He aha te Tafamidis: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

He rongoā motuhake te Tafamidis i hangaia hei whakaiti i te haere whakamua o ētahi mate ngakau me ngā uaua onge e pā ana ki te putunga pūmua hē. E mahi ana tēnei rongoā whakahau mā te whakapumau i tētahi pūmua e kīia ana ko te transthyretin, e ārai ana i te wehenga me te hanga i ngā pūhui kino i roto i ō pūngao.

Mēnā kua whakahaua e tō tākuta te tafamidis, tērā pea kei te raru koe i tētahi āhuatanga e pā ana ki te āhua o te tukatuka o tō tinana i tēnei pūmua nui. Ahakoa he nui ēnei āhuatanga, ko te whai i tētahi whiringa rongoā whai hua ka taea te whakahoki mai i te tūmanako me te āwhina i te pupuri i tō kounga o te ora mō ngā wā roa ake.

He aha te Tafamidis?

He whakapūmau pūmua te Tafamidis e ārai ana i te transthyretin mai i te wetewete me te whara i tō ngakau me ō uaua. Whakaarohia he kāpia ngota e pupuri ana i tēnei pūmua i roto i tōna āhua tika, pumau.

No tētahi rōpū e kīia ana ko ngā whakapūmau transthyretin te rongoā, e waihanga ana i te rongoā tuatahi o tōna momo i whakaaetia mō te rongoā i ngā momo motuhake o te amyloidosis. Ka whakaputa noa tō ate i te pūmua transthyretin, engari i ētahi tāngata, ka noho kore pūmau tēnei pūmua, ka hanga i ngā putunga kino i roto i ngā pūngao.

E rua ngā momo o te Tafamidis: ngā kāpene auau me tētahi momo hou, kaha ake e kīia ana ko te tafamidis meglumine. E mahi ana ngā mea e rua i te ara kotahi engari he rerekē te kaha me te auau inenga.

He aha te Tafamidis e whakamahia ana mō?

E rongoā ana te Tafamidis i ngā āhuatanga e rua: te transthyretin amyloid cardiomyopathy me te hereditary transthyretin amyloidosis me te polyneuropathy. E pā ana ngā mea e rua ki te pūmua raruraru kotahi engari e pā ana ki ngā wāhanga rerekē o tō tinana.

I roto i te transthyretin amyloid cardiomyopathy, ka putu te pūmua kore pūmau i roto i tō uaua ngakau, ka mārō, ka iti te kaha ki te papu toto. Ka taea e tēnei āhuatanga te pā ki te poto o te manawa, te ngenge, me te pūhihi i ō waewae me te puku.

Ko te amyloidosis transthyretin tuku iho me te polyneuropathy e pā ana ki ō uaua o waho, e pā ana ki te ngongo, te ngau, me te ngoikore i ō ringa me ō waewae. Ka tukuna tēnei momo mā ngā whānau, ā, ka tīmata i te pakeketanga.

Ka whakapūmau tō tākuta i tō tātaritanga mā ngā whakamātautau motuhake, tae atu ki te whakamātautau ira me ngā karapa ngakau motuhake, ngā rangahau uaua rānei. He onge ēnei āhuatanga, e pā ana ki te tokoiti noa iho o ngā mano tāngata puta noa i te ao, engari ka nui te pānga ki tō oranga o ia rā, ki te kore e tika te rongoā.

Me pēhea te mahi a Tafamidis?

Ka mahi a Tafamidis mā te here ki te pūmua transthyretin me te pupuri i te pūmau i roto i ō toto. Mā tēnei ka ārai i te pūmua mai i te pakaru me te hanga i ngā pūhui piri e kino ana ki ō okana.

I raro i ngā āhuatanga noa, ka kawe a transthyretin i ngā homoni thyroid me te huaora A puta noa i tō tinana. Heoi, i roto i ngā tāngata e pangia ana e te amyloidosis, ka kore tēnei pūmua e pūmau, ka hē te takai, ka hanga i ngā putunga kino e kīia ana ko ngā muka amyloid.

Ka mahi te rongoā nei hei whakapūmau ngota, e mau ana i te pūmua ki tōna āhua tika. Kāore tēnei e whakahoki i te kino o mua, engari ka whakaroa nui i te hanganga o ngā putunga pūmua hou, e āwhina ana ki te tiaki i tō mahi okana i te roanga o te wā.

E whakaarohia ana he rongoā kaha a Tafamidis me te mahi whāinga. Ehara i te rongoā, engari e whakaatu ana ngā rangahau haumanu ka taea e ia te whakaroa i te haere o te mate me te whakapai ake i ngā reiti oranga ina tīmata wawe i te tukanga mate.

Me pēhea taku tango i a Tafamidis?

Tangohia a Tafamidis kia rite ki te tohutohu a tō tākuta, te tikanga kotahi ia rā me te kore kai, me te kai rānei. Ko te horopeta paerewa he 20mg ia rā (kotahi pūmua) he 61mg ia rā (e whā pūmua), e ai ki tō āhuatanga motuhake me te hanganga i tohutohutia.

Ka taea e koe te tango i tēnei rongoā me te wai, te miraka, te wai hua rānei - kāore te kai e pā kaha ki te āhua o te tango a tō tinana. Heoi, ngana ki te tango i te wā kotahi i ia rā kia mau tonu ai ngā taumata i roto i ō toto.

Horomia ngā kāpene katoa me te kore e whakatuwhera, e kuru, e ngaungau rānei. Ki te uaua ki a koe te horomia i ngā kāpene, kōrero ki tō tākuta mō ētahi atu whiringa, me tango tika te rongoā kia whai hua ai.

Whakaorangia tō rongoā i te pāmahana rūma, i te wāhi makuku me te wera. Puritia ki roto i tōna ipu taketake me te pākete whakamaroke kia kore ai e pakaru i te makuku, ka pā ki te kaha o te rongoā.

Kia Pēhea Te Roa E Tango Ai Au i te Tafamidis?

Ko te Tafamidis te tikanga he rongoā wā-roa me tango tonu e koe kia mau tonu ai ōna pānga whakamarumaru. I te mea e whakaroa ana i te haere o te mate, kaua e rongoā i te āhua, ka mutu te rongoā ka hoki anō te hanga o ngā pūmua kino.

Ka aroturukihia e tō tākuta tō urupare mā ngā arowhai auau, ngā whakamātautau toto, me ngā rangahau whakaahua. Ka āwhina ēnei ki te aromatawai mēnā kei te whakaroa tika te rongoā i te haere o tō mate me te hiahia kia whakatika i te horopeta.

Ko te nuinga o te hunga e pai ana te urupare ki te tafamidis ka tango tonu mō ngā tau. Ka kitea ngā painga o te rongoā i te wā, me ngā rangahau e whakaatu ana i ngā rerekētanga nui i te haere o te mate i muri i te 12 ki te 18 marama o te rongoā tonu.

Kaua rawa e mutu te tango i te tafamidis me te kore e kōrero tuatahi ki tō tākuta. Kāore te whakamutu ohorere e pā ki ngā tohumate tangohanga mōrearea, engari ka taea e tō āhua te haere tere atu i te mea e haere tonu ana te rongoā.

He Aha Ngā Pānga Taha o te Tafamidis?

Ko te nuinga o te hunga e pai ana ki te tafamidis, ko ngā pānga taha he ngawari, he whakahaere. He pai te ahua haumaru o te rongoā ki te whakataurite ki ētahi atu rongoā mō ngā mate onge.

Koinei nga paanga taha e tino korerotia ana ka pa ki a koe:

• Nga raruraru o te nakunaku penei i te whakapairuaki, te korere, te mamae puku ranei
• Te ānini, te whanoke ranei
• Te ngenge, te ngenge ranei atu i te tikanga
• Nga mate o te ara rererangi o runga
• Nga mate o te ara mimi

Ko enei paanga taha noa ka pai ake i te wa e urutau ana to tinana ki te rongoa i nga wiki tuatahi o te maimoatanga.

Ahakoa he onge, ka pa ki etahi tangata nga paanga taha nui ake e hiahia ana kia wawe te rongoa:

• Nga tauhohenga mate pāwera nui me te ponana, te pupuhi, te uaua ranei ki te manawa
• Te toto rereke, te maru ranei
• Te mamae puku nui tonu
• Nga tohu o nga raruraru ate penei i te kowhai o te kiri, o nga kanohi ranei
• Nga tohu ngakau kino, e kino haere ana ranei

Whakapa atu ki to taakuta i tenei wa tonu mena ka pa ki a koe etahi o enei paanga taha nui. Ka taea e te nuinga o nga tangata te tango haumaru i te tafamidis me te aro turuki tika me te tautoko.

Ko wai e kore e tango Tafamidis?

Kaore e tika ana te Tafamidis mo te katoa, a ka ata aromatawaihia e to taakuta mena he tika mo to ahuatanga motuhake. Ko nga tangata e mohiotia ana he mate pāwera ki te tafamidis, ki etahi o ona kai ranei, me karo tenei rongoa.

Ka tino tupato to taakuta mena he mate ate nui koe, na te mea kare pea to tinana e tukatuka tika i te rongoa. Ahakoa kare nga raruraru ate ngawari e whakakore aunoa i a koe, tera pea ka hiahia ki te whakatikatika i te horopeta, ki te aro turuki tata ranei.

Kaua nga wahine hapu e tango tafamidis, na te mea kaore i te tino marama ona paanga ki nga pepi e tipu ana. Mena kei te whakamahere koe ki te hapu, ki te kite ranei kei te hapu koe i te wa e tango ana i tenei rongoa, korerohia nga huarahi kee ki to taakuta i tenei wa tonu.

Me karo hoki e nga whaea e whangai ana i te u te tafamidis, na te mea kaore i te mohiotia mena ka uru te rongoa ki roto i te miraka u. Ka taea e to taakuta te awhina i a koe ki te pauna i nga painga me nga tupono mena kei te ngote koe.

Me mōhio ana te hunga e tino mate ana i te pūkahukahu ki te whakatika i te horopeta, ahakoa te ngawari ki te āhua o te pūkahukahu, kāore e aukati i te whakamahi i te tafamidis. Ka aroturukihia e tō tākuta te mahi o tō pūkahukahu i ngā wā katoa o te rongoā.

Ngā Ingoa Waitohu Tafamidis

E wātea ana te Tafamidis i raro i ngā ingoa waitohu e rua: Vyndaqel me Vyndamax. E rua ngā mea kei roto i te whakauru kaha kotahi engari he rerekē te hanganga me te horopeta.

Kei roto i te Vyndaqel te tafamidis meglumine, ā, ka tae mai i roto i ngā pūtau 20mg, ka tangohia i te wā kotahi i te rā. Koinei te putanga tuatahi i whakaaetia, ā, kei te whānui tonu te tohutohu mō ngā momo ngākau me ngā momo io o te mate.

Kei roto i te Vyndamax te tafamidis (kāore he meglumine) i roto i ngā pūtau 61mg, ka tangohia hoki i te wā kotahi i te rā. He rite tēnei hanganga hou ki ngā pūtau Vyndaqel e whā, ā, he pai ake te whiriwhiri mō tōna mahinga horopeta ngawari.

He rite tonu te whai hua o ngā waitohu e rua - ko te whiriwhiri i waenga i a rātou e pā ana ki te hiahia o tō tākuta, te inihua, me te hanganga e pai ake ana mō te tango i te wā katoa.

Ngā Kōwhiringa kē mō Tafamidis

I tēnei wā, he iti noa ngā kōwhiringa kē mō te tafamidis mō te rongoā i te transthyretin amyloidosis. Ko te onge o ēnei āhuatanga te tikanga he iti tonu ngā kōwhiringa rongoā, e whai hua ana te tafamidis.

Mō te hereditary transthyretin amyloidosis me te polyneuropathy, ko te patisiran me te inotersen he rongoā aukati RNA e mahi rerekē ana i te tafamidis. Ka whakaiti ēnei rongoā i te hanga o te pūmua transthyretin, kaua ki te whakapumau.

Ka taea te whakaaro ki te whakawhiti ate mō ētahi tāngata e whai ana i ngā momo tuku iho o te mate, nā te mea ka hangaia e te ate te nuinga o te pūmua raruraru. Heoi, ko tēnei pokanga nui e tika ana mō ngā tāngata i tohua āta, ā, kāore e āwhina i ngā tohu e pā ana ki te ngākau.

Mō te whakahaere tohu, ka tohua pea e tō tākuta he rongoā hei āwhina i te ngoikore o te ngākau, te mamae o te io, ētahi atu raruraru rānei. E mahi tēnei rongoā tautoko i te taha o te tafamidis hei whakapai ake i tō kounga o te oranga.

Kei te rangahaua te rongoā ira me ētahi atu rongoā whakamātau, engari ko te tafamidis tonu te rongoā matua kua whakamatauria hei whakaiti i te haere whakamua o te mate i te nuinga o ngā tūroro.

He Pai Ake Anei te Tafamidis i Ētahi Atu Rongoā?

He painga motuhake te Tafamidis hei rongoā waha tuatahi kua whakamatauria hei whakaiti i te haere whakamua i te amyloidosis transthyretin. Mō te nuinga o ngā tūroro, he whiringa rongoā whai hua tēnei e māmā ake ana te whakahaere i ngā rongoā werohia.

Ki te whakataurite ki te patisiran me te inotersen, he iti ake ngā pānga taha kino o te tafamidis, ā, kāore e hiahiatia te aroturuki i ngā wā katoa mō te paitini o te ate, te huringa rānei o te tatauranga toto. Nō reira, he whiringa haumaru ake tēnei mō te wā roa mō te nuinga o ngā tāngata.

Nā te hanganga waha i te tafamidis he painga nui mō te wātea i ngā rongoā werohia. Ka taea e koe te tango i tēnei i te kāinga me te kore e haere ki te hōhipera, e māmā ake ai te pupuri i te rongoā i ngā wā katoa.

Heoi, ko te rongoā

Ka aroturukihia e tō tākuta te mahi o tō ngākau i ngā wā katoa i a koe e tango ana i te tafamidis. Kāore te rongoā e kino ai ētahi atu āhuatanga o te ngākau, ā, tērā pea ka āwhina i te tiaki i te mahi o te ngākau mā te aukati i ētahi atu putunga pūmua.

Me pēhea taku mahi mēnā ka tango au i te nui rawa o te Tafamidis?

Mēnā ka tango ohorere koe i te tafamidis nui atu, whakapā atu ki tō tākuta, ki te pūtau whakahaere paitini rānei i te wā tonu. Ahakoa he iti noa ngā mōhiohio mō te horopeta nui, nā te mea he rongoā hou tēnei, he mea nui kia whiwhi tohutohu hauora.

Kaua e ngana ki te whakapōkae i a koe anō, ki te tango rānei i ētahi atu rongoā hei whakakore i te horopeta nui. Kia mau ki te nui o te rongoā nui atu i tangohia e koe me te wā, nā te mea ka āwhina tēnei mōhiohio i ngā kaiwhakarato hauora ki te whakatau i te huarahi pai hei whakatutuki.

Me pēhea taku mahi mēnā ka ngaro i ahau tētahi horopeta o te Tafamidis?

Mēnā ka ngaro i a koe tētahi horopeta, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, waiho te horopeta i ngaro, ka haere tonu i tō hōtaka auau.

Kaua rawa e tango i ngā horopeta e rua i te wā kotahi hei utu mō te horopeta i ngaro. Mēnā he maha ngā wā e wareware ana koe i ngā horopeta, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i te pupuri i te rongoā rite tonu.

Āhea ka taea e au te whakamutu i te tango i te Tafamidis?

Me whakamutu anake e koe te tango i te tafamidis i raro i te tohutohu a tō tākuta. I te mea he rongoā wā roa mō tētahi āhuatanga haere tonu, kāore i te tikanga te whakamutu ki te kore koe e pā ana ki ngā pānga taha nui, ki te huri nui rānei tō āhuatanga.

Tērā pea ka whakaarohia e tō tākuta te whakamutu mēnā ka whanake ētahi atu raruraru hauora e kore ai e haumaru te rongoā tonu, ki te whakaatu rānei te aroturuki auau kāore te rongoā e whai hua ana mō tō āhuatanga motuhake.

Ka taea e au te tango i te Tafamidis me ētahi atu rongoā?

He iti noa nga pānga o Tafamidis ki etahi atu rongoā, he mea e pai ana ki te nuinga o nga rongoā e hiahia ana koe mo etahi atu mate. Heoi, me whakamōhio tonu ki tō tākuta mō ngā rongoā katoa, ngā tāpiringa, me ngā hua otaota e whakamahia ana e koe.

Ka arotake tō tākuta i tō rārangi rongoā katoa kia mōhio kei te kore he pānga raruraru. Ko ētahi rongoā ka hiahia ki te whakatikatika i te wā, ki te whakarerekē rānei i te horopeta kia pai ai te mahi me te tafamidis.