He aha te werohanga Polymyxin B: Ngā whakamahinga, te inenga, ngā pānga taha, me ētahi atu

Ko te werohanga Polymyxin B he rongoā paturopi kaha e whakamahia ana e ngā tākuta hei rongoā i ngā mate pāwera kino i te wā e kore ai ētahi atu paturopi e whai hua. No tētahi rōpū e kīia ana ko ngā paturopi polymyxin tēnei rongoā, ā, he mea hanga motuhake hei whawhai i ētahi momo huakita ka pā mai i ngā mate e mōrearea ana ki te ora. Ahakoa e kiia ana he rongoā kaha me ngā pānga taha ka puta, he kōwhiringa rongoā nui tēnei i te wā e tū ana koe ki ngā mate kino e kore e whai hua ki ētahi atu rongoā.

He aha te Polymyxin B?

Ko te Polymyxin B he paturopi e mahi ana mā te wawahi i te pakitara o waho o ētahi huakita, e whakangaro ana i a rātou mai i waho ki roto. Koinei te mea e kīia ana e ngā tākuta he paturopi "kōwhiringa whakamutunga" nā te mea e rāhui ana mō ngā mate kino i pā mai i ngā huakita gram-negative e kore e whai hua ki ngā paturopi haumaru ake. Whakaarohia he taputapu motuhake e toro atu ana ngā tākuta i te wā e hiahia ana rātou ki tētahi mea tino kaha ki te whawhai i ngā mate mārō.

Kua noho mai tēnei rongoā mai i ngā tau 1940, ā, ahakoa kua whanakehia ngā paturopi hou, kei te whai hua tonu te polymyxin B mō te rongoā i ētahi momo huakita ātete. E wātea ana anake hei werohanga nā te mea me tuku tika ki roto i tō toto kia tino whai hua ai.

He aha te Polymyxin B e whakamahia ana?

Ka rongoā te werohanga Polymyxin B i ngā mate pāwera kino e kore e taea e ētahi atu paturopi te rongoā whai hua. Ka tohutohu pea tō tākuta i tēnei rongoā i te wā e pā ana koe i tētahi mate kino, ā, e whakaatu ana ngā whakamātau taiwhanga he ātete ngā huakita e pā mai ana i tō mate ki ētahi atu rongoā. He tino whai hua mō ngā mate i roto i tō toto, ngā pūkahukahu, te ara mimi rānei.

Ko ngā momo mate ka hiahia pea ki te polymyxin B ko te pūkahukahu, te sepsis (mate toto), me ngā mate i roto i ngā ara mimi i puta mai i ētahi huakita pēnei i te Pseudomonas aeruginosa, Acinetobacter, me ētahi momo E. coli. Kua whakawhanakehia e ēnei huakita te ātete ki te maha o ngā paturopi noa, nā reira ka waiho te polymyxin B hei rongoā nui.

I ētahi wā, ka whakamahi hoki ngā tākuta i te polymyxin B mō ngā mate i tō puku, i ngā mate rānei ka puta i muri i te pokanga. Ko te whakatau ki te whakamahi i tēnei rongoā ka puta tonu i muri i te whakaaro nui ki tō mate motuhake me ngā hua o te ahurea huakita.

Me pēhea te mahi a te Polymyxin B?

Ka mahi te Polymyxin B mā te whai i te kiriwaho o ngā huakita, ina koa ngā huakita gram-negative. Ka piri ki ngā wāhanga i roto i te pakitara pūtau huakita e kiia nei ko te lipopolysaccharides, e pakaru ai te pakitara pūtau me te turuturu. Ko tēnei tukanga ka mate i te huakita e pā ana ki tō mate.

E kiia ana he kaha rawa tēnei rongoā i roto i te ao paturopi. Ahakoa te kaha e whai hua ana ki ngā huakita ātete, ko te tikanga ka pā hoki ki ō pūtau ake ki ētahi tohu, koinei te take e mātakitaki tata ana ngā tākuta i a koe i te wā o te rongoā. Ka tere te mahi a te rongoā i te wā e tae ana ki te wāhi mate mā tō toto.

Nō te mea he kaha rawa te polymyxin B, ka whakamahi noa ngā tākuta i te wā e tino tika ana. Ehara i te paturopi tuatahi, engari he taputapu kaha i rahuitia mō ngā āhuatanga kāore i angitu ngā paturopi ngawari.

Me pēhea taku tango i te Polymyxin B?

Ka hāpai tonu ngā tāngata hauora i te werohanga polymyxin B i roto i te hōhipera, i te wāhi haumanu rānei. Kāore koe e tango i tēnei rongoā i te kāinga nā te mea me mātakitaki nui me te whakahaere tika. Ko te tikanga ka hāpai te rongoā mā te raina IV (intravenous) tika ki tō uaua, e āhei ai te huri i tō tinana katoa.

Ka hoatu e tō rōpū hauora te werohanga ki a koe i te wā roa, i roto i te 1-2 haora. Mā tēnei whakahaere haere e āwhina te whakaiti i te tūponotanga o ngā pānga taha, ā, ka taea e tō tinana te whakahaere pai ake i te rongoā. Ka rerekē pea te wā me te tikanga i runga i tō āhuatanga motuhake me te pēhea te urupare o tō tinana ki te rongoā.

I te wā o te rongoā, kāore koe e mōhio ki ngā rāhui kai, ki te tango rānei i te rongoā me ngā kai i te mea ka tukuna tika ki roto i ō toto. Heoi, he mea nui kia noho pai te wai, nō reira ka akiaki pea tō rōpū hauora i a koe ki te inu nui i te wai, ki te kore he take hauora hei rāhui i te wai.

Ka aroturuki tō rōpū hauora i te mahi o ō tākihi, te rongo, me te urupare whānui ki te rongoā i te wā o tō rongoā. Ka whakatika rātou i te horopeta, i te wā rānei, ki te hiahiatia i runga i te pēhea te whakahaere o tō tinana i te rongoā.

Kia Pēhea te Roa o taku Tango i te Polymyxin B?

Ko te roa o tō rongoā polymyxin B e whakawhirinaki ana ki te momo me te kaha o tō mate, me te tere o te urupare o tō tinana ki te rongoā. Ko te nuinga o ngā akoranga rongoā e 7 ki te 14 rā, engari ka rerekē nui tēnei i runga i tō āhuatanga takitahi.

Ka aroturuki tō tākuta i ō tohu mate mā ngā whakamātautau toto me ētahi atu aromatawai hei whakatau i te wā e pai ana ki te whakamutu i te rongoā. Ka rapu rātou i ngā tohu e whakakorea ana ngā huakita me te pai o te whakaora o tō tinana. Ko ētahi mate ka hiahia pea ki ngā akoranga poto ake o te 5-7 rā, i te mea ka hiahia pea ngā mate nui ake, uaua ake rānei ki ngā wā rongoā roa ake.

He mea nui kia whakaoti i te akoranga rongoā katoa, ahakoa ka tīmata koe ki te pai ake i mua i te otinga. Mā te whakamutu wawe rawa ka taea e ngā huakita te ora me te whanake pea i te ātete nui ake ki ngā paturopi. Ka whakatau tō rōpū hauora i ngā whakatau mō te huri, te whakamutu rānei i tō rongoā i runga i tō ahunga whakamua me ngā hua whakamātautau.

He aha ngā pānga taha o te Polymyxin B?

Pērā i te nuinga o ngā rongoā kaha, ka taea e te polymyxin B te pānga taha, ahakoa kāore te katoa e pā ana ki a rātou. Ko ngā pānga taha tino noa he mea whakahaere, ā, he maha ngā wā ka pai ake i te wā e whakatika ana tō tinana ki te rongoā, i muri rānei i te mutunga o te rongoā.

Koinei ngā pānga taha ka pā ki a koe, ā, he mea nui kia mahara kei te mātakitaki tata tō rōpū hauora i a koe kia kitea, kia whakatikahia hoki ngā take i te wā wawe:

Ngā pānga taha noa ko:

• Te mamae, te whero, te pūhi rānei i te wāhi werohanga
• Te whakapairuaki, te puku rānei
• Te whanoke, te māmā rānei te mahunga
• Te ānini
• Te pānga kiri, te mānukanuka rānei
• Te ngoikore o ngā uaua, te ngenge rānei

Ngā pānga taha nui ake e hiahia ana kia āwhina tonu te rongoā ko:

• Ngā raruraru o te whatukuhu (ngā huringa i te mimi, te pūhi i ngā waewae)
• Ngā huringa whakarongo, te tangi rānei i ngā taringa
• Ngā pānga mate pāwera nui (te uaua ki te hā, te pānga kiri nui, te pūhi o te mata, te korokoro rānei)
• Ngā tohu neurological (raruraru, ngā hopu, te whanoke nui)
• Te ngoikore nui o ngā uaua, te pararutiki rānei

Kei te mātakitaki tata tō rōpū hauora i a koe mō ēnei pānga nui ake, ina koa te mahi whatukuhu me ngā huringa whakarongo, koinei ngā pānga taha e pā ana ki te mōhio. Ka tirohia e rātou ō toto i ngā wā katoa, ā, ka pātai mō ngā tohu e pā ana ki a koe.

Ko te nuinga o ngā pānga taha he wā poto, ā, ka ngaro i muri i te mutunga o te rongoā. Heoi anō, i ngā wā onge, ka mau tonu ētahi pānga ki te whakarongo, ki te mahi whatukuhu rānei, koinei te take e whakamahi ana ngā tākuta i tēnei rongoā i te wā e tika ana.

Ko wai kāore e tika kia tango Polymyxin B?

Kāore e tika ana kia whiwhi te hunga ētahi i te werohanga polymyxin B, ā, ka āta arotake tō tākuta i tō hītori hauora i mua i te whakahau. Ko te mea nui rawa atu ko te mea kua pā tō tinana ki te pānga mate ki te polymyxin B, ki ngā paturopi rite rānei i mua.

Ka tūpato rawa tō tākuta ki te whakahau polymyxin B mēnā he raruraru tākihi tōna, nā te mea ka taea e tēnei rongoā te whakapōrearea i te mahi o te tākihi. Ka āta whakaarohia hoki e rātou ngā tūponotanga mēnā he raruraru rongo tōna, he hītori rānei mō ngā mate ngoikore uaua pērā i te myasthenia gravis.

Mēnā e hapū ana koe, e whāngai u ana rānei, ka āta whakataurite tō tākuta i ngā painga ki ngā tūponotanga. Ahakoa pea e tika ana te polymyxin B mō ngā mate kino, ka āta aroturukihia koe me tō pēpi mēnā e hiahiatia ana te rongoā.

Ko te hunga e tango ana i ētahi atu rongoā, inā rā ngā mea ka pā ki te mahi tākihi, ki te rongo rānei, tērā pea ka hiahiatia he aroturuki motuhake, he whakatikatika rānei i te inenga. Ka arotake tō rōpū hauora i ō rongoā katoa kia mōhio ai kei te haumaru te rongoā.

Ngā Ingoa Waitohu Polymyxin B

Ko te ingoa waitohu mō te werohanga polymyxin B ko Poly-Rx. Heoi, e wātea ana hoki tēnei rongoā hei rongoā whānui, ko te tikanga tērā pea ka whiwhi koe i tēnei i raro i tōna ingoa whānui

Ahakoa te whakamahi pinepine a te polymyxin B mō ngā mate atete, he wā anō he rongoā paturopi kē atu e pai ana mō tō āhuatanga. E whakawhirinaki ana ēnei rongoā kē atu ki te momo huakita e pā ana ki tō mate me ō rātou tauira atete.

Ko ētahi atu rongoā paturopi ka whakaarohia e ngā tākuta ko te colistin (he rite tonu ki te polymyxin B), ētahi rongoā paturopi beta-lactam hou, rānei ngā rongoā whakakotahi e whakamahi ana i ngā rongoā paturopi maha. I ētahi wā, ko te tigecycline, ētahi rongoā paturopi hou pēnei i te ceftazidime-avibactam rānei ngā kōwhiringa.

E whakawhirinaki ana te kōwhiringa o te rongoā paturopi ki ngā hua o tō ahurea huakita me ngā whakamātautau tairongo. Mā tō tākuta e kōwhiri te rongoā e tika ana i runga i te mea ka whai hua ki tō mate motuhake, me te kore e nui ngā pānga taha.

I ētahi wā, he pai ake te rongoā whakakotahi e whakamahi ana i te polymyxin B me ētahi atu rongoā paturopi i te whakamahi i tētahi rongoā paturopi anake. Mā tō rōpū hauora e whakatau te huarahi pai rawa atu i runga i ō āhuatanga takitahi.

He Pai Ake Te Polymyxin B I Te Colistin?

He rongoā paturopi tino rite te polymyxin B me te colistin, nō te whānau kotahi, ā, he rite tonu te mahi. E whakaarohia ana he rite tonu te whai hua ki ngā huakita gram-negative atete, ā, ko te kōwhiringa i waenga i a rāua e whakawhirinaki ana ki te wātea me te hiahia o tō tākuta.

E ai ki ētahi rangahau, he māmā ake pea te polymyxin B ki ngā whatukuhu i te colistin, engari he rite tonu ngā tūponotanga o ngā rongoā e rua, ā, me āta aroturuki. He iti noa te rerekētanga o ngā pānga taha, ā, e whakaarohia ana he kōwhiringa tika ngā rongoā e rua mō ngā mate atete.

Ka whakatau pea tō tākuta i waenga i ēnei paturopi e rua i runga i ngā āhuatanga pēnei i tō mahi tākihi, ngā hua o te ahurea huakita, i te rānei ko tēhea rongoā e wātea ana i tō whare rongoā. He rongoā whai hua ngā mea e rua mō ngā mate kino e ātete ana.

I ētahi wā, ka huri pea tō tākuta mai i tētahi ki tētahi i runga i tō urupare ki te rongoā, i te rānei ka puta ngā pānga taha. Ko te mea nui ko te whiwhi koe i te rongoā tika mō tō mate, ahakoa ko tēhea paturopi polymyxin e whakamahia ana.

Ngā Pātai Auau mō Polymyxin B

Q1. He Haumaru a Polymyxin B mō te Hunga e Pāngia ana e te Mate Tākihi?

Me tūpato anō ki te whakamahi i te Polymyxin B mō te hunga e pāngia ana e te mate tākihi, nā te mea ka kino pea te mahi tākihi. Heoi anō, i ētahi wā ka whakahau tonu ngā tākuta i tēnei rongoā mō ngā mate kino i te wā e nui ake ana ngā painga i ngā tūponotanga. Ki te pāngia koe e ngā raruraru tākihi, ka whakatika pea tō tākuta i tō inenga, ā, ka tino mātakitaki i tō mahi tākihi i te wā o te rongoā.

Ka tirohia e tō rōpū hauora tō mahi toto i ngā wā katoa kia mōhio ai kei te tika te whakahaere a ō tākihi i te rongoā. Ka whakarite pea rātou kia pai tō wai, ā, ka karo i ētahi atu rongoā ka pēhi anō i ō tākihi i te wā o te rongoā.

Q2. Me Pēhea Taku Mahi ki te Whiwhi Au i te Nui Rawa o te Polymyxin B?

I te mea ka hoatu noa te polymyxin B e ngā tohunga hauora i ngā wāhi haumanu, he tino onge te nui rawa o te rongoā. Ki te māharahara koe mō tō inenga, i te rānei e pā ana ki ngā tohu rerekē i te wā o te rongoā, whakamōhio tonu ki tō rōpū hauora. Ka taea e rātou te arotake i tō āhuatanga, ā, ka whakarato i te manaakitanga tika ki te hiahiatia.

Ka mātakitaki tō rōpū hauora i tō inenga, ā, ka whakatika i runga i tō taumaha, tō mahi tākihi, me tō urupare ki te rongoā. Kua whakangungua rātou ki te mōhio ki ngā tohu o ngā pānga o te rongoā, ā, ka mahi tika rātou ki te puta mai ētahi raruraru.

Q3. Me pēhea taku mahi mēnā ka ngaro i ahau tētahi horopeta o Polymyxin B?

I te mea ka tukuna te polymyxin B e ngā tākuta hauora i roto i te hōhipera, i te wāhi haumanu rānei, e kore koe e whai kawenga ki te wā i ō horopeta. Ka whakahaere tō rōpū hauora i tō hōtaka rongoā, ā, ka whakarite kia whiwhi koe i ngā horopeta i ngā wā tika.

Mēnā he roa te wā i tō horopeta kua whakaritea nā te tikanga rongoā, ētahi atu āhuatanga rānei, ka whakatika tō rōpū hauora i tō mahere rongoā. Ka whakarite rātou kia whiwhi koe i te akoranga rongoā katoa e hiahiatia ana e tō mate.

Q4. Āhea ahau e mutu ai te tango i te Polymyxin B?

Kaua rawa koe e mutu i te rongoā polymyxin B i runga i a koe anō, ahakoa kei te pai ake koe. Ko te whakatau ki te whakamutu i te rongoā ka mahia tonu e tō rōpū hauora i runga i ō tohu mate, te whakapai ake i te haumanu, me te whakaoti i te akoranga kua whakaritea.

Ka aroturuki tō tākuta i tō ahunga whakamua mā ngā whakamātautau toto me ngā whakamātautau tinana hei whakatau i te wā e haumaru ana ki te whakamutu i te rongoā. Ko te whakamutu wawe rawa ka taea e ngā huakita te ora me te whanake i te ātete, ka uaua ake te rongoā i ngā mate a muri ake nei.

Q5. Ka taea e au te whakawhanake i te ātete ki te Polymyxin B?

Ahakoa ka taea e te ātete huakita ki te polymyxin B te whanake, he mea noa tonu i te whakataurite ki te ātete ki ētahi atu paturopi. Heoi, koinei tētahi take e rahuitia ai e ngā tākuta tēnei rongoā mō ngā mate nui, ā, ka whakarite kia whakaotia e koe te akoranga rongoā katoa.

Ko te tango i te rongoā i te tika tonu i te mea kua whakaritea, me te whakaoti i te akoranga rongoā katoa ka āwhina i te aukati i te whanaketanga ātete. Ka whakamahi tō rōpū hauora i te polymyxin B i runga i te tika kia mau tonu tōna whai huatanga mō ngā tūroro a muri ake nei e hiahia ana ki tērā mō ngā mate e whakararu ana i te ora.