He aha te Tavaborole: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu mea

Ko te Tavaborole he rongoā antifungal ā-rohe e rongoā ana i ngā mate harore whao, ina koa te onychomycosis. He rerekē tana mahi mai i ētahi atu rongoā antifungal mā te aukati i tētahi enzyme motuhake e hiahiatia ana e te harore kia ora ai, kia tipu ai. Ko tēnei rongoā i runga i te whakahaunga he otinga mārama ka whakamahia tika ki ngā whao waewae kua pangia kotahi ia rā mō te 48 wiki.

He aha te Tavaborole?

Ko te Tavaborole he otinga antifungal i runga i te whakahaunga i hangaia mō ngā mate harore whao waewae. No tētahi momo rongoā antifungal motuhake e kiia nei ko ngā aukati i runga i te boron, he rerekē ai i ngā rongoā antifungal tuku iho.

E aro ana te rongoā ki ngā mate harore i te taumata pūtau mā te whakararu i te hanga pūmua i roto i ngā pūtau harore. Mā tēnei huarahi ka whakawātea i te mate i te wā e tupu ana te kiko whao hauora i te roanga o te wā.

He rongoā hou te Tavaborole ki ētahi atu rongoā antifungal, i whakaaetia e te FDA i te tau 2014. He huarahi kē mō ngā tāngata kāore i pai te urupare ki ētahi atu rongoā antifungal ā-rohe, ki te kore rānei e hiahia ki te tango rongoā antifungal waha.

He aha te Tavaborole e whakamahia ana mō?

E rongoā ana te Tavaborole i te onychomycosis, e mōhiotia ana ko te harore whao waewae, te mate harore whao rānei. Ko tēnei āhuatanga ka matotoru, ka huri te tae, ka ngāwari te whati, ā, i ētahi wā ka mamae ngā whao.

He pai rawa atu te mahi a te rongoā ki ngā mate harore whao ngawari ki te āhua, kāore anō kia horapa ki te matrix whao (te wāhi e tīmata ai te tipu whao). He tino whai hua ina pā te mate ki te iti iho i te 50% o te mata whao.

Ka tūtohu pea tō tākuta i te tavaborole mēnā he mate harore whao tō, mēnā kāore anō ētahi atu rongoā ā-rohe i whai hua. Ka whakaarohia hoki ina kāore e tika ana ngā rongoā antifungal waha nā te pānga rongoā pea, ngā āwangawanga ate rānei.

Me pēhea te mahi a te Tavaborole?

Ka mahi a Tavaborole mā te aukati i tētahi whākōkī e kīia ana ko te leucyl-tRNA synthetase, e hiahiatia ana e ngā pūtau harore hei hanga pūmua e whai pānga ana ki te oranga. He huarahi anti-harore tēnei he kaha ngawari e aro ana ki ngā pūtau harore me te kore e pā nui ki ngā pūtau tangata.

Ka uru te rongoā ki roto i te pereti whao kia tae ki te wāhi pangia i raro i te whao. Kia tae ki reira, ka raru te kaha o te harore ki te whakaputa uri me te tiaki i a ia anō, ka horoi haere i te pangia i roto i ngā marama maha.

Kāore i rite ki ētahi anti-harore pūnaha kaha ake, ka mahi a tavaborole i te wāhi tono. Ko tēnei huarahi e aro ana he iti ake ngā pānga taha puta noa i tō tinana i te wā e whakarato tonu ana i te rongoā whai hua mō te wāhi pangia.

Me pēhea taku tango i te Tavaborole?

Whakamahia te tavaborole kotahi i te rā ki ngā whao waewae mā, maroke, he pai ake i te wā kotahi i ia rā. Kāore koe e hiahia ki te tango i te rātou me te kai, te miraka rānei i te mea ka whakamahia ki runga, kaua ki te horomia.

I mua i te whakamahi, horoia ō ringa me ō waewae ki te hopi me te wai, ka whakamaroke rawa. Whakamahia tētahi paparanga angiangi o te otinga ki te mata katoa o te whao, tae atu ki te moenga whao me raro i te pito o te whao ki te taea.

Tukua te rongoā kia maroke rawa i mua i te whakakakahu i ngā tōkena, i ngā hū rānei, e pā ana ki te 2-3 meneti. Kaua e horoi i te wāhi kua rongoatia mō te 6 haora i muri i te whakamahi kia pai ai te ngongo.

Ka taea e koe te kai noa i te mea he rongoā kaupapa tēnei, engari karo i te rongoā ki te kiri hauora huri noa i te whao i te mea ka taea. Ki te rongoā koe i tētahi wāhi ki te kiri e tata ana, kāore i te kino engari ka puta pea te riri ngawari.

Kia Pēhea te Roa o taku Tango i te Tavaborole?

Me whakamahi te nuinga o te tangata i te tavaborole mō te 48 wiki (tata ki te kotahi tau) kia kite i ngā hua katoa. He mea tika tēnei wā rongoā roa nā te mea he puhoi te tipu o ngā whao waewae, ā, he wā e hiahiatia ana kia whakakapi te whao hauora i ngā wāhanga pangia.

Ka tīmata pea koe ki te kite i ngā whakapainga i te āhua o te whao i muri i te 24 wiki, engari he mea nui kia haere tonu te rongoā mō te wā i whakaritea. Ko te whakamutu wawe ka hoki mai te mate, nā te mea kei te noho tonu te harore i roto i te kiko whao e titiro ana he hauora.

Ka aroturukihia e tō tākuta tō haere i te wā o te rongoā, ā, ka whakatika pea i te roa i runga i te urupare o ō whao. Ko ētahi tāngata e tino kaha ana te mate ka hiahia rongoā neke atu i te 48 wiki, i te wā e kite ana ētahi atu he ngawari ake te mate i te whakawātea katoa i mua ake.

He aha ngā pānga taha o Tavaborole?

He pai te aro o te nuinga o te tāngata ki te tavaborole, ā, he ngawari noa iho ngā pānga taha, ā, he iti noa iho ki te wāhi e whakamahia ana. Ko ngā pānga taha e pā ana ki te kiri me ngā whao te mea tino noa.

Koinei ngā pānga taha ka pā ki a koe, me te mōhio he wā poto noa iho te nuinga, ā, he ngawari te whakahaere:

• Te riri kiri, te whero rānei i te taha o te whao e rongoatia ana
• Te wera ngawari, te ngau rānei i te wā tuatahi e whakamahia ana
• Te kiri maroke, te kiri kiri rānei i te taha o te wāhi e whakamahia ana
• Te huringa tae whao, te huringa rānei i te āhua o te whao
• Te pūhi ngawari o te matimati, o te kiko rānei e tata ana

Ko te tikanga, ka pai ake ēnei urupare i te wā e urutau ana tō kiri ki te rongoā i ngā wiki tuatahi o te rongoā.

Ka puta pea ngā pānga taha onge engari tino kaha ake i ētahi tāngata, ahakoa e pā ana ēnei ki te iti iho i te 1% o ngā kaiwhakamahi:

• Ngā urupare mate pāwera kaha me te pūwhāwhā whānui, te uaua rānei ki te hā
• Te wera tonu, te mamae rānei e kaha ake ana i te wā
• Ngā tohu o te mate huakita tuarua (te whero nui ake, te mahana, te pūhi)
• Te wehenga whao mai i te moenga whao (onycholysis)
• Te pūwhāwhā kiri kaha, te whewhe rānei

Mēnā ka pā ki a koe ētahi urupare kaha, whakapā atu ki tō kaiwhakarato hauora tonu, nā te mea ka hiahia pea ēnei ki te whakamutu i te rongoā, ki te rongoā atu rānei.

Ko wai kāore e tika kia tango Tavaborole?

Kāore a Tavaborole e tika ana mō te katoa, ā, ko ētahi āhuatanga ka kore e pai, ka hiahiatia rānei ngā whakatūpato motuhake. Ko ngā tāngata e mōhio ana ki te mate pāwera ki a tavaborole, ki ētahi atu whakauru rānei, me karo tēnei rongoā.

Me kōrero koe i ngā huarahi kē ki tō tākuta mēnā he nui te kino o ō whao, he mate rānei e pā ana ki te neke atu i te 50% o te mata o te whao. He pai rawa te rongoā nei mō ngā mate ngawari ki te āhua, ā, kāore pea e whai hua mō ngā take matatau.

Ko ngā tāngata e ngoikore ana te pūnaha ārai mate, pērā i te hunga e mate huka ana, e mate HIV ana, e tango rongoā ārai mate rānei, tērā pea ka nui ake te aroturuki i te wā o te rongoā. Ahakoa kāore i te rāhuitia te whakamahi, ka pā ēnei āhuatanga ki te whakaora me te whakanui i ngā tūponotanga o te mate.

Me whakamahi ngā wāhine hapū me te whāngai ū i te tavaborole mena ka nui ake ngā painga i ngā tūponotanga. He iti noa ngā raraunga e pā ana ki tōna haumaru i te wā o te hapū, nō reira ka āta whakatau tō tākuta i tō āhuatanga motuhake.

Ingoa Waitohu Tavaborole

Ka hokona a Tavaborole i raro i te ingoa waitohu Kerydin i te United States. Koinei anake te waitohu kua whakaaetia e te FDA kei roto a tavaborole hei whakauru kaha.

Ka hangaia a Kerydin e Anacor Pharmaceuticals (nāianei he wāhanga o Pfizer) ā, ka tae mai hei otinga kaupapa 5% i roto i te pounamu me te paraihe tono. Ko te hanganga ingoa waitohu te mea i akohia i roto i ngā whakamātau haumanu, ā, kua whakaaetia mō te rongoā i te harore o te whao.

Kāore anō kia wātea whānuitia ngā putanga whānui o te tavaborole, nō reira ka whakakiia te nuinga o ngā rēhitatanga ki te ingoa waitohu Kerydin. Ka rerekē pea tō inihua mō ngā rongoā ingoa waitohu, nō reira me whakapā atu ki tō kaiwhakarato mō ngā kōwhiringa inihua.

Ngā Huarahi Kē ki a Tavaborole

He maha ngā rongoā kē e wātea ana mō te harore o te whao mēnā kāore a tavaborole e tika ana, e whai hua ana rānei mōu. Kei roto i ēnei kōwhiringa ētahi atu rongoā ārai harore kaupapa, rongoā waha, me ngā rongoā tukanga.

Ko ētahi atu rongoā rongoā antifungal ko te ciclopirox (Penlac), efinaconazole (Jublia), me te amorolfine (kāore i te wātea i te US). E mahi ana ēnei mā ngā momo tikanga rerekē, ā, he whai hua pea i te wā e kore ai te tavaborole e whai hua.

Ko ngā rongoā antifungal waha pēnei i te terbinafine (Lamisil) me te itraconazole (Sporanox) he kōwhiringa kaha ake mō ngā mate kino. Heoi anō, he nui ake ngā tūponotanga o ngā pānga taha me ngā pānga rongoā i te whakataurite ki ngā rongoā rongoā.

Ko ngā rongoā hou ko te rongoā laser, te rongoā photodynamic, me te tango i te whao mā te pokanga i ngā wā kino. Ka taea e tō tākuta te āwhina ki te whakatau ko tēhea te kōwhiringa kē ka pai ake i runga i tō mate motuhake me te āhuatanga hauora.

He Pai Anei te Tavaborole i te Ciclopirox?

He whai hua ngā rongoā antifungal rongoā tavaborole me te ciclopirox, engari e mahi ana mā ngā momo tikanga rerekē, ā, he rerekē ngā painga. He pai ake pea te tavaborole mō ētahi tāngata nā te mea he mahi aukati enzyme ahurei.

E whakaatu ana ngā rangahau haumanu e tutuki ana te tavaborole i ngā reiti whakaora katoa o te 6-9% i te whakataurite ki te reiti 5-8% o te ciclopirox. Ahakoa te ahua iti o tēnei rerekētanga, he pai ake pea te mahi hou a te tavaborole mō ngā mate e ātete ana ki ngā rongoā antifungal tuku iho.

Me tono ia rā te ciclopirox me te tango ia wiki mā te whakamahi i te waipiro mirimiri, i te wā e whai ana te tavaborole i te mahinga tono kotahi i te rā. E pai ana ētahi tāngata ki te mahinga tono māmā ake o te tavaborole, ā, kāore rātou e aro ki te roa ake o te wā rongoā.

Ko te kōwhiringa i waenga i ēnei rongoā e whakawhirinaki ana ki tō momo harore motuhake, ngā urupare rongoā o mua, me ngā hiahia whaiaro. Ka taea e tō tākuta te āwhina ki te whakatau ko tēhea te kōwhiringa e tuku ana i te tupono pai rawa atu o te angitu mō tō keehi motuhake.

Ngā Pātai Auau Mō te Tavaborole

He Haumaru Anei te Tavaborole mō te Mate Huka?

Ka taea te whakamahi marie a Tavaborole e te nuinga o te hunga mate huka, engari me tino aro turuki me te tiaki waewae. Ka taea e te mate huka te whakaroa i te whakaora me te whakanui i nga tupono o te mate, no reira ka hiahia to taakuta ki te whai i to ahunga whakamua.

Me tirotiro nga tangata e mate huka ana i o ratou waewae i ia ra mo nga tohu o te riri, o te mate tuarua ranei i te wa e whakamahi ana i te tavaborole. Ko te whakahaere pai i te huka toto ka awhina i te whakaora me te whakaiti i te tupono o nga raruraru i te wa e rongoa ana.

Ka tohutohu pea to kaiwhakarato hauora kia maha ake nga tirotirohanga kia mohio ai kaore te rongoa e riri nui ana, e huna ana ranei i nga tohu o etahi atu raruraru waewae e pa ana ki te mate huka.

Me aha ahau ki te whakamahi pohehe au i te Tavaborole nui rawa atu?

Mena ka nui rawa te tavaborole e whakamahia ana e koe, kaua e mataku – he uaua tenei te raru nui na te mea he rongoa kaupapa. Tangohia nga otinga nui me te kiko ma, me te karo i te whakamahi i etahi atu kia tae ra ano ki to horopeta e whai ake nei.

Ko te whakamahi nui rawa atu e kore e tere ake te mahi o te rongoa, ka piki ake pea te riri o te kiri huri noa i te waahi e rongoatia ana. Mena ka nui ake te wera, te whero, te riri ranei, ka taea e koe te horoi marie i te waahi ki te wai matao.

Haere tonu ki to waarangi tono i ia ra, ma te whakamahi i te nui e taunakitia ana. Mena ka mau tonu te riri, ka kino ake ranei, whakapā atu ki to kaiwhakarato hauora mo te aratohu mena ka haere tonu te maimoatanga.

Me aha ahau ki te ngaro ahau i te horopeta o Tavaborole?

Mena ka ngaro koe i te horopeta, whakamahia te tavaborole i te wa e mahara ana koe, ki te kore e tata ana ki te wa mo to tono e whai ake nei. I tera keehi, pekehia te horopeta i ngaro ka haere tonu ki to waarangi.

Kaua e takirua nga horopeta ma te whakamahi i etahi atu rongoa hei utu mo te tono i ngaro. E kore tenei e tere ake te whakaora, ka piki ake pea te tupono o te riri o te kiri.

Whakamātauria te whakatū i tētahi hōtaka rite tonu, ā, pea me tono te rongoā i te wā kotahi i ia rā, hei āwhina i te mahara ki ngā horopeta. He mea whai hua te whakatū i tētahi whakamārama waea i te wā o te wā roa o te rongoā.

Āhea Ānei Ka Taea e Au te Kati te Tango i te Tavaborole?

Me haere tonu koe ki te whakamahi i te tavaborole mō te wā katoa i whakaritea, te tikanga 48 wiki, ahakoa ka tīmata te pai ake o ō mākou whao i mua. Ko te kati wawe rawa te nuinga o te wā ka hoki mai te mate nā te mea ka noho tonu te harore i roto i te kiko whao e ahua hauora ana.

Ka arotakehia e tō tākuta tō ahunga whakamua i ngā haerenga whai muri, ā, ka whakatau i te wā e haumaru ana te kati i te rongoā. Ko te whakawātea whao katoa, i te wā e ahua hauora ana, e noa ana te whao katoa, te whāinga i mua i te whakamutu.

I muri i te kati i te tavaborole, me haere tonu te mahi i te akuaku waewae pai me te tiaki whao hei ārai i te mate hoki. Ka tūtohu pea tō tākuta i ngā arotake wā hei whakarite kia kore te mate e hoki mai.

Ka Taea e Au te Kāka i te Wāhi Whakapaipai Whao i te Wā e Whakamahi ana i te Tavaborole?

He pai ake te karo i te wāhi whakapaipai whao i te wā e whakamahi ana i te tavaborole, nā te mea ka raru pea i te kaha o te rongoā ki te kuhu ki roto i te whao, ā, ka tae ki te mate. Ka uaua hoki te wāhi whakapaipai whao ki te aroturuki i tō ahunga whakamua rongoā.

Mēnā me kāka koe i te wāhi whakapaipai whao mō ngā wā motuhake, tangohia katoatia i mua i tō tono tavaborole e whai ake nei, ā, tatari kia 24 haora i muri i te tono i te rongoā i mua i te tono anō i te wāhi whakapaipai.

Aronga ki te hauora whao i te wā o te rongoā, kaua ki te āhua – mahara ko ngā whao hauora, mārama te whāinga nui o tō haerenga rongoā 48-wiki.