhuatanga motuhake, kaua ki te mea kotahi e tino pai ana.

Ngā Pātai Auau mō Fidaxomicin

He Haumaru te Fidaxomicin mō te Tāngata e mate huka ana?

Āe, he haumaru te fidaxomicin mō te tāngata e mate huka ana. Kāore te rongoā e pā nui ana ki ngā taumata huka toto nā te mea ka noho tonu i roto i tō ara kūnatu, kaua ki te uru ki roto i tō toto.

Heoi, ka pā te mate C. diff ki tō hiahia me ō tauira kai, ka pā pea tō mana whakahaere huka toto. Aroturukihia ō taumata kūhuka toto pērā i mua, ā, whakapā atu ki tō kaiwhakarato hauora mēnā ka kite koe i ētahi huringa rerekē i te wā e rongoā ana.

Me Pēhea Taku Mahi Mēnā Ka Nui Rawa Taku Fidaxomicin?

Mēnā ka nui rawa tō rongoā fidaxomicin, kaua e mataku. Nā te mea kāore te rongoā e uru nui ana ki roto i tō toto, kāore pea ngā tohu o te nui rawa o te rongoā e kaha.

Whakapā atu ki tō tākuta, ki te kaimātai rongoā rānei mō te āwhina, ina koa i te wā i nui rawa atu tō rongoā i te mea i tohua. Ka taea e rātou te tohutohu i a koe mēnā e hiahia ana koe ki te āwhina hauora me te pēhea te whakatika i tō hōtaka inu i te wā e haere ana.

Me Pēhea Taku Mahi Mēnā Ka Ngaro Taku Inenga Fidaxomicin?

Mēnā ka ngaro tō inenga, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō inenga e whai ake nei. I taua wā, waiho te inenga i ngaro, ka haere tonu ki tō hōtaka auau - kaua e rua ngā inenga.

Whakamātauria te pupuri i te 12-haora te wā i waenga i ngā horopeta i te wā e taea ana. Mēnā e wareware ana koe ki ngā horopeta, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i a koe kia mau tonu ki tō maimoatanga.

Āhea Ānei Ka Taea e Au te Kati te Tango Fidaxomicin?

Kati anake te tango fidaxomicin i te wā i oti i a koe te akoranga 10-rā katoa i whakaritea e tō tākuta, ahakoa e pai ana koe. Ko te whakamutu wawe ka nui ake te tūponotanga o te hokinga mai o te mate.

Mēnā ka pā ki a koe ngā pānga taha kino, ngā tauhohenga pāwera rānei, whakapā atu ki tō tākuta tonu mō te tohutohu. Akene me whakatika e rātou tō maimoatanga, engari kaua e whakamutua te rongoā i runga i a koe anō me te kore e tirotirohia e te rōpū hauora.

Ka Taea e Au te Tango Probiotics me Fidaxomicin?

He maha ngā tākuta e tūtohu ana kia tatari kia oti i a koe tō akoranga fidaxomicin i mua i te tīmatanga o te probiotics. Mā tēnei ka taea e te paturopi te mahi whai hua me te kore e raru mai i ngā huakita tāpiri, tae atu ki ngā mea whai hua.

I muri i te whakaotinga o te fidaxomicin, ka āwhina pea te probiotics ki te whakahoki i te taurite o ō huakita whekau, engari kōrerohia tēnei ki tō kaiwhakarato hauora i te tuatahi. Ka taea e rātou te tūtohu i te wā tika me ngā momo probiotics i runga i ō hiahia whakaora motuhake.