He aha te Maraviroc: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu

He rongoā rongoā a Maraviroc i hangaia hei rongoā i te mate HIV i roto i ngā pakeke. No roto i tētahi rōpū ahurei o ngā rongoā HIV e kiia nei ko ngā CCR5 antagonists, e mahi rerekē ana i ētahi atu rongoā HIV mā te aukati i tētahi kuaha motuhake e whakamahia ana e te HIV ki te uru ki ō pūtau ārai mate.

Kāore tēnei rongoā i te rongoā mō te HIV, engari he taputapu kaha i roto i tō huinga rongoā. Ki te whakamahia hei wāhanga o te rongoā whakakotahi me ētahi atu rongoā HIV, ka āwhina a maraviroc ki te pupuri i te huaketo i raro i te mana whakahaere me te tautoko i te kaha o tō pūnaha ārai mate kia kaha tonu.

He aha te Maraviroc?

He rongoā antiretroviral a Maraviroc e whai ana i te huarahi e uru ai te HIV ki ō pūtau CD4. Whakaarohia he raka motuhake e aukati ana i te HIV ki te whakamahi i tētahi o ōna wāhi urunga matua ki roto i ō pūtau ārai mate.

Kāore i rite ki te maha o ētahi atu rongoā HIV e mahi ana i muri i te pangia o te huaketo i ō pūtau, ka mahi a maraviroc i te tīmatanga tonu o te tukanga pangia. Ka aukati i te kaiwhakawhiwhi CCR5, he rite ki te kuaha e whakamahia ana e ētahi momo HIV ki te uru ki roto i ō pūtau ārai mate hauora.

Ka whakamahia tonu tēnei rongoā i te taha o ētahi atu rongoā HIV, kaua rawa ko ia anake. Ko te tikanga ka tohua e tō tākuta hei wāhanga o te mea e kiia nei ko te rongoā antiretroviral whakakotahi, cART rānei, e whakamahi ana i ngā rongoā maha ki te whakaeke i te HIV mai i ngā koki rerekē.

He aha te Maraviroc e whakamahia ana?

Ko te mea nui e whakamahia ana a Maraviroc ki te rongoā i te mate HIV-1 i roto i ngā pakeke he momo HIV motuhake tō rātou e kiia nei ko te huaketo CCR5-tropic. I mua i te tohutohu i tēnei rongoā, me whakamātau tō tākuta i tō HIV kia mōhio ai he momo tika tēnei e taea ai e maraviroc te whai hua.

He mea nui rawa atu tēnei rongoā mō te hunga kua whai parenga ki ētahi atu rongoā HIV. Mēnā kāore te rongoā HIV e mahi ana i tōna pai, mēnā rānei kua whakamātau koe i ngā momo rongoā maha kāore i angitu, tērā pea ka whai wāhi hou a maraviroc ki te aukati i te huaketo.

Ka whakaaro pea tō tākuta ki te whakamahi i te maraviroc mō te wā tuatahi e tīmata ana koe i te rongoā HIV, ina koa ka whakaatu ngā whakamātautau kei a koe te HIV CCR5-tropic. Heoi, he nui ake te whakamahi i roto i ngā tūroro kua whai wheako rongoā e hiahia ana ki ētahi atu kōwhiringa.

Me pēhea te mahi a Maraviroc?

E mahi ana a Maraviroc hei rongoā HIV kaha, mā te aukati i tētahi ara motuhake e whakamahia ana e te HIV ki te pangia ō pūtau. E kiia ana he rongoā whai i te whāinga, nā te mea e arotahi ana ki tētahi tikanga motuhake o te pangia HIV.

I te wā e ngana ana te HIV ki te uru ki ō pūtau CD4, me piri ki ētahi kaiwhiwhi i te mata o te pūtau. Ka aukati tika a Maraviroc i te kaiwhiwhi CCR5, e ārai ana i te HIV CCR5-tropic kia kore e uru angitu, kia kore e pangia ō pūtau ārai mate hauora.

Ka puta tēnei mahi aukati i waho o ō pūtau, he mea motuhake a maraviroc i roto i ngā rongoā HIV. Ko te nuinga o ētahi atu rongoā HIV e mahi ana i roto i ngā pūtau i muri i te pangia, engari ka aukati a maraviroc i te tukanga pangia i mua i te tīmatanga.

E whakawhirinaki ana te whai huatanga o te rongoā ki te mea he CCR5-tropic tō HIV. He CXCR4-tropic HIV ētahi tāngata, he HIV rua-tropic rānei, e whakamahi ana i ngā wāhi uru rerekē kāore e taea e maraviroc te aukati.

Me pēhea taku tango i te Maraviroc?

Ko te tikanga ka tangohia a Maraviroc hei papa e rua ngā wā i te rā, me te kai, me te kore kai rānei. Ka taea e koe te tango me te wai, te miraka, te wai rānei - ahakoa te mea e pai ana ki tō puku.

Ko te tango i te maraviroc me te kai ka āwhina pea ki te whakaiti i te puku, ahakoa kāore i te hiahiatia. E kitea ana e ētahi tāngata ko te tango me te paramanawa māmā, te kai rānei, ka māmā ake te mahara, ā, he ngawari ake ki tō rātou pūnaha kūnatu.

He mea nui te wā o āu horopeta i te mea e kai ana koe i ngā kai. Whakamātau ki te tango i āu horopeta tata ki te 12 haora te wehenga, i ngā wā kotahi i ia rā. Ka āwhina tēnei ki te pupuri i ngā taumata pūmau o te rongoā i roto i tō pūnaha.

Mēnā kei te tango koe i ētahi atu rongoā HIV, me whakatikatika e koe te wā me te maraviroc. Ko ētahi huinga rongoā me tango ngātahi, engari he pai ake ētahi atu ina wehea. Ka taea e tō kaiwhakawhāiti rongoā te āwhina i a koe ki te hanga i tētahi hōtaka e mahi ana me ō rongoā kē atu.

Kia Pēhea te Roa e Tango Ana ahau i te Maraviroc?

Ko te Maraviroc te tikanga he rongoā wā-roa e tango ana koe i te wā e whai hua tonu ana ki te whakahaere i tō HIV. Ko te nuinga o te hunga e pai ana ki ngā hōtaka kei roto maraviroc e tango ana i te mea e kore e mutu hei wāhanga o tā rātou maimoatanga HIV e haere tonu ana.

Ka aroturukihia e tō tākuta tō uta viral i ia wā kia mōhio ai kei te pai te mahi a te maraviroc. Mēnā ka noho kore e kitea tō uta viral, ā, ka pūmau, ka pai ake rānei tō tatau CD4, ka haere tonu pea koe ki te tango.

Kei te whakawhirinaki hoki te roa o te maimoatanga ki te pai o tō whakamanawanui i te rongoā me te noho tonu o tō HIV ki te CCR5-tropic. Ka taea e te HIV o ētahi tāngata te huri i te wā, ka noho pea e ātete ana ki te maraviroc, ka huri rānei ki te whakamahi i ngā ara urunga rerekē.

Kaua rawa e mutu te tango i te maraviroc me te kore e kōrero tuatahi ki tō tākuta. Ko te mutu ohorere i ngā rongoā HIV ka puta he hokinga mai o te viral me te whanaketanga pea o te ātete rongoā.

He Aha ngā Pānga taha o te Maraviroc?

Pērā i ngā rongoā katoa, ka taea e te maraviroc te pānga taha, ahakoa he maha ngā tāngata e pai ana ki te tango. Ko te nuinga o ngā pānga taha he ngawari ki te āhua, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā.

Koinei ngā pānga taha noa ake ka pā ki a koe, ā, he mea āwhina ki te mōhio ki te aha e tūmanako ana kia taea ai e koe te kōrero i ngā āwangawanga ki tō rōpū hauora:

• Te whakapairuaki me te puku puku
• Te korere, te kumete ranei
• Te ānini
• Te ngenge, te ngenge rānei
• Te whanoke, ina koa ka tū ake
• Te uaua ki te moe
• Te mamae o ngā uaua, o ngā hononga rānei
• Ngā huringa o te hiahia kai

Ko ēnei pānga taha noa ka iti ake te raruraru i roto i ngā wiki tuatahi o te rongoā. Mēnā ka mau tonu, ka raru rānei i tō oranga o ia rā, ka taea e tō tākuta te whakaaro i ngā rautaki hei āwhina i te whakahaere i a rātou.

Ko ngā pānga taha nui ake he iti noa iho te noa, engari me āta tirotiro hauora tonu. Kei roto i ēnei ngā tohu o ngā raruraru ate pēnei i te kōwhai o tō kiri, o ō kanohi rānei, te mamae puku nui, te ngenge rānei kāore e pai ake i te okiokinga.

Ka pā mai pea te tauhohenga pānga ki ētahi tāngata, ka uru pea ki te pāwera, te mōmona, te pūhi, te uaua rānei ki te hā. Mēnā ka kite koe i ētahi o ēnei tohu, whakapā atu ki tō kaiwhakarato hauora tonu.

He pānga taha onge engari nui hoki kei reira, ka āta tirotirohia e tō tākuta mā ngā whakamātautau toto me ngā arotake auau. Kei roto pea i ēnei ngā huringa i roto i te mahi ate, ngā raruraru ngākau, ngā mate rānei kāore i te noa.

Ko wai kāore e tika kia tango Maraviroc?

Kāore a Maraviroc i te tika mō te katoa, ā, ka āta arotakehia e tō tākuta mēnā koinei te whiringa tika mō tō āhuatanga motuhake. Ko te mea nui ko te whai HIV CCR5-tropic, nā te mea kāore te rongoā e mahi ki ētahi atu momo HIV.

Me whakamahi tūpato te hunga whai raruraru ate nui, me karo rānei i te maraviroc. I te mea ka tukatukahia te rongoā mā tō ate, ka uaua ake pea i te mate ate o nāianei ki tō tinana te whakahaere i te rongoā i runga i te haumaru.

Mēnā he āhuatanga ngākau ō, ina koa ko ēnei e pā ana ki tō manawataki, me āta whakatau e tō tākuta ngā painga me ngā tūponotanga. I ētahi wā ka pā te maraviroc ki te mahi ngākau, ina koa ki te hunga whai raruraru ngākau o mua.

Anei ngā āhuatanga e kore ai e tika te maraviroc, ā, ka kōrero tō tākuta i ēnei āhuatanga ki a koe i te wā o tō kōrero:

• Te mate HIV CXCR4-tropic, dual-tropic rānei
• Te mate ate nui, te kore rānei o te ate
• Ētahi mate o te manawa
• Te mate tākihi nui
• Te hapū (he iti noa ngā raraunga haumaru e wātea ana)
• Te whāngai ū
• Te pakeke kei raro i te 18 tau (kāore i whakaaetia mō te whakamahi tamariki)

Ka whakaaro hoki tō tākuta ki ō rongoā kē atu, nā te mea ka pāhekoheko ētahi rongoā ki te maraviroc i ngā huarahi e iti ai te whai hua, e nui ake ai ngā pānga taha.

Mēnā he hītori tō koe mō te pōuri, ētahi atu āhuatanga hauora hinengaro rānei, ka mātakitaki pū tō tākuta i a koe, nā te mea ka pā mai ngā huringa o te ngākau ki ētahi tāngata i te wā e tīmata ana i ngā rongoā HIV hou.

Ngā Ingoa Waitohu Maraviroc

E wātea ana te Maraviroc i raro i te ingoa waitohu Selzentry i te United States me Celsentri i ētahi atu whenua. He rite tonu te whakauru kaha i roto i ngā mea e rua, ā, he rite tonu te mahi.

Ka tae mai te rongoā i roto i ngā papa 150mg me te 300mg, ā, ka whakatau tō tākuta i te kaha tika i runga i ō rongoā kē atu me ō hiahia takitahi. Ka rerekē te inenga i runga i ngā rongoā HIV kē atu e tango ana koe.

Ka wātea pea ngā putanga whānui o te maraviroc i ētahi rohe, engari ko ngā putanga ingoa waitohu tonu te mea e tino tohua ana. Ka āwhina tō kai rongoā i a koe ki te mārama ki ngā mea e wātea ana i tō rohe.

Ngā Kōwhiringa Maraviroc

Mēnā kāore te maraviroc e tika ana mō koe, he maha ētahi atu kōwhiringa rongoā HIV e wātea ana. Ko te kōwhiringa pai rawa atu e whakawhirinaki ana ki tō momo HIV, tō hītori rongoā, me te pai o tō urupare ki ētahi atu rongoā.

Ko ētahi atu rongoā aukati urunga ko te enfuvirtide, ahakoa ka hākinahia, ā, he iti noa te whakamahi i tēnei rā. I te nuinga o te wā, ka whakaaro pea tō tākuta ki ngā aukati whakawhiti whenu integrase pēnei i te dolutegravir, raltegravir rānei.

Ko ngā aukati protease pēnei i te darunavir, i te atazanavir rānei, he momo rongoā HIV anō e mahi ana mā tētahi tikanga rerekē. He pai pea ēnei hei kōwhiringa kē atu mēnā he HIV CXCR4-tropic tō, kāore e aro ki te maraviroc.

Ko ngā aukati transcriptase huri whakamuri kore-nucleoside (NNRTIs) pēnei i te efavirenz, i te rilpivirine rānei, e tuku ana i tētahi atu huarahi ki te rongoā HIV. Ka whakaaro tō tākuta ki ngā āhuatanga pēnei i tō tauira aukati huaketo me ngā pānga taha pea ka kōwhiri i ngā kōwhiringa kē.

He Pai Anei te Maraviroc i Ētahi Atu Rongoā HIV?

Kāore i te pai ake, i te kino ake rānei te maraviroc i ētahi atu rongoā HIV – he rerekē noa iho, he tino whai hua mō ngā āhuatanga motuhake. Ko te rongoā HIV “pai” ko te mea e mahi ana i te tino whai hua mō ō āhuatanga takitahi.

Ki te whakataurite ki ētahi rongoā HIV hou, e hiahia ana te maraviroc kia rua ngā horopeta i ia rā, he mea e kitea ana e ētahi tāngata he iti ake te watea i ngā kōwhiringa kotahi i ia rā. Heoi, nā tōna tikanga mahi ahurei ka kore e taea te whakakapi mō ētahi āhuatanga rongoā.

Mō te hunga whai HIV CCR5-tropic kua whakawhanake i te aukati ki te maha o ētahi atu rongoā, ka taea e te maraviroc te whakaora. E whakaeke ana i te HIV mai i tētahi koki kāore e mahia e ētahi atu rongoā, ko te tikanga ka taea te mahi ahakoa kua mutu te whai hua o ētahi atu rongoā.

He pai te aro o te rongoā e te nuinga o te tāngata, me ngā pānga taha e taea ana te whakahaere. E pai ana ētahi tāngata ki te maraviroc nā te mea kāore e pā ana ētahi o ngā pānga taha noa e pā ana ki ētahi atu momo rongoā HIV.

Ngā Pātai Auau mō te Maraviroc

He Haumaru te Maraviroc mō te Hunga e Pā ana ki te Mate Ate?

E hiahia ana te maraviroc kia tino whakaarohia mēnā he mate ate tō. Ka taea e te hunga e pā ana ki ngā raruraru ate ngawari te tango i te maraviroc me te mātakitaki tata, engari ko te hunga e pā ana ki te mate ate nui pea me karo katoa.

Ka tono pea tō tākuta i ngā whakamātautau mahi ate i ngā wā katoa hei aroturuki i te āhua o tō ate e whakahaere ana i te rongoā. Mēnā he mate hepatitis B, C rānei tōna me te HIV, ka nui ake te hiranga o te mahi ate ki te aroturuki tata.

Ngā tohu o ngā raruraru ate ko te kōwhai o tō kiri, o ō kanohi rānei, te mimi pouri, ngā tūtae mā, te mamae puku tonu rānei. Mēnā ka pā tētahi o ēnei tohu ki a koe, whakapā atu ki tō tākuta tonu.

Me Pēhea Taku Mahi Mēnā Ka Inu Au i te Maraviroc Nui Rawa?

Mēnā ka inu koe i te maraviroc nui atu i te mea i whakaritea, kaua e mataku, engari whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei mō te tohutohu. Ko te inu i ngā horopeta atu ka piki ake te tūponotanga o ngā pānga taha pēnei i te whanoke, te whakapairuaki, te huringa rānei o te manawa.

Kaua rawa e ngana ki te "whakatika" i te horopeta nui mā te karo i tō horopeta e whai ake nei. Engari, hoki atu ki tō hōtaka horopeta i te mea i tohutohutia e tō kaiwhakarato hauora.

Mēnā kei te pā tētahi o ngā tohu nui ki a koe pēnei i te uaua ki te hā, te mamae o te uma, te ngaro rānei o te māramatanga, rapua tonu te manaakitanga hauora ohorere. Puritia te pounamu rongoā ki a koe kia kite ai ngā kaimahi hauora i te aha me te nui i inumia e koe.

Me Pēhea Taku Mahi Mēnā Ka Ngaro Au i tētahi Horopeta o Maraviroc?

Mēnā ka ngaro koe i tētahi horopeta o maraviroc, inumia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, karohia te horopeta i ngaro, ka haere tonu ki tō hōtaka i ngā wā katoa.

Kaua rawa e inu i ngā horopeta e rua i te wā kotahi hei whakatika i te horopeta i ngaro. Ka piki ake tēnei i tō tūponotanga o ngā pānga taha me te kore e whai hua atu.

Mēnā he maha ngā wā e wareware ana koe i ngā horopeta, whakaarohia te whakatakoto i ngā whakaoho waea, te whakamahi i te kaiwhakarite pire, te pātai rānei ki tō kaiwhakawhāiti mō ngā taputapu whakamahara. He mea nui te horopeta rite tonu mō te pupuri i tō HIV i raro i te mana.

Āhea Āhau e Kati ai te Inu i te Maraviroc?

Kaua rawa koe e whakamutu i te tango maraviroc me te kore e kōrero tuatahi ki tō tākuta. He pai ake te mahi a ngā rongoā HIV ina tangohia i ngā wā katoa, ā, ko te whakamutu ohorere ka arai i te hokinga mai o te huaketo me te whanaketanga ātete.

Ka whakaaro pea tō tākuta ki te huri i tō rongoā mēnā kei te pā koe i ngā pānga taha e kore e taea te whakawhāiti, mēnā ka whanake te ātete o tō HIV ki te maraviroc, mēnā rānei ka wātea mai ngā kōwhiringa rongoā pai ake mō tō āhuatanga.

Ka taea e ētahi tāngata te huri ki ngā momo rongoā HIV rerekē i te roanga o te wā, engari me whakatau tēnei whakatau i ngā wā katoa i te mahi tahi me tō rōpū hauora i runga i tō utaina huaketo, te tatau CD4, me te āhua hauora whānui.

Ka taea e Maraviroc te pāhekoheko ki ētahi atu rongoā?

Āe, ka taea e maraviroc te pāhekoheko ki ētahi atu rongoā, koinei te take me mōhio tō tākuta ki ngā mea katoa e tango ana koe, tae atu ki ngā rongoā e hokona ana i te tatau, ngā tāpiringa, me ngā hua otaota.

Ka taea e ētahi rongoā te whakanui i ngā taumata maraviroc i roto i tō toto, ka arai pea i te nui ake o ngā pānga taha. Ko ētahi atu ka taea te whakaiti i ngā taumata maraviroc, ka iti ake te whai hua ki te HIV.

Me whakatika pea tō tākuta i tō inenga maraviroc mēnā kei te tango koe i ētahi rongoā pēnei i ētahi paturopi, rongoā antifungal, rongoā rānei mō te hopu. Me tirotiro tonu ki tō kai rongoā i mua i te tīmatanga i ngā rongoā hou i te wā e tango ana koe i te maraviroc.