He aha te Guanidine: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te Guanidine he rongoā rongoā e whakamahia ana hei rongoā i tētahi āhua ngoikore uaua onge e kīia ana ko te mate myasthenic Lambert-Eaton (LEMS). E pā ana tēnei āhua ki te hononga i waenga i ō uaua me ō uaua, e uaua ai ngā mahi o ia rā pēnei i te hikoi, te piki i ngā arawhata, te pupuri rānei i ngā mea, he uaua kore i whakaarohia.

Ahakoa ehara te guanidine i te ingoa whare pēnei i ētahi atu rongoā, he mea nui te whiringa rongoā mō te hunga e noho ana me ngā āhua neuromuscular motuhake. Whakaarohia he taputapu motuhake e āwhina ana ki te whakahoki mai i ētahi o ngā kōrero i waenga i tō pūnaha io me ō uaua ina kore e pai ana tērā hononga.

He aha te Guanidine?

Ko te Guanidine he rongoā e mahi ana i ngā tohu hiko i waenga i ō io me ō uaua. No tētahi momo rongoā e āwhina ana ki te whakapai ake i te kōrero io-uaua, ina koa ka raru ētahi āhua autoimmune i tēnei tukanga.

Kua whakamahia tēnei rongoā i roto i ngā mahi rongoā mō ngā tau maha, ahakoa e kiia ana he rongoā motuhake, kaua ko te rongoā tuatahi. Ka whakaaro te tākuta ki te guanidine ina kāore ētahi atu rongoā i whai hua, i te wā rānei ka waiho tō āhua motuhake hei whiringa tino pai.

He aha te Guanidine e whakamahia ana?

Ko te Guanidine te mea nui e tohua ana mō te mate myasthenic Lambert-Eaton (LEMS), he āhua autoimmune onge e pā ana ki te 1 i roto i te 100,000 tāngata. I roto i te LEMS, ka whakaeke hē tō pūnaha ārai mate i ngā awa konupūmā i roto i ō pito io, e whakararu ana i ngā tohu e kī ana ki ō uaua kia kirimoko.

I ētahi wā ka whakaaro pea ngā tākuta ki te whakamahi i te guanidine mō ētahi atu āhuatanga e pā ana ki te ngoikoretanga o ngā uaua, ahakoa he iti noa iho tēnei. Ko ēnei pea ko ētahi momo mate uaua e raru ana te hononga o te io-uaua, engari ko ēnei whakamahinga ka rāhuihia mō ngā āhuatanga motuhake kāore anō ētahi atu rongoā i whai hua.

He pai rawa te rongoā mō ngā tāngata e pai ake ana te ngoikoretanga o ngā uaua i te whakamahinga tonu o ngā uaua e pā ana. Ki te kite koe e pai ake ana tō kaha i a koe e haere tonu ana i te rā, he mea whai hua pea te guanidine mō tō āhuatanga.

Me pēhea te mahi a Guanidine?

Ka mahi a Guanidine mā te whakanui i te tuku o tētahi karere matū e kīia ana ko te acetylcholine i te hononga i waenga i ō io me ō uaua. Whakaarohia te acetylcholine hei kī e iriti ana i te kirimana uaua - ki te kore koe e nui, kāore e taea e ō uaua te urupare tika ki ngā tohu io.

Ko tēnei rongoā e āwhina ana i ō pito io ki te tuku i te acetylcholine nui ake, e whakakaha ana i te tohu e tae ana ki ō uaua. He rite ki te whakanui i te rōrahi o tētahi tohu irirangi ngoikore kia pai ake ai tō rongo i te waiata.

E kiia ana ko Guanidine he rongoā kaha i roto i ōna pānga. Kāore i te kaha pērā i ētahi atu rongoā mō te ngoikoretanga o ngā uaua, engari ka taea e ia te whakarato i te whakapai ake mō te nuinga o ngā tāngata e mate ana i te LEMS, ina koa ka honoa ki ētahi atu rongoā.

Me pēhea taku tango i te Guanidine?

Ka tīmata tō tākuta i a koe ki te horopeta iti o te guanidine, ka piki haere i runga i tō urupare. Ko te nuinga o ngā tāngata ka tīmata ki te 10-15 mg mō ia kirokaramu o te taumaha o te tinana ia rā, ka wehea ki ētahi horopeta iti i te rā.

Ka taea e koe te tango i te guanidine me te kore kai rānei, ahakoa ko te tango me ngā kai ka āwhina pea ki te whakaiti i te puku puku ki te pā koe. He pai ki te whakatakoto i ō horopeta i te rā kia mau tonu ngā taumata i roto i tō pūnaha.

Ahakoa te mea i penei, he mea nui te rite tonu ki tēnei rongoā. Whakamātauria te tango i ō horopeta i ngā wā kotahi i ia rā, kaua hoki e ngaro i ngā horopeta ahakoa kei te pai koe. Kei te whakawhirinaki te kaha o ō uaua ki te pupuri i ngā taumata tika o te rongoā i roto i tō pūnaha.

Kia Pēhea te Roa e Tango Ana ahau i te Guanidine?

He rerekē te roa o te maimoatanga guanidine mai i te tangata ki te tangata, ā, kei runga i tō āhuatanga taketake. Mō te mate myasthenic syndrome a Lambert-Eaton, he maha ngā tāngata e hiahia ana ki te tango guanidine mō te wā roa ki te pupuri i te kaha me te mahi o ō rātou uaua.

Ka aroturukihia e tō tākuta tō urupare ki te rongoā i roto i ngā wiki ki ngā marama. Ka kite ētahi tāngata i te whakapai ake i roto i ngā rā, i ētahi atu rānei ka hiahiatia ētahi wiki ki te wheako i ngā painga katoa.

He mea nui ngā whakaritenga whai-whai i ngā wā katoa nā te mea me aromatawai tō tākuta i te whai huatanga o te maimoatanga me te mātakitaki mō ētahi pānga taha. Kaua rawa e mutu te tango guanidine ohorere me te kore e kōrero ki tō kaiwhakarato hauora, nā te mea ka puta tēnei ki te hokinga mai o te ngoikoretanga o te uaua.

He Aha ngā Pānga Taha o te Guanidine?

Pērā i ngā rongoā katoa, ka taea e te guanidine te pānga taha, ahakoa kāore te katoa e wheako ana. Ko te māramatanga ki te aha e tūmanakohia ana ka āwhina i a koe kia pai ake te whakarite me te mōhio ki te wā ki te whakapā atu ki tō tākuta.

Ko ngā pānga taha tino noa he ngawari, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā:

• Te whakapairuaki, te pōhara rānei o te puku
• Te korere, te tūtae rānei
• Te whanoke, te māmā rānei
• Te pūhihi kiri, te mōmiti rānei
• Te ānini
• Te ngenge, te ngenge rānei

Ko ēnei pānga taha noa ka tau i roto i ētahi rā ki ngā wiki i te wā e waia ana tō tinana ki te rongoā. Mēnā ka mau tonu, ka pōhara rānei, ka taea e tō tākuta te whakatika i tō horopeta, i te wā rānei ki te āwhina i te whakaiti i a rātou.

He iti noa iho te puta o ngā pānga kino e tino nui ana, engari me whai wawe tonu te āwhina hauora. Kei roto i ēnei ko ngā tauhohenga mate pāwera nui, ngā huringa nui i te manawataki o te ngākau, ngā tohu rānei o ngā raruraru o te pūkahukahu pēnei i ngā huringa i ngā tauira mimi, te pūhihi rānei i ō waewae me ō waewae.

Ka pā tētahi ki ētahi tāngata i ngā pānga onge engari e pā ana ki te āwangawanga pēnei i te wiri uaua nui, te pōraruraru, te uaua rānei ki te hā. Ahakoa he mea onge ēnei, he mea nui kia mōhio koe ka taea e te manaaki hauora wawe te whakatika i ēnei take.

Ko wai kāore e tika kia tango Guanidine?

Me karo ētahi tāngata i te guanidine, me whakamahi rānei me te tūpato anō. Ka arotake tō tākuta i tō hītori hauora i mua i te whakahau i tēnei rongoā kia mōhio ai he haumaru mōu.

Ko ngā tāngata e pā ana ki ngā raruraru pūkahukahu nui me karo i te guanidine, i te mea ka tukatukahia te rongoā mā ngā pūkahukahu. Ki te whai koe i te mate pūkahukahu, me mātakitaki tō tākuta i a koe, me whakaaro rānei ki ētahi atu rongoā.

I tua atu, kāore pea te guanidine e tika ana mēnā he raruraru ngākau tōu, ina koa ko ēnei e pā ana ki ngā manawataki ngākau kōaro. I ētahi wā ka pā te rongoā ki te mahi ngākau, nō reira ka arotake tō tākuta i tō hauora ngākau i mua i te tīmatanga o te rongoā.

Me kōrero ngā wāhine hapū me te whāngai i ngā pēpi i ngā tūponotanga me ngā painga me tō rātou kaiwhakarato hauora, i te mea he iti noa iho ngā kōrero mō te haumaru o te guanidine i te wā o te hapū me te whāngai.

Ngā Ingoa Waitohu Guanidine

E wātea ana te Guanidine i raro i ētahi ingoa waitohu, ahakoa he rerekē te wātea i ia whenua. I ētahi rohe, ka kite pea koe i te hokohoko hei Guanidine HCl, i raro rānei i ngā ingoa waitohu rongoā motuhake.

Ka taea e tō kai rongoā te āwhina i a koe ki te tautuhi i te waitohu motuhake, i te putanga whānui rānei e wātea ana i tō rohe. Ko te whakauru kaha tonu te mea kotahi ahakoa te kaihanga, ahakoa ka kite ētahi tāngata he rerekē te urupare ki ngā hanganga rerekē.

Ngā Kōwhiringa Guanidine

Mēnā kāore te guanidine e tika ana mōu, kāore rānei e whai hua ana, he maha ngā rongoā kē atu mō te mate o Lambert-Eaton myasthenic syndrome me ētahi atu mate e pērā ana.

Ko te 3,4-diaminopyridine (3,4-DAP) te rongoā tuatahi mō te LEMS, ā, he nui ake pea te whai hua i te guanidine mō te nuinga o te tāngata. He rite te mahi o tēnei rongoā, engari he iti ake ngā pānga kino, ā, he pai ake te manawanui.

Ko ngā rongoā whakaheke i te pūnaha ārai mate pēnei i te prednisone, azathioprine, mycophenolate rānei, he kōwhiringa pea, ina koa he kaha te wāhanga ārai-aunoa o tō mate. E mahi ana ēnei rongoā mā te whakaiti i te whakaeke a te pūnaha ārai mate ki ngā hononga o ngā uaua me ngā io.

I ētahi wā, ka tūtohutia te whakawhiti plasma, te rongoā immunoglobulin rānei (IVIG), ina koa i ngā wā e kaha ake ana ngā tohu.

He Pai Anei te Guanidine i te 3,4-Diaminopyridine?

Ko te 3,4-diaminopyridine (3,4-DAP) te nuinga e whakaarohia ana he pai ake i te guanidine mō te rongoā i te Lambert-Eaton myasthenic syndrome. E tūtohu ana te nuinga o ngā aratohu hauora i te 3,4-DAP hei rongoā tuatahi, nā te mea ka pai ake te whakapai i ngā tohu me te iti ake o ngā pānga kino.

Heoi, he whai hua tonu te guanidine mō te hunga kāore i te pai ki te 3,4-DAP, kāore rānei e manawanui ki ōna pānga kino. Ko ētahi tāngata ka pai ake te urupare ki te guanidine, koinei te take he mea nui te whai i ngā kōwhiringa rongoā maha.

Ka whakaarohia e tō tākuta ō tohu motuhake, te hītori hauora, me te urupare ki ētahi atu rongoā i te wā e whakatau ana i waenga i ēnei rongoā. I ētahi wā, ko te whakakotahi i ngā rongoā e rua i ngā horopeta iti ka pai ake i te whakamahi i tētahi anake.

Ngā Pātai Auau mō te Guanidine

He Haumaru Anei te Guanidine mō te Hunga Mate Huka?

Ka taea te whakamahi i te guanidine mō te hunga mate huka, engari me mātakitaki pai. Ka pā pea te rongoā ki ngā taumata huka toto i ētahi tāngata, ahakoa ehara tēnei i te mea noa.

Ka hiahia tō tākuta ki te aroturuki i tō huka toto i te wā e tīmata ana te guanidine, ina koa he mate huka tō. Me mōhio ki te kōrero ki tō kaiwhakarato hauora mō ngā huringa i roto i ō tauira huka toto, i ngā rongoā mate huka rānei.

Me Pēhea Taku Mahi Mēnā Ka Nui Rawa Taku Guanidine?

Mēnā ka nui rawa tō guanidine i tō te rongoā, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei tonu. Ko te nui rawa ka pā mai ngā pānga taha nui, tae atu ki te whakapairuaki nui, te ruaki, te wiri o ngā uaua, te raruraru rānei o te manawa.

Kaua e ngana ki te whakapairuaki i a koe anō ki te kore e tohutohutia e tētahi tohunga hauora. Kia mau ki te pounamu rongoā i a koe e rapu ana i te āwhina hauora kia mōhio ai ngā kaiwhakarato hauora ki te aha me te nui i tangohia e koe.

Me Pēhea Taku Mahi Mēnā Ka Ngaro Taku Inenga Guanidine?

Mēnā ka ngaro tō inenga guanidine, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō inenga e whai ake nei. I taua wā, waiho te inenga i ngaro, ka haere tonu ki tō hōtaka auau.

Kaua rawa e tango i te inenga rua hei utu mō tētahi i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga taha. Mēnā he maha ngā wā e wareware ana koe i ngā inenga, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i a koe kia noho i runga i te ara.

Āhea Taku Mutu i te Tango Guanidine?

Me mutu anake te tango guanidine i raro i te tirotiro a tō tākuta. Mō te nuinga o te tangata e mate ana i te mate myasthenic syndrome a Lambert-Eaton, ka hoki mai te ngoikore o ngā uaua i te mutu i te rongoā.

Ka kī tō tākuta kia whakaheke haere i tō inenga, kaua e mutu ohorere. Mā tēnei huarahi e whakaiti te tūponotanga o ngā tohumate whakawātea, ā, ka taea e koe te aroturuki i te urupare o tō tinana ki ngā inenga iti.

Ka Taea e Au te Taraiwa i te Wā e Tango Ana i te Guanidine?

Ka pā mai te guanidine i te whanoke, i te ngenge rānei ki ētahi tāngata, ā, ka pā mai pea tō kaha ki te taraiwa haumaru. I te wā e tīmata ana koe ki te tango i te rongoā, he pai ki te karo i te taraiwa kia mōhio rawa koe ki te pānga ki a koe.

Inā kua noho koe i runga i te horopeta pūmau mō tētahi wā, ā, kāore anō koe i pāngia e te whēkau, ētahi atu pānga taha rānei e pā ana ki te āwangawanga, ka taea e te nuinga o te tangata te taraiwa noa. Heoi anō, whakamahia ō whakaaro, kaua hoki e taraiwa ki te kore koe e pai, e tino ngenge rānei.