He aha te Riluzole: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha, me Ētahi Atu

Ko te Riluzole he rongoā rongoā i hangaia hei āwhina i te hunga e noho ana me te ALS (amyotrophic lateral sclerosis), e mōhiotia ana ko te mate a Lou Gehrig. E mahi ana tēnei rongoā mā te tiaki i ngā pūtau io i tō roro me tō tuaiwi, ka āhei pea te whakaroa i te haere o tēnei āhuatanga uaua.

Ahakoa ehara te riluzole i te rongoā mō te ALS, he kōwhiringa rongoā nui e āhei ana ki te whakaroa i te wā kounga me te hunga e arohaina ana. Mā te māramatanga ki te mahi o tēnei rongoā me te aha e tūmanakohia ana ka āwhina i a koe kia māia ake mō tō haerenga rongoā.

He aha te Riluzole?

Ko te Riluzole he rongoā neuroprotective e aro ana ki te pūnaha io. No te akomanga rongoā e kīia ana ko te glutamate inhibitors, e mahi ana mā te whakaiti i te kaha o te mahi io e taea ai te kino o ngā neuron motika.

Ka tae mai te rongoā hei papa waha e tango ana koe mā te waha e rua ngā wā ia rā. Kua whakaaetia e te FDA mai i te tau 1995, ā, kua āwhina i ngā mano o te tangata ki te whakahaere i ā rātou tohumate ALS i te whai hua ake.

Whakaarohia te riluzole hei whakangungu rakau mō ō pūtau io. Ahakoa e kore e taea e ia te whakatika i te kino kua pā, ka āwhina pea ia ki te whakaroa i te kino haere o ngā neuron motika e whakahaere ana i ō uaua.

He aha te Riluzole e whakamahia ana?

Ko te Riluzole te mea nui e tohua ana mō te rongoā i te ALS, he mate neurological haere tonu e pā ana ki ngā pūtau io e whakahaere ana i te nekehanga uaua whai-ā-tinana. Ka ngoikore haere tēnei āhuatanga i ngā uaua puta noa i tō tinana, ka uaua ake ngā mahi o ia rā.

Ko te rongoā te mea e taunakitia ana mō te hunga i ngā wāhanga tuatahi ki te wāhanga ngawari o te ALS. Ka tohutohu pea tō tākuta ki te tīmata i te riluzole i muri tata i tō tātaritanga kia whakanuia ai ōna painga tiaki.

I ētahi wā, ka tohutohu pea ngā tākuta i te riluzole i waho i te tapanga mō ētahi atu mate neuron motika, mō ngā āhuatanga neurological rānei. Heoi anō, ko te ALS tonu tana whakamahinga tuatahi me te mea kua tino rangahaua, i reira kua whakaatu ngā whakamātau haumanu i ngā painga nui.

Me pēhea te mahi a Riluzole?

Ka mahi a Riluzole mā te aukati i te nui rawa o te glutamate, he karere matū i roto i tō pūnaha io. Ka piki rawa ngā taumata glutamate, ka taea e ia te whara, te patu rānei i ngā neuron motika e whakahaere ana i ō uaua.

E kiia ana ko te rongoā he rongoā neuroprotective kaha-āhua. Kāore e whai wāhi tonu te whakamaarama i ngā tohumate pērā i ētahi rongoā kaha ake, engari ka mahi haere i te wā ki te tiaki i tō mahi io e toe ana i te wā.

I tua atu, ka āwhina pea a riluzole ki te whakapumau i te mahi hiko i roto i ngā pūtau io me te whakaiti i te mumura i roto i tō pūnaha io. Ko ēnei pānga tahi ka waihanga i tētahi taiao whakamarumaru ake mō ō neuron motika, ka ārai pea i te haere whakamua o te mate.

Me pēhea taku tango i te Riluzole?

Tangohia te riluzole kia rite ki tā te tākuta i tohutohu ai, te tikanga kotahi papa 50mg e rua i te rā, tata ki te 12 hāora te wā i waenga. Ko te horopeta rā katoa paerewa he 100mg, engari ka whakatika pea tō tākuta i tēnei i runga i ō hiahia takitahi.

He pai ake te tango i te riluzole i runga i te puku kau, kia kotahi hāora i mua i te kai, kia rua hāora rānei i muri i te kai. Ka taea e te kai te whakaiti i te nui o te rongoā e ngāwari ana tō tinana, ka iti ake te whai hua.

Whakamātauria te tango i ō horopeta i ngā wā kotahi i ia rā kia mau tonu ngā taumata i roto i tō pūnaha. He maha ngā tāngata e kite ana he āwhina ki te whakatakoto i ngā whakamaharatanga waea, ki te whakamahi rānei i tētahi kaiwhakarite pire kia mau tonu ki tā rātou hōtaka horopeta.

Horomia ngā papa katoa me te karaihe wai katoa. Kaua e kuru, e ngaungau, e whati rānei i ngā papa, nā te mea ka pā tēnei ki te pēhea te tuku o te rongoā i roto i tō tinana.

Kia pēhea te roa e tango ai au i te Riluzole?

Ko te Riluzole he rongoā wā-roa te tikanga, ka haere tonu te tango i a koe i te wā e whai hua ana, e pai ana hoki. Ko te nuinga o te hunga e mate ana i te ALS e tango ana i tēnei rongoā mō ngā marama ki ngā tau, i runga i te ahunga o te mate o ia tangata.

Ka aroturukihia e tō tākuta tō urupare ki te rongoā, me te tirotiro mō ngā pānga taha. Ka arotakehia e rātou mēnā kei te whai hua tonu te riluzole i te wā e huri ana tō āhuatanga.

Kaua rawa e mutu te tango i te riluzole ohorere, me te kore e kōrero tuatahi ki tō rōpū hauora. Ahakoa kāore koe e kite i ngā whakapainga tonu, kei te whai pānga tiaki nui pea te rongoā mō ō pūtau io.

He aha ngā Pānga Taha o te Riluzole?

He pai te riluzole ki te nuinga o te tāngata, engari pērā i ngā rongoā katoa, ka pānga taha pea. Mā te māramatanga ki ngā mea e tūmanakohia ana ka āwhina koe ki te pūmau ake, me te mōhio ki te wā hei whakapā atu ki tō tākuta.

Koinei ngā pānga taha tino noa ka pā ki a koe, e pā ana ki te 10-20% o te hunga e tango ana i te riluzole:

• Te whakapairuaki me te pōpōtanga o te puku
• Te ngoikore, te ngenge rānei
• Te whanoke, te māmā rānei te mahunga
• Te ngaro o te hiahia kai
• Te korere
• Ngā ngāwari i ngā ringa, i ngā waewae rānei

He ngawari noa iho ēnei tohumate, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā i ngā wiki tuatahi.

Ka pā mai pea ngā pānga taha kāore i te noa, engari he nui ake te kino, ahakoa e pā ana ki te iti iho i te 5% o te hunga e tango ana i te riluzole:

• Ngā raruraru ate (teitei ake ngā enzyme ate)
• Ngā urupare mate pāwera nui
• Ngā raruraru pūkahukahu, te uaua rānei ki te hā
• Te toto rere ke, te pānga rānei
• Te ngenge nui, te ngoikore rānei

Ka aroturukihia e tō tākuta tō mahi ate mā ngā whakamātautau toto auau, te tikanga ia marama mō ngā marama tuatahi e toru, ā, ia toru marama i muri iho.

Ngā pānga taha kāore i te noa, engari he nui te kino, me whakapā atu tonu ki te tākuta:

• Ngā tohu o te pāngia o te ate (te kōwhai o te kiri, o ngā kanohi rānei, te mimi pōuri, te mamae nui o te puku)
• Ngā tauhohenga mate pāwera nui (te uaua ki te hā, te pūhi o te mata, o te korokoro rānei)
• Te kirika kāore i whakamāramahia me ngā tohu pērā i te rewharewha
• Te mare tonu, te uaua rānei ki te hā

Mēnā ka pā ki a koe ētahi o ēnei tohu nui, whakapā atu ki tō tākuta tonu, rapu rānei i te manaakitanga hauora ohorere.

Ko wai kāore e tika kia tango Riluzole?

Kāore a Riluzole e tika ana mō te katoa, ā, ko ētahi āhuatanga hauora, āhuatanga rānei ka kore e haumaru mōu. Ka āta arotakehia e tō tākuta tō hītori hauora i mua i te whakahau i tēnei rongoā.

Kāore koe e tika kia tango riluzole mēnā he mate pāwera tō te rongoā, ōna kai rānei. Ko ngā tohu o ngā tauhohenga mate pāwera ka uru ki te pāhēhē, te mōmiti, te pūhi, te uaua rānei ki te hā.

Ko ngā tāngata e pāngia ana e te mate ate nui, e te nui rawa rānei o ngā whākōrere ate, me karo i te riluzole, nā te mea ka pōuri ake te mahi o te ate i te rongoā. Ka tirohia e tō tākuta te mahi o tō ate i mua i te tīmatanga o te rongoā.

He āta tūpato e hiahiatia ana mēnā he:

• Mate tākihi, te iti rānei o te mahi tākihi
• Hītori o ngā raruraru pūkahukahu, te uaua rānei ki te hā
• Ngā mate toto, ngā raruraru rānei o te pūwhā
• Hītori o ngā tauhohenga mate pāwera nui ki ngā rongoā

Me āta whakaaro ki te hapū me te whāngai ū, nā te mea kāore i te mōhiotia katoatia ngā pānga o te riluzole ki ngā pēpi e whanake ana. Ka whakatauritehia e tō tākuta ngā painga ka taea ki ngā tūponotanga ka taea.

Kāore te pakeke anake e aukati i te whakamahi riluzole, engari ko ngā pakeke ake pea me āta aroturukihia nā te nui ake o te tairongo ki ngā pānga taha, me ngā pānga pea ki ētahi atu rongoā.

Ngā Ingoa Waitohu Riluzole

Kei te wātea a Riluzole i raro i ētahi ingoa waitohu, ko Rilutek te waitohu taketake e mōhiotia ana. Koinei te putanga tuatahi i whakaaetia e te FDA mō te rongoā ALS.

Ko Tiglutik tētahi ingoa waitohu mō te riluzole, engari he whakatārewatanga waha (wai) tēnei, kāore i te papa. He pai tēnei āhua mō te hunga e uaua ana ki te horo i ngā pire nā te haere whakamua o te ALS.

He wātea noa hoki ngā momo riluzole generic, kei roto anō te whakauru kaha kotahi me ngā momo waitohu. Ko ēnei kōwhiringa generic te nuinga he iti ake te utu, i te wā e whai hua ana.

Ngā Kōwhiringa Riluzole

I tēnei wā, ko te riluzole tētahi o ngā rongoā tuatahi i whakaaetia mō te rongoā ALS. Heoi anō, kei reira ētahi atu kōwhiringa rongoā ka whakamahia tahi, hei rānei i te riluzole i ētahi wā.

Ko Edaravone (ingoa waitohu Radicava) tētahi atu rongoā i whakaaetia e te FDA mō te ALS, he rerekē te mahi i te riluzole. Ka hoatu mā te ruku i roto i te uaua, ā, ka whakamahia tahi pea me te riluzole mō ētahi tāngata.

Ko te phenylbutyrate-taurursodiol konutai (ingoa waitohu Relyvrio) he rongoā hou i whakaaetia e te FDA mō te rongoā ALS. E whakakotahi ana i ngā pūhui e rua, ā, ka āwhina pea ki te tiaki i ngā pūtau io mā ngā momo mahi rerekē.

Ka tūtohu pea tō tākuta i ngā rongoā tautoko pērā i te rongoā tinana, te rongoā mahi, te rongoā kōrero, te tautoko kai rānei. Kāore ēnei huarahi e whakakapi i te riluzole, engari ka tino whakapai ake i te kounga o te oranga i te taha o te rongoā.

He Pai Anei te Riluzole i te Edaravone?

He rerekē te mahi a te riluzole me te edaravone, nō reira kāore i te tika te whakataurite i a rāua. Kua whakaatu ngā rongoā e rua i ngā painga i roto i ngā whakamātau haumanu, engari e tiaki ana i ngā pūtau io i ngā momo huarahi rerekē.

He māmā ake te whakamahi i te riluzole nā te mea he rongoā waha ka tango koe i te kāinga e rua ngā wā i te rā. E hiahia ana te Edaravone ki te ruku i roto i te uaua i te whare hauora, he nui ake te wā me te kore watea.

Ka whai hua pea etahi tāngata ki te tango i ngā rongoā e rua ngātahi, nā te mea e whai ana rātou i ngā āhuatanga rerekē o te haere whakamua o te ALS. Ka whakaaro tō tākuta ki tō āhuatanga motuhake, te wāhanga o te mate, me te hauora whānui i te wā e tūtohu ana i te huarahi rongoā pai rawa atu.

Ko te whiriwhiri i waenga i ēnei rongoā e pā ana ki ngā āhuatanga whaihua pēnei i tō kaha ki te haere mō ngā whakaurunga, te kapinga inihua, me te pai o tō manawanui ki ngā pānga taha o ia rongoā.

Ngā Pātai e Pātai pinepine ana mō Riluzole

He Haumaru a Riluzole mō te Hunga e Mate ana i te Ngākau?

E whakaarohia ana he haumaru a Riluzole mō te hunga e mate ana i te ngākau, nā te mea kāore e pā tika ana ki te mahi o te ngākau. Heoi anō, ka hiahia tō tākuta ki te aroturuki i a koe i te tata ake mēnā he āhuatanga ngākau me te toto tōu.

I ētahi wā ka pā te whāwhā, te ngenge rānei ki te rongoā, ā, ka kitea pea tēnei mēnā kei te tango kē koe i ngā rongoā ngākau. Tera pea me whakatika e tō tākuta te horopeta, te wā rānei o ō rongoā rerekē hei whakaiti i ngā pānga tahi.

Me aha au mēnā ka tango au i te nui rawa o Riluzole?

Mēnā ka tango koe i te nui rawa o te riluzole i te mea i tohua, whakapā atu ki tō tākuta, ki te pūtau whakahaere paitini rānei tonu. Ko te tango i te nui rawa ka piki ake te tūponotanga o ngā pānga taha kino, ina koa ngā raruraru ate.

Kaua e ngana ki te

Kaua rawa e tango e rua nga horopeta i te wa kotahi hei utu i te horopeta i ngaro, na te mea ka piki ake te tupono o nga paanga taha. Whakaritea nga whakamaharatanga i runga i to waea, whakamahia ranei he kaiwhakarite pire hei awhina i a koe ki te mahara ki o horopeta i nga wa katoa.

Ahea Ka Taea e Au te Kati te Tango Riluzole?

Ko te whakatau ki te whakamutu i te riluzole me mahi tonu i runga i te korero ki to taakuta. Ka whakaaro pea koe ki te whakamutu mena ka pa ki a koe nga paanga taha nui kaore e pai ake, mena kaore ano te rongoa e whai hua ana.

Ma to taakuta koe e awhina ki te pauna i nga painga ka puta mai i te haere tonu o te maimoatanga ki nga tupono, ki nga paanga taha ranei e pa ana ki a koe. Ka kii pea ratou ki te whakamatau i nga whakatikatika horopeta, i etahi atu rautaki ranei i mua i te whakamutu katoa.

Ka Taea e Au te Inu waipiro i te wa e tango ana i te Riluzole?

He pai ake te whakaiti, te karo ranei i te waipiro i te wa e tango ana i te riluzole, na te mea ka pa te paanga o nga matū e rua ki to ate. Ko te whakakotahi i a raatau ka piki ake te tupono o nga raru o te ate, ka kino ake nga paanga taha penei i te whanoke, i te ngenge ranei.

Mena ka whiriwhiria e koe te inu i etahi wa, korerohia tenei ki to taakuta i te tuatahi. Ka tohutohu pea ratou ki te aroturuki i te mahi ate, ki te kii ranei i nga rohe motuhake i runga i to hauora takitahi.