He aha te Icatibant: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā motuhake te Icatibant i hangaia hei rongoā i te angioedema tuku iho (HAE), he mate ira onge e puta ai te pupuhi ohorere, nui. E mahi ana tēnei rongoā whakahau mā te aukati i ngā kaiwhakawhiwhi motuhake i tō tinana e whakaoho ana i ēnei wāhanga pupuhi mōrearea, e whakarato ana i te oranga i te wā e tino hiahia ana koe.

Mēnā kua tātai koe, tētahi rānei e arohaina ana e koe ki te HAE, mā te māramatanga ki te icatibant e āwhina i a koe kia rite ake, kia māia hoki ki te whakahaere i tēnei āhuatanga. E tohu ana tēnei rongoā i tētahi whakatutukitanga nui i roto i te rongoā i ngā whakaeke HAE, e tuku ana i te tūmanako me te oranga whaihua mō te hunga e noho ana me tēnei mate uaua.

He aha te Icatibant?

He rongoā waihanga te Icatibant e whai ana i tētahi pūmua tūturu i tō tinana e kīia ana ko te bradykinin receptor antagonist. I hangaia motuhake hei aukati i te raupapa o ngā kaupapa e arahi ana ki ngā whakaeke HAE mā te aukati i ngā kaiwhakawhiwhi bradykinin B2.

Whakaarohia te bradykinin hei kī e iriti ana i te pupuhi i tō tinana. E mahi ana te Icatibant me te huri i ngā raka kia kore ai e mahi taua kī. Ka tae mai tēnei rongoā hei syringe kua whakakiia i mua i te wa, ka werohia e koe i raro i tō kiri, e wātea ana mō te whakamahi ohorere i te kāinga, i ngā wāhi rongoā rānei.

No tētahi akomanga rongoā te rongoā e kīia ana ko bradykinin receptor antagonists, ā, ko tētahi o ngā rongoā tino whāinga e wātea ana mō ngā whakaeke HAE. Kāore i rite ki ngā rongoā anti-inflammatory whānui, i hangaia motuhake te icatibant ki te whakatika i te take pūtake o te pupuhi HAE.

He aha te Icatibant e whakamahia ana mō?

Ko te Icatibant te mea nui e whakamahia ana hei rongoā i ngā whakaeke koi o te angioedema tuku iho i ngā pakeke me ngā taiohi. He mate ira onge te HAE e pā ana ki te 1 i roto i te 50,000 tāngata puta noa i te ao, e puta ai ngā wāhanga ohorere o te pupuhi nui.

I te wā o te whakaekenga HAE, ka pā pea te pōrohe kino ki tō mata, korokoro, ringa, waewae, puku rānei. Ka mōrearea ēnei wāhanga, inā koa ka pā ki tō ara rererangi, ka pā rānei te mamae puku nui e rite ana ki ētahi atu āhuatanga ohorere.

Kua whakaaetia te rongoā mō ngā whakaekenga HAE, kāore hoki e whakamahia mō ētahi atu momo pānga mate pāwera, pōrohe rānei. Ka tohutohu tō tākuta i te icatibant mō te hunga kua whakapūmautia te tātaritanga o te HAE mā te whakamātau ira, te hītori whānau rānei, me ngā whakamātau toto e whakaatu ana i te ngoikoretanga, i te kore rānei o te C1 esterase inhibitor.

Me pēhea te mahi a Icatibant?

Ka mahi a Icatibant mā te aukati i ngā kaiwhiwhi bradykinin B2 puta noa i tō tinana, ko rātou ngā mea nui e pā ana ki ngā whakaekenga HAE. I te wā e whakahohehia ana ēnei kaiwhiwhi, ka whakaoho rātou i te rārangi mumura e arahi ana ki te pōrohe motuhake o te HAE.

E kiia ana tēnei rongoā he rongoā kaha, e whāia ana te whāinga, nā te mea e aukati ana i te ara motuhake e pā ana ki ngā tohu HAE. Kāore i rite ki ngā antihistamines, corticosteroids rānei, e mahi whānui ana i runga i te pūnaha ārai mate, ka aro te icatibant ki te tikanga tika e pā ana ki tō pōrohe.

Ko te tikanga ka tīmata te mahi a te rongoā i roto i te 30 meneti ki te 2 hāora i muri i te werohanga, me te nuinga o te tangata e kite ana i te whakapai ake i ō rātou tohu i tēnei wā. Ka roa pea ngā pānga mō ētahi hāora, e whai wā ana tō tinana ki te whakaoti i te whakaekenga.

Me pēhea taku tango i te Icatibant?

Ka hoatu te Icatibant hei werohanga i raro i te kiri, ko te tikanga ka werohia i raro i te kiri, kaua ki roto i te uaua, i te uaua rānei. Ko te horopeta paerewa he 30 mg, ka tukuna mā te syringe kua whakakiia i mua i te wā, i hangaia mō te whakamahi kotahi.

Ka werohia e koe te icatibant ki roto i te kiko ngako o tō puku, tō huha, tō ringa rānei o runga. Mā tō tākuta e ako i a koe, i tētahi mema rānei o te whānau, me pēhea te whakahaere tika i te werohanga, kia taea ai e koe te whakamahi i te wā ohorere. Me mā te wāhi werohanga, ā, me huri ngā wāhi ki te hiahia koe i ngā horopeta maha.

Kāore i rite ki te maha o ngā rongoā, kāore te icatibant e hiahia kia tangohia me te kai, te wai rānei, nā te mea ka werohia. Heoi anō, me penapena e koe te rongoā ki tō pouaka whakamātao, me tuku kia tae ki te pāmahana rūma i mua i te werohanga. Kaua rawa e rūrū te syringe, nā te mea ka pā kino tēnei ki te rongoā.

Mēnā kāore tō horopeta tuatahi e whai hua i muri i te 6 hāora, ka tūtohu pea tō tākuta i tētahi werohanga tuarua. E hiahiatia ana e ētahi tāngata tētahi horopeta tuatoru, engari me mahi tēnei i raro i te tirotiro hauora.

Kia Pēhea te Roa e Tangohia ai e Au te Icatibant?

Ka whakamahia te Icatibant i runga i te hiahia i te wā o ngā whakaeke HAE, kaua i te rongoā ā-rā hei ārai. Ka rongoatia ia whakaeke i te wehe, ā, ka whakamahi koe i te icatibant i te wā e pā ana koe ki ngā tohumate HAE kaha.

E kitea ana e te nuinga o te tāngata kotahi te werohanga e whai hua ana mō te whakaeke katoa, e mau ana te nuinga mō te 1-5 rā kāore he rongoā. Ki te icatibant, he maha ngā whakaeke ka ngaro wawe, i te nuinga o te wā i roto i te 4-8 hāora i muri i te werohanga.

E kore tō tākuta e whakahau i te icatibant mō te whakamahi ā-rā mō te wā roa. Engari, ka whakarite rātou kia whai koe i te rongoā mō ngā tūāhuatanga ohorere, ā, ka kōrero pea rātou mō ngā rongoā ārai mēnā ka pā koe ki ngā whakaeke auau.

He Aha ngā Pānga Taha o te Icatibant?

Pērā i ngā rongoā katoa, ka taea e te icatibant te pānga taha, ahakoa ka pai te nuinga o te tāngata ki te whakaaro ki te kaha o ngā whakaeke HAE. Ko ngā pānga taha tino noa he ngawari, he wā poto.

Koinei ngā pānga taha e pūrongotia ana e te nuinga ka pā pea ki a koe:

• Ngā pānga ki te wāhi werohanga tae atu ki te whero, te pūpū, te mamae ngawari rānei
• Māuiui, te mārō rānei
• Te whakapairuaki, te puku rānei
• Te ānini
• Kirika, te mahana rānei
• Ngenge, te ngenge rānei

Ko ēnei pānga taha noa ka ngaro noa iho i roto i ngā hāora torutoru, ā, he nui ake te whakahaere i te whakaeke HAE.

He onge ngā pānga taha nui ake, engari ka puta. Me rapu tonu koe i te āwhina hauora mēnā ka pā ki a koe:

• Ngā tauhohenga mate pāwera nui tae atu ki te uaua ki te hā, te pāhau whānui rānei
• Te mamae o te uma, te ngākau rānei e rere ana i te ara rerekē
• Te māuiui nui, te ngaro rānei
• Ngā tohu o te whiu pēnei i te ngoikore ohorere, te rangirua, te uaua rānei ki te kōrero
• Ngā tauhohenga nui ki te wāhi werohanga me te whero e horapa ana, te mahana rānei

Ko te nuinga o te tangata e kite ana he nui ake ngā painga o te icatibant i ngā tūponotanga, ina koa ka whakaarohia te kino o ngā whakaeke HAE kāore i rongoatia.

Ko wai kāore e tika kia tango Icatibant?

Kāore te Icatibant e tika ana mō te katoa, ā, ka āta arotake tō tākuta mēnā e tika ana mōu. Kāore te rongoā i te tūtohutia mō ngā tamariki kei raro i te 18 tau, nā te mea kāore anō kia whakatauhia te haumaru me te whai huatanga i roto i tēnei taupori.

Kāore koe e whakamahi i te icatibant mēnā he pāwera koe ki te rongoā, ki ētahi o ōna kai rānei. Kōrero atu ki tō tākuta mō ētahi tauhohenga o mua ki ngā rongoā rite, mēnā rānei he hītori tōu mō ngā mate pāwera rongoā nui.

Ko ngā tāngata e whai ana i ētahi āhuatanga ngākau ka hiahia pea ki te aroturuki motuhake i te wā e whakamahi ana i te icatibant. Ka tūpato tō tākuta mēnā he hītori tōu mō te mate ngākau, te whiu, te mate toto rānei.

Me whai whakaaro motuhake te hapū me te whāngai ū. Ahakoa kāore anō kia nui te rangahau i te icatibant i roto i ngā wahine hapū, ka whakataurite tō tākuta i ngā painga ka puta ki ngā tūponotanga mēnā kei te hapū koe, ā, kei te pā ki a koe ngā whakaeke HAE nui.

Ingoa Waitohu Icatibant

Kei te hokona a Icatibant i raro i te ingoa waitohu Firazyr i te nuinga o nga whenua, tae atu ki te United States me Europe. Koinei te ingoa waitohu tuatahi ka tutaki koe i te wa e tohutohu ana to taakuta i tenei rongoa.

Na Takeda Pharmaceuticals i hanga a Firazyr, ka tae mai i roto i te syringe kua whakakiia i mua i te 30 mg o te icatibant. Ko te kete kikorangi me te ma e ngawari ana te mohio mo nga ahuatanga ohorere.

I tenei wa, karekau he momo generic o te icatibant e waatea ana, no reira ko Firazyr anake te whiringa mo tenei rongoa motuhake. Ma to inihua me nga painga o te whare rongoa e whakatau nga utu ka utua e koe mo tenei maimoatanga motuhake.

Nga Whakaaro ke atu ki a Icatibant

He maha atu ano nga rongoa ka taea te rongoa i nga whakaeke HAE, ahakoa he rereke te mahi a ia, a tera pea e pai ake mo nga ahuatanga rereke. Ma to taakuta e awhina ki te whakatau ko wai te whiringa pai mo o hiahia motuhake.

Ko te Ecallantide (ingoa waitohu Kalbitor) tetahi atu rongoa werohanga e mahi ana ma te aukati i te kallikrein, he enzyme e uru ana ki nga whakaeke HAE. Kaore i rite ki te icatibant, me hoatu te ecallantide e te kaiwhakarato hauora na te mea he nui ake te tupono o nga tauhohenga mate pāwera nui.

Ko nga kukume aukati C1 esterase, e waatea ana hei Berinert, Cinryze, Ruconest ranei, e mahi ana ma te whakakapi i te pūmua e ngoikore ana, e kore ranei e mahi i roto i te HAE. Ka tukuna enei rongoa ma te uaua, ka taea te whakamahi mo te rongoa i nga whakaeke me te aukati i a raatau.

I whakamahia te plasma hou i mua i te wa i waatea ai enei rongoa hou, engari inaianei ka kiia he whiringa iti na te tupono o nga mate e pa ana ki te toto me te rereke o te whai huatanga.

He pai ake a Icatibant i te Ecallantide?

He rongoa whai hua a Icatibant me te ecallantide mo nga whakaeke HAE, engari he painga motuhake o ia tangata i runga i to ahuatanga. Ko te whiringa i waenga i a raatau ka heke iho ki te waatea, nga whakaaro haumaru, me to urupare takitahi.

Ko te painga nui o Icatibant ko te mea ka taea e koe te whakahaere i a koe i te kainga, he mea nui i nga wa ohorere ka uaua pea te tae wawe atu ki te hōhipera. He iti ake hoki te tupono o nga tauhohenga mate pāwera nui ki te ecallantide.

Ka tere ake pea te mahi a Ecallantide i roto i etahi tangata, a he tino whai hua mo etahi momo whakaeke HAE. Heoi, me hoatu e te kaiwhakarato hauora na te mea ka tupono ka puta te anaphylaxis, e whakaiti ana i tana whakamahinga i nga ahuatanga ohorere o te kainga.

Ka whakaarohia e to taakuta nga mea penei i to oranga, te auau o te whakaeke, te uru ki te manaaki hauora, me nga hiahia whaiaro i te wa e taunaki ana i waenga i enei whiringa. He maha nga tangata e kite ana he pai ake te icatibant mo te whakamahi ohorere, i te mea ka pai etahi atu ki te ecallantide mo nga whakaeke ka puta i nga waahi rongoa.

Nga Pātai e Pātai pinepine ana mo Icatibant

He Haumaru te Icatibant mo te Mate Ngakau?

Ka taea e nga tangata e mate ana i te ngakau te whakamahi i te icatibant, engari me ata tirotirohia, me te aro turuki. Ka taea e te rongoa te pa ki te toto me te manawataki o te ngakau i roto i etahi tangata, no reira me mahi tahi to tohunga ngakau me te tohunga HAE.

Ka arotakehia e to taakuta to ahuatanga ngakau, nga rongoa o naianei, me te hauora katoa i mua i te whakahau i te icatibant. Ka tohutohu pea ratou i etahi atu aroturuki, i etahi atu rongoa ranei mena he kino, he kore ranei to ahuatanga ngakau.

He maha nga tangata e mate ngakau ngawari ana ki te ngawari kua whakamahi i te icatibant mo nga whakaeke HAE. Ko te mea nui ko te whakawhitiwhiti korero me to roopu hauora mo o ahuatanga hauora katoa me nga rongoa.

Me aha ahau ki te whakamahi pohehe ahau i te nui rawa o te Icatibant?

Mena ka werohia e koe te nui rawa o te icatibant i whakaritea, whakapā atu ki to taakuta, ki nga ratonga ohorere ranei. Ahakoa he onge te nui o te horopeta na te hoahoa syringe kua whakakiia i mua, ko te nui rawa o te tango ka piki ake to tupono ki nga paanga taha.

Mātai pū te āhua o tō tinana mō ngā tohu pērā i te whanoke nui, te whakapairuaki, ngā pānga rānei i te wāhi werohanga. Kaua e ngana ki te whakawātea i te horopeta nui i runga i a koe anō, tērā pea ka uaua ake tō rongoā.

Puritia te pōkai rongoā, ka mau ki te hōhipera kia kite ngā kaiwhakarato hauora i te aha me te nui i tangohia e koe. He mea nui te wā, no reira kaua e whakaroa ki te rapu āwhina hauora mēnā e māharahara ana koe mō te horopeta nui.

Me Pēhea Taku Mahi Mēnā Kua Ngaro Taku Inenga Icatibant?

I te mea ka whakamahia te icatibant i ngā wā o te whakaekenga HAE anake, kaua i runga i te hōtaka, kāore e taea e koe te

Āe, ka taea e koe te haere me te icatibant, engari me whakamahere i mua i te mea me whakamatao te rongoa, ā, me mau e koe ngā taputapu werohanga. Te nuinga o ngā kamupene rererangi e whakaae ana ki ngā rongoā e tika ana i te taha hauora i roto i ngā pēke kawe me ngā tuhinga tika.

Me mau mai he reta mai i tō tākuta e whakamārama ana i tō āhua me te hiahia ki te rongoā. Whakakīa te icatibant ki roto i tētahi pēke whakawera me ngā pōkai huka, ā, whakaarohia te mau mai i ētahi atu taputapu mō te wā e roa ai te haere.

Rangahaua ngā whare hauora i tō ūnga mō te wā e hiahia ana koe ki te tiaki ohorere, ki ētahi atu rongoā rānei. He maha ngā tohunga HAE e āhei ana ki te tohutohu i te haere haumaru me tō āhua me ngā rongoā.