He aha te Pazopanib: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā mate pukupuku whāinga a Pazopanib e mahi ana mā te aukati i ngā pūmua motuhake e āwhina ana i ngā pūtau mate pukupuku ki te tipu me te horapa. He wāhanga tēnei o te rōpū rongoā e kīia ana ko ngā aukati tyrosine kinase, e mahi ana hei arai i ngā tohu tipu o te mate pukupuku.

He ahunga whakamua nui tēnei rongoā i roto i te rongoā mate pukupuku nā te mea ka taea e ia te whakaiti i te tipu o te puku i te wā e āhei ana koe ki te pupuri i te kounga o te oranga pai ake i te rongoā matū tuku iho. Ka tohua e tō tākuta te pazopanib ina hiahia ana rātou ki te whāinga i tō mate pukupuku mā te huarahi whai wāhi.

He aha te Pazopanib e Whakamahia Ana?

Ko te Pazopanib te mea nui e tohua ana hei rongoā i te mate pukupuku whatukuhu matatau, e kīia ana ko te carcinoma pūtau whatukuhu. Ka whakamahia motuhake ina kua horapa te mate pukupuku ki tua atu i te whatukuhu, i te wā rānei kāore he whai wāhi o te pokanga.

Ka tūtohu pea tō tākuta i te pazopanib mō ētahi momo sarcomas kiko ngawari, he mate pukupuku tēnei e whanake ana i roto i ngā uaua, ngako, ngā oko toto, ētahi atu kiko tautoko puta noa i tō tinana. He mate pukupuku tēnei kāore i te pāpā, engari kua whakaatu a pazopanib i ngā hua pai ki te whakaiti i tō rātou haere whakamua.

Ko te rongoā e pai ana mō ngā wāhanga matatau o ēnei mate pukupuku ko te whāinga ki te whakahaere i te mate me te āwhina i a koe ki te pupuri i tō kounga o te oranga. Kāore i te nuinga o te wā he rongoā tuatahi mō ngā mate pukupuku wāhanga tuatahi ka taea te tango mā te pokanga.

Me pēhea te Mahi a Pazopanib?

Ka mahi a Pazopanib mā te aukati i ētahi pūmua matua e hiahia ana ngā pūtau mate pukupuku ki te tipu me te hanga i ngā oko toto hou. Whakaarohia he tapahi i ngā rārangi tuku o te mate pukupuku, kaua ki te whakaeke tika i ngā pūtau mate pukupuku ake.

Ka whāinga motuhake te rongoā i ngā pūmua e kīia ana ko VEGFR, PDGFR, me c-Kit, he rite ki ngā huri e kī ana ki ngā pūtau mate pukupuku kia nui ake me te hanga i ngā oko toto hou. Mā te aukati i ēnei huri, ka whakamate a pazopanib i te puku o ngā matūkai me te hāora e hiahia ana ki te tipu.

Na te mea he rongoā mate pukupuku kaha te pazopanib, he ngawari ake te whakahaere i te rongoā matū tuku iho. Ahakoa te kaha ki te whakaroa i te haere whakamua o te mate pukupuku, he iti ake nga paanga kino i nga rongoā mate pukupuku tawhito.

Me pēhea taku tango i te Pazopanib?

Tangohia te pazopanib i runga i nga tohutohu a to taakuta, i te nuinga o te wā kotahi i te rā i runga i te puku kau. Ko te tikanga me tango i te iti rawa i te haora kotahi i mua i te kai, e rua rānei haora i muri i tō kai whakamutunga.

Horomia katoatia ngā papa ki te wai – kaua e kuru, e ngaungau, e wawahi rānei. Me ngongo tika te rongoā, ā, ko te wawahi i ngā papa ka pā ki te nui e uru ana ki tō tinana.

Whakamātauria ki te tango i tō horopeta i te wā kotahi i ia rā kia mau tonu ngā taumata i tō tinana. He maha ngā tāngata e kite ana he pai ki te tango i te ata tonu, katahi ka tatari i te iti rawa i te haora kotahi i mua i te parakuihi.

Kaua e kai karepe me te wai karepe i te wā e tango ana i te pazopanib, nā te mea ka piki ake ngā taumata o te rongoā i roto i tō toto, ā, ka nui ake pea ngā pānga kino.

Kia Pēhea te Roa o taku tango i te Pazopanib?

Ka haere tonu koe ki te tango i te pazopanib i te wā e āwhina ana ki te whakahaere i tō mate pukupuku, ā, e pai ana tō tinana ki te rongoā. Ka roa pea mō ngā marama, tau rānei, i runga i te āhua o te urupare a tō tinana.

Ka aroturukihia e tō tākuta tō ahunga whakamua mā ngā karapa me ngā whakamātautau toto i ia wā kia kite i te pai o te mahi a te rongoā. Ka mātakitaki hoki rātou i ngā pānga kino ka hiahia pea ki te whakatika i tō horopeta, ki te whakamutu rānei i te rongoā.

Ko te whakatau ki te haere tonu, ki te whakamutu rānei i te pazopanib e whakawhirinaki ana ki ētahi mea: mehemea kei te pūmau, kei te haere whakamua rānei tō mate pukupuku, me pēhea tō āhua whānui, mehemea ka nui ake ngā painga i ngā pānga kino e pā ana ki a koe.

He aha ngā Pānga Kino o te Pazopanib?

Ko te nuinga o te tangata e tango ana i te pazopanib ka pa ki etahi paanga taha, engari he ngawari tonu te whakahaere me te manaaki tika me te aroturuki. Ma te mohio ki nga mea e tumanakohia ana ka awhina koe ki te whakarite me te mohio ki te wa ki te whakapā atu ki to roopu hauora.

Anei nga paanga taha tino noa ka pa ki a koe:

• Te korere me te puku pouri
• Te ngenge me te ngenge
• Te whakapairuaki me te iti o te hiahia
• Te toto tiketike
• Nga huringa tae makawe (ka ma, ka hina ranei)
• Te pupuhi kiri, te kiri maroke ranei
• Te mamae o te uaua me te hononga

Ko enei paanga taha ka pai ake i te wa e urutau ana to tinana ki te rongoa, a ka taea e to taakuta te awhina ki te whakahaere ma te maimoatanga tautoko.

Ko nga paanga taha iti noa engari he nui ake te kino e hiahia ana kia aro mai te rongoa tonu. Ahakoa kaore enei e pa ana ki te katoa, he mea nui kia mohio ki a raatau:

• Nga raruraru ate nui (te kowhai o te kiri, o nga kanohi ranei, te mimi pouri)
• Nga huringa manawataki ngakau, te mamae ranei o te uma
• Te nui o te toto, te maru rereke ranei
• Nga tohu o te toto toto (te poto o te manawa ohorere, te pupuhi waewae)
• Nga tauhohenga kiri nui, nga patito ranei o te waha
• Nga raruraru thyroid (te tino ngenge, nga huringa taumaha)

Ka aroturukihia koe e to roopu rongoa mo enei paanga ma nga whakamatautau toto me nga arowhai i nga wa katoa. Ko te nuinga o nga paanga taha ka taea te whakahaere ina mau wawe.

Ko wai e kore e tango Pazopanib?

Kaore e tika ana te Pazopanib mo te katoa, a ka ata arotakehia e to taakuta to hitori rongoa i mua i te whakahau. Ko etahi ahuatanga ka kore e haumaru, ka iti ake ranei te whai hua o tenei rongoa.

Kaua koe e tango pazopanib mena he mate ate nui koe, na te mea ka kino ake te mahi ate o te rongoa. Ko nga tangata e pa ana ki etahi ahuatanga ngakau, te toto tiketike kaore i te whakahaerehia, nga raruraru toto tata nei ranei, me karo ano tenei maimoatanga.

Mēnā kei te hapū koe, kei te whāngai u rānei, ka taea e te pazopanib te whara i tō pēpi, ā, kāore i te tūtohutia. Me whakamahi ngā wāhine e whai tamariki ana i te mana whakawhānau whai hua i te wā o te rongoā, me ngā wiki maha i muri i te whakamutu i te rongoā.

Ka whakaaro hoki tō tākuta ki ētahi atu rongoā e inu ana koe, nā te mea ka taea e te pazopanib te pā ki te maha o ngā rongoā, tae atu ki ētahi rongoā whakaheke toto, rongoā ngākau, me ētahi taapiri otaota.

Ngā Ingoa Waitohu Pazopanib

E hokona ana te Pazopanib i raro i te ingoa waitohu Votrient i te nuinga o ngā whenua, tae atu ki te United States. Koinei te āhua tino noa ka kitea e koe i ngā whare rongoā.

Ka rerekē pea ngā ingoa waitohu, ngā putanga rānei i ētahi whenua. Me mōhio tonu kei te whiwhi koe i te rongoā tika mā te tirotiro ki tō kaiwhakarongoā mēnā he pātai āu mō te ingoa, te āhua rānei o āu pire.

Ngā Kōwhiringa Pai mō Pazopanib

He maha atu ngā rongoā whāinga e mahi ana i te rite ki te pazopanib mō te rongoā i te mate pukupuku whatukuhu me ngā sarcoma kiko ngawari. Ka whakaaro pea tō tākuta ki ēnei kōwhiringa pai mēnā kāore te pazopanib e tika ana mōu, e mutu ana rānei te mahi whai hua.

Mō te mate pukupuku whatukuhu, ko ngā kōwhiringa pai ko te sunitinib (Sutent), sorafenib (Nexavar), me ngā rongoā hou pēnei i te cabozantinib (Cabometyx) rānei nivolumab (Opdivo). He painga me te āhua o ngā pānga taha ōna ake.

Mō ngā sarcoma kiko ngawari, ko ngā kōwhiringa pea ko te chemotherapy i runga i te doxorubicin, ifosfamide, ētahi atu rongoā whāinga rānei pēnei i te trabectedin. Ko te kōwhiringa pai rawa atu ka whakawhirinaki ki tō momo sarcoma me te hauora whānui.

Ka āwhina tō tākuta mate pukupuku i a koe ki te mārama he aha rātou i tūtohu ai i te pazopanib i runga i ēnei kōwhiringa pai, me te whakaaro ki tō momo mate pukupuku, te hītori rongoā, me ngā hiahia whaiaro.

He Pai Anei te Pazopanib i te Sunitinib?

He rongoā whai hua a Pazopanib me sunitinib mō te mate pukupuku whatukuhu kua piki ake, engari he rerekē te āhua o tā rāua mahi, ā, he rerekē ngā pānga taha. Kāore tētahi i te tino pai ake i tētahi – kei runga i tō āhuatanga ake.

Kua whakaatu ngā rangahau he rite te whai huatanga o te pazopanib me te sunitinib ki te whakaiti i te pikinga o te mate pukupuku me te whakaroa i te oranga. Heoi, he maha ngā tāngata e kite ana he māmā ake te pazopanib ki te whakamahi i ia rā, he iti ake te ngenge me te iti ake o ngā patito i te waha.

Ka whakamahia te Sunitinib i roto i ngā huringa me ngā wā okioki, i te mea ka whakamahia tonu te pazopanib. He pai ki ētahi tāngata te huarahi tonu, i te mea e pai ana ētahi ki te whai wā okioki i te rongoā. Ka whakaarohia e tō tākuta tō āhua noho, ētahi atu āhuatanga hauora, me ō hiahia ake i te wā e whiriwhiri ana i waenga i a rāua.

He maha ngā wā ka heke te whakatau ki te rongoā e pai ake ana ki tō oranga me ngā pānga taha e pai ana koe ki te whakahaere.

Ngā Pātai Auau mō Pazopanib

He Haumaru te Pazopanib mō te Tāngata e Pā ana ki te Mate Ngākau?

Ka pā te Pazopanib ki tō ngākau me te pēhanga toto, nō reira me mātakitaki ngā tāngata e pā ana ki te mate ngākau. Ka arotakehia e tō tākuta tō hauora ngākau i mua i te tīmatanga o te rongoā, ā, ka tono pea i ngā whakamātautau ngākau pēnei i te echocardiogram, te EKG rānei.

Mēnā he iti noa iho ō raru ngākau, ka taea tonu pea e koe te tango pazopanib me te mātakitaki tata me te rongoā ngākau pea hei whakahaere i te pēhanga toto. Heoi, ko te ngoikore ngākau nui, ngā whakaeke ngākau tata rānei, ka nui te mōrearea o te pazopanib.

Ka mahi tahi tō rōpū cardio-oncology ki te whakatau mēnā ka nui ake ngā painga o te rongoā mate pukupuku i ngā mōrearea ngākau i tō āhuatanga motuhake.

Me Pēhea Taku Mahi Mēnā Ka Tango Au i te Nui Rawa o te Pazopanib?

Mēnā ka tango koe i te nui rawa o te pazopanib i te mea kua whakaritea, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei i te wā tonu. Kaua e tatari kia kite mēnā ka rongo koe i ngā tohu – ko te whiwhi tohutohu hauora i te wawe tonu te huarahi haumaru.

Mena ka nui rawa te pazopanib ka pā ngā pānga kino nui pēnei i te toto tino iti, ngā raruraru o te manawa, te kino rānei o te ate. Kāore pea ēnei pānga e puta tonu, nō reira he mea nui te aroturuki hauora ahakoa kei te pai koe.

Me kawe mai tō pounamu rongoā ki te hōhipera, kia wātea rānei ina waea ana koe, kia mōhio ai ngā kaiwhakarato hauora ki te aha me te nui i tango koe.

Me aha au ki te ngaro i te horopeta o Pazopanib?

Mēnā i ngaro koe i tētahi horopeta, ā, kua iti iho i te 12 hāora mai i tō wā tonu, tangohia i te wā e mahara ana koe. Mēnā kua roa ake i te 12 hāora, waiho te horopeta i ngaro, ka tango i tō horopeta e whai ake nei i te wā tonu.

Kaua rawa e tango i ngā horopeta e rua i te wā kotahi hei utu mō tētahi horopeta i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga kino nui. He pai ake te ngaro i tētahi horopeta i te rua.

Mēnā he maha ngā wā e wareware ana koe ki ngā horopeta, kōrero ki tō rōpū hauora mō ngā rautaki hei āwhina i a koe ki te mahara, pēnei i ngā whakaoho waea, ngā whakarite pire, ngā taupānga atamai rānei i hangaia mō ngā whakamaharatanga rongoā.

Āhea e taea ai e au te whakamutu i te tango Pazopanib?

Me whakamutu anake e koe te tango pazopanib i raro i te tohutohu a tō tākuta. Ahakoa kei te pai ake koe, kei te pā rānei ngā pānga kino, ko te whakamutu ohorere me te kore e tirotirohia e te tākuta ka taea e tō mate pukupuku te tipu tere ake.

Ka tūtohu tō tākuta kia whakamutua te pazopanib mēnā ka piki ake tō mate pukupuku ahakoa te rongoā, mēnā ka whanake koe i ngā pānga kino nui e kore e taea te whakahaere, mēnā rānei ka pai ake ētahi atu rongoā mō tō āhuatanga.

I ētahi wā ka āhei pea tō tākuta te whakamutu i te rongoā mō tētahi wā kia ora ai tō tinana i ngā pānga kino, katahi ka tīmata anō i te horopeta iti ake. Ka taea e tēnei huarahi te āwhina i a koe ki te whai hua tonu mai i te rongoā i te wā e noho pai ana koe.

Ka taea e au te inu waipiro i te wā e tango ana au i te Pazopanib?

He pai ake te karo i te waipiro, inu ranei i nga rahinga iti rawa i te wa e tango ana i te pazopanib. Ka taea e te waipiro me te pazopanib te pa ki to ate, a, ko te whakakotahi i a raua ka nui ake te tupono o te kino o te ate.

Ka taea hoki e te waipiro te whakapoke i etahi o nga paanga taha o te pazopanib, penei i te whakapairuaki, te whanoke, me te ngenge. Mena ka whiriwhiria e koe te inu i etahi wa, whakawhāitihia koe ki te inu kotahi me te aro ki te ahua o to tinana.

Me matapaki tonu te whakamahi waipiro ki to roopu hauora, na te mea ka taea e ratou te tohutohu whaiaro i runga i o whakamatautau mahi ate me te ahua o to hauora.