He aha te Osimertinib: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu mea

Ko te Osimertinib he rongoā mate pukupuku e whāinga ana, e rongoā ana i ētahi momo mate pukupuku pūkahukahu. No roto i te rōpū rongoā e kīia ana ko te tyrosine kinase inhibitors, e mahi ana mā te aukati i ngā pūmua motuhake e āwhina ana i ngā pūtau mate pukupuku kia tipu me te horapa.

Kua hurihia e tēnei rongoā te rongoā mō ngā tūroro e mate ana i te mate pukupuku pūkahukahu kore-iti (NSCLC) he huringa ira motuhake. I hangaia kia tika ake i te rongoā matū tuku iho, e whāinga ana anake i ngā pūtau mate pukupuku, i te nuinga o te wā ka iti ake ngā pānga taha kino.

He aha te Osimertinib?

Ko te Osimertinib he rongoā mate pukupuku waha e whāinga ana i ngā huringa ira motuhake i roto i ngā pūtau mate pukupuku pūkahukahu. Koinei te mea e kīia ana e ngā tākuta he

E whakaaetia ana te rongoa mo nga ahuatanga e rua. Tuatahi, ka whakamahia hei rongoa tuatahi mo te NSCLC kua kitea hou me etahi huringa EGFR. Ko te tikanga tenei ka taea te rongoa tuatahi mo te mate pukupuku ka whiwhi koe i muri i te tātaritanga, kaua ki te timata ki te rongoa matū.

Tuarua, ka rongoa a osimertinib i te NSCLC kua whakawhanake i te aukati ki etahi atu aukati EGFR me te huringa motuhake e kiia nei ko T790M. Ka taea e tenei huringa te whakawhanake i te wa e urutau ana nga pūtau mate pukupuku ki nga rongoa o mua, a i hangaia a osimertinib hei wikitoria i tenei aukati.

Ka whakamahia ano te rongoa ina kua horapa te mate pukupuku pūkahukahu ki te roro, na te mea ka taea e ia te whakawhiti i te arai toto-roro i te pai ake i etahi atu rongoa whaainga. Na tenei ka tino whai hua mo nga turoro kua horapa te mate pukupuku ki te roro.

Me pehea te mahi a Osimertinib?

Ka mahi a Osimertinib ma te aukati i nga pūmua EGFR kua huri e mahi ana ano he huringa he i roto i nga pūtau mate pukupuku. I roto i nga pūtau hauora, ka awhina nga pūmua EGFR ki te whakahaere i te tipu o te pūtau noa, engari i roto i nga pūtau mate pukupuku, ka kaha rawa enei pūmua ka akiaki i te tipu kore.

Whakaarohia me te momotu i te hikoi whakatere pakaru i roto i te motuka e piri ana ki te tuunga

Me inu a Osimertinib kotahi i te ra hei papa, me tango e koe i te wa kotahi i ia ra kia mau tonu nga taumata i roto i to tinana. Ka taea e koe te tango me te kore kai ranei, engari ngana kia rite tonu ki to whiringa hei awhina i te ngongo.

Horomia te papa katoa me te karaihe wai. Kaua e kuru, e ngaungau, e wawahi ranei i te papa, na te mea ka pa tenei ki te ahua o te rongoa e ngongo ana, ka puta pea nga paanga taha. Mena he uaua ki a koe te horomia i nga papa, korero ki to roopu hauora mo etahi atu huarahi hei tango i to rongoa.

Mena ka hiahia koe ki te tango i te rongoa ma te ngongo kai, ka taea e to kaiwhakarato hauora te whakaatu ki a koe me pehea te whakakore i te papa ki te wai i runga i te haumaru. Me mahi tenei i muri noa i nga tohutohu motuhake mai i to roopu rongoa.

He mea nui ki te tango i te osimertinib i te mea i tohua, ahakoa kei te pai koe. Ko nga rongoa mate pukupuku e pai ana ina tangohia i nga wa katoa, a ko te peke i nga pota ka taea e nga pūtau mate pukupuku te timata ki te tipu ano.

Kia Pehea Te Roa E Tango Ai Ahau i te Osimertinib?

Ka haere tonu koe ki te tango i te osimertinib i te wa e mahi ana ki te whakahaere i to mate pukupuku me te pai ki a koe. Ka roa pea tenei i nga marama, i nga tau ranei, i runga i te ahua o to mate pukupuku ki te maimoatanga.

Ka aroturukihia e to taakuta to ahunga whakamua ma nga karapa me nga whakamatautau toto i nga wa katoa kia kite i te pai o te mahi o te rongoa. Ko enei arowhai ka awhina ki te whakatau mena me haere tonu koe ki te maimoatanga kotahi, mena ka hiahiatia nga whakatikatika.

Ka tango etahi turoro i te osimertinib mo etahi tau mena kei te whai hua tonu. Ko etahi atu ka hiahia ki te huri ki nga maimoatanga rereke mena ka whakawhanake to ratou mate pukupuku i te aukati ki te rongoa, ki te uaua rawa ranei nga paanga taha ki te whakahaere.

Kaua rawa e mutu te tango i te osimertinib ohorere me te kore korero ki to taakuta i te tuatahi. Ahakoa kei te pa ki a koe nga paanga taha, ka taea e to roopu hauora te whakatika i to mahere maimoatanga hei awhina i a koe ki te haere tonu ki te whai hua mai i te rongoa i runga i te haumaru.

He aha ngā pānga taha o Osimertinib?

Ahakoa te nuinga o te wā he iti ake ngā pānga taha kino o te osimertinib i te rongoā matū tuku iho, ka taea tonu e ia ētahi tohumate hōhā. Ko te nuinga o ngā pānga taha ka taea te whakahaere mā te manaaki tika me te aroturuki mai i tō rōpū hauora.

Ko ngā pānga taha tino noa ka pā ki a koe ko te korere, te pānga kiri, te kiri maroke, ngā huringa o ngā whao, me te ngenge. Ko ēnei tohumate ka pai ake i te roanga o te wā i te wa e urutau ana tō tinana ki te rongoā, ā, ka taea e tō rōpū hauora te whakarato rautaki hei āwhina i te whakahaere i a rātou.

Anei ngā pānga taha tino noa e pā ana ki ngā tūroro:

• Te korere, e taea ana te whakahaere mā ngā huringa kai me ngā rongoā e hokona ana i te tākaro
• Te pānga kiri me te kiri maroke, ka puta i roto i ngā wiki tuatahi o te rongoā
• Ngā huringa ki ō whao, tae atu ki te ngoikore, te huringa rānei o te tae
• Te ngenge me te pōuri atu i te tikanga
• Te iti o te hiahia me te ngaronga taumaha pea
• Ngā patito waha, te stomatitis rānei

Ko ēnei pānga taha noa, ahakoa he hōhā, he ngawari ki te āhua, ā, ka taea te whakahaere mā te manaaki tautoko. Ka mahi tō rōpū hauora ki a koe hei whakaiti i ēnei pānga me te āwhina i a koe ki te pupuri i tō kounga o te oranga.

He pānga taha anō he iti noa iho engari he nui ake te kino e hiahia ana kia tere te rongoā. Ahakoa ka pā ēnei ki te iti o ngā tūroro, he mea nui kia mōhio koe ki a rātou kia tere ai te rapu āwhina ki te hiahiatia.

Ngā pānga taha kino e hiahia ana kia tere te rongoā:

• Ngā raruraru o te pūkahukahu, tae atu ki te mumura o ngā pūkahukahu (pneumonitis), ka pā ki te poto o te manawa, ki te mare rānei
• Ngā raruraru o te ngākau, tae atu ki ngā huringa o te manawataki, ki te hekenga rānei o te mahi o te ngākau
• Ngā tauhohenga kiri kaha e hipoki ana i ngā wāhi nui o tō tinana
• Ngā raruraru o te kanohi, tae atu ki ngā huringa o te tirohanga, ki te mamae kanohi kaha rānei
• Ngā raruraru o te pūata toto, ka pā ki te pūpū rānei, ki te mamae rānei i ō waewae

Mēnā ka pā ki a koe ētahi o ēnei tohumate nui, whakapā atu ki tō tākuta i te wā tonu. Mā te kimi wawe me te rongoā i ēnei pānga taha ka āwhina i te ārai i ngā raruraru nui ake.

Ko wai kāore e tika kia tango Osimertinib?

Kāore a Osimertinib e tika ana mō te katoa, ā, ka āta arotake tō tākuta mēnā koinei te rongoā tika mō tō āhuatanga motuhake. E whai hua ana te rongoā mō ngā mate pukupuku e whai huringa EGFR motuhake ana, nō reira he mea nui te whakamātautau ira i mua i te tīmatanga o te rongoā.

Kāore koe e tika kia tango osimertinib mēnā he pāwera koe ki te rongoā, ki ētahi o ōna whakauru rānei. Kōrero ki tō tākuta mō ngā tauhohenga pāwera o mua ki ngā rongoā, inā koa ki ētahi atu rongoā mate pukupuku, ki ngā aukati tyrosine kinase rānei.

Kāore ngā wāhine hapū e tika kia tango osimertinib nā te mea ka whara i te pēpi e tipu ana. Mēnā he wāhine koe kei te whānau tamariki, me whakamahi koe i te mana whakawhānau whai hua i te wā o te rongoā, ā, mō te ono wiki i muri i tō horopeta whakamutunga.

Me whakamahi hoki ngā tāne e tango ana i te osimertinib i te mana whakawhānau whai hua i te wā o te rongoā, ā, mō te whā marama i muri i te horopeta whakamutunga, nā te mea ka pā te rongoā ki te pūtau purapura, ā, ka whara pea i te pēpi e tipu ana.

Ko ngā tāngata e whai āhuatanga ngākau motuhake ana, ngā raruraru tākihi kaha, te mate ate kaha rānei, tērā pea ka hiahia ki te aroturuki motuhake, ki te whakatikatika rānei i te horopeta. Ka arotake tō tākuta i tō hītori hauora katoa hei whakatau mēnā he haumaru te osimertinib mōu.

Ngā Ingoa Waitohu Osimertinib

Ko Osimertinib te nuinga e mōhiotia ana e tōna ingoa waitohu Tagrisso, he mea hanga e AstraZeneca. Koinei te ingoa ka kitea e koe i runga i tō pounamu rongoā me te pōkai rongoā.

I ētahi whenua, ka wātea pea te osimertinib i raro i ngā ingoa waitohu rerekē, i te rongoā whānui rānei. Heoi anō, ko Tagrisso te puka tino rongonui me te wātea o tēnei rongoā i te ao katoa.

Me mōhio tonu kei te whiwhi koe i te rongoā tika mā te tirotiro i te ingoa whānui (osimertinib) me te ingoa waitohu (Tagrisso) ki tō kai rongoā. Mā tēnei ka mōhio kei te whiwhi koe i te rongoā tika me te horopeta tika.

Ngā Kōwhiringa kē mō Osimertinib

Mēnā kāore te osimertinib e tika ana mōu, ka mutu rānei te mahi whai hua, he maha ngā rongoā kē e wātea ana mō te mate pukupuku pūkahukahu EGFR-mutated. Ka whakaaro tō tākuta ki ō āhuatanga mate pukupuku me te hītori rongoā i te wā e tūtohu ana i ngā kōwhiringa kē.

Ko ētahi atu aukati EGFR ko erlotinib (Tarceva) me afatinib (Gilotrif), e whakamahia ana i te nuinga o te wā hei rongoā tuatahi. E mahi ana ēnei rongoā i te rite ki te osimertinib engari he pai ake pea mō ētahi momo EGFR mutations, mō ngā tūāhua tūroro rānei.

Mō ngā tūroro kua piki ake te mate pukupuku i runga i ngā rongoā whāinga maha, ka tūtohutia pea ngā rongoā whakakotahi. Ka uru pea ēnei ki te osimertinib i te tahi me te chemotherapy, ētahi atu rongoā whāinga rānei, i runga i ngā āhuatanga motuhake o tō mate pukupuku.

He mea nui tonu te chemotherapy tuku iho, ina koa mō ngā tūroro kāore nei ō rātou mate pukupuku i ngā mutations e whāia ana, kua whakawhanake rānei i te ātete ki ngā rongoā whāinga maha. Mā tō tākuta mate pukupuku e āwhina ki te whakatau i te raupapa rongoā pai rawa atu mō tō tūāhua takitahi.

He Pai Anei te Osimertinib i te Erlotinib?

He pai ngā rongoā Osimertinib me erlotinib hei aukati i te EGFR, engari he pai ake te mahi i roto i ngā āhuatanga rerekē. Ko te Osimertinib te mea e kiia ana he pai ake mō te maimoatanga tuatahi o te mate pukupuku pūkahukahu EGFR-mutated, ā, kua whakaatu i ngā hua pai ake i roto i ngā whakamātau haumanu.

Kua whakaatu ngā rangahau he roa ake te oranga kore-whakawhanake a Osimertinib i te erlotinib i te wā e whakamahia ana hei maimoatanga tuatahi. Ko te tikanga, ka roa ake te wā ka tīmata anō te tipu o te mate pukupuku o ngā tūroro i te wā e rongoāhia ana ki te Osimertinib i te tuatahi.

He pai ake hoki te uru o te Osimertinib ki te roro, e whai hua ana ki te ārai, ki te rongoā rānei i ngā metastases roro. He mea nui tēnei nā te mea ka horapa te mate pukupuku pūkahukahu ki te roro.

Heoi, ka pai ake pea te erlotinib i ētahi āhuatanga, pēnei i te wā e nui ana te utu, i te wā rānei e pā ana ki te tūroro ētahi pānga taha e kore ai e tika te Osimertinib. Ka whakaarohia e tō tākuta ēnei mea katoa i te wā e tūtohu ana i te maimoatanga pai rawa atu mō tō āhuatanga motuhake.

Ngā Pātai Auau mō Osimertinib

He Haumaru te Osimertinib mō te hunga e mate ana i te mate ngākau?

Ka taea te whakamahi i te Osimertinib mō te hunga e mate ana i te mate ngākau, engari me mātakitaki tōtika, ā, me whakatika pea te horopeta. I ētahi wā ka pā te rongoā ki te manawataki, ki te mahi rānei o te ngākau, nō reira ka arotakehia e tō tākuta tō hauora ngākau i mua i te tīmatanga o te maimoatanga.

Mēnā he hītori tō mate ngākau, ka tono pea tō tākuta i ngā whakamātau ngākau, tae atu ki te electrocardiogram (ECG) me te echocardiogram. Ka āwhina ēnei whakamātau ki te whakatau i te mahi o tō ngākau i tēnei wā, ā, ka whakarato i te pūtake mō te mātakitaki i te wā o te maimoatanga.

I te wā o te maimoatanga, ka whai koe i ngā arotake auau hei mātakitaki i te mahi o tō ngākau. Mēnā ka puta ētahi pānga taha e pā ana ki te ngākau, ka taea e tō tākuta te whakatika i tō horopeta, te whakarato rānei i ētahi atu maimoatanga hei tiaki i tō ngākau i te wā e haere tonu ana tō maimoatanga mate pukupuku.

Me pēhea ahau ki te mahi mēnā ka inu au i te nui rawa o te Osimertinib?

Mēnā ka inu koe i te nui rawa o te osimertinib i te mea i tohua, whakapā atu ki tō kaiwhakarato hauora, ki te pokapū whakahaere paitini rānei tonu. Kaua e tatari kia kite mēnā ka puta ngā tohumate, nā te mea he mea nui te whiwhi tohutohu hauora tere mō tō haumaru.

Ko te inu i te nui rawa o te osimertinib ka piki ake te tūponotanga o ngā pānga taha nui, ina koa ko ērā e pā ana ki tō ngākau, pūkahukahu, kiri rānei. Ka taea e ngā kaiwhakarato hauora te aroturuki i a koe kia tata ake, me te whakarato i te manaaki tautoko mēnā e tika ana.

Kawea mai tō pounamu rongoā ki a koe mēnā e hiahia ana koe ki te rapu āwhina hauora, nā te mea ka āwhina tēnei i ngā kaiwhakarato hauora ki te mārama ki te aha me te nui i inu koe. Kaua rawa e ngana ki te "whakatika" i te horopeta nui mā te karo i ngā horopeta kei te heke mai.

Me pēhea ahau ki te mahi mēnā ka ngaro au i tētahi horopeta Osimertinib?

Mēnā ka ngaro koe i tētahi horopeta osimertinib, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, pekehia te horopeta i ngaro, ka haere tonu ki tō hōtaka auau.

Kaua rawa e inu i ngā horopeta e rua i te wā kotahi hei whakatika i tētahi horopeta i ngaro, nā te mea ka piki ake tō tūponotanga o ngā pānga taha. Mēnā kāore koe i te mōhio mō te wā, whakapā atu ki tō kaiwhakarato hauora, ki te kaimātai rongoā rānei mō te ārahitanga.

Hei āwhina i te mahara ki tō horopeta ia rā, whakaarohia te whakatakoto i te whakaoho waea, te whakamahi rānei i te kaiwhakarite pire. Ko te inu i tō rongoā i te wā kotahi i ia rā ka āwhina i te pupuri i ngā taumata rite i tō tinana, me te whakapai ake i te whai huatanga o te maimoatanga.

Āhea ka taea e au te whakamutu i te inu Osimertinib?

Me whakamutu noa koe i te inu osimertinib i raro i te ārahitanga tika o tō tohunga mate pukupuku. Ko te whakatau ki te whakamutu i te maimoatanga e hāngai ana ki ētahi mea, tae atu ki te pai o te whakahaere a te rongoā i tō mate pukupuku, me te pai o tō whakawhanaunga i ngā pānga taha.

Ka whakamahia e tō tākuta ngā karapa me ngā whakamātautau toto i ngā wā katoa hei aroturuki i te urupare o tō mate pukupuku ki te rongoā. Mēnā e whakaatu ana ngā karapa kei te tipu tō mate pukupuku ahakoa te rongoā, mēnā rānei ka pā mai ngā pānga taha nui e kore e taea te whakahaere, ka tūtohu pea tō tākuta kia whakamutua te osimertinib.

Ka haere tonu ētahi tūroro ki te tango osimertinib mō ngā tau mēnā kei te whakahaere pai i tō rātou mate pukupuku me ngā pānga taha ka taea te whakahaere. Ko ētahi atu pea me huri ki ētahi rongoā rerekē mēnā ka whakawhanake tō rātou mate pukupuku i te ātete, mēnā rānei ka uaua rawa ngā pānga taha.

Ka taea e au te inu waipiro i te wā e tango ana au i te Osimertinib?

Kāore he pānga motuhake i waenga i te osimertinib me te waipiro, engari e tūtohutia ana kia whakawhāitihia te inu waipiro i te wā o te rongoā mate pukupuku. Ka taea e te waipiro te whakapōrearea i ētahi pānga taha pēnei i te ngenge, te whakapairuaki, me ngā raruraru kōhauhau.

Mēnā ka whiriwhiria e koe te inu waipiro i ētahi wā, me mahi i roto i te āhua ngawari me te aro ki te urupare o tō tinana. E kitea ana e ētahi tūroro ka kaha ake te pānga o te waipiro ki a rātou i te wā e rongoā ana i te mate pukupuku, ahakoa i roto i ngā rahinga iti.

Me kōrero tonu ki tō rōpū hauora mō te inu waipiro, ina koa kei te tango koe i ētahi atu rongoā i te taha o te osimertinib. Ka taea e rātou te whakarato tohutohu whaiaro i runga i tō mahere rongoā katoa me te āhua o tō hauora.