He aha te Fosaprepitant: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu mea

Ko te Fosaprepitant he rongoā e tukuna ana mā te raina IV (intravenous) hei āwhina i te aukati i te whakapairuaki me te ruaki, ina koa kei te whiwhi koe i te rongoā matū, kei te pokanga rānei. He putanga wai tēnei o te aprepitant e mahi ana mā te aukati i ētahi kaiwhakawhiwhi i tō roro e whakaoho ana i ēnei ngākau kino.

No tētahi kāwai tēnei rongoā e kiia nei ko NK1 receptor antagonists. Whakaarohia he whakangungu rakau ngawari i tō roro ki ngā tohu e whakapairuaki ai koe.

He aha te Fosaprepitant?

Ko te Fosaprepitant he prodrug, ko te tikanga ka huri ki te rongoā kaha (aprepitant) ka uru ana ki tō tinana. I hangaia motuhake kia tukuna mā te IV ina kore e taea e koe te tango pire mā te waha, ina hiahia rānei ngā tākuta kia tere ake te mahi o te rongoā.

Ko te āhua IV ka taea e ngā kaiwhakarato hauora te tuku i te rongoā ki tō toto. He tino whai hua tēnei ina whakapairuaki ana koe, ina hiahia rānei koe i te whakamarumaru tonu i mua i te mahi rongoā.

Kāore i rite ki ētahi rongoā anti-whakapairuaki e mahi ana i tō puku, ka mahi te fosaprepitant i te pokapū ruaki o tō roro. Ko tēnei huarahi whāinga ka whai hua rawa mō te whakapairuaki i puta mai i te rongoā matū, kāore nei e pai te urupare ki ētahi atu rongoā.

He aha te Fosaprepitant e whakamahia ana mō?

Ko te Fosaprepitant te mea nui e whakamahia ana hei aukati i te whakapairuaki me te ruaki i puta mai i ngā rongoā matū. He tino whai hua ki ngā mea e kiia ana e ngā tākuta ko te

Ko te rongoā nei e whakamahia ana hei wāhanga o te huarahi whakakotahi. Anei ngā wā e tohutohu ana ngā tākuta:

• I mua i te whiwhinga i ngā rongoā kaha mō te mate pukupuku pērā i te cisplatin, i te cyclophosphamide rānei
• Hei wāhanga o te huinga rongoā e toru me ētahi atu rongoā anti-nausea
• Ki te kaha te nausea i ngā maimoatanga o mua
• I mua i ngā pokanga nui e tūpono ana te nausea i muri i te pokanga
• Ki te kore e whai hua, e whai pānga rānei ngā rongoā waha

He mea tika kia mōhio ko te fosaprepitant te pai ki te whakamahi i mua i te tīmatanga o te nausea, kaua ki te rongoā i te nausea kua tīmata kē. Koinei te take e hoatu ana e ngā tākuta i mua i te tīmatanga o tō rongoā mate pukupuku, i tō pokanga rānei.

Me pēhea te mahi a Fosaprepitant?

Ka mahi a Fosaprepitant mā te aukati i ngā kaiwhakawhiwhi NK1 i te pokapū ruaki o tō roro. Ko ēnei kaiwhakawhiwhi te tikanga ka whakautu ki te matū e kīia nei ko te matū P, e whakaoho ana i te nausea me te ruaki i te wā o te rongoā mate pukupuku, i te ahotea rānei.

Ka uru te rongoā ki tō toto, ka huri tere ki te aprepitant, te momo kaha. Ka haere tēnei rongoā kaha ki tō roro, ka "noho" i ngā kaiwhakawhiwhi NK1, e ārai ana i te matū P kia kore e herea ki a rātou.

E kiia ana he rongoā anti-nausea kaha. He kaha ake i ngā rongoā anti-nausea taketake pērā i te ondansetron anake, engari kāore i te kaha, i te whakatōpū rānei. Ka taea te pānga aukati mō ētahi rā i muri i te horopeta kotahi.

Ko te mea e whai hua ana a fosaprepitant ko te aro ki te nausea i tōna pūtake i te roro, kaua ki te rongoā i ngā tohumate i tō pūnaha kūnatu. Koinei te take e pai ana te mahi mō te nausea i puta mai i te rongoā mate pukupuku, e kore nei e whakautu ki ngā maimoatanga e arotahi ana ki te puku.

Me pēhea taku tango i te Fosaprepitant?

Ka hoatu tonu a Fosaprepitant e ngā tāngata ngaio hauora mā te raina IV i te hōhipera, i te whare haumanu rānei. Kāore koe e hiahia ki te whakarite, ki te tango rānei i tēnei rongoā i tō kāinga.

Ko te rongoā nei ka tukuna mā te riringi pōturi i roto i te 20-30 meneti. Ka āta titiro tō nēhi i te tere o te riringi kia mōhio ai kei te pai koe, ā, kāore he pānga kino e puta.

Kāore koe e hiahia ki te nohopuku i mua i te whiwhinga i te fosaprepitant, ā, ka taea e koe te kai noa iho ki te kore te tākuta i hoatu ētahi atu tohutohu ki a koe e pā ana ki tō rongoā mate pukupuku, ki tō pokanga rānei. Ko te kai i tētahi paramanawa māmā i mua ka āwhina i a koe kia pai ake te ngākau.

Anei ngā mea e tika ana kia tatari i te wā o tō riringi:

1. Ka tīmata tō nēhi i tētahi rārangi IV ki te kore anō tētahi
2. Ka konatunatua te rongoā ki te wai tote
3. Ka rere pōturi te riringi i roto i te 20-30 meneti
4. Ka aroturukihia koe mō ngā pānga i te wā o te riringi me muri iho
5. Ka taea e koe te hoki ki ngā mahi noa tonu i muri tonu iho

He mea nui kia noho wai koe i mua me muri i tō riringi. Ko te inu i te wai nui ka āwhina i tō tinana ki te tukatuka i te rongoā i te pai ake, ā, ka whakaiti pea i te tūponotanga o ngā pānga taha.

Kia Pēhea te Roa o taku tango i te Fosaprepitant?

Ko te fosaprepitant te tikanga ka tukuna hei horopeta kotahi i mua i te rongoā mate pukupuku, i te pokanga rānei. Ka taea e ngā pānga o te horopeta kotahi te roa mō ētahi rā, he nui pea tēnei ki te ārai i te whakapairuaki i te wā o tō maimoatanga.

Mō ngā tūroro rongoā mate pukupuku, ka whiwhi pea koe i te fosaprepitant i mua i ia huringa maimoatanga. Mā tō tākuta mate pukupuku e whakatau te hōtaka tika i runga i tō hōtaka rongoā mate pukupuku motuhake me te pai o tō urupare ki te rongoā.

Ka whakawhirinaki te roa o te maimoatanga ki tō āhuatanga hauora. Ki te pokanga koe, ka whiwhi pea koe i te rongoā kotahi anake. Ki te whai koe i ngā huringa maha o te rongoā mate pukupuku, ka whiwhi pea koe i te rongoā i mua i ia huringa i roto i ētahi marama.

Ka aroturukihia e tō rōpū hauora te pai o te mahi a te rongoā mōu, ā, ka whakatikatikaina te mahere maimoatanga i runga i te hiahia. Ko ētahi tāngata e kite ana e hiahia ana rātou i te rongoā mō ia huringa haumanu, ēngari ko ētahi anake e hiahia ana i te rongoā mō ngā maimoatanga tuatahi.

He aha ngā pānga taha o te Fosaprepitant?

He pai te whakamanawanui a te nuinga o ngā tāngata ki te fosaprepitant, ā, he iti noa ngā pānga taha kino. Ko ngā pānga taha e puta pinepine ana he ngawari, he wā poto noa iho.

Me tīmata ki ngā pānga taha noa ka pā ki a koe, e ngaro ana i te nuinga o te wā i roto i te rā, e rua rānei:

• Te ngenge, te pōuri rānei
• Te ānini
• Te whanoke
• Te pāpāpā
• Te ngaro o te hiahia
• Te hī
• He mamae ngawari, he riri rānei i te wāhi IV

Ko ēnei pānga noa i te nuinga o te wā kāore e hiahia maimoatanga, ā, ka pai ake i te wā e urutau ana tō tinana ki te rongoā. Mā te noho wai, te okiokinga hoki e āwhina i te whakahaere i ēnei tohumate.

Ko ngā pānga taha kāore i te noa, engari he nui ake te āwangawanga, e hiahia ana kia aro mai te tākuta. Ahakoa he onge ēnei, he mea nui kia mōhio ki ngā mea hei mātakitaki:

• Ngā tauhohenga mate pāwera nui (te pūwha, te pūpū, te uaua ki te hā)
• Te ngākau pōrearea, te mamae rānei o te uma
• Te whanoke nui, te ngaro rānei o te mōhiotanga
• Ngā tohu o ngā raruraru ate (te kōwhai o te kiri, o ngā kanohi, te mimi pouri)
• Te mamae nui o te puku
• Ngā huringa āhua rerekē, te rangirua rānei

Ko ēnei pānga taha tino kino ka puta i roto i te iti iho i te 1% o ngā tāngata, engari e hiahia ana kia aro mai te tākuta i te wā tonu mēnā ka puta.

Ko wai kāore e tika kia tango Fosaprepitant?

Kāore te Fosaprepitant e tika mō te katoa, ā, ka āta arotakehia e tō tākuta tō hītori hauora i mua i te whakahau i te rongoā. Ko te āwangawanga nui ko te pānga o tēnei rongoā ki ētahi atu rongoā e tango ana koe.

Me mōhio atu ki tō tākuta mēnā he hītori tō koe mō ngā pānga pāwera ki te fosaprepitant, ki te aprepitant rānei. Ahakoa he pānga pāwera ngawari i mua, ka tohu pea tēnei rongoā kāore i te haumaru mōu.

Ko ngā tāngata e whai ana i ētahi āhuatanga hauora, me mātua tūpato, me karo rānei i te fosaprepitant:

• Te mate ate nui, te kore rānei o te ate
• Ngā raruraru o te manawa
• Te mōhiotanga ki te pāwera ki ngā kaiwhakatūtū NK1
• Te mate tākihi nui
• Ngā raruraru toto e kaha ana

Me whai whakaaro motuhake ki te hapū me te whāngai ū. Ahakoa kāore i te nui te rangahau mō te fosaprepitant i ngā wāhine hapū, ka whakatau tō tākuta i ngā painga me ngā tūponotanga mēnā kei te hapū koe, kei te whāngai ū rānei.

Ka taea e te rongoā te pā ki ētahi atu rongoā, tae atu ki ngā rongoā whakaheke toto, ētahi paturopi, me ētahi rongoā anti-seizure. Koinei te take he mea nui kia hoatu e koe ki tō rōpū hauora te rārangi katoa o ngā rongoā me ngā tāpiringa e tango ana koe.

Ngā Ingoa Waitohu o te Fosaprepitant

Kei te wātea te fosaprepitant i raro i te ingoa waitohu Emend for Injection i te United States. Koinei te ingoa waitohu e mōhiotia ana mō te whakatakotoranga IV.

He rerekē pea ngā ingoa waitohu o ngā whenua rerekē mō te rongoā kotahi. Ka taea e tō kaiwhakawhāiti rongoā, tō tākuta rānei te kōrero ki a koe ko tēhea te waitohu e whiwhi ana koe.

Kei te wātea hoki ngā putanga generic o te fosaprepitant, kei roto i te mea kaha kotahi engari he iti ake pea te utu. He rite tonu te whai hua o ngā putanga generic ki te rongoā waitohu.

Ngā Kōwhiringa kē mō te Fosaprepitant

He maha ētahi atu rongoā anti-nausea ka taea te whakamahi hei utu mō te fosaprepitant, hei taha rānei. Ka whakaaro pea tō tākuta ki ēnei kōwhiringa kē i runga i tō āhuatanga motuhake me tō hītori hauora.

Ko ētahi atu rongoā he ondansetron (Zofran), e mahi ana mā te aukati i ngā kaiwhakawhiwhi rerekē i tō roro. Ko Metoclopramide (Reglan) tētahi atu kōwhiringa e mahi ana i tō roro me tō pūnaha kūnatu.

Koinei ngā kōwhiringa matua ka whakaarohia e tō tākuta:

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• Ondansetron (Zofran) - aukati i ngā kaiwhakawhiwhi serotonin
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• Granisetron (Kytril) - tētahi atu aukati i ngā kaiwhakawhiwhi serotonin
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• Dexamethasone - he steroid e whakaiti ana i te mumura
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• Metoclopramide (Reglan) - āwhina i te putanga o te puku
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• Prochlorperazine (Compazine) - aukati i ngā kaiwhakawhiwhi dopamine
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• Aprepitant waha (Emend capsules) - ki te taea e koe te tango pire
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He maha ngā tākuta e whakamahi ana i ngā huarahi whakakotahi, e whakaranu ana i te fosaprepitant me ētahi atu rongoā anti-nausea kia whai hua ai. He pai ake te mahi a tēnei huarahi maha-rongoā i tētahi rongoā anake.

He Pai Ake Anei te Fosaprepitant i te Ondansetron?

He rerekē te mahi a Fosaprepitant me te ondansetron, ā, he maha ngā wā e whakamahia ngātahi ana, kaua hei kōwhiringa whakataetae. E whai ana rāua i ngā ara rerekē i te pokapū nausea o tō roro, e whai pānga ana rāua, kaua hei whakataetae.

Te tikanga he pai ake te fosaprepitant mō te nausea kua roa, ka puta pea 24-72 haora i muri i te chemotherapy. He pai ake te mahi a Ondansetron mō te nausea tonu e puta ana i te wā, i muri tata rānei i te maimoatanga.

Mō te chemotherapy tino emetogenic, e whakaarohia ana he pai ake te fosaprepitant i te ondansetron anake. Heoi, he maha ngā wā e pai ana te ondansetron mō te nausea ngawari ki te āhua, nā te mea he iti ake ngā pānga rongoā, ā, he iti ake te utu.

Ko te kōwhiringa

Āe, he pai tonu te fosaprepitant mō te hunga mate huka. Kāore te rongoā e pā tika ana ki ngā taumata huka toto, nō reira kāore e pā ki tō whakahaere i te mate huka.

Heoi anō, ki te whiwhi koe i te rongoā mō te mate pukupuku, ka pā pea te pēhanga o te rongoā me ngā huringa pea i ngā tauira kai ki tō huka toto. He mea nui kia mātakitaki i ō taumata kūkō i te wā o te rongoā, me te kōrero i ngā āwangawanga katoa ki tō rōpū hauora.

Me pēhea taku mahi ki te whiwhi au i te nui rawa o te Fosaprepitant?

I te mea ka hoatu te fosaprepitant e ngā tāngata ngaio hauora i roto i te wāhi haumanu, he tino onge te nui rawa o te rongoā. Ka āta tatau me te mātakitaki i te inenga i te wā o te whakahaere.

Ki te āwangawanga koe mō te whiwhi i te nui rawa o te rongoā, kōrero tonu ki tō nēhi, tākuta rānei. Ka taea e rātou te arotake i tō inenga me te mātakitaki i a koe mō ngā tohumate rerekē. Kāore he rongoā motuhake mō te nui rawa o te fosaprepitant, engari ka taea e te manaaki tautoko te whakahaere i ngā tohumate katoa ka puta.

Me pēhea taku mahi ki te ngaro au i tētahi inenga o te Fosaprepitant?

Ki te ngaro koe i tētahi whakaurunga fosaprepitant kua whakaritea, whakapā atu ki tō kaiwhakarato hauora i te wā tonu. Mā rātou koe e āwhina ki te whakarite anō, me te whakatau mēnā e hiahia ana koe i te whakamarumaru anti-nausea atu.

Mō ngā tūroro rongoā mō te mate pukupuku, ka taea e te ngaro i te rongoā anti-nausea te tino kore mārie i tō rongoā. Ka tohutohu pea tō tākuta mate pukupuku i ētahi atu rongoā hei āwhina i te aukati i te nausea kia taea anō e koe te whiwhi i tō inenga fosaprepitant.

Āhea ka taea e au te whakamutu i te tango i te Fosaprepitant?

Ka taea e koe te whakamutu i te fosaprepitant i te wā e whakatau ana tō tākuta kāore koe e hiahia ana. Ko te tikanga tēnei ka oti i a koe ō rongoā mō te mate pukupuku, ka ora rānei i te pokanga.

E kitea ana e ētahi tāngata me hiahia rātou ki te fosaprepitant mō ia huringa rongoā matū, ā, ko ētahi anake pea e hiahia ana mō ngā maimoatanga tuatahi. Ka mahi tō tākuta mate pukupuku ki a koe ki te whakatau i te hōtaka pai rawa atu i runga i tō urupare me te kaha o tō rongoā.

Ka taea e au te taraiwa i muri i te whiwhinga i te Fosaprepitant?

Ka taea e te Fosaprepitant te pā ki te whanoke me te ngenge, nō reira me karo koe i te taraiwa i muri tonu i te whiwhinga i te rongoā. He pai ake te whai i tētahi hei taraiwa i a koe ki te kāinga mai i tō tūpono maimoatanga.

E pai ana te nuinga o te tāngata ki te taraiwa i te rā e whai ake nei, engari whakarongo ki tō tinana. Ki te whanoke tonu koe, ki te ngenge rānei koe, tatari kia ngaro ēnei pānga i mua i te eke ki te wīra. Me noho tonu tō haumarutanga me te haumarutanga o ētahi atu i runga i te rori ki te tuatahi.