He aha te Nintedanib: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

He rongoā whakahau a Nintedanib e āwhina ana ki te whakaiti i te kiko kiko i roto i ngā pūkahukahu o te hunga e pā ana ki ētahi mate pūkahukahu nui. I hangaia motuhake hei whai i ngā pūmua e pā ana ki te hanga nui o te kiko kiko i roto i ō pūkahukahu, e whai wāhi ana tō tinana ki te manawa māmā ake i te wā.

He whakatutukitanga nui tēnei rongoā i te rongoā i ngā āhuatanga i whakaarohia i mua kāore i te rongoā. Ahakoa kāore e taea te rongoā i te kiko kiko o te pūkahukahu, ka taea e ia te whakaiti i tōna haere whakamua me te āwhina i te pupuri i tō kounga o te oranga.

He aha te Nintedanib?

He rongoā whai i te whāinga a Nintedanib e pā ana ki te kāwai rongoā e kīia ana ko te tyrosine kinase inhibitors. Whakaarohia he taputapu tika e aukati ana i ngā pūmua motuhake e kawenga ana mō te hanga nui o te kiko kiko i roto i ō pūkahukahu.

Ka tae mai te rongoā i roto i te puka pūtau ngawari, ā, ka tangohia mā te waha e rua ngā wā i te rā. I hangaia motuhake mō te hunga e pakaru ana ō rātou pūkahukahu e ngā tukanga kiko kiko hē e uaua ai te manawa.

Kāore i rite ki ngā rongoā tawhito e whakahaere ana i ngā tohu anake, ka whai a nintedanib i te tukanga mate i raro. Mā tēnei ka waiho hei rongoā whakarerekē i te mate, kaua ko te whakaiti i ngā tohu anake.

He aha te Nintedanib e whakamahia ana?

Ko te Nintedanib te mea nui e whakamahia ana ki te rongoā i te idiopathic pulmonary fibrosis (IPF), he āhuatanga pūkahukahu nui e whakakapi ana i te kiko pūkahukahu hauora ki te kiko kiko. Kua whakaaetia hoki mō ētahi atu momo mate kiko kiko pūkahukahu e haere whakamua ana.

E pā ana te IPF ki te 100,000 tāngata i roto i te United States, ā, ka puta i te hunga neke atu i te 50 tau. Ko te kupu "idiopathic" te tikanga kāore ngā tākuta e mōhio ana he aha te tino take, engari nā te kiko kiko ka mārō ō pūkahukahu, ā, ka uaua te manawa.

Ka tohua pea e tō tākuta te nintedanib mō te mate pūkahukahu tūāwhiwhi e pā ana ki te sclerosis pūnaha (SSc-ILD). Ka puta tēnei i te wā e pā ana tētahi āhuatanga ārai-a-tinana e kīia ana ko te scleroderma ki ō pūkahukahu, e pā ana ki ngā raruraru kiko rite.

I ētahi wā, ka whakamahi pea ngā tākuta i te nintedanib mō ētahi atu momo fibrosis pūkahukahu haere tonu i te wā e haere tonu ana te kino o te kiko ahakoa ētahi atu rongoā. Heoi, me tino arotake tēnei whakamahinga e tētahi tohunga pūkahukahu.

Me pēhea te mahi a Nintedanib?

Ka mahi a Nintedanib mā te aukati i ngā kaiwhakawhiwhi tupu motuhake e toru e akiaki ana i te tukanga kiko i ō pūkahukahu. Ko ēnei kaiwhakawhiwhi te tikanga e āwhina ana i te whakaora, engari i roto i te fibrosis pūkahukahu, ka kaha rawa atu rātou, ka nui rawa te kiko.

E whakaarohia ana te rongoā he rongoā kaha āhua e hiahia ana kia tino aroturukihia. Ehara i te rongoā ngawari, engari he pai te whakamanawanui i te wā e whakamahia ana i raro i te tirotiro hauora tika.

Mā te aukati i ēnei tohu kaha rawa atu, ka āwhina a nintedanib ki te whakaiti i te tere e whakakapia ai te kiko pūkahukahu hauora e te kiko. Ka āwhina tēnei ki te pupuri i tō mahi pūkahukahu me te kaha manawa mō ngā wā roa ake.

He pānga anti-inflammatory anō te rongoā, e āwhina ana ki te whakaiti i te kino e haere tonu ana ki tō kiko pūkahukahu. Heoi, ko tōna kaha tuatahi kei te aukati i te tukanga kiko, kaua ki te whakahoki i te kino o nāianei.

Me pēhea taku tango i te Nintedanib?

Me tango tika te nintedanib i te mea i tohua e tō tākuta, te tikanga 150 mg e rua i te rā, tata ki te 12 hāora te wā. He mea nui te tango i te kai, nā te mea ka whakaiti nui tēnei i te pōpō i te puku me te āwhina i tō tinana ki te ngongo tika i te rongoā.

Horomia ngā kāpene katoa me te karaihe wai katoa. Kaua e whakatuwhera, e kuru, e ngaungau rānei i ngā kāpene, nā te mea ka riri tēnei ki tō waha me tō korokoro, ā, ka pā pea ki te mahi o te rongoā.

He mea nui te tango i te nintedanib me te kai, te paramanawa nui rānei mō tō whakamarie. Kāore he nui o te kai e hiahiatia ana, engari mā te whai i tētahi mea i roto i tō puku ka āwhina i te aukati i te whakapairuaki me te pōraruraru i te kūnatu e pā ana ki tēnei rongoā.

Whakamātau ki te tango i ō horopeta i ngā wā kotahi i ia rā kia mau tonu ngā taumata i roto i tō pūnaha. He maha ngā tāngata e kite ana he āwhina ki te tango i tētahi horopeta me te parakuihi me tētahi atu me te kai tina.

Mēnā ka pā tō puku ki te pōraruraru nui, tērā pea ka whakaiti tō tākuta i tō horopeta mō tētahi wā, ka tūtohu rānei i ngā kai motuhake e pai ana ki te rongoā. Kaua rawa e whakatika i tō horopeta me te kore tohutohu hauora.

Kia Pēhea te Roa e Tango Ana ahau i te Nintedanib?

Ko te nintedanib te tikanga he rongoā wā-roa e hiahia ana koe ki te haere tonu i ngā wā katoa, i te wā e āwhina ana ki te whakaroa i te kiko kiko o tō pūkahukahu, me te pai o tō tū. He maha ngā tāngata e tango ana mō ngā tau, kaua mō ngā marama.

Ka aroturuki tō tākuta i tō ahunga whakamua mā ngā whakamātautau mahi pūkahukahu, ngā karapa pouaka, me ngā mahi toto. Ka āwhina ēnei ki te whakatau mēnā kei te pai te mahi o te rongoā, me te haumaru ki a koe ki te haere tonu.

Ko te whāinga he whakaroa i te haere o te kiko kiko o te pūkahukahu mō te wā e taea ana. Ko te whakamutu i te rongoā te tikanga ka taea e te tukanga kiko kiko te hoki ki tōna tere o mua, koinei te take e tūtohu ana te rongoā tonu.

Tērā pea ka hiahia ētahi tāngata ki te tango i ngā wā whakatā mai i te rongoā mēnā ka whanake ngā pānga taha e hiahia ana ki te wā ki te whakaoti. Ka mahi tō tākuta ki a koe ki te kimi i te taurite tika i waenga i te whai hua me te pai.

He Aha ngā Pānga Taha o te Nintedanib?

Pērā i ngā rongoā katoa, ka taea e te nintedanib te pānga taha, ahakoa kāore te katoa e pā ana ki a rātou. Ko ngā pānga taha tino noa he mea whakahaere, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā.

Me tīmata tātou ki ngā pānga taha e tino tūpono ana koe ki te tūtaki, e pā ana ki te maha o ngā tāngata e tango ana i tēnei rongoā:

• Te korere (e pā ana ki te 60% o te tangata) - he ngawari, he āhua ngawari rānei, ā, ka taea te whakahaere mā te whakatikatika i te kai
• Te whakapairuaki me te pōhara o te puku - ka tino āwhina te tango i te rongoā me te kai
• Te iti o te hiahia me te whakaheke taumaha - ka āta aroturukihia tēnei e tō tākuta
• Te mamae o te puku, te kōpū rānei - he maha ngā wā ka pai ake i te wā, me te kai tika
• Te ruaki - he iti ake te auau i te whakapairuaki, engari ka puta, ina koa i ngā wiki tuatahi

Ko ēnei pānga taha ki te kūnatu te amuamu auau, engari he maha ngā wā ka ngawari ake i te wā e urutau ana tō tinana ki te rongoā.

Ka pā ki ētahi tāngata ngā pānga taha he iti ake te auau, engari he mea nui tonu kia mōhiotia, me āta aroturuki:

• Te pikinga o ngā whākōkī ate - ka kitea mā ngā whakamātautau toto, te nuinga kāore he tohu
• Te ngenge, te pōuri rānei - ka pā ki te rongoā, ki tō mate pūkahukahu rānei
• Te ānini - te nuinga he ngawari, ā, ka pai ki ngā rongoā mamae kaore e hiahiatia he rēhita
• Te whanoke - he nui ake te auau i te tīmatanga o te rongoā, i te whakanui rānei i te horopeta
• Te pāwera kiri, te mānukanuka rānei - te nuinga he ngawari, engari me pūrongo ki tō tākuta

Ka tirohia e tō tākuta tō mahi ate i ngā wā katoa, nā te mea ka pā te nintedanib ki ngā whākōkī ate i ētahi tāngata.

Ināianei, me kōrero tātou mō ngā pānga taha he onge, engari he nui ake te kino, e hiahia ana kia āta rongoā:

• Ngā raruraru ate nui - ko ngā tohu ko te kōwhai o te kiri, o ngā kanohi rānei, te mimi pouri, te mamae nui o te puku rānei
• Ngā raruraru ngākau - te mamae o te uma, te ngākau pōrearea, te poto o te manawa
• Ngā raruraru toto - te rere toto rerekē, te pānga rānei, ina koa he nui
• Ngā raruraru pūkahukahu nui - te mare hou, te kino rānei, te kirika, te uaua rānei ki te hā
• Ngā pānga kiri nui - te pāwera whānui, te pupuhi, te kiri rānei e tihore ana

He onge ēnei pānga taha nui, engari he mea nui kia mōhio ki a rātou, me rapu āwhina hauora tonu mēnā ka puta.

Ko wai e kore e tika kia tango Nintedanib?

Kāore a Nintedanib e tika ana mō te katoa, ā, ka āta tātari tō tākuta mō te haumaru o tēnei rongoā mōu, i runga i tō hītori hauora me te āhua o tō hauora i tēnei wā.

Kaua koe e tango nintedanib mēnā he pānga tō tinana ki tēnei rongoā, ki te soya, ki te pīnati rānei, nā te mea kei roto i ngā kāpene te lecithin soya. Ko ngā tāngata e mōhiotia ana he tairongo ki tētahi wāhanga o te rongoā, me karo katoa.

He maha ngā āhua hauora ka tūpono he mōrearea a nintedanib, me whai whakatūpato motuhake:

• Te mate ate nui, ngā raruraru ate rānei - ka taea e te rongoā te whakapōrearea i te mahi ate
• Te whakaeke ngākau tata nei, te mate ngākau rānei kāore i te pūmau - ka pā te nintedanib ki te manawataki o te ngākau
• Ngā mate toto e kaha ana - ka taea e te rongoā te whakanui i te tūponotanga o te toto
• Te mate tākihi nui - ka āwhina ō tākihi ki te tukatuka i te rongoā
• Te pokanga nui tata nei - te whakanui i te tūponotanga o te toto i te wā e ora ana

He aukati tino nui te hapū me te whāngai ū, nā te mea ka taea e nintedanib te whara i ngā pēpi e tipu ana, ā, ka uru pea ki te waiu ū.

Me nui ake te aroturuki i ētahi tāngata, engari ka taea tonu e rātou te tango nintedanib me ngā whakatikatika:

• Ngā raruraru ate ngawari ki te pōturi - me whakatika te horopeta me te aroturuki auau
• Hītori o ngā raruraru ngākau - me whai aromatawai ngākau me te aroturuki tonu
• Te tango i ngā rongoā whakaheke toto - me tino kōrero ki tō tākuta
• Ngā kaumātua - tērā pea ka iti ake ngā horopeta nā te nui ake o te tairongo
• Ngā tāngata e pā ana ki te whewhe puku - te tūponotanga nui ake o ngā raruraru kūnatu

Ka whakataurite tō tākuta i ngā painga ki ngā tūponotanga mō tō āhuatanga motuhake, ā, tērā pea ka tūtohu i ētahi atu rongoā mēnā kāore a nintedanib e tika ana mōu.

Ngā Ingoa Waitohu Nintedanib

Kei te wātea a Nintedanib i raro i te ingoa waitohu Ofev i te nuinga o ngā whenua, tae atu ki te United States. Koinei te ingoa waitohu e mōhiotia whānuitia ana mō te rongoā.

I ētahi rohe, ka tūtaki pea koe ki te nintedanib i raro i ngā ingoa waitohu rerekē, engari ko Ofev te waitohu matua e whakamahia ana e te nuinga o ngā kaiwhakarato hauora me ngā whare rongoā.

Ko te rongoā nei i hangaia e Boehringer Ingelheim, he kamupene rongoā e tohunga ana ki ngā rongoā manawa. Kāore anō ngā putanga whānui o te nintedanib i te wātea whānui i te nuinga o ngā mākete.

I te wā e kōrero ana koe mō tō rongoā ki ngā kaiwhakarato hauora, ki ngā kaimahi rongoā rānei, ka taea e koe te kōrero mā tōna ingoa whānui (nintedanib) rānei, mā tōna ingoa waitohu (Ofev) rānei. E rua ngā ingoa e pā ana ki te rongoā kotahi.

Ngā Kōwhiringa kē mō te Nintedanib

Mēnā kāore te nintedanib e tika ana mōu, kāore rānei e pai te mahi, he maha ngā rongoā kē e wātea ana mō te fibrosis pūkahukahu. Mā tō tākuta e āwhina ki te whakatau i te kōwhiringa pai rawa atu i runga i tō āhuatanga motuhake me te hītori hauora.

Ko te Pirfenidone (ingoa waitohu Esbriet) tētahi atu rongoā kua whakaaetia e te FDA mō te idiopathic pulmonary fibrosis. He rerekē tōna mahi i te nintedanib mā te whakaiti i te mumura me te whakaroa i te hanganga o te kiko kiko mā ngā ara rerekē.

Mō ētahi tāngata, ka tika tonu ngā rongoā tuku iho:

• Ngā Corticosteroids - āwhina ki te whakaiti i te mumura engari he iti te whai huatanga mō te IPF
• Ngā rongoā immunosuppressive - ka whakamahia pea mō ētahi momo fibrosis pūkahukahu
• Te rongoā hāora - āwhina ki ngā tohumate manawa engari kāore e whakaroa i te haere o te mate
• Te whakahou pūkahukahu - ngā hōtaka whakakori tinana me te manawa ki te pupuri i te mahi

I ngā keehi matatau, ka whakaarohia pea te whakawhitinga pūkahukahu mō ngā tūroro e tika ana kāore e aro ki ngā rongoā.

E whai hua ana ētahi tāngata mai i ngā huarahi whakakotahi, pēnei i te whakamahi rongoā me te rongoā hāora me te whakahou pūkahukahu. Mā tō tohunga pūkahukahu e hanga tētahi mahere rongoā whānui i hangaia mō ō hiahia.

He Pai Anei te Nintedanib i te Pirfenidone?

He rongoā whai hua a te nintedanib me te pirfenidone mō te idiopathic pulmonary fibrosis, engari he rerekē ā rāua mahi, ā, he rerekē hoki ngā pānga taha. Kāore tētahi i te tino pai ake i tētahi mō ngā tūroro katoa.

E whakaatu ana ngā rangahau e taea ana e ngā rongoā e rua te whakaiti i te hekenga o te mahi o te pūkahukahu i ngā rahinga rite tonu. Ko te whiriwhiri i waenga i a rāua e pā ana ki ngā pānga taha ka taea e koe te whakawhitiwhiti, me ō āhuatanga hauora takitahi.

Ko te nintedanib te tikanga ka nui ake ngā pānga taha o te kōhauhau pērā i te korere me te whakapairuaki, i te wā e nui ake ana te pirfenidone i te tairongo kiri ki te rā me te pōpōtanga o te puku. Ka pai ake te tūpono o tētahi i tētahi.

Ka whakaaro tō tākuta i ētahi mea i te wā e whiriwhiri ana i waenga i ēnei rongoā, tae atu ki ō atu āhuatanga hauora, ngā rongoā o nāianei, me ngā āhuatanga o te noho. Ko te whiriwhiri

Mena ka inu koe i te nui ake o te nintedanib i te mea i tohua, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini tonu. Kaua e tatari kia kite mena ka puta he tohu, he mea nui te mahi tere mo tō haumaru.

Ko te inu i te nui rawa o te nintedanib ka piki ake te tūponotanga o ngā pānga taha kino, ina koa ngā raruraru ate me ngā raruraru toto. Ahakoa te pai o tō tū, he mea tika te arotake hauora kia mōhio kei te pai koe.

Kawea mai te pounamu rongoā ki a koe ki te rūma ohorere, kia wātea rānei i te wā e waea ana koe mō te āwhina. Mā tēnei mōhiohio e āwhina ngā tākuta ki te whakatau i te huarahi pai.

Q3. Me pēhea ahau ki te ngaro i te horopeta o Nintedanib?

Mēnā ka ngaro i a koe tētahi horopeta o te nintedanib, tangohia i te wā e mahara ana koe, i roto i ngā hāora ruarua o tō wā i whakaritea. Heoi, mēnā kua tata te wā mō tō horopeta e whai ake nei, pekehia te horopeta i ngaro, ka haere tonu ki tō wā i whakaritea.

Kaua rawa e inu i ngā horopeta e rua i te wā kotahi hei utu mō te horopeta i ngaro, nā te mea ka piki ake tō tūponotanga o ngā pānga taha. He pai ake te peke i tētahi horopeta i te rua.

Mēnā he maha ngā wā e wareware ana koe ki ngā horopeta, whakaarohia te whakamahi i tētahi kaiwhakarite pire, te whakatakoto rānei i ngā whakamaharatanga waea. Mā te horopeta rite tonu e āwhina ki te pupuri i ngā taumata rongoā i roto i tō pūnaha mō te whai hua.

Q4. Āhea ahau e mutu ai te inu i te Nintedanib?

Me mutu anake te inu i te nintedanib i raro i te tohutohu a tō tākuta. Ko te tikanga he rongoā wā-roa tēnei, ā, ko te whakamutu i te rongoā ka taea e te tukanga kiko pūkahukahu te haere tonu i tōna tere o mua.

Ka tohutohu pea tō tākuta ki te whakamutu i te nintedanib mēnā ka puta ngā pānga taha kino kāore e pai ake i te whakatikatika horopeta, mēnā kei te haere tonu te heke o tō mahi pūkahukahu ahakoa te rongoā, mēnā kāore anō koe i te kaha ki te aro ki te rongoā.

I ētahi wā, he mea tika te okiokinga poto mai i te rongoā hei whakahaere i ngā pānga taha, engari ka hoki te nuinga o te tāngata ki te rongoā i te wā e ngaro ana ngā raruraru. Me kōrero tonu i ō āwangawanga ki tō rōpū hauora i mua i te huri i tō mahere rongoā.

Q5. Ka taea e au te tango Nintedanib me ētahi atu rongoā?

Ka taea e Nintedanib te pā ki ētahi atu rongoā, nō reira he mea nui kia kōrero ki tō tākuta mō ngā rongoā katoa i runga i te whakahaunga, ngā rongoā ka taea te hoko, me ngā tāpiringa e tango ana koe. Ka mōrearea ētahi huinga, ka whakaiti rānei i te whai huatanga o ō rongoā.

Ko ngā rongoā whakaheke toto pēnei i te warfarin e hiahia ana kia aro nui mai, nā te mea ka taea e nintedanib te whakanui i te tūponotanga o te toto. Me mātakitaki tō tākuta i tō toto e pūhi ana i te tata ake mēnā e tango ana koe i ngā rongoā e rua.

Ka taea e ētahi paturopi, rongoā anti-harore, me ngā rongoā hopu i te roro te pā ki te āhua o te tukatuka o tō tinana i te nintedanib. Ka hiahia pea tō tākuta ki te whakatika i ngā inenga, ki te whiriwhiri rānei i ētahi atu rongoā hei karo i ngā pānga kino.