He aha te Waikawa Obeticholic: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te waikawa Obeticholic he rongoā rongoā e āwhina ana ki te rongoā i ētahi mate ate mā te whai i tētahi mea tūturu e hangaia ana e tō tinana hei tukatuka i te waihonga. E mahi ana tēnei rongoā mō te hunga e mate ana i te cholangitis biliary tuatahi, he mate ārai-aunoa onge e pōturi ana te whakangaro i ngā ngongo waihonga i tō ate.

Mēnā kua tohua tēnei rongoā e tō tākuta, he pātai pea āu mō te āhua o tana mahi me te aha e tūmanakohia ana. Me haere tātou i ngā mea katoa e hiahia ana koe ki te mōhio mō te waikawa obeticholic i roto i ngā kupu māmā, tika tonu.

He aha te Waikawa Obeticholic?

Ko te waikawa Obeticholic he putanga waihanga o te waikawa waihonga e puta ana i tō tinana. No tētahi rōpū rongoā e kīia ana ko ngā kaiwhakahohe kaiwhiwhi farnesoid X, he uaua tēnei engari ko te tikanga he whakahohe i ngā kaiwhiwhi motuhake i tō ate.

Ko te tikanga ka hangaia e tō ate ngā waikawa waihonga hei āwhina i te keri ngako me te tango i ngā hua para. Ki te whai koe i ētahi āhuatanga ate, kāore tēnei tukanga e mahi tika ana. Ka uru mai te waikawa Obeticholic ki te āwhina i te whakahoki mai i ētahi o tēnei mahi noa mā te tohu i tō ate ki te whakaiti i te hanga waikawa waihonga me te whakaiti i te mumura.

He rongoā hou tēnei ki te mākete, i whakaaetia e te FDA i te tau 2016. He tohu nui tēnei i roto i te rongoā i ngā mate ate onge i mua i te iti o ngā whiringa rongoā.

He aha te Waikawa Obeticholic e Whakamahia Ana?

Ko te waikawa Obeticholic te mea nui e tohua ana hei rongoā i te cholangitis biliary tuatahi (PBC), i mua i te mōhiotia ko te cirrhosis biliary tuatahi. He mate ārai-aunoa tēnei e whakaeke hē ana tō pūnaha ārai mate i ngā ngongo waihonga iti i tō ate.

Ka tohua pea tēnei rongoā e tō tākuta mēnā he PBC tōu, ā, kāore e taea e koe te whakamahi i te waikawa ursodeoxycholic (te rongoā tuatahi) kāore rānei i pai te urupare ki a ia. Ko te whāinga he whakaiti i te pūmautanga o te kino o te ate me te whakaiti i te tūponotanga o ngā raruraru pēnei i te cirrhosis.

I tēnei wā, kua whakaaetia te waikawa obeticholic mō ngā pakeke e whai PBC ana. Kei te rangahau ngā kairangahau i tōna whakamahinga mō ētahi atu āhuatanga o te ate, tae atu ki te steatohepatitis kore-waipiro (NASH), engari kei te whakamātau tonu ēnei whakamahinga.

Me pēhea te mahi a te waikawa Obeticholic?

Ka mahi te waikawa obeticholic mā te whakahohe i ngā kaiwhiwhi farnesoid X i tō ate, whekau, me ngā whatukuhu. Whakaarohia ēnei kaiwhiwhi hei huri e whakahaere ana i te āhua o te whakahaere a tō tinana i ngā waikawa pūtaiao me te mumura.

Inā whakamahi koe i tēnei rongoā, ka kī atu ki tō ate kia whakaiti i te hanga o ngā waikawa pūtaiao me te whakaiti i te tango o ngā waikawa pūtaiao mai i ō whekau. Ka āwhina tēnei ki te whakaiti i te kohinga paitini o ngā waikawa pūtaiao ka taea te kino i ngā pūtau ate i roto i ngā tāngata e whai PBC ana.

He pānga anti-mumura hoki te rongoā, ka āwhina i te whakaiti i te whakaeke a te pūnaha ārai mate i ō rākau pūtaiao. E kiia ana he rongoā kaha tēnei ka taea te whai pānga nui ki ngā whakamātautau mahi ate, engari ka mahi haere i roto i ngā marama, kaua ki te whakarato i te āwhina tonu.

Me pēhea taku whakamahi i te waikawa Obeticholic?

Me whakamahi koe i te waikawa obeticholic kia rite ki te tohutohu a tō tākuta, i te nuinga o te wā kotahi i te rā me te kai, kāore rānei. Ka tae mai te rongoā hei papa e horomia katoa ana e koe ki te wai.

Ka tīmata te nuinga o te tāngata ki te horopeta iti ka piki haere pea i runga i te pai o tō whakamahi i te rongoā me te āhua o te urupare o tō ate. Ka aroturuki tō tākuta i ō whakamātautau mahi ate i ngā wā katoa hei whakatau i te horopeta tika mōu.

Ka taea e koe te tango i tēnei rongoā me te kore kai rānei, engari ngana ki te tango i te wā kotahi i ia rā kia mau tonu ai ngā taumata i tō tinana. Ki te raru koe ki te horo i ngā pire, kōrero ki tō tākuta mō ō kōwhiringa, engari kaua e kuru, e whati rānei i ngā papa.

Kia Pēhea te Roa e Tango Ana ahau i te Waikawa Obeticholic?

Ko te waikawa obeticholic te tikanga he rongoā wā-roa e hiahia ana koe ki te haere tonu mō te roa kia mau tonu ai ōna painga. I te mea he mate tawhito te PBC, ko te whakamutu i te rongoā te tikanga ka haere tonu te mate.

Ka aroturuki tō tākuta i tō urupare ki te rongoā mā ngā whakamātautau toto e tirotiro ana i tō mahi ate. Mā ēnei whakamātautau e āwhina ana ki te whakatau mēnā kei te pai te mahi o te rongoā me te hiahia kia whakatikatika i te horopeta.

He rerekē te roa o te rongoā mō ia tangata, engari he maha ngā tāngata e mate ana i te PBC e hiahia ana ki te tango rongoā ate mō te ora. Ka kōrero tō tākuta i tō mahere rongoā takitahi me te āwhina i a koe ki te mārama ki ngā mea e tūmanako ana mō tō āhuatanga motuhake.

He aha ngā Pānga taha o te Waikawa Obeticholic?

Pērā i ngā rongoā katoa, ka taea e te waikawa obeticholic te pānga taha, ahakoa kāore te katoa e pā ana ki a rātou. Ko te pānga taha tino noa ko te mōmona, e pā ana ki te maha o ngā tāngata e tango ana i tēnei rongoā.

Anei ngā pānga taha noa ka pā ki a koe:

• Te mōmona nui (pruritus), ina koa i te pō
• Te ngenge, te āhua rānei e ngenge ana
• Te mamae puku, te kore rānei o te pai
• Te mamae tahi
• Te mamae korokoro
• Te whanoke
• Te pāpā
• Te pūwhā kiri

Ka tino raruraru te mōmona, ā, ka raru pea i te moe. Ki te pēnei, ka whakatika pea tō tākuta i tō horopeta, ka tūtohu rānei i ngā rongoā hei āwhina i te whakahaere i te mōmona.

Ko ngā pānga taha kāore i te noa engari he nui ake te kino ka uru:

• Te pōraruraru o te mahi ate (he onge engari ka taea)
• Ngā tauhohenga mate pāwera nui
• Ngā huringa nui i ngā taumata cholesterol
• Ngā raruraru o te pūpū

Whakapā atu ki tō tākuta tonu mēnā ka pā ki a koe te mamae nui o te puku, ngā tohu o ngā raruraru ate pēnei i te kōwhai o tō kiri, o ō kanohi rānei, ētahi tauhohenga mate pāwera nui rānei.

Ko wai kāore e tika kia tango i te waikawa obeticholic?

Kāore te waikawa obeticholic e tika mō te katoa, ā, ka āta arotake tō tākuta mēnā e tika ana mōu. Ko ngā tāngata e pā ana ki ētahi āhuatanga me karo tēnei rongoā, me whakamahi rānei me te tino tūpato.

Kāore koe e tika kia tango i te waikawa obeticholic mēnā he:

• Te aukati biliary katoa (ngā ara bile kua aukatia)
• Cirrhosis ate nui (Child-Pugh Class B, C rānei)
• Te mate pāwera e mōhiotia ana ki te waikawa obeticholic, ki ētahi o ōna whakauru rānei
• Te mate tākihi nui

Ka tūpato anō tō tākuta ki te whakahau i tēnei rongoā mēnā kei te hapū koe, kei te whāngai ū rānei, kei te whakamahere rānei koe kia hapū, nā te mea kāore i te nui ngā raraunga haumaru mō ēnei āhuatanga.

Ko ngā tāngata he hītori mō te mate pūpū, te cholesterol tiketike, ētahi atu āhuatanga ate rānei, tērā pea ka hiahia ki te aroturuki motuhake i te wā e tango ana i tēnei rongoā. Me kōrero tonu ki tō tākuta mō ō āhuatanga hauora katoa me ngā rongoā i mua i te tīmatanga o te maimoatanga.

Ngā Ingoa Waitohu o te Waikawa Obeticholic

Ko te ingoa waitohu mō te waikawa obeticholic ko Ocaliva, i hangaia e Intercept Pharmaceuticals. Koinei anake te waitohu e wātea ana i te United States.

Ka tae mai a Ocaliva i roto i te puka papa i ngā kaha rerekē, te tikanga 5 mg me te 10 mg papa. Ka whakahau tō tākuta i te kaha e tika ana i runga i ō hiahia takitahi me te urupare ki te maimoatanga.

Kāore anō kia wātea ngā momo rongoā o te waikawa obeticholic i Amerika, nō reira ko Ocaliva anake te kōwhiringa i tēnei wā. He nui pea te utu o tēnei rongoā, nō reira kōrerohia te inihua me ngā hōtaka āwhina tūroro ki tō tākuta me te kai rongoā.

Ngā Kōwhiringa kē mō te Waikawa Obeticholic

Mēnā kāore e taea e koe te tango i te waikawa obeticholic, kāore rānei e pai ana mōu, he kōwhiringa maimoatanga kē anō mō te PBC. Ko te kōwhiringa tino noa ko te waikawa ursodeoxycholic (UDCA), he maha ngā wā koinei te maimoatanga tuatahi.

Ko ētahi atu kōwhiringa ka whakaarohia e tō tākuta ko:

• Waikawa Ursodeoxycholic (Actigall, Urso) - he maha ngā wā ka whakamātauhia i te tuatahi
• Bezafibrate (kāore i whakaaetia e te FDA mō te PBC engari ka whakamahia i waho o te tapanga)
• Budesonide (mō ētahi keehi)
• Whakawhitinga ate (mō ngā keehi matatau)

Ka mahi tahi tō tākuta me koe ki te kimi i te huarahi maimoatanga pai rawa atu i runga i tō āhuatanga motuhake, ētahi atu āhuatanga hauora, me te pai o tō whakamanawanui i ngā rongoā rerekē. I ētahi wā he pai ake te whakakotahitanga o ngā maimoatanga i te rongoā kotahi.

He Pai Anei te Waikawa Obeticholic i te Waikawa Ursodeoxycholic?

He rerekē te mahi a te waikawa obeticholic me te waikawa ursodeoxycholic (UDCA), ā, he rerekē ngā tūranga e mahia ana e rāua i te maimoatanga PBC. Ko te UDCA te rongoā tuatahi ka whakamātauhia e ngā tākuta nā te mea kua whakamahia marie mō ngā tau maha.

Ko te waikawa obeticholic te nuinga ka rahuitia mō ngā tāngata kāore e pai ana ki te UDCA, kāore rānei e taea te whakamanawanui. E whakaatu ana ngā rangahau ka nui ake te whai hua o te waikawa obeticholic i te UDCA anake i te whakapai ake i ētahi whakamātautau mahi ate.

Heoi, "pai ake" kei runga i tō āhuatanga takitahi. He iti ake ngā pānga taha o te UDCA, ā, kua whakamahia marie mō ngā tau tekau. He kaha ake pea te waikawa obeticholic engari ka nui ake ngā pānga taha whakararuraru pēnei i te mōmona nui.

Ka whai whakaaro tō tākuta ki ngā hua o tō taiwhanga, ngā tohumate, me te pai o tō urupare ki ētahi atu rongoā i te whakatau i te rongoā pai mōu. I ētahi wā ka whakamahia ngātahi ngā rongoā e rua kia kaha ake ai te whai hua.

Ngā Pātai e Pānuia ana mō te Waikawa Obeticholic

He Haumaru te Waikawa Obeticholic mō te Tāngata e Mate Huka ana?

Ka taea te whakamahi i te waikawa obeticholic e te tāngata e mate huka ana, engari me mātakitaki pū. Ka pā te rongoā ki ngā taumata huka toto, ā, ka pā tahi pea ki ngā rongoā mate huka.

Ka mātakitaki tō tākuta i tō huka toto i te wā e tīmata ana koe ki te waikawa obeticholic, ina koa ki te tango koe i te insulin, i ētahi atu rongoā mate huka rānei. Ētahi tāngata ka hiahia ki te whakatikatika i tā rātou mahere rongoā mate huka.

Whakamōhio tonu ki tō tākuta mō tō mate huka me ngā rongoā mate huka katoa e tango ana koe. Ka taea e rātou te āwhina i a koe ki te whakahaere i ngā āhuatanga e rua i runga i te haumaru me te whai hua.

Me Pēhea Taku Mahi Mēnā Ka Tango Au i te Waikawa Obeticholic Nui Rawa?

Mēnā ka tango koe i te waikawa obeticholic nui atu i te mea i whakaritea, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei tonu. Ko te tango nui rawa ka kino ake pea ngā pānga taha, ka pā rānei ki ngā raruraru ate.

Kaua e ngana ki te whakapōkae i a koe anō ki te kore i tohutohutia e tētahi kaiwhakarato hauora. Puritia te pounamu rongoā ki a koe i te wā e rapu ana i te āwhina hauora kia mōhio ai ngā kaiwhakarato hauora ki te aha me te nui i tango koe.

Mātakitaki mō ngā tohu o ngā pānga taha kino pērā i te mōmiti kaha, te mamae nui o te puku, i ngā huringa rānei i te tae o tō kiri, o ō kanohi rānei. Rapua te āwhina hauora tonu mēnā ka pā ki a koe ētahi tohumate e pā ana.

Me Pēhea Taku Mahi Mēnā Ka Ngaro Au i tētahi Inenga o te Waikawa Obeticholic?

Mēnā ka ngaro koe i tētahi inenga o te waikawa obeticholic, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō inenga e whai ake nei. I taua wā, waiho te inenga i ngaro, ka haere tonu ki tō hōtaka auau.

Kaua rawa e tango e rua nga horopeta i te wa kotahi hei utu i te horopeta i ngaro, na te mea ka piki ake te tupono o nga paanga taha. Mēnā he maha ngā wā e wareware ana koe ki ngā horopeta, whakaarohia te whakatakoto i te whakaoho o ia rā, te whakamahi rānei i tētahi kaiwhakarite pire.

Mēnā ka ngaro i a koe te maha o ngā horopeta, he āwangawanga rānei mō ngā horopeta i ngaro e pā ana ki tō rongoā, whakapā atu ki tō tākuta mō te ārahitanga. He mea nui te horopeta o ia rā mō te pupuri i te whai huatanga o te rongoā.

Āhea e taea ai e au te whakamutu i te tango i te waikawa obeticholic?

Kaua rawa koe e whakamutu i te tango i te waikawa obeticholic me te kore e kōrero tuatahi ki tō tākuta. I te mea he āhuatanga tawhito te PBC, ko te whakamutu i te rongoā te tikanga ka haere tonu te mate.

Ka whakaaro pea tō tākuta ki te whakamutu, ki te huri rānei i tō rongoā mēnā ka pā ki a koe ngā paanga taha kino e kore e taea te whakahaere, mēnā ka nui te kino o te mahi ate, mēnā rānei ka puta he raruraru.

Ko te aroturuki i ngā wā katoa me ngā whakamātautau toto ka āwhina i tō tākuta ki te whakatau mēnā kei te whai hua tonu te rongoā me te haumaru mō koe. Ka whakatau rātou i ngā whakatau mō te whakamutu, te huri rānei i tō rongoā i runga i tō urupare takitahi me te hauora whānui.

Ka taea e au te inu waipiro i te wā e tango ana i te waikawa obeticholic?

Ko te tikanga he pai ki te karo i te waipiro i te wā e tango ana i te waikawa obeticholic, ina koa he mate ate tōu. Ka taea e te waipiro te whakapōrearea i te ate, ā, ka raru pea te whai huatanga o te rongoā.

I te mea kua tohua te waikawa obeticholic mō ngā āhuatanga ate, kei te mahi kē tō ate i te ahotea e pā ana ki te mate. Ko te tāpiri waipiro ka nui ake te pēhanga ki tō ate, ā, ka kino pea tō āhuatanga.

Mēnā kei te inu waipiro koe i tēnei wā, kōrerohia te pono ki tō tākuta mō tō whakamahi waipiro. Ka taea e rātou te whakarato tohutohu whaiaro i runga i tō āhuatanga ate me tō tūnga hauora whānui.