He aha te Ranibizumab: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu mea

He rongoā tākuta te Ranibizumab e werohia tika ana e ngā tākuta ki tō kanohi hei rongoā i ētahi raruraru tirohanga. Mā tēnei rongoā motuhake e āwhina te whakaiti, te aukati rānei i te tipu o ngā oko toto hē i roto i tō retina, ka pōraru te tirohanga ki te kore e rongoatia.

No roto te rongoā i tētahi rōpū rongoā e kīia ana ko ngā āpiha anti-VEGF, e mahi ana mā te aukati i tētahi pūmua e whakatairanga ana i te tipu o ēnei oko toto raruraru. Ahakoa te whakaaro o te werohanga kanohi e āwangawanga ana, kua āwhina tēnei rongoā i miriona tāngata ki te tiaki i ō rātou tirohanga, ā, i ētahi wā, kua whakapai ake i ō rātou tirohanga.

He aha te Ranibizumab e whakamahia ana mō?

Ka rongoatia e te Ranibizumab ētahi mate kanohi nui e pā ana ki te tipu o ngā oko toto hē, te kohinga wai rānei i roto i te retina. Ka tūtohu pea tō tākuta i tēnei rongoā mēnā he mate pāpā o te macular e pā ana ki te pakeke, koinei te take nui o te pōraru tirohanga nui i roto i ngā tāngata neke atu i te 50 tau.

Ka āwhina hoki te rongoā i ngā tāngata e mate ana i te edema macular diabetic, he raruraru o te mate huka e kohikohi ana te wai i waenganui o tō retina. Ka taea e tēnei āhuatanga te pōraru, te hē rānei i tō tirohanga matua, he uaua ki te pānui, te taraiwa, te kite rānei i ngā kanohi.

I tua atu, ka rongoatia e te ranibizumab te retinopathy diabetic, tētahi atu raruraru kanohi e pā ana ki te mate huka e pakaru ai te huka toto tiketike i ngā oko toto i roto i tō retina. Ka whakamahi hoki ētahi tākuta i tēnei mō te edema macular i puta mai i te aukati i te uaua retinal, e pā ana ki te wā e aukatia ana ngā oko toto i roto i tō retina.

Me pēhea te mahi a te Ranibizumab?

Ka mahi te Ranibizumab mā te aukati i tētahi pūmua motuhake e kīia ana ko VEGF (vascular endothelial growth factor) e whakaputaina ana e tō tinana i te wā e hiahia ana ki te whakatipu oko toto hou. I roto i ngā kanohi hauora, ka āta whakahaerehia tēnei tukanga, engari i roto i ētahi mate kanohi, ka nui rawa te VEGF e hangaia ana e tō tinana.

Ki te nui rawa te VEGF, ka tupu ngā oko toto hē i ngā wāhi e kore e tika, ina koa i tō rātou whatu. Ko ēnei oko toto hou he ngoikore, he turuturu tonu, e pū ana te wai, ā, ka puta te toto ka pā ki tō tirohanga.

Mā te aukati i te VEGF, ka āwhina te ranibizumab ki te aukati i tēnei tupu oko toto hē, me te whakaiti i te turuturu wai. Mā tēnei ka pai ake te mahi a tō whatu, ā, ka āwhina ki te whakapumau, ki te whakapai ake rānei i tō tirohanga. E kiia ana he kaha te rongoā, he tino whāinga, e mahi ana ki ngā wāhi raruraru i tō kanohi.

Me pēhea taku tango i te Ranibizumab?

Ka hāpai te ranibizumab hei werohanga tika ki tō kanohi, ka mahia e tō tākuta kanohi i roto i tā rātou tari, i te hōhipera rānei. Kāore koe e hiahia ki te tango i tētahi mea mā te waha, ki te whakarite rānei i ngā kai, i ngā inu motuhake i mua i tō rātou tūpono.

I mua i te werohanga, ka horoi tō tākuta i tō kanohi, ka whakamahi i ngā maturuturu whakangohe kia pai ai te mahi. Ka whakamahi hoki rātou i ngā maturuturu patu huakita hei aukati i te mate. He hēkona noa te roa o te werohanga, ā, ko te nuinga o te tangata e kī ana he pēnei te ahua o te pēhanga poto, kaua ko te mamae.

I muri i te werohanga, ka hiahia koe ki tētahi hei taraiwa i a koe ki te kāinga, nā te mea ka pōkae tō tirohanga mō tētahi wā. Ka hoatu e tō tākuta ngā tohutohu motuhake mō te tiaki kanohi mō te rā, e rua rānei e whai ake nei, ko te tikanga ko te whakamahi i ngā maturuturu kanohi patu huakita, me te karo i te mirimiri i tō kanohi.

Kia pehea te roa taku tango i te Ranibizumab?

Ko te roa o tō maimoatanga ranibizumab e whakawhirinaki ana ki tō āhuatanga kanohi motuhake, me te pai o tō urupare ki te rongoā. Ko te nuinga o te tangata ka tīmata ki ngā werohanga ia marama mō ngā marama tuatahi, ā, ka whakatikatikahia te auau i runga i te pai o te whakaora o ō kanohi.

Mō te mate macular e pā ana ki te pakeke, ka hiahia pea koe ki ngā werohanga i ia marama, i ia marama rānei mō ētahi marama, ētahi tau rānei. Ka aroturuki tō tākuta i tō ahunga whakamua mā ngā whakamātautau kanohi auau me ngā whakamātautau whakaahua motuhake hei whakatau i te hōtaka pai mōu.

Ko ētahi tāngata e pā ana ki ngā raruraru kanohi huka, ka hiahia pea ki te rongoā tonu hei pupuri i tō rātou āhuatanga kia tū, ā, ko ētahi atu ka taea pea te okioki i waenga i ngā werohanga. Ka mahi tō tākuta kanohi ki a koe ki te kimi i te tauira rongoā e whai hua ana ki a koe me te iti rawa o ngā werohanga ka taea.

He aha ngā pānga taha o Ranibizumab?

Pērā i ngā rongoā katoa, ka taea e ranibizumab te pānga taha, ahakoa te nuinga o te tāngata e pai ana ki te rongoā. Ko ngā pānga taha tino noa he ngawari, he wā poto, e pā ana ki tō kanohi, ki tō tirohanga rānei mō te wā poto i muri i te werohanga.

Koinei ngā pānga taha ka pā ki a koe, ka tīmata mai i ngā mea tino noa e ngaro ana i a rātou anō:

• Te whero, te riri rānei o te kanohi mō te wā poto, e mau ana i te rā, i ngā rā e rua rānei
• Te mamae kanohi ngawari, te hāneanea rānei, he rite ki te mea he mea kei tō kanohi
• Te pikinga o te pēhanga kanohi mō te wā poto ka aroturukihia e tō tākuta
• Ngā ira iti, ngā "maanu" rānei i tō tirohanga e ngaro ana i roto i ētahi rā
• Te tirohanga pōuri mō te wā poto i muri tonu i te werohanga
• Te āhua o te kanohi maroke, te rakuraku rānei

Ko ēnei pānga taha noa he ngawari, ka pai ake i roto i ētahi rā i te wa e urutau ana tō kanohi ki te rongoā.

Ahakoa he iti noa iho, ka pā pea ki ētahi tāngata ngā pānga taha e kitea ana e hiahia ana ki te aro:

• He mamae nui i te kanohi karekau e pai ake ana i nga rongoa mamae kaore i te tohua e te taote
• Te whero tonu, te pupuhi ranei e kino haere ana, kaua e pai ake
• Nga huringa i roto i te tirohanga e roa ake ana i etahi ra
• Te nui haere o te tairongo ki te marama e whakararu ana i nga mahi o ia ra
• Te rere mai i te kanohi tera pea e tohu ana i te mate

He onge engari he kino nga paanga taha ka puta, ahakoa he iti iho i te 1 i roto i te 100 nga tangata e pa ana. Kei roto i enei ko nga mate kanohi nui, te nui haere o te pehanga o te kanohi, te wehenga o te retina, te ngaronga nui ranei o te tirohanga. Ahakoa he mea noa enei raruraru, me tono tonu he rongoa.

I te wa ano, ka pa ki etahi tangata nga paanga taha e pa ana ki etahi atu wahanga o to ratou tinana, penei i te whiu, i nga raruraru ngakau ranei, ahakoa he iti ake te tupono ki nga werohanga kanohi i te rongoa e tangohia ana ma te waha.

Ko wai e kore e tango Ranibizumab?

Kaore a Ranibizumab e tika ana mo te katoa, a ka ata tirotirohia e to taakuta mena he haumaru mo koe. Kaua koe e whiwhi i tenei rongoa mena he mate koe ki te ranibizumab, ki etahi atu mea ranei, ki te mea kei a koe he mate kaha i roto, i te taha ranei o to kanohi.

Ka hiahia to taakuta ki te mohio ki to hitori rongoa katoa i mua i te tiimata i te maimoatanga. Ko nga tangata e pa ana ki etahi mate ngakau, nga whiu tata nei, nga mate toto ranei, tera pea ka hiahia ki te aroturuki motuhake, kaore ranei pea he kaitono pai mo tenei maimoatanga.

Mena kei te hapu koe, kei te ngana ranei koe ki te hapu, korerohia tenei ki to taakuta, na te mea ka raru pea te ranibizumab i te tamaiti kaore ano i whanau. Ko nga wahine e u ana ki te u, me korero ano ki o raatau kaiwhakarato hauora mo nga tupono me nga painga.

Ko nga tangata e mate ana i te toto toto tiketike kaore i te whakahaerehia, i te pokanga kanohi tata nei ranei, tera pea ka tatari, ka whiwhi ranei i etahi atu maimoatanga i mua i te tiimata i te ranibizumab. Ka tirohia ano e to taakuta kanohi nga tohu o te mate, te mumura ranei e tika ana kia rongoatia i te tuatahi.

Nga Ingoa Waitohu Ranibizumab

Kei te wātea te Ranibizumab i raro i te ingoa waitohu Lucentis, koinei te momo rongoā e tino tohua ana. Koinei te hanganga taketake kua tino rangahaua, kua whakamahia mō ngā tau maha.

He kōwhiringa hōu anō hoki e kiia nei ko Byooviz, he momo rongoā koiora o te ranibizumab. Ko ngā rongoā koiora he rongoā e mahi ana i te ara kotahi ki te rongoā taketake engari he mea hanga e ngā kamupene rerekē, ā, he iti ake te utu.

Ka whiriwhiria e tō tākuta te momo e tika ana i runga i tō āhuatanga motuhake, te inihua, me ētahi atu āhuatanga. E mahi ana ngā momo e rua i te ara kotahi, ā, he rite te whai huatanga me te haumaru.

Ngā Kōwhiringa kē mō te Ranibizumab

He maha atu ngā rongoā e mahi ana i te ara rite ki te ranibizumab mō te rongoā i ngā āhuatanga kanohi e pā ana ki te tipu o ngā oko toto kōaro. Ko Aflibercept (Eylea) tētahi atu rongoā anti-VEGF e whakamahia ana mō ngā āhuatanga kotahi, ā, tērā pea ka iti ake ngā werohanga.

I ētahi wā ka whakamahia te Bevacizumab (Avastin) i waho o te tapanga mō ngā āhuatanga kanohi, ahakoa i hangaia tuatahi mō te rongoā mate pukupuku. E pai ana ētahi tākuta kanohi ki a ia nā te mea he iti ake te utu, engari kāore i whakaaetia mō te whakamahi kanohi.

Ko ngā kōwhiringa hōu ko te brolucizumab (Beovu) me te faricimab (Vabysmo), tērā pea ka roa ake te wā i waenga i ngā werohanga mō ētahi tāngata. Mā tō tākuta kanohi koe e āwhina ki te mārama ko tēhea kōwhiringa pea te mea pai mō tō āhuatanga motuhake me tō oranga.

Ko te whiriwhiri i waenga i ēnei rongoā e whakawhirinaki ana ki ngā āhuatanga pēnei i tō āhuatanga kanohi motuhake, te āhua o te urupare o ō kanohi ki te rongoā, tō inihua, me te auau o tō haerenga mai mō ngā werohanga.

He Pai Anei te Ranibizumab i te Aflibercept?

He pai rawa atu a ranibizumab me aflibercept mō te rongoā i ngā āhuatanga o te kanohi e pā ana ki te tipu o ngā oko toto kerekere, ā, e whakaatu ana ngā rangahau he rite tonu te pai o tō rāua mahi mō te nuinga o te tāngata. Ko te whiriwhiri i waenga i a rāua e pā ana ki ngā āhuatanga takitahi, kaua ki te mea kotahi he pai ake i tētahi.

Ka roa pea te mahi a Aflibercept i waenga i ngā werohanga mō ētahi tāngata, ā, ka hiahia pea ki ngā werohanga ia 6-8 wiki, kaua ki te marama. He pai ake pea tēnei mēnā he uaua ki a koe te haere ki ngā tūpono auau, mēnā rānei e hiahia ana koe kia iti ake ngā tikanga katoa.

Heoi anō, kua roa te whakamahi i te ranibizumab, ā, he nui ake ngā rangahau e tautoko ana i tōna haumaru me tōna whai huatanga. He pai ake te urupare a ētahi tāngata ki tētahi rongoā i tētahi atu, ā, ka whakamātau pea tō tākuta i ngā mea e rua kia kite ko wai te mea e pai ana mōu.

Ka whakaaro tō tākuta kanohi ki ngā āhuatanga pēnei i tō āhuatanga kanohi motuhake, te kāhua o te oranga, te inihua, me te pēhea te urupare o ō kanohi ki te rongoā i te wā e whiriwhiri ana i waenga i ēnei kōwhiringa.

Ngā Pātai Auau mō Ranibizumab

P1. He Haumaru a Ranibizumab mō te Tāngata e mate huka ana?

Āe, he haumaru te ranibizumab mō te tāngata e mate huka ana, ā, koinei tētahi o ngā rongoā tuatahi mō ngā raruraru kanohi e pā ana ki te mate huka. Kua whakaaetia te rongoā mō te edema macular diabetic me te retinopathy diabetic, e rua ngā raruraru kanohi nui ka puta mēnā kāore te mate huka i te pai te whakahaere.

Heoi anō, ko te mate huka te tikanga me nui ake te aroturuki i te wā o te rongoā. Ka mahi tahi tō tākuta kanohi me tō rōpū tiaki mate huka kia pai ai te pūmautanga o ō taumata huka toto, nā te mea ka pai ake te whakahaere i te mate huka ka pai ake te mahi o te rongoā kanohi.

P2. Me pēhea ahau ki te ngaro ohorere i te horopeta o Ranibizumab?

Mēnā ka ngaro koe i tētahi werohanga ranibizumab kua whakaritea, whakapā atu ki te tari o tō tākuta kanohi i te wa e taea ai ki te whakarite anō. Kaua e tatari kia tae ra ano ki tō tūpono kua whakaritea i muri mai, nā te mea ko te whakaroa i te rongoā ka taea te kino ake o tō āhua kanohi.

Mā tō tākuta e whakatau te wā pai mō tō werohanga whakakī i runga i te wā i tika ai kia whiwhi koe, me te pēhea te urupare o ō kanohi ki te rongoā. Ka whakatika pea rātou i tō hōtaka werohanga ā muri ake nei kia hoki anō koe ki te ara.

Q3. Me pēhea taku mahi mēnā ka pā mai ngā pānga taha nui?

Mēnā ka pā mai te mamae kanohi nui, ngā huringa ohorere o te tirohanga, ngā tohu o te mate pēnei i te rerenga wai, te whero haere rānei, ētahi tohu rānei e pā ana ki a koe, whakapā atu ki tō tākuta kanohi tonu. He maha ngā tākuta kanohi he tau whakapā ohorere mō ngā tūāhuatanga ohorere.

Mō ngā pānga taha nui pēnei i te ngaronga ohorere o te tirohanga, te mamae kanohi nui, ngā tohu rānei o te mate nui, kaua e tatari – rapua te manaakitanga hauora ohorere tonu. Ahakoa he onge ngā raruraru nui, ka taea e te rongoā tere te ārai i te kino tūturu.

Q4. Āhea e taea ai e au te whakamutu i te tango i te Ranibizumab?

Ko te whakatau ki te whakamutu i te rongoā ranibizumab kei runga i te pai o te urupare o ō kanohi, me te pūmau rānei o tō āhua. Mā tō tākuta kanohi e aroturuki tō haere mā ngā whakamātautau kanohi auau me ngā whakamātautau whakaahua hei whakatau i te wā ka noho haumaru ai te okioki.

Ka taea e ētahi tāngata te whakamutu i te rongoā i te wā e pūmau ana tō rātou āhua, i te mea e hiahia ana ētahi atu ki ngā werohanga tonu hei pupuri i tō rātou tirohanga. Kaua rawa e whakamutu i te rongoā i runga i ō ake – mahi tonu me tō tākuta kanohi ki te whakatau i tēnei whakatau i runga i te haumaru.

Q5. Ka taea e au te taraiwa i muri i te werohanga Ranibizumab?

Kaua koe e taraiwa i muri tonu i te whiwhinga i te werohanga ranibizumab, nā te mea ka pā mai te pōkaikaha o tō tirohanga mai i ngā maturuturu whakamoe me te werohanga tonu. Whakaritea kia whai tangata hei taraiwa i a koe ki te kāinga mai i tō tūpono.

Ka taea e te nuinga o te tangata te hoki ki nga mahi o ia rā, tae atu ki te taraiwa, i roto i te rā, e rua rā rānei i muri i te werohanga i te wā e mārama ana te tirohanga. Ka hoatu e tō tākuta he tohutohu motuhake ki a koe mō te wā e haumaru ana ki te taraiwa anō i runga i te āhua o te whakaora o ō kanohi.