He aha te Raltegravir: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu

He rongoā HIV te Raltegravir e āwhina ana ki te pupuri i te huaketo i roto i tō tinana. No roto i te rōpū rongoā e kīia nei ko ngā aukati integrase, e mahi ana mā te aukati i te HIV mai i te tārua i a ia anō me te horapa ki ngā pūtau hauora.

Kua noho tēnei rongoā hei wāhanga nui o te rongoā HIV hou nā te mea he pai te manawanui me te whai hua. Ka tangohia e koe hei wāhanga o te rongoā whakakotahi me ētahi atu rongoā HIV, e āwhina ana ki te hanga i tētahi parenga kaha ki te huaketo.

He aha te Raltegravir?

He rongoā antiviral rongoā a Raltegravir i hangaia hei rongoā i te mate HIV-1. E mahi ana mā te aro ki tētahi enzyme motuhake e hiahia ana te HIV ki te whakaputa anō i a ia anō i roto i tō tinana.

I te tuatahi i whakaaetia te rongoā e te FDA i te tau 2007, ā, mai i tērā wā kua āwhina i te miriona tāngata ki te whakahaere i tā rātou HIV. E kiia ana he kōwhiringa rongoā tuatahi, ko te tikanga he maha ngā tākuta e tūtohu ana i tēnei hei rongoā tuatahi mō ngā tāngata kua kitea he mate hou.

Ka rongo pea koe i tō kaiwhakarato hauora e kōrero ana ki a ia i tōna ingoa waitohu, Isentress, i te aukati integrase rānei. Ka tae mai te rongoā i roto i te ahua papa, ā, i hangaia kia tangohia waha me te kore kai rānei.

He aha te Raltegravir e whakamahia ana?

Ko te Raltegravir te mea nui e whakamahia ana hei rongoā i te mate HIV-1 i roto i ngā pakeke me ngā tamariki e 4.4 pauna (2 kirokaramu) te taumaha. Ka whakamahia tonu i roto i te whakakotahitanga me ētahi atu rongoā HIV, kaua rawa e whakamahia anake.

Ka tohua pea e tō tākuta te raltegravir mēnā kua kitea he mate HIV hou, mēnā rānei me huri koe mai i tētahi atu rongoā HIV. He tino āwhina mō ngā tāngata kua whakawhanake i te ātete ki ētahi atu rongoā HIV, ki te hunga rānei e pā ana ki ngā pānga taha raru mai i ngā rongoā rerekē.

Ka whakamahia hoki te rongoa nei ki nga turoro kua rongoa i mua, kua atete to ratou HIV ki etahi atu rongoa. I enei keehi, ka taea e te raltegravir te whakarato i tetahi huarahi hou ki te whakahaere i te huaketo i te wa kaore ano etahi atu whiringa i pai.

Me pehea te mahi a Raltegravir?

Ka mahi a Raltegravir ma te aukati i te enzyme e kiia nei ko te integrase e hiahia ana te HIV ki te whakauru i ana rauemi ira ki roto i o pūtau hauora. Whakaarohia te integrase hei ki e whakamahia ana e te HIV hei iriti me te uru ki roto i o pūtau.

Ka pangia e te HIV tetahi pūtau, me whakauru tana waehere ira ki roto i te DNA o te pūtau kia whakaputa ano. Ko te raltegravir te mea e aukati ana i tenei tukanga, e aukati ana i te huaketo mai i te whakatu i tetahi waahi pumau i roto i o pūtau.

E kiia ana he kaha te rongoa nei, he tino whai hua ina whakamahia hei waahanga o te rongoa whakakotahi. Kaore e rongoa i te HIV, engari ka taea e ia te whakaiti i te nui o te huaketo i roto i to toto ki nga taumata kaore e kitea, e awhina ana ki te tiaki i to punaha aukati me te aukati i te tuku ki etahi atu.

Me pehea taku tango i te Raltegravir?

Me tango e koe te raltegravir i runga i nga tohutohu a to taakuta, te tikanga e rua nga wa ia ra me te kore ranei he kai. Ko te horopeta pakeke paerewa ko te 400 mg e rua nga wa ia ra, engari ka whakatau to taakuta i te nui tika mo to ahuatanga motuhake.

Ka taea e koe te tango i tenei rongoa me nga kai, nga paramanawa, i runga ranei i te puku kau - ahakoa he aha te mea pai mo to tikanga. E kitea ana e etahi tangata he maamaa ake te mahara ki o raatau horopeta ina tangohia e ratou me te parakuihi me te tina.

Whakamātauria ki te tango i o horopeta i te wa kotahi i ia ra kia mau tonu nga taumata o te rongoa i roto i to punaha. Ko te whakarite i nga whakamaharatanga waea, te whakamahi ranei i te kaiwhakarite pire ka awhina i a koe kia rite tonu ki to mahinga horopeta.

Horomia nga papa katoa me te wai, tetahi atu inu ranei. Kaua e kuru, e ngaungau, e wawahi ranei i nga papa, na te mea ka pa tenei ki te ahua o te rongoa e uru ana ki roto i to tinana.

Kia pehea te roa e tango ana ahau i te Raltegravir?

Tērā pea ka hiahia koe ki te tango raltegravir mō te toenga o tō oranga hei wāhanga o tō rongoā HIV. He herenga wā-roa te rongoā HIV, ā, ka taea e te whakamutu i ngā rongoā te whakapiki i te huaketo me te whanake i te ātete.

Ka aroturukihia e tō tākuta tō ahunga whakamua mā ngā whakamātautau toto i ngā wā katoa e ine ana i tō uta huaketo me te tatau pūtau CD4. Mā ēnei whakamātautau e āwhina ki te whakatau i te pai o te mahi a te rongoā me te hiahia ki te whakatika i tō mahere rongoā.

E mōhio ana ētahi tāngata ki te tango rongoā mō ake tonu atu, engari kia mahara ko te rongoā tonu e āwhina ana i a koe ki te pupuri i tō hauora me te ārai i te HIV mai i te haere ki te AIDS. He maha ngā tāngata e tango ana i te rongoā HIV whai hua e ora ana i te oranga roa, hauora, me te iti o te pānga ki ā rātou mahi o ia rā.

He aha ngā pānga taha o te Raltegravir?

He pai te rongo a te nuinga o te tāngata ki te raltegravir, engari pērā i ngā rongoā katoa, ka taea e ia te pānga taha. Ko te rongo pai ko te kore noa iho o ngā pānga taha nui, ā, he iti noa iho ngā tāngata e pā ana ki te iti, ki te kore rānei he raruraru.

Koinei ngā pānga taha tino noa ka pā ki a koe, me te mōhio he maha ngā tāngata e pā ana ki ngā tohu ngawari e pai ake ana i te wā:

• Te mamae o te upoko
• Te whakapairuaki
• Te korere
• Te ngenge, te pōuri rānei
• Te whanoke
• Te raruraru moe
• Te mamae o te puku
• Ngā mamae uaua

Ko ēnei pānga taha noa ka iti ake te kitea i te wā e urutau ana tō tinana ki te rongoā i ngā wiki tuatahi o te rongoā.

Ahakoa he iti noa iho, he pānga taha nui ake e hiahia ana kia aro mai i te tākuta. Ko ēnei urupare onge engari nui ko:

• Ngā urupare kiri nui, te pā rānei
• Ngā tohu o ngā raruraru ate (te kōwhai o te kiri, o ngā kanohi, te mimi pouri, te mamae puku nui)
• Te mamae uaua nui, te ngoikore rānei
• Ngā huringa hauora hinengaro pērā i te pōuri, i ngā whakaaro whakamomori rānei
• Ngā urupare pāwera nui

Mena ka pā mai ētahi o ēnei tohu kino ake, whakapā atu ki tō tākuta i te wā tonu. Kia mahara, he nui ake ngā painga o te rongoā HIV i ngā tūponotanga o ngā pānga taha.

Ko wai kāore e tika kia tango Raltegravir?

Kāore a Raltegravir e tika ana mō te katoa, ā, ka āta titiro tō tākuta ki tō hītori hauora i mua i te whakahau i te rongoā. Kaua koe e tango i tēnei rongoā mēnā he pānga tō tinana ki a raltegravir, ki ētahi o ōna whakauru rānei.

Ka hiahia tō tākuta ki te mōhio mō ētahi āhuatanga me ngā rongoā ka pā tahi pea ki a raltegravir. Me kōrero ki a rātou mēnā kei a koe:

• Te mate ate, te hepatitis rānei
• Ngā raruraru tākihi
• Ngā āhuatanga hauora hinengaro, ina koa te pōuri
• Ngā mate uaua
• He hītori o ngā pānga kiri kino ki ngā rongoā

Ka taea e ngā wahine hapū me ngā wahine e whāngai ana i ngā pēpi te tango raltegravir, engari me āta aroturuki tēnei e tētahi tākuta e mōhio ana ki te rongoā HIV. He wāhanga nui te rongoā ki te ārai i te tuku HIV mai i te whaea ki te tamaiti.

Ka titiro hoki tō tākuta ki ō rongoā katoa e inu ana koe, tae atu ki ngā rongoā whakahau, ngā rongoā ka taea te hoko, me ngā tāpiringa, kia tirohia mō ngā pānga tahi pea.

Ngā Ingoa Waitohu o Raltegravir

Ko te nuinga o te wā e mōhiotia ana a Raltegravir i tōna ingoa waitohu ko Isentress, i hangaia e Merck & Co. Koinei te hanganga taketake e whiwhi ai te nuinga o te tangata i te wā e whakahaua ana a raltegravir.

Kei reira hoki a Isentress HD, he hanganga horopeta teitei ake e āhei ai ētahi tāngata ki te tango i te rongoā kotahi noa i te rā, kaua ki te rua i te rā. Mā tō tākuta e whakatau ko tēhea hanganga te mea pai mō tō āhuatanga motuhake.

Ka wātea pea ngā putanga whānui o raltegravir, ka taea te āwhina i te whakaiti i te utu o te rongoā. Kei roto i ēnei rongoā whānui te whakauru kaha kotahi, ā, he rite tonu te whai hua ki ngā putanga ingoa waitohu.

Ngā Kōwhiringa kē mō Raltegravir

Mēnā kāore i te pai te raltegravir mōu, he pānga taha rānei e raru ana, he maha atu ngā rongoā HIV ka whakaarohia e tō tākuta. Ko ētahi atu aukati integrase ko te dolutegravir (Tivicay) me te bictegravir (Biktarvy).

Ka tūtohu pea tō kaiwhakarato hauora i ngā rongoā mai i ngā momo rongoā rerekē, pēnei i ngā aukati transcriptase huri whakamuri kore-nucleoside (NNRTIs) rānei, i ngā aukati protease rānei, i runga i tō āhuatanga motuhake me ngā tauira aukati rongoā.

Ko te kōwhiri i ngā rongoā kē atu e whakawhirinaki ana ki ngā mea pēnei i tō utaina huaketo, te tatau CD4, ngā rongoā HIV i tangohia e koe i mua, me tō hauora whānui. Ka mahi tō tākuta ki a koe ki te kimi i te huinga tino whai hua me te pai ki te whakamahi.

Kia mahara me mahi tonu te huri i ngā rongoā HIV i raro i te tirotiro hauora. Ka whakamahere tō tākuta i ngā huringa katoa kia mōhio ai ka haere tonu te aukati huaketo i te wā o te whakawhiti.

He Pai Anei te Raltegravir i te Dolutegravir?

He aukati integrase whai hua te raltegravir me te dolutegravir, engari he rerekētanga ō rāua ka pai ake tētahi mōu i tētahi atu. Ko te dolutegravir te nuinga ka tangohia kotahi i te rā, i te mea ko te raltegravir te nuinga ka tangohia e rua i te rā.

E whakaatu ana ngā rangahau ka nui ake te arai ki te aukati i te dolutegravir, ko te tikanga he uaua ake te HIV ki te whakawhanake i te aukati ki a ia. Heoi, kua roa te raltegravir e noho ana, ā, he rekoata whānui mō te haumaru me te whai huatanga.

Ka pōturi pea te dolutegravir i te pikinga taumaha me ngā raruraru moe i ētahi tāngata, i te mea he pai ake te raltegravir i te taha o ēnei pānga taha motuhake. Ko te kōwhiri i waenga i a rāua e whakawhirinaki ana ki ō āhuatanga me ō hiahia.

Ka whakaaro tō tākuta i ngā mea pēnei i tō oranga, ētahi atu rongoā e tangohia ana e koe, me ngā hītori rongoā o mua i te wā e tūtohu ana i te aukati integrase e pai ana mōu.

Ngā Pātai Auau mō te Raltegravir

He Haumaru a Raltegravir mō te hunga e mate ate ana?

He maha ngā wā ka taea te whakamahi i te raltegravir i runga i te haumaru mō te hunga e mate ate ana, engari me mātakitaki pū. Me tirotiro tō tākuta i te mahi o tō ate i ngā wā katoa mā ngā whakamātautau toto kia mōhio ai kāore te rongoā e pā ana ki ētahi raruraru.

Ko te hunga e pangia ana e te mate hepatitis B, C rānei, ka taea te tango raltegravir, engari me nui ake te mātakitaki. Ko te rongoā te nuinga e kiia ana he haumaru ake mō te ate i ētahi atu rongoā HIV, koinei te take e pai ai ngā tākuta ki te hoatu ki ngā tāngata e pā ana ki te ate.

Me aha au mēnā ka tango au i te nui rawa o te Raltegravir?

Mēnā ka tango koe i te nui rawa o te raltegravir i te mea i whakaritea, whakapā atu ki tō kaiwhakarato hauora, ki te pokapū whakahaere paitini rānei tonu. Ahakoa he onge te nui rawa o te rongoā, he mea nui kia whiwhi tohutohu hauora mō te aha e whai ake nei.

Kaua e ngana ki te whakakī i te horopeta atu mā te karo i tō horopeta e whai ake nei. Engari, whai i ngā tohutohu a tō tākuta mō te wā ki te tīmata anō i tō hōtaka horopeta noa. Kia mau ki te wā i tango ai koe i te horopeta atu hei āwhina i ngā kaiwhakarato hauora ki te aromatawai i te āhuatanga.

Me aha au mēnā ka ngaro au i tētahi horopeta o Raltegravir?

Mēnā ka ngaro koe i tētahi horopeta o raltegravir, tangohia tonu i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, karo i te horopeta i ngaro, ka haere tonu ki tō hōtaka auau.

Kaua rawa e tango i ngā horopeta e rua i te wā kotahi hei whakakī i tētahi horopeta i ngaro. Mēnā he maha ngā wā e wareware ana koe i ngā horopeta, kōrero ki tō kaiwhakarato hauora mō ngā rautaki hei āwhina i a koe ki te mahara, pēnei i te whakatakoto whakaoho waea, te whakamahi rānei i tētahi kaiwhakarite pire.

Ko te ngaro i ngā horopeta i ētahi wā kāore i te mōrearea, engari ko te ngaro tonu i ngā horopeta ka taea e te HIV te whakawhanake i te aukati ki te rongoā, ka iti ake te whai hua i te wā.

Āhea ka taea e au te whakamutu i te tango Raltegravir?

Kaua rawa koe e whakamutu i te tango raltegravir me te kore e kōrero tuatahi ki tō tākuta. Ko te rongoā HIV te tikanga he mō te wā roa, ā, mā te whakamutu i ngā rongoā ka taea e te huaketo te whakanui tere, ā, ka whai wāhi ki te whakawhanake i te aukati.

Ka whakaaro pea tō tākuta ki te huri i tō rongoā HIV mēnā kei te pā koe i ngā pānga taha nui, mēnā rānei kāore te rongoā e whai hua ana. Heoi anō, me mātua whakamahere me te tirotiro i ngā huringa katoa ki tō mahere rongoā.

Mēnā he āwangawanga āu mō tō rongoā, kei te whakaaro rānei koe ki te whakamutu i te rongoā, kōrerohia tō āwangawanga me ō rātou otinga pea ki tō tākuta.

Ka taea e au te inu waipiro i te wā e tango ana au i te Raltegravir?

He pai te inu waipiro i te wā e tango ana i te raltegravir, engari he pai ake te kōrero i ō tikanga inu waipiro ki tō tākuta. Kāore te waipiro e pā tika ana ki te raltegravir, engari ka pā ki tō ate me tō pūnaha ārai mate.

Mēnā he mate ate tō, ētahi atu rānei āhuatanga hauora, ka tohutohu pea tō tākuta ki te whakaiti, ki te karo rānei i te waipiro. Kia mahara hoki, ka uaua pea te waipiro ki te mahara ki te tango i ō rongoā i ngā wā katoa.

Kia pono ki tō tākuta mō tō inu waipiro kia taea e rātou te hoatu ki a koe te tohutohu pai mō tō āhuatanga motuhake, me te aroturuki i tō hauora.