He aha te Whakauru Levodopa: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu

Ko te whakauru Levodopa he rongoā whakahirahira e tuku ana i te levodopa ki ō pūkahukahu mā te pūrere whakauru motuhake. Mā tēnei rongoā auaha e āwhina ana i te hunga e mate ana i te mate o Parkinson ki te whakahaere i ngā wā "whakaweto" ohorere i te wā e kore ai ā rātou rongoā waha e whakarato i te whakahaere tohu e tika ana.

Kāore i rite ki ngā pire levodopa tuku iho me haere mā tō punaha kūnatu, ka tere te uru o te āhua whakauru ki tō toto mā ō pūkahukahu. Mā tēnei tuku tere e āwhina ana ki te whakahoki i tō nekehanga me te whakaiti i te mārō i roto i ngā meneti, kaua ki te tatari 30-60 meneti kia whai pānga ai ngā rongoā waha.

He aha te Whakauru Levodopa?

Ko te whakauru Levodopa he āhua paura maroke o te levodopa e hāpai ana koe mā te whakamahi i tētahi whakauru motuhake e kīia ana ko te pūrere Inbrija. He mea hanga motuhake hei rongoā whakaora mō te hunga e mate ana i te mate o Parkinson e pā ana ki ngā wā "whakaweto" e kore e taea te matapae puta noa i te rā.

Kei roto i te rongoā te whakauru kaha kotahi i roto i ngā pire levodopa waha, engari he mea hanga hei matūriki iti ka taea te uru mā tō kiko pūkahukahu. I te wā e hāpai ana koe i te paura, ka tere te uru ki tō toto me te haere ki tō roro, kei reira ka huri ki te dopamine hei āwhina i te whakapai ake i ō tohu motuka.

I whakaaetia tēnei āhua whakauru e te FDA i te tau 2018 hei rongoā whakauru tuatahi me te rongoā anake mō ngā wā whakaweto o te mate o Parkinson. Ko te tikanga kia mahi tahi me āu rongoā Parkinson waha, kaua e whakakapi katoa.

He aha te Whakamahinga o te Whakauru Levodopa?

Ka whakamahia te whakauru Levodopa ki te rongoā i ngā wā "whakaweto" i roto i te hunga e mate ana i te mate o Parkinson e tango ana i te rongoā carbidopa/levodopa. Ko ngā wā whakaweto he wā e ngaro ai tō rongoā i te pānga, ka hoki mai, ka kino rānei ō tohu Parkinson.

I ngā wā okiokinga nei, ka piki ake pea ō wiri, te mārō o ngā uaua, te pōturi o te neke, te uaua rānei ki te hikoi. Ka pā ēnei wāhanga i te wā e kore e kitea i te roanga o te rā, ahakoa kei te tango koe i ō rongoā waha i te mea i whakaritea. Ka whai wāhi te levodopa i te hā ki te whakatau tere i te wā e puta ana ēnei tohu.

Ka tohua anake tēnei rongoā e tō tākuta mēnā kua whakatūria kē koe ki runga i te hōtaka tūmau o te carbidopa/levodopa waha. Kāore i te whakaaro mō te hunga i te wā i kitea ai te mate o Parkinson, mō te hunga rānei kāore anō i whakamātau i te rongoā levodopa waha i te tuatahi.

Me pēhea te mahi a te Levodopa i te hā?

Ka mahi te levodopa i te hā mā te tuku rongoā tika ki ō pūkahukahu, kei reira ka tere te uru ki roto i ō toto. Ka karo katoa tēnei i tō pūnaha kūnatu, koinei te take e tere ake ai te mahi i ngā rongoā waha.

Kia tae te levodopa ki tō roro, ka huri ki te dopamine e tētahi enzyme e kīia ana ko te aromatic L-amino acid decarboxylase. Ko te Dopamine te neurotransmitter e āwhina ana ki te whakahaere i te neke, ā, ko te hunga e mate ana i te mate o Parkinson kua heke te taumata o tēnei matū nui i roto i ō rātou roro.

Ko te āhua i te hā e whakaarohia ana he rongoā kaha-āhua e whai wāhi ana i te wā poto, kaua i te whakahaere tohu wā-roa. Ka tīmata te mahi i roto i te 10-15 meneti, ā, ka whai wāhi i te whakapai ake i ngā tohu mō te 1-2 haora, e whai wāhi ana ki a koe mō tō horopeta waha e whai ake nei kia whai pānga.

Me pēhea taku tango i te Levodopa i te hā?

Me tango e koe te levodopa i te hā i te mea i tohua e tō tākuta, mā te whakamahi anake i te pūrere Inbrija inhaler motuhake e haere tahi ana me tō rongoā. Ko te horopeta paerewa ko te pōkai kotahi (84 mg) i te hā i te wā e pā ana ki a koe tētahi wāhanga okiokinga, me te nui rawa o te 5 horopeta ia rā.

I mua i te whakamahi i te inhaler, kia mōhio he ma, he maroke ō ringaringa. Tangohia tētahi pūtau mai i te pōkai pūpū i mua noa i te whakamahi, ka whakatakoto ki roto i te rūma inhaler. Puritia te pūrere ki runga, whakapūhā katoa, ka whakatakoto ō ngutu ki te waha, ka hā mai i te hōhonu, i te tere hoki kia mōhio ka whiwhi koe i te horopeta katoa.

Ka taea e koe te whakamahi i tēnei rongoā me te kore kai rānei, ā, kāore koe e hiahia ki te inu wai i mua, i muri rānei i te hā. Heoi, he mea nui ki te horoi i tō waha ki te wai i muri i ia whakamahinga kia tangohia ngā puehu e toe ana, kia whakaiti i te tūponotanga o te riri i te korokoro. Kaua e kai, e inu rānei i tētahi mea mō te 5 meneti i muri i te tango i tō horopeta.

Kia mau tonu tō inhaler me ngā pūtau ki te wāhi maroke i te pāmahana rūma. Kaua rawa e horoi i te pūrere inhaler ki te wai, ka whakakapi i te mea e ai ki ngā tohutohu a tō tākuta, te tikanga ia marama torutoru.

Kia Pēhea te Roa e Tango Ai au i te Hā Levodopa?

Me haere tonu koe ki te tango i te hā levodopa i te roa e tūtohu ana tō tākuta, ko te tikanga i te roa e pā ana koe ki ngā wāhanga o waho me tō mate Parkinson. I hangaia tēnei rongoā mō te whakamahi wā-roa hei rongoā whakaora i te taha o ō rongoā waha auau.

Ka arotakehia e tō tākuta i ngā wā katoa mēnā kei te āwhina tonu te levodopa i ngā tohumate, ā, ka whakatika pea i tō mahere rongoā Parkinson whānui i te roanga o te wā. Ko ētahi tāngata ka hiahia ki te whakamahi i te maha o ngā wā i te rā, i te mea ko ētahi atu ka hiahia anake i te wā e puta ana ngā wāhanga o waho.

E whakawhirinaki ana te roa o te rongoā ki te pēhea te haere o tō mate Parkinson, me te pai o ō rongoā atu e whakahaere ana i ō tohumate. Kaua rawa e mutu te whakamahi i tēnei rongoā ohorere me te kore e kōrero tuatahi ki tō tākuta, nā te mea ka puta tēnei ki te kino o ō tohumate.

He Aha ngā Pānga Taha o te Hā Levodopa?

Pērā i ngā rongoā katoa, ka pānga ngā pānga taha ki te whakauru levodopa, ahakoa he maha ngā tāngata e pai ana ki te whakamahi. Ko ngā pānga taha e tino kitea ana he ngawari noa iho, ā, e pā ana ki te tukanga whakauru.

Me titiro ki ngā pānga taha ka pā ki a koe, ka tīmata mai i ngā mea e tino kitea ana e pā ana ki tō pūnaha manawa:

• Kōroke (e pā ana ki te 15% o ngā tāngata)
• Mate i te ara manawa o runga
• Te riri, te mamae rānei o te korokoro
• Te huringa tae o te hūpē (ka pouri ake pea tō hūpē)
• Te reo kāre, te huringa rānei o te reo

Ko ēnei pānga ki te manawa ka puta mai i te mea ka riri te paura i ō ara manawa, engari he ngawari noa iho, he wā poto. Mā te horoi i tō waha i muri i ia whakamahinga ka āwhina i te whakaiti i te riri o te korokoro.

I tua atu i ngā pānga ki te manawa, ka pā pea ki a koe ngā pānga taha e rite ana ki ērā mai i ngā rongoā levodopa waha:

• Te whakapairuaki, te pōhara rānei o te puku
• Te whanoke, te māmā rānei o te mahunga
• Dyskinesia (ngā nekehanga kore e hiahiatia)
• Ngā pōhewa, te raruraru rānei
• Ngā huringa i te pēhanga toto

Ka puta ēnei pānga nā te mea ka pānga te levodopa ki tō tinana katoa i te wā e uru ana ki tō toto, ehara i te roro anake.

Ko ētahi pānga taha onge engari he nui te kino me whai wāhi tonu mai te rongoā. Kei roto i ēnei ko te uaua ki te manawa, te mamae o te uma, ngā huringa nui i te manawataki o te ngākau, te ohorere rānei o te moe nui. Ki te pā ki a koe ētahi o ēnei tohumate, whakapā atu ki tō tākuta tonu, rapu rānei i te rongoā ohorere.

Ko wai kāore e tika kia tango i te whakauru Levodopa?

He maha ngā rōpū tāngata kāore e tika kia whakamahi i te whakauru levodopa nā te āwangawanga haumaru. Ka āta arotake tō tākuta mēnā e tika ana tēnei rongoā mō tō āhuatanga motuhake.

Ko ngā tāngata e pā ana ki ētahi āhuatanga o te pūkahukahu me karo i tēnei rongoā nā te mea ka kino ake pea ā rātou raruraru manawa mā te whakauru i te paura:

• Te mate huango kaha, he hītori rānei mō ngā whakaeke huango
• Te mate pūkahukahu aukati mau tonu (COPD)
• Ētahi atu mate pūkahukahu mau tonu e pā ana ki te hā
• Ngā mate manawa tata nei, te pūkahukahu rānei

Ka taea e ngā matūriki paura te whakaoho i ngā uaua ki te hā, te whakapōrearea rānei i te mumura o te pūkahukahu i ēnei āhuatanga.

I tua atu, ko ētahi āhuatanga hauora me ngā pānga o ngā rongoā ka kore e haumaru te ngōtanga o te levodopa:

• Ngā tāngata e tango ana i ngā aukati monoamine oxidase (MAOIs) i roto i ngā rā 14 kua pahure
• Ko te hunga e whai glaucoma koki whāiti ana
• Ngā tāngata e whai whara kiri whakapae ana, he hītori rānei mō te melanoma
• Ngā tāngata e whai mate ngākau nui ana, he whakaeke ngākau tata nei rānei
• Ngā tāngata e whai mate tākihi, ate rānei (ka hiahiatia pea ngā whakatikatika horopeta)

Ka whakaaro hoki tō tākuta ki tō tau, ētahi atu rongoā, me te āhua o tō hauora whānui i mua i te whakarite i tēnei rongoā.

Ingoa Waitohu mō te Ngōtanga Levodopa

Ko te ingoa waitohu mō te ngōtanga levodopa ko Inbrija, he mea hanga e Acorda Therapeutics. Koinei anake te momo levodopa e ngōtatia ana kua whakaaetia e te FDA e wātea ana i te United States.

Ka tae mai a Inbrija hei pūnaha oti e uru ana ngā pūtau paura maroke me te pūrere ngōtanga motuhake. Kāore e taea e koe te whakamahi i ngā pūtau me ētahi atu momo ngōtanga, ā, kāore e taea e koe te whakamahi i ētahi atu rongoā me te pūrere ngōtanga Inbrija.

E wātea ana te rongoā mā te whakahaunga anake, ā, ko te tikanga ka hipokina e te nuinga o ngā mahere inihua mō ngā tāngata e whai mate Parkinson e tutuki ana i ngā paearu motuhake mō tōna whakamahinga.

Ngā Kōwhiringa kē mō te Ngōtanga Levodopa

Mēnā kāore te ngōtanga levodopa e tika ana mōu, he maha ētahi atu kōwhiringa hei whakahaere i ngā wā o te mate Parkinson. Ka taea e tō tākuta te āwhina i a koe ki te tūhura i ēnei kōwhiringa i runga i ō hiahia motuhake me tō hītori hauora.

Ko ētahi atu rongoā tere mō ngā wā o te mate ko:

• Ngā werohanga Apomorphine (Apokyn) - ka mahi i roto i te 10-20 meneti
• Ngā rīpene apomorphine sublingual (Kynmobi) - ka rewa i raro i tō arero
• Levodopa/carbidopa waha tuku tonu - ahakoa he puhoi ake i ngā momo whakauru
• Te whakatikatika i te wā, i te horopeta rānei o tāu rongoā waha auau

E mahi ana ēnei momo rongoā kē mā ngā tikanga tuku rerekē engari ko te whāinga kia whakahokia ngā taumata dopamine i roto i tō roro.

Mō ētahi tāngata, ko te arotau i tā rātou rongoā waha auau ka nui pea hei whakaiti i ngā wā o waho. Ka taea e tēnei te huri ki ngā hanganga tuku roa, te tāpiri i ētahi atu rongoā Parkinson pēnei i ngā kaiwhakahohe dopamine, te whakatikatika rānei i te wā kai hei whakapai ake i te urunga o te rongoā.

He pai ake te whakauru Levodopa i te Levodopa waha?

Kāore i te pai ake te whakauru Levodopa i te levodopa waha, engari he rerekē te kaupapa i roto i tāu mahere maimoatanga whānui. I hangaia te momo whakauru hei whakakī i ō rongoā waha auau, kaua hei whakakapi katoa.

Ko te painga nui o te levodopa whakauru ko te tere. Ahakoa te 30-60 meneti te roa o te levodopa waha ki te mahi, ka timata te mahi o te momo whakauru i roto i te 10-15 meneti. Nō reira he mea nui mō te whakahaere i ngā wā o waho e kore e tatari ana ka hiahia koe ki te āwhina tere.

Heoi anō, ko te levodopa waha te tūāpapa o te nuinga o ngā mahere maimoatanga Parkinson nā te mea e whakarato ana i te whakahaere tohumate roa puta noa i te rā. E mahi ana te momo whakauru mō te 1-2 haora noa iho, nō reira kāore i te tika hei rongoā tuatahi.

Ka āwhina tō tākuta i a koe ki te whakatau i te huinga rongoā pai rawa atu i runga i ō tauira tohumate, te oranga, me te pai o tō whakamanawanui i ngā maimoatanga rerekē. He maha ngā tāngata e kite ana ko te whakamahi i ngā momo e rua ngātahi e whakarato ana i te whakahaere tohumate tino whānui.

Ngā Pātai Auau mō te Whakauru Levodopa

He haumaru te Whakauru Levodopa mō ngā tāngata e mate ana i te ngākau?

Me mātua whakaaroaro te whakauru i te levodopa mēnā he mate tō ngākau. Ka pā te rongoā nei ki te tere o tō ngākau me te pēhanga toto, ka puta pea ngā raruraru ki ngā tāngata e pāngia ana e te mate ngākau.

Me aromatawai tō tākuta i tō āhuatanga ngākau me ngā rongoā e inu ana koe i mua i te whakahau i te levodopa e whakauruhia ana. Ka tūtohu pea rātou i te aroturuki atu i tō ngākau, i te whakatika rānei i ō rongoā ngākau kia mōhio ai kei te haumaru te whakamahi. I ētahi wā, me karo pea e ngā tāngata e pāngia ana e te mate ngākau nui tēnei rongoā.

Me pēhea taku mahi mēnā ka whakamahi au i te nui rawa o te whakauru Levodopa?

Mēnā ka whakauru koe i te nui rawa atu i tō horopeta i whakahaua, whakapā atu ki tō tākuta, ki te pūtau whakahaere paitini rānei i te wā tonu. Ko te inu i te nui rawa o te levodopa ka puta ngā pānga taha nui tae atu ki te whakapairuaki nui, te ruaki, te ngākau pōrearea, te pohehe, te moe nui rānei.

Kaua e ngana ki te ruaki i a koe anō, kāore hoki tēnei e āwhina ki te tango i te rongoā kua mimiti kē i ō pūkahukahu. Aroturukitia koe mō ngā tohumate rerekē, ā, rapua te manaakitanga hauora ohorere mēnā ka pā te mamae o te uma, te uaua ki te hā, te ngaro rānei o te mahara.

Me pēhea taku mahi mēnā ka ngaro au i tētahi horopeta o te whakauru Levodopa?

Mēnā ka ngaro koe i tētahi horopeta i te wā o te wāhanga kore, ka taea e koe te tango i te wā tonu e mahara ana koe, i te mea kāore koe e neke ake i te 5 horopeta i te rā kotahi. Kāore i rite ki ngā rongoā kua whakaritea, ka whakamahia te whakauru levodopa i te mea e hiahiatia ana mō ngā tohumate pakaru.

Kaua e tango i ngā horopeta atu hei whakakī i ngā mea i ngaro, ā, me whakatakoto tonu ō horopeta kia 2 haora te wā i waenga. Mēnā kei te maha ngā wāhanga kore e ngaro ana koe i ngā whai wāhitanga ki te rongoā, kōrerohia tēnei ki tō tākuta i te mea ka hiahia koe ki te whakatika i ō rongoā waha.

Āhea au e mutu ai te tango i te whakauru Levodopa?

Ka taea e koe te whakamutu i te tango i te levodopa inhalation ina whakatau koe me tō tākuta kāore koe e hiahia ana ki te whakamahi i te rongoā nei mō te whakahaere i ngā wā o waho. Ka tupu pea tēnei mehemea ka whakatikahia ō rongoā waha, ā, ka pai ake te whakahaere i ngā tohumate, mehemea rānei ka iti ake te auau, te kaha rānei o ō wā o waho.

Me kōrero tonu ki tō tākuta i mua i te whakamutu i tēnei rongoā, kaua e whakamutu noa i a koe anō. Ka taea e rātou te āwhina i a koe ki te arotake mehemea kei te whai hua tonu te rongoā, ā, ka ārahi i a koe i roto i ngā whakatikatika e tika ana ki tō mahere maimoatanga whānui.

Ka taea e au te haereere me te Levodopa Inhalation?

Āe, ka taea e koe te haereere me te levodopa inhalation, engari me whai koe i ētahi whakatūpato anō. Me mau tonu tō rongoā i roto i tōna pōkai taketake me te tapanga whakahaunga, me te kawe mai i tētahi reta mai i tō tākuta e whakamārama ana i tō hiahia hauora mō te pūrere inhaler.

I te wā e rere ana, waiho tō rongoā ki tō pēke kawe-ā-ringa, kaua ki te pēke i te wāhi uta hei karo i ngā pāmahana nui me te ngaronga pea. Ka whakaae te TSA ki ngā inhalers rongoā mā roto i te haumarutanga, engari mā te whai tuhinga ka tere ake te tukanga arotake. Whakaarohia te kawe mai i ētahi pūtau anō mō ngā whakaroa haerenga.