He aha te Lifitegrast: Ngā Whakamahinga, te Inenga, ngā Pānga Taha me Ētahi Atu

Ko te Lifitegrast he rongoā tōtō kanohi i runga i te whakahaunga e āwhina ana ki te rongoā i te mate kanohi maroke mā te whakaiti i te mumura i runga i te mata o ō kanohi. He rerekē te mahi o tēnei rongoā i ngā roimata horihori mā te aro ki tētahi o ngā take pūtake o te kanohi maroke, kaua ki te whakarato i te makuku rangitahi noa.

Mēnā kei te raru koe i te kanohi maroke, riri tonu, e kore nei e pai ake mā ngā tōtō rongoā kore-whakahaunga, tērā pea i tūtohu tō tākuta kanohi i te lifitegrast hei whiringa rongoā e whai ana i te whāinga. Me haere tātou i ngā mea katoa e hiahia ana koe ki te mōhio mō tēnei rongoā i roto i ngā kupu māmā.

He aha te Lifitegrast?

Ko te Lifitegrast he tōtō kanohi anti-mumura e noho ana ki tētahi rōpū rongoā e kīia ana ko te lymphocyte function-associated antigen-1 (LFA-1) antagonists. I roto i ngā kupu māmā, he rongoā motuhake tēnei e aukati ana i ētahi tohu pūnaha ārai mate e whai wāhi ana ki te mumura me te maroke o te kanohi.

Kāore i rite ki ngā roimata horihori noa e tāpiri ana i te makuku ki ō kanohi, ka mahi te lifitegrast ki te whakamārie i te tukanga mumura e pā ana ki ō tohumate kanohi maroke. Whakaarohia he rongoā i te raruraru i raro iho, kaua ki te huna noa i ngā tohumate.

Ka tae mai tēnei rongoā hei otinga mārama, koretake e whakamahia ana e koe ki ō kanohi mā te whakamahi i ngā pounamu kotahi-whakamahi. Kei ia pounamu tētahi inenga tika, e āwhina ana ki te ārai i te whakapoke me te whakarite kei te whiwhi koe i te nui tika o te rongoā.

He aha te Lifitegrast e Whakamahia Ana?

Ko te Lifitegrast te mea nui e whakamahia ana ki te rongoā i te mate kanohi maroke, e mōhiotia ana ko te keratoconjunctivitis sicca. Ka puta tēnei āhuatanga ka kore ō kanohi e whakaputa i ngā roimata nui, i te wā rānei ka tere rawa te ngaro o ngā roimata, ka waiho ō kanohi kia maroke, kia rakuraku, kia kore e pai.

Ka tohua pea e tō tākuta te lifitegrast mēnā ka pā ki a koe ngā tohumate e mau tonu ana kāore i pai ake mā te roimata horihori, ētahi atu rānei rongoā taketake. Ko ēnei tohumate ko te nuinga o te wā he ahua kirikiri, onepu rānei i ō kanohi, he pānga wera, he ngau rānei, he whero, ā, i ētahi wā ka nui rawa te roimata i te mea e ngana ana ō kanohi ki te utu i te maroke.

I hangaia te rongoā mō te mate kanohi maroke āhua ki te kaha, i te wā e whai wāhi nui ana te mumura. He tino whai hua mō te hunga he kanohi maroke nā ngā āhuatanga pēnei i te mate a Sjögren, te korenga o te repe meibomian, ētahi atu rānei āhuatanga mumura e pā ana ki te mata o te kanohi.

Me pēhea te mahi a Lifitegrast?

Ka mahi a Lifitegrast mā te aukati i ngā ara motuhake o te pūnaha ārai mate e whai wāhi ana ki te mumura o te kanohi. E aro ana ki tētahi mea e kiia nei ko LFA-1, he pūmua tēnei e āwhina ana i ngā pūtau ārai mate ki te piri me te whakangaro i te mata o ō kanohi i te wā o ngā urupare mumura.

Ka puta te mumura i ō kanohi, ka kaha rawa ētahi pūtau ārai mate, ka tīmata ki te whakaeke i te kiko kanohi hauora. Ka mahi a Lifitegrast pēnei i te pūwāhi ngawari i tēnei tukanga, e ārai ana i ēnei pūtau ārai mate mai i te whakangaro atu i ō repe whakaputa roimata me te mata o te kanohi.

E kiia ana he āhua kaha tēnei rongoā i te taha o ōna pānga anti-mumura. He nui ake te aro i ngā rongoā anti-mumura whānui, ko te tikanga ka whai hua i te wā e iti ana te pānga taha i ngā rongoā kaha ake. Ka tīmata te nuinga o te tangata ki te kite i ngā whakapainga i ō rātou tohumate i roto i te 2-4 wiki o te whakamahi auau.

Me pēhea taku tango i te Lifitegrast?

Me whakamahi te Lifitegrast i te mea i tohua e tō tākuta kanohi, te nuinga o te wā kotahi topata ki ia kanohi e pā ana e rua ngā wā i te rā, tata ki te 12 hāora te wā i waenga. Ka tae mai te rongoā i roto i ngā pounamu iti, kotahi te whakamahi e hiahia ana koe ki te whakatuwhera hou mō ia horopeta.

Anei me pēhea te tono i ngā topata i runga i te haumaru me te whai hua:

1. Horoi tino pai ō ringa i mua i te whakahaere i te rongoā
2. Tangohia ō arotahi mēnā kei te mau koe (tatari kia 15 meneti i muri i te whakamahi i ngā topata i mua i te whakahoki mai)
3. Whakatuwherahia he pounamu hou mā te whiri i te tihi
4. Whakaheke paku i tō upoko, ka tōia marie iho tō kamo o raro
5. Puritia te pounamu ki runga ake i tō kanohi, ka kōpeke marie kia tukuna kia kotahi topata
6. Katia tō kanohi mō te 30 hēkona pea hei āwhina i te horapa o te rongoā
7. Maka atu te pounamu i muri i te whakamahi, ahakoa he rongoā kei roto

Ka taea e koe te whakamahi i te lifitegrast me te kore rānei he kai, i te mea ka whakamahia tika ki ō kanohi, kaua ki te waha. Mēnā me whakamahi koe i ētahi atu rongoā kanohi, tatari kia 5 meneti i waenga i ngā topata rerekē hei ārai i a rātou kia kaua e horoi tētahi i tētahi.

Whakamātauria te whakamahi i ō horopeta i ngā wā rite tonu i ia rā kia mau tonu te taumata o te rongoā i ō kanohi. He maha ngā tāngata e kite ana he āwhina ki te here i ā rātou horopeta ki ngā mahi o ia rā pēnei i te parai i ō rātou niho i te ata me te ahiahi.

Kia Pēhea te Roa e Whakamahi ai au i te Lifitegrast?

He rerekē te roa o te maimoatanga ki te lifitegrast mai i te tangata ki te tangata, engari ko te nuinga o ngā tāngata me whakamahi mō te 3-6 marama pea kia kite i te whakapai ake i ngā tohu o ō rātou kanohi maroke. Ko ētahi tāngata me whakamahi mō te wā roa kia mau tonu ā rātou hua.

Ko te tikanga ka hiahia tō tākuta kanohi ki te kite i a koe i muri i te 6-8 wiki pea o te maimoatanga kia arotakehia te pai o te mahi o te rongoā mōu. I tēnei haerenga, ka tirohia e rātou ngā whakapainga i ō tohu me te tātari i ō kanohi kia kite mēnā kei te heke te mumura.

He mea nui ki te whakamahi tonu i te lifitegrast ahakoa kāore koe e kite i te whakapai ake tonu. Kāore i rite ki ngā roimata horihori e whakarato ana i te āwhina tonu, ko ngā rongoā anti-inflammatory pēnei i te lifitegrast e mahi ana i te wā hei whakatika i ngā take o ō kanohi maroke. Ko te nuinga o ngā tāngata ka tīmata ki te wheako i ngā painga ka kitea i muri i te 2-4 wiki o te whakamahi tonu.

Kaua e whakamutua te whakamahi i te lifitegrast ohorere me te kore e kōrero tuatahi ki tō tākuta. Mēnā ka whakamutua ohoreretia te rongoā, ka hoki mai pea ō tohu kanohi maroke i te hokinga mai o te mumura.

He aha ngā pānga taha o te Lifitegrast?

He pai te whakamanawanui a te nuinga o te tāngata ki te lifitegrast, engari pērā i ngā rongoā katoa, ka pānga taha pea ki ētahi tāngata. Ko ngā pānga taha tino noa he ngawari noa iho, ā, ka pai ake i te wā e urutau ana ō kanohi ki te rongoā.

Koinei ngā pānga taha e pūrongotia ana i te nuinga o te wā:

• Te wera, te ngau rānei mō te wā poto i te wā tuatahi ka whakamahi koe i ngā topata
• Te pāhoro o te tirohanga mō ētahi meneti i muri i te whakamahinga
• Te riri, te whero rānei o te kanohi
• Te reka rerekē i tō waha (ka pā tēnei nā te mea ka rere te rongoā mā ō rāpoi roimata)
• Te ānini
• Te nui haere o te roimata i te tīmatanga

Ko ēnei pānga taha noa ka iti ake te kitea i te wā e whakamahi tonu ana koe i te rongoā. Ko te ngau, i te nuinga o te wā, ka tino iti ake i muri i ngā rā tuatahi o te whakamahinga.

Ko ngā pānga taha kāore i te noa engari he nui ake te kino, ka uru pea te mamae nui o te kanohi, ngā huringa o te tirohanga, ngā tohu rānei o te tauhohenga pāwera pērā i te pūhihi huri noa i ō kanohi, te uaua ki te hā, te pūhihi whānui rānei. Mēnā ka pā ki a koe ētahi o ēnei tohu, whakapā atu ki tō tākuta tonu.

Ka pā pea ki ētahi tāngata te rerenga mai i ō rātou kanohi, te nui haere rānei o te tairongo ki te mārama. Ahakoa kāore ēnei i te mōrearea, ka raru pea, ā, me kōrero ki tō kaiwhakarato tiaki kanohi.

Ko wai kāore e tika kia tango i te Lifitegrast?

Kāore te Lifitegrast i te pai mō te katoa, ā, ka whakaaro tō tākuta i ētahi mea i mua i te whakahau. Kāore te rongoā i te tūtohutia mō te hunga kua whakaatu i ngā tauhohenga pāwera ki te lifitegrast, ki ōna kai rānei.

Me kōrero koe ki tō tākuta mēnā kei a koe ētahi o ngā āhuatanga e whai ake nei i mua i te tīmatanga o te lifitegrast:

• Ngā mate kanohi kaha (pūhuruhuru, huaketo, harore rānei)
• Ngā pokanga kanohi, whara rānei i tērā wā
• Te hapū, ngā mahere rānei kia hapū
• Te whāngai ū
• Ētahi atu āhuatanga kanohi nui atu i te mate kanohi maroke

Kāore anō kia tino whakatūria te haumaru o te lifitegrast i te wā o te hapū me te whāngai ū, nō reira ka tātai tō tākuta i ngā painga ka puta ki ngā tūponotanga ka puta. Mēnā kei te ngana koe ki te hapū, ka kitea rānei kua hapū koe i te wā e whakamahi ana koe i te lifitegrast, kōrerohia tēnei ki tō kaiwhakarato hauora tonu.

Kāore ngā tamariki me ngā taiohi kei raro i te 18 tau e whakamahi i te lifitegrast, nā te mea kāore anō kia whakatūria tōna haumaru me tōna whai huatanga i ngā rōpū reanga tamariki. Kua whakaaetia te rongoā mō te whakamahi a ngā pakeke anake.

Ngā Ingoa Waitohu o Lifitegrast

Kei te wātea te Lifitegrast i raro i te ingoa waitohu Xiidra, e hangaia ana e Novartis. Koinei anake te putanga ingoa waitohu o te lifitegrast e wātea ana i te United States.

Ka tae mai a Xiidra i roto i ngā ipu whakamahi kotahi kei roto i te 5% otinga lifitegrast. Ko te nuinga o ngā pouaka kei roto i te 60 ipu, e whakarato ana i te rāhui mō te marama kotahi ina whakamahia e rua ngā wā ia rā i te mea kua tohua.

Kāore anō kia wātea ngā putanga whānui o te lifitegrast, ko te tikanga ko Xiidra anake te kōwhiringa mō tēnei rongoā motuhake. Heoi, tērā pea he ētahi atu kōwhiringa pai ake ā tō inihua, tērā pea ka tūtohu tō tākuta i ētahi atu rongoā kanohi maroke mēnā he take te utu.

Ngā Kōwhiringa kē mō Lifitegrast

Mēnā kāore te lifitegrast i te tika mōu, kāore rānei e whakarato i te whakamaunga tika, he maha ngā rongoā kē e wātea ana mō te mate kanohi maroke. Ka taea e tō tākuta kanohi te āwhina i a koe ki te tūhura i ēnei kōwhiringa i runga i ō tohu me ō hiahia.

Ko ētahi atu rongoā kanohi mō ngā kanohi maroke ko:

• Cyclosporine (Restasis) - he rongoā anti-inflammatory tētahi atu e mahi ana i tētahi ara rerekē atu i te lifitegrast
• Varenicline (Tyrvaya) - he rehu ihu e whakaihiihi ana i te hanga roimata
• Cequa - he hanganga hou o te cyclosporine

Kei roto i ngā kōwhiringa kore-whakahaunga ngā roimata horihori kore-pūtiro, ngā kōpeke mahana, ngā tāpiringa waikawa ngako omega-3, me ngā whakarerekētanga o te noho, pēnei i te whakamahi i te whakamākū, i te okiokinga rānei mai i te wā mata.

He pai ki ētahi tāngata ngā tikanga pēnei i ngā mono punctal, he taputapu iti e whakaurua ana ki ngā awa roimata hei āwhina i te pupuri i te makuku i roto i ngā kanohi. Ka tūtohu pea tō tākuta ki te rongoā i ngā āhuatanga o raro pēnei i te blepharitis, i te kore rānei o te mahi o te repe meibomian.

He Pai Ake Anei te Lifitegrast i te Cyclosporine?

He rongoā whai hua te lifitegrast me te cyclosporine mō te mate kanohi maroke, engari he rerekē te mahi, ā, he pai ake pea mō ngā tāngata rerekē. Kāore tētahi rongoā e tino

Mēnā he mate huka tō, ka hiahia tō tākuta kanohi ki te aroturuki i a koe i te wā e whakamahi ana koe i te lifitegrast kia mōhio ai kei te pūmau tonu te hauora o ō kanohi. He wā ka uaua ake te rongoā i te kanohi maroke o te hunga mate huka, nō reira ka tūtohu pea tō tākuta i ētahi atu rongoā hei tāpiri atu ki te lifitegrast.

Q2. Me pēhea ahau ki te whakamahi auau i te nui rawa o te Lifitegrast?

Mēnā i whakamahi auau koe i te nui rawa atu i te kotahi topata, i whakamahi rānei i tētahi horopeta anō, kaua e mataku. Horoi noa i ō kanohi ki te wai mā, ka haere tonu ki tō hōtaka horopeta. Kāore pea te whakamahi auau i te nui rawa o te lifitegrast e whai raruraru nui.

Ka pāngia pea e koe te pikinga o ngā pānga kino pēnei i te wera, te pānga rānei o te tirohanga, engari me ngaro noa ēnei. Mēnā e māharahara ana koe, e pāngia ana rānei e ngā tohumate nui, whakapā atu ki tō tākuta kanohi, ki te kaimātai rongoā rānei mō te ārahitanga.

Q3. Me pēhea ahau ki te kore e whakamahi i tētahi horopeta o te Lifitegrast?

Mēnā ka ngaro i a koe tētahi horopeta o te lifitegrast, whakamahia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, waiho te horopeta i ngaro, ka haere tonu ki tō hōtaka auau - kaua e rua ngā horopeta.

Whakamātau ki te pupuri i tētahi hōtaka rite tonu mō ngā hua pai. Mēnā ka wareware koe i ngā horopeta, whakaarohia te whakatakoto i ngā pūoho waea, te whakamahi rānei i tētahi taupānga whakamahara rongoā hei āwhina i a koe kia noho i runga i te ara.

Q4. Āhea ahau e mutu ai te tango i te Lifitegrast?

Me mutu anake te tango i te lifitegrast i muri i te kōrero ki tō tākuta kanohi. He maha ngā tāngata e hiahia ana ki te whakamahi tonu i te wā roa kia mau tonu ai te whakapai ake i ngā tohumate kanohi maroke.

Mēnā ka whakatau koe me tō tākuta ki te whakamutu i te lifitegrast, me whakaiti pea koe i te horopeta, me whai rongoā kē rānei. Ko te whakamutu ohorere ka hoki mai pea ō tohumate kanohi maroke i te wā e ngaro ana ngā pānga anti-inflammatory.

Q5. Ka taea e au te mau i ngā arotahi i te wā e whakamahi ana i te Lifitegrast?

Ka taea e koe te mau i ngā arotahi i te wā e whakamahi ana i te lifitegrast, engari me tango e koe i mua i te whakamahi i ngā topata, ā, me tatari koe kia 15 meneti i mua i te whakahoki anō. Mā tēnei wā tatari e whakarite kia whai wā te rongoā ki te mahi me te kore e mimiti e ō arotahi.

E kite ana ētahi tāngata ka pai ake te tūāhua o ā rātou arotahi i te wā e whakamahi ana i te lifitegrast, nā te mea ka āwhina te rongoā ki te whakaiti i te mumura ka kore ai e pai te mau arotahi. Heoi, me whai tonu i ngā tohutohu motuhake a tō tākuta kanohi mō te whakamahi arotahi i te wā e rongoā ana.