He aha te Tafenoquine: Ngā Whakamahinga, te Inenga, Ngā Pānga taha me ētahi atu

Ko te Tafenoquine he rongoā rongoā antimalarial e āwhina ana ki te ārai me te rongoā i ngā mate malaria. Ko tēnei rongoā hou he kōwhiringa kaha mō te tiaki i te malaria ina haere koe ki ngā wāhi mōrearea, e hiahia ana rānei koe ki te rongoā mō ētahi momo mate malaria.

Hei wāhanga o te rōpū rongoā e kiia nei ko 8-aminoquinolines, he rerekē te mahi a te tafenoquine i ētahi atu rongoā malaria. E whāia ana e ia te pirinoa i ngā wāhanga maha o tōna huringa ora, e whai hua ana mō te ārai me te rongoā malaria.

He aha te Tafenoquine?

Ko te Tafenoquine he rongoā antimalarial e ārai ana, e rongoā ana i te malaria i pā mai i ngā pirinoa Plasmodium. No te kāwai rongoā e kiia nei ko 8-aminoquinolines, e mōhiotia ana mō tō rātou kaha ki te whakakore i ngā pirinoa malaria i tō tinana.

I whakaaetia tēnei rongoā e te FDA i te tau 2018, ā, he ahunga whakamua nui i roto i te rongoā malaria. Kāore i rite ki ētahi rongoā antimalarial tawhito, ka taea e te tafenoquine te whāia ngā pirinoa moe e huna ana i tō ate, e ārai ana i ngā wāhanga malaria anamata.

Ka tae mai te rongoā hei papa waha, ā, e wātea ana anake mā te rēhitatanga. Māu tō tākuta e whakatau mēnā he tika te tafenoquine mōu i runga i tō āhuatanga me tō hītori hauora.

He aha te Tafenoquine e whakamahia ana?

E rua ngā kaupapa matua o te Tafenoquine i roto i te tiaki malaria: te ārai me te rongoā. Ka tohutohu pea tō tākuta i tēnei rongoā hei tiaki i a koe i te mate malaria, hei rongoā rānei i tētahi mate e tū ana.

Mō te ārai, ka mahi te tafenoquine hei prophylaxis malaria ina haere koe ki ngā wāhi e pā ana te malaria. He tino whai hua mō ngā haerenga roa, mō te wā rānei e hiahia ana koe ki te tiaki whānui i muri i tō hokinga mai ki te kāinga.

Ka whakamahia hoki te rongoā hei rongoā i te malaria Plasmodium vivax, tētahi momo motuhake ka pā mai i ngā mate hoki. Anei te wā ka tūtohu pea tō tākuta i te tafenoquine:

• Te ārai i te malaria i te wā e haere ana ki ngā wāhi e pā ana te mate
• Te rongoā i ngā mate malaria P. vivax kua whakapūmautia
• Te ārai i te hokinga mai o te malaria mai i ngā pirinoa ate moe
• Te rongoā ārai i muri i te haerenga i muri i te roanga o te pānga

Ka whakaarohia e tō tākuta hauora ō mahere haerenga, te hītori hauora, me ngā tūponotanga malaria motuhake i tō ūnga i te wā e whakatau ana mēnā he tika te tafenoquine māu.

Me pēhea te mahi a Tafenoquine?

E kiia ana he rongoā antimalarial kaha te Tafenoquine e mahi ana mā te whakaeke i ngā pirinoa malaria i ngā wāhanga rerekē o tō rātou huringa ora. Ka raru te kaha o te pirinoa ki te ora me te whakaputa uri i tō tinana.

He tino whai hua te rongoā nā te mea ka taea e ia te whakakore i ngā hypnozoites, arā, ngā momo moe o te pirinoa malaria e huna ana i tō ate. Ka taea e ēnei pirinoa moe te whakahohe anō i ngā wiki, i ngā marama rānei i muri mai, ka puta he wāhanga malaria e hoki mai ana.

Mā te whai i ngā pirinoa kaha me ngā pirinoa moe, ka whakarato a tafenoquine i te whakamarumaru whānui. Ka raru te rongoā i ngā tukanga pūtau o te pirinoa, ka mutu ka mate rātou, ka ārai i a rātou mai i te mate.

Me pēhea taku tango i te Tafenoquine?

Tangohia te tafenoquine kia rite ki te tohutohu a tō tākuta, te tikanga me te kai hei whakaiti i te puku. Me tango te rongoā me te karaihe wai katoa i te wā, i muri rānei i te kai.

Mō te ārai malaria, ka tangohia e koe tētahi papa i ia wiki, ka tīmata 1-2 wiki i mua i te haerenga me te haere tonu mō te wiki kotahi i muri i te hokinga mai. Ka hoatu e tō tākuta ki a koe ngā tohutohu wā motuhake i runga i ō mahere haerenga.

I te wā e rongoā ana i te malaria, he rerekē pea te hōtaka inenga, ā, he maha ngā wā ka uru ki te tango i te rongoā i ia rā mō te wā poto. Anei ngā aratohu nui hei whai:

• Me kai tahi me te kai, te miraka rānei hei whakapai ake i te urunga me te whakaiti i te whakapairuaki
• Horomia katoatia ngā papa me te nui o te wai
• Me tango i te wā kotahi i ia rā kia mau tonu ai ngā taumata
• Kaua e kuru, e ngaungau, e wehe rānei i ngā papa
• Haere tonu te tango ahakoa kei te pai koe

Mēnā he uaua ki a koe te horomia i ngā papa, kōrero ki tō tākuta mō ētahi atu huarahi. Kaua rawa e whakatika i tō horopeta me te kore tohutohu hauora, nā te mea ka pā tēnei ki te whai huatanga o te rongoā.

Kia Pēhea te Roa o taku tango i te Tafenoquine?

Ko te roa o te maimoatanga tafenoquine e whakawhirinaki ana mēnā kei te whakamahi koe mō te ārai, te rongoā rānei. Ka hoatu e tō tākuta ngā tohutohu motuhake i runga i tō āhuatanga takitahi.

Mō te ārai malaria i te wā o te haerenga, ka tango koe i te tafenoquine mō te roa o tō haerenga me te wā atu i mua me muri. Ko te tikanga tēnei ko te tīmata i te 1-2 wiki i mua i te wehenga me te haere tonu mō te wiki kotahi i muri i te hokinga mai ki te kāinga.

I te wā e rongoā ana i te mate malaria kaha, he poto ake te akoranga engari he kaha ake. Ka taea e te roa o te maimoatanga te whānui mai i ētahi rā ki ētahi wiki, i runga i te momo malaria me tō urupare ki te rongoā.

Kaua rawa e mutu te tango i te tafenoquine i mua, ahakoa kei te tino pai koe. Ka taea e te maimoatanga kāore i oti te arahi ki ngā mate e hoki mai ana, te aukati rongoā rānei, e uaua ai te rongoā malaria i te wā anō.

He aha ngā Pānga taha o te Tafenoquine?

Pērā i ngā rongoā katoa, ka taea e te tafenoquine te pānga taha, ahakoa kāore te katoa e pā ana ki a rātou. Ko te nuinga o ngā pānga taha he ngawari, he mārama, engari ko ētahi ka nui ake te kino.

Ko ngā pānga taha noa e pā ana ki te nuinga o te tangata ko te whakapairuaki, te ruaki, me te kore mārie o te puku. Ko ēnei raruraru keri kai ka pai ake i te wā e tango ana koe i te rongoā me te kai.

Anei ngā pānga taha e pūrongohia ana e te nuinga ka kite pea koe:

• Te whakapairuaki me te ruaki
• Te mamae puku, te kōpū rānei
• Te ānini
• Te whanoke
• Te ngenge, te ngoikore rānei
• Te raruraru moe
• Te ngaro o te hiahia

Ka puta pea ngā pānga taha tino nui, ina koa ki ngā tāngata e whai ana i ētahi āhuatanga ira. Kei roto i tēnei ko te anemia nui, ngā tohumate hinengaro pērā i te āwangawanga, te pōuri rānei, me ngā huringa o te manawa.

Ko ngā pānga taha onge engari tino nui e hiahia ana kia āta tirohia e te tākuta, kei roto ko ngā tauhohenga mate pāwera nui, te ruaki tonu, te ngenge rerekē, te kōwhai o te kiri, o ngā kanohi rānei, me ngā huringa nui o te ngākau. Whakapā atu ki tō tākuta i te wā tonu mēnā ka pā ki a koe ētahi tohumate e pā ana ki a koe.

Ko wai kāore e tika kia tango Tafenoquine?

Kāore i te haumaru te Tafenoquine mō te katoa, ā, me karo ētahi tāngata i tēnei rongoā. Ka tirohia koe e tō tākuta mō ētahi āhuatanga motuhake i mua i te whakahau i te tafenoquine.

Ko ngā tāngata e whai ana i te ngoikoretanga o te G6PD, he āhuatanga ira e pā ana ki ngā pūtau toto whero, kāore rātou e tika kia tango tafenoquine. Ka taea e tēnei rongoā te whakaputa i te anemia nui i roto i ngā tāngata e whai ana i tēnei āhuatanga, ka mōrearea pea te ora.

I mua i te whakahau i te tafenoquine, ka tono pea tō tākuta i tētahi whakamātautau toto hei tirotiro mō te ngoikoretanga o te G6PD. Anei ētahi atu āhuatanga kāore pea e tika te tafenoquine:

• Te ngoikoretanga o te G6PD e mōhiotia ana
• Te mate tākihi, te ate rānei
• Te hītori o ngā raruraru hinengaro
• Te hapū, te whāngai ū rānei
• Ētahi raruraru o te manawa
• Ngā tauhohenga mate pāwera nui ki ngā rongoā rite

Ka āta arotake tō tākuta i tō hītori hauora, ā, ka tono pea i ētahi atu whakamātautau hei whakarite kia haumaru te tafenoquine mōu. Me kōrero tonu ki tō kaiwhakarato hauora mō ngā rongoā katoa e tango ana koe, me ō āhuatanga hauora katoa.

Ngā Ingoa Waitohu Tafenoquine

Kei te wātea te Tafenoquine i raro i te ingoa waitohu Arakoda mō te ārai i te malaria me Krintafel mō te rongoā i te malaria. E rua ngā rongoā kei roto te whakauru kaha kotahi engari he rerekē pea ngā hōtaka inenga.

Kua whakaaetia te Arakoda mō te ārai i te malaria i roto i ngā pakeke e haere ana ki ngā wāhi e pā ana te malaria. Ka whakamahia te Krintafel me ētahi atu rongoā anti-malaria hei rongoā i te malaria P. vivax.

Ka tohua e tō tākuta te waitohu tika i runga i te hiahia ārai, rongoā rānei. E rua ngā momo e hiahia ana i te rēhitatanga, me whakamahi anake i raro i te tirotiro hauora.

Ngā Kōwhiringa kē mō Tafenoquine

He maha atu ngā rongoā anti-malaria e wātea ana mēnā kāore te tafenoquine e tika ana mōu. Ka taea e tō tākuta te tūtohu i ngā kōwhiringa kē i runga i ō hiahia me tō hītori hauora.

Ngā kōwhiringa kē mō te ārai i te malaria ko te atovaquone-proguanil (Malarone), doxycycline, me te mefloquine. He rerekē ngā painga me ngā pānga taha o ia rongoā.

Mō te rongoā i te malaria, ko ngā kōwhiringa kē pea ko te chloroquine, ngā rongoā whakakotahi i runga i te artemisinin, rānei te primaquine. Ka whakawhirinaki te whiriwhiri ki te momo malaria, tō wāhi, me ngā tauira ātete o te rohe.

Ka whakaaro tō kaiwhakarato hauora i ngā āhuatanga pēnei i tō haerenga, te roa o te haerenga, te hītori hauora, me ētahi atu rongoā i te wā e whiriwhiri ana i te kōwhiringa anti-malaria pai mōu.

He Pai Anei te Tafenoquine i te Primaquine?

He rongoā anti-malaria 8-aminoquinoline te Tafenoquine me te primaquine, engari he painga tō te tafenoquine i runga i te primaquine. Ko te painga nui ko te tafenoquine e hiahia ana i ngā inenga iti ake nā te roa o ōna pānga i tō tinana.

Ahakoa te primaquine e hiahia ana i te inenga ia rā mō te 14 rā, ka taea te hoatu te tafenoquine hei inenga kotahi, he akoranga poto rānei. Mā tēnei ka māmā ake te whakaoti i te rongoā me te whakaiti i te tūponotanga o ngā inenga kua ngaro.

He rite tonu ngā tūponotanga o ngā rongoā e rua, inā koa mō te hunga e mate ana i te ngoikoretanga o te G6PD. Heoi anō, nā te roa o te mahi a te tafenoquine ka noho roa ki tō tinana, he painga tērā, he āwangawanga anō.

Ka whakaaro tō tākuta ki tō āhuatanga motuhake, tae atu ki tō kaha ki te tango rongoā ia rā, me ō āhuatanga tūpono, i te wā e whiriwhiri ana i waenga i ēnei kōwhiringa.

Ngā Pātai Auau mō Tafenoquine

He Haumaru te Tafenoquine mō te Hunga e Mate ana i te Ngākau?

Ka pā te tafenoquine ki te manawataki o te ngākau i ētahi tāngata, nō reira me tino whakaaro mēnā he mate ngākau tōu. Ka arotake tō tākuta i tō āhuatanga ngākau motuhake, ā, ka tono pea i ētahi atu whakamātautau i mua i te whakahau i tēnei rongoā.

Mēnā he hītori tōu mō ngā raruraru manawataki ngākau, tērā pea ka tūtohu tō kaiwhakarato hauora i ētahi atu rongoā anti-malaria. Me kōrero tonu ki tō tākuta mō tō hītori ngākau katoa i mua i te tīmatanga o te tafenoquine.

Me Pēhea Taku Mahi Mēnā Ka Tango Au i te Tafenoquine Nui Rawa?

Mēnā ka tango koe i te tafenoquine nui rawa, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei, ināianei tonu. Ko te tango i te nui atu i te mea i whakaritea ka piki ake te tūponotanga o ngā pānga taha kino, inā koa mēnā he ngoikoretanga G6PD tōu.

Kaua e ngana ki te rongoā i te horopeta nui rawa atu i a koe anō. Rapua te āwhina hauora ngaio tonu, ahakoa e pai ana tō tū. Mauria mai te pounamu rongoā ki a koe hei āwhina i ngā kaiwhakarato hauora ki te mārama ki te aha me te nui i tangohia e koe.

Me Pēhea Taku Mahi Mēnā Ka Ngaro Au i tētahi Horopeta o Tafenoquine?

Mēnā ka ngaro koe i tētahi horopeta o tafenoquine, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. Kaua e tango i ngā horopeta e rua i te wā kotahi hei utu mō tētahi horopeta i ngaro.

Mō te ārai, mēnā ka ngaro koe i tētahi horopeta ia wiki, tangohia i te wā e taea ai, ā, ka haere tonu ki tō hōtaka auau. Whakapā atu ki tō tākuta mēnā ka ngaro koe i ngā horopeta maha, nā te mea ka pā tēnei ki tō whakamarumaru i te malaria.

Āhea Ka Taea e Au te Kati te Tango i te Tafenoquine?

Kati te tango i te tafenoquine ina korero tō tākuta ki a koe, ahakoa kei te pai koe. Ko te whakamutu wawe rawa ka hua te korenga o te rongoā, te hokinga mai rānei o te mate malaria.

Mō te ārai, me haere tonu koe ki te tango i te tafenoquine mō te wā i whakaritea, tae atu ki muri i te hokinga mai i te haere. Mō te rongoā, whakaotia te akoranga katoa i te ara i tohutohutia kia mōhio ka ngaro katoa ngā pirinoa.

Ka taea e au te inu waipiro i te wā e tango ana i te Tafenoquine?

He pai ake te whakaiti i te inu waipiro i te wā e tango ana i te tafenoquine, nā te mea ka pā ngā mea e rua ki tō ate, ā, ka piki ake pea ngā pānga taha. Ka kino pea te waipiro i ngā pānga taha o te kōpū pērā i te whakapairuaki me te pōpōtanga o te puku.

Mēnā ka whiriwhiria e koe te inu, inu i te āhua tika, ā, kia mōhio ki tō āhua. Kōrero ki tō tākuta mō te whakamahi waipiro, ina koa kei a koe ngā raruraru ate, kei te tango rānei koe i ētahi atu rongoā.