He aha te Thalidomide: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te Thalidomide he rongoā rongoā e pā ana ki te kāwai rongoā e kiia nei ko te immunomodulators, ko te tikanga e āwhina ana ki te whakahaere i tō pūnaha ārai mate. I te tuatahi i hangaia i ngā tau 1950 hei rongoā moe, kua kitea e tēnei rongoā he oranga hou hei rongoā nui mō ētahi momo mate pukupuku me ngā āhuatanga ārai mate. I tēnei rā, ka tohua e ngā tākuta te thalidomide mō te myeloma maha, he momo mate pukupuku toto, ā, ka whakamahia hoki mō ngā āhuatanga mumura motuhake i te wā kāore anō ētahi atu rongoā i whai hua.

He aha te Thalidomide?

Ko te Thalidomide he rongoā kaha e mahi ana mā te huri i te āhua o tō pūnaha ārai mate me te pānga ki te tipu o ngā oko toto hou. Koinei te mea e kīia ana e ngā tākuta he rongoā immunomodulatory, ko te tikanga ka taea e ia te whakanui, te whakaiti rānei i ngā wāhanga rerekē o tō urupare ārai mate i runga i te hiahia o tō tinana.

He hītori uaua tēnei rongoā he mea nui kia māramahia. I ngā tau whakamutunga o te 1950 me te timatanga o te 1960, i puta te thalidomide i ngā hē whānau nui i te wā i tukuna ai ki ngā wāhine hapū hei āwhina i te moe. Ko tēnei wā pouri i arahi ki ngā ture haumaru rongoā tino kaha puta noa i te ao. I tēnei rā, ka wātea anake te thalidomide mā ngā hōtaka tino whakahaere e whakarite ana kia whakamahia i runga i te haumaru me te tika.

Ka tae mai te rongoā hei kāpene ka tangohia e koe mā te waha. Ka hangaia i raro i ngā aratohu tino kaha, ā, ka tukuna anake mā ngā whare rongoā motuhake e whai wāhi ana ki ngā hōtaka aroturuki haumaru.

He aha te Thalidomide e Whakamahia Ana?

Ka rongoā te Thalidomide i ētahi āhuatanga nui, ko tōna whakamahinga tuatahi mō te myeloma maha, he mate pukupuku e pā ana ki ngā pūtau plasma i roto i tō wheua wheua. Ka tohua pea e tō tākuta me ētahi atu rongoā mate pukupuku hei āwhina i te whakahaere i tēnei mate me te whakapai ake i tō kounga o te oranga.

I tua atu i te rongoā mate pukupuku, ka āwhina te thalidomide ki te whakahaere i ētahi āhuatanga mumura. I ētahi wā ka tohua mō te erythema nodosum leprosum, he āhuatanga kiri mamae ka puta i roto i ngā tāngata e pangia ana e te repera. Ka taea hoki te whakamahi i te rongoā mō ētahi atu mate mumura i te wā kāore anō ngā rongoā paerewa i whai hua.

I ētahi wā, ka whakaaro pea ngā tākuta ki te thalidomide mō ētahi atu mate pukupuku toto, āhuatanga rānei e pā ana ki te ārai mate. Heoi anō, ka āta arotakehia ēnei whakamahinga i runga i te take takitahi, me te whakatau i ngā painga pea ki ngā tūponotanga.

Me pēhea te mahi a Thalidomide?

Ka mahi a Thalidomide mā ngā momo tikanga i tō tinana, he rerekē rawa atu i te maha atu o ngā rongoā. Ko te mea nui ka whāia e ia ko tō pūnaha ārai mate me te hanganga o ngā oko toto hou, koinei te take i whai hua ai ki te mate pukupuku me ngā āhuatanga mumura.

Mō te rongoā mate pukupuku, ka āwhina te thalidomide mā te aukati i ngā puku kia kaua e hanga oko toto hou e hiahiatia ana e rātou hei tipu. Ko tēnei tukanga, e kīia ana ko te angiogenesis, he rite ki te tapahi i te pūtake kai o te puku. Ka whakahihiri hoki te rongoā i ētahi wāhanga o tō pūnaha ārai mate kia pai ake te mōhio me te whakaeke i ngā pūtau mate pukupuku.

Mō ngā āhuatanga mumura, ka whakaiti te thalidomide i te hanga o te tumor necrosis factor-alpha, he matū e whakatairanga ana i te mumura i tō tinana. Whakaarohia me te whakaiti i te rōrahi o te urupare mumura o tō tinana i te wā kua kaha rawa atu.

E kiia ana he rongoā kaha tēnei me ngā pānga nui ki ngā pūnaha o tō tinana. Ka āta aroturukihia koe e tō tākuta i a koe e tango ana i tēnei kia mōhio ai kei te whai hua, me te mātakitaki mō ētahi huringa e pā ana ki te āwangawanga.

Me pēhea taku tango i te Thalidomide?

Tangohia te thalidomide kia rite ki tā te tākuta i whakahau ai, te tikanga kotahi ia rā i te wā moe me te karaihe wai ki tonu. Ko te tango i te pō ka āwhina ki te whakaiti i ētahi pānga taha pēnei i te moe me te whanoke ka pā pea ki a koe i te awatea.

Ka taea e koe te tango i te thalidomide me te kore ranei he kai, engari ngana kia rite tonu ki tāu i whiriwhiri ai. Ki te kite koe e pōraru ana tō puku, mā te tango me te paramanawa māmā pea e āwhina. Kaua e whati, e ngaungau, e whakatuwhera rānei i ngā kāpene - horomia katoatia kia mōhio ai koe kei te whiwhi koe i te horopeta tika.

Anei ētahi aratohu nui hei whai i te wā e tango ana koe i te thalidomide:

• Tangohia tō horopeta i te wā kotahi i ia ahiahi kia mau tonu ai ngā taumata i tō tinana
• Kaua e rua ngā horopeta ki te ngaro i tētahi - tangohia noa tō horopeta i whakaritea e whai ake nei
• Puritia te rongoā i roto i tōna ipu taketake, kia matara atu i te wera, te makuku, me te mārama
• Kaua rawa e tiritiri i tō rongoā ki ētahi atu, ahakoa he rite ō rātou tohumate
• Kia tūpato ki te whakahaere i ngā kāpene, me te horoi i ō ringa i muri i te pā atu ki a rātou

Ka tīmata pea tō tākuta i a koe ki te horopeta iti ake, ka piki haere i runga i te āhua o tō urupare ki te rongoā. Mā tēnei huarahi tūpato e āwhina ki te whakaiti i ngā pānga taha i te wā e kimi ana i te horopeta tino whai hua mō tō āhua.

Kia Pēhea te Roa e Tango Ana Ahau i te Thalidomide?

He rerekē te roa o te rongoā thalidomide i runga i tō āhua motuhake me te pai o tō urupare ki te rongoā. Mō te myeloma maha, ka tango pea koe mō ētahi marama ki ngā tau, i ngā wā maha i roto i ngā huringa me ngā wā okioki i waenga i ngā wā rongoā.

Ka arotakehia e tō tākuta i ngā wā katoa te āhua o tō urupare ki te rongoā mā ngā whakamātautau toto, ngā rangahau whakaahua, me ngā whakamātautau tinana. Mā ēnei arowhai e āwhina ki te whakatau mēnā ka haere tonu, ka whakatika, ka mutu rānei tō rongoā i runga i ngā painga e pā ana ki a koe me ngā pānga taha ka puta pea.

Mō ngā āhua mumura, he poto ake pea te roa o te rongoā, i ētahi wā he marama noa iho kia pai ake ai ngā tohumate. Heoi, ka hiahia pea ētahi tāngata ki ngā wā rongoā roa ake ki te kaha te āhua o tō rātou āhua ki te mura i te wā e mutu ana te rongoā.

Kaua e mutu te tango thalidomide ohorere me te kore e kōrero tuatahi ki tō tākuta. I runga i tō āhuatanga, ko te whakamutu ohorere ka hoki mai, ka kino ake rānei ō tohu. Mā te rōpū hauora koe e āwhina ki te whakawhanake i tētahi mahere mō te whakamutu haumaru i te rongoā ina tika te wā.

He aha ngā pānga taha o Thalidomide?

Ka pā ngā pānga taha maha o Thalidomide, mai i te ngawari ki te tino kino. Mā te māramatanga ki ngā mea e tūmanakohia ana ka āwhina koe ki te mōhio ki te wā hei whakapā atu ki tō kaiwhakarato hauora me te wā e taea ai te whakahaere i ngā pānga taha i te kāinga.

Ko ngā pānga taha tino noa ka pā ki a koe ko te moe, te whanoke, me te ngenge. Ko ēnei pānga te nuinga ka kitea i te wā tuatahi ka tīmata koe ki te tango i te rongoā, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana. Mā te tango i tō horopeta i te wā moe ka āwhina ki te whakaiti i te pānga o te moe ki ō mahi o ia rā.

Ko ēnei ngā pānga taha e pā ana ki te nuinga o te iwi:

• Te moe me te ngenge ka roa pea ki te rā e whai ake nei
• Te whanoke, ina koa ka tū ohorere
• Te pāpā, te nuinga ka taea te whakahaere mā ngā huringa kai
• Te waha me te kiri maroke
• Te whakapairuaki, te puku rānei
• Te ngoikore o ngā uaua, te mamae tahi rānei
• Ngā ānini

Ka pā pea ki ētahi tāngata ngā pānga taha e pā ana ki te nui ake o te āwangawanga e hiahia ana ki te āwhina hauora tonu. Kei roto i ēnei ko te neuropathy taha, e pā ana ki te ngau, te ngaro o te rongo, te mamae rānei i ō ringa me ō waewae. Ka tūturu pea tēnei kino o te io i ētahi wā, nō reira he mea nui kia pūrongo tonu i ngā rongo rerekē ki tō tākuta.

Ko ngā pānga taha kino e hiahia ana ki te āwhina hauora ohorere ko:

• Ngā tohu o ngā pūpū toto pērā i te ohorere o te manawa, te mamae o te uma, te pūhi o te waewae rānei
• Te toto rere ke, te pāpā rānei
• Ngā tohu o te mate pērā i te kirika, te wiri, te korokoro mamae rānei e mau tonu ana
• Ngā tauhohenga kiri kaha, te pā rānei
• Te manawataki ke, te mamae rānei o te uma
• Te whanoke kaha, te ngaro rānei
• Ngā huringa o te ngākau, te pōuri rānei

Ko ngā raruraru onge engari he nui te kino ka uru mai te heke nui o ngā pūtau toto, e pā ana ki te kaha o tō tinana ki te whawhai i ngā mate me te whakahaere i te toto. Ka aroturukihia e tō tākuta ō toto i ngā wā katoa kia kite wawe i ēnei huringa.

Ko wai kāore e tika kia tango Thalidomide?

Kāore rawa e tika te tango Thalidomide e ngā wāhine hapū nā te kaha o ōna pānga teratogenic, te tikanga ka taea e ia te whakaputa i ngā hē whānau nui. Me whakamahi ngā wāhine o te tau whānau i ngā tikanga aukati hapū pono, me te whai i ngā whakamātautau hapū i ngā wā katoa i te wā e tango ana i tēnei rongoā.

Kāore e tika kia tango te hunga e pā ana ki ētahi āhuatanga hauora, me whai aroturuki motuhake rānei mēnā e tika ana te rongoā. Ka arotake tō tākuta i tō hītori hauora i mua i te whakarite i tēnei rongoā.

Kāore e tika kia tango thalidomide mēnā kei a koe:

• Te mate pāwera mō thalidomide, ētahi rongoā rite rānei
• Te hapū, te mahere rānei kia hapū
• Te kore e kaha ki te whai i ngā tikanga aukati hapū e hiahiatia ana
• Te neuropathy taha taha kaha
• Ētahi momo mate ngākau
• Ngā mate kaha e kaha ana

He mea nui te tūpato mēnā he hītori tō koe mō ngā pūpū toto, ngā raruraru ngākau, te mate tākihi, te raruraru ate rānei. Me whakatika pea e tō tākuta tō horopeta, me aroturuki rānei i a koe i ngā wā katoa mēnā kei a koe ēnei āhuatanga.

He take anō te pakeke i te whakatau mēnā e tika ana te thalidomide mōu. Ka nui ake pea te tairongo o ngā pakeke ki ngā pānga taha, ā, me iti ake pea ngā horopeta, me nui ake rānei te aroturuki.

Ngā Ingoa Waitohu Thalidomide

Kei te wātea te Thalidomide i raro i ētahi ingoa waitohu, ko Thalomid te hanganga e tino tohua ana i te United States. Ko tēnei putanga ingoa waitohu e hangaia ana e Celgene Corporation, ā, koinei te momo e mōhio ana te nuinga o ngā tākuta ki te whakahau.

Ko ētahi atu ingoa waitohu ko Contergan i ētahi mākete o te ao, ahakoa he rerekē te wātea i runga i te whenua. Kei te wātea pea te putanga generic o te thalidomide, engari kei raro tonu i ngā mana whakahaere tohatoha rite tonu ki ngā putanga ingoa waitohu.

Ahakoa te waitohu, te putanga generic rānei ka whiwhi koe, ka tukuna katoa ngā hua thalidomide mā ngā hōtaka whare rongoā motuhake e whakarite ana i te whakahaere tika me te aroturuki i te tūroro. Ka whakawhiwhia e tō kaiwhakawhārangi ngā kōrero taipitopito mō tō hanganga motuhake me ētahi whakaritenga rokiroki, whakahaere rānei.

Ngā Kōwhiringa kē mō Thalidomide

He maha ngā kōwhiringa kē mō te thalidomide, i runga i tō āhuatanga motuhake me ngā hiahia maimoatanga. Mō te myeloma maha, ka whakaaro pea tō tākuta ki te lenalidomide (Revlimid) rānei, te pomalidomide (Pomalyst) rānei, he rongoā e pā ana ki te akomanga rongoā kotahi engari he rerekē pea ngā pānga taha.

Ko ētahi atu kōwhiringa maimoatanga mō te myeloma maha ko ngā aukati proteasome pēnei i te bortezomib (Velcade) rānei, te carfilzomib (Kyprolis) rānei. E mahi ana ēnei mā ngā tikanga rerekē i te thalidomide, ā, he pai ake pea mō tō āhuatanga motuhake.

Mō ngā āhuatanga mumura, ko ngā kōwhiringa kē pea ko ngā corticosteroids, ētahi atu rongoā aukati i te pūnaha ārai mate, rānei, ngā rongoā koiora whāinga rānei. Ka whakawhirinaki te kōwhiri ki tō tātaritanga motuhake, ngā urupare maimoatanga o mua, me te mana hauora whānui.

Ka āwhina tō tākuta i a koe ki te whakatau i ngā painga me ngā tūponotanga o ia kōwhiringa kia kitea te maimoatanga e tika ana mō ō āhuatanga takitahi. I ētahi wā, he pai ake te mahi tahi o ngā rongoā rerekē i te rongoā kotahi anake.

He Pai Anei te Thalidomide i te Lenalidomide?

E kore e tika te whakataurite i te thalidomide ki te lenalidomide nā te mea he painga me ngā ngoikoretanga motuhake o ngā rongoā e rua. He maha ngā tūroro e pai ana ki te lenalidomide nā te mea he iti ake ngā pānga kino, inā koa te iti o te neuropathy peripheral me te moe.

He pai ake pea te thalidomide mō ētahi momo myeloma maha, inā koa ka whakamahia i te taha o ētahi atu rongoā. Heoi, he pai ake te aro ki te lenalidomide, ā, ka taea e te tangata te pupuri i te kounga o te oranga i te wā o te rongoā.

Ko te whiriwhiri i waenga i ēnei rongoā e whakawhirinaki ana ki ētahi mea, tae atu ki ngā āhuatanga motuhake o tō mate pukupuku, ngā rongoā o mua, ētahi atu āhuatanga hauora, me ngā hiahia whaiaro. Ka whakaaro tō tākuta mate pukupuku ki tō pikitia hauora katoa i te wā e tūtohu ana i te rongoā e tika ana mōu.

Ka taea hoki e te utu me te inihua te pā ki te whakatau, nā te mea he utu nui ēnei rongoā. Ka mahi tō rōpū hauora ki a koe ki te kimi i te rongoā whai hua rawa atu e wātea ana i roto i tō āhuatanga pūtea.

Ngā Pātai Auau mō Thalidomide

He Haumaru te Thalidomide mō te Mate Ngākau?

Me tino whakaaro ki te thalidomide mēnā he mate ngākau tō, nā te mea ka piki ake te tūponotanga o te toto toto, ā, ka pā pea ki te manawataki o te ngākau. Me mahi tahi tō tākuta ngākau me tō tākuta mate pukupuku ki te whakatau mēnā he nui ake ngā painga i ngā tūponotanga i roto i tō āhuatanga motuhake.

Mēnā ka tango koe i te thalidomide me te mate ngākau, me nui ake te aroturuki, tae atu ki ngā EKG me ngā whakamātautau toto. Ka tohutohu pea tō tākuta i ngā rongoā whakaheke toto hei whakaiti i te tūponotanga o te toto, ahakoa ka tāpirihia tēnei ki te uaua o tō mahere rongoā.

Me aha au mēnā ka tango au i te nui rawa o te Thalidomide?

Mēnā ka inu koe i te thalidomide nui atu i te mea i tohua, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei i te wā tonu, ahakoa kei te pai koe. Ko te inu nui rawa ka pā te moe nui, te rangirua, me ētahi atu pānga kino kāore pea e puta tonu.

Kaua e ngana ki te whakapōkae i a koe anō mēnā kāore i tohutohutia e te kaiwhakarato hauora. Puritia te pounamu rongoā ki a koe i te wā e rapu ana i te manaakitanga hauora kia mōhio ai ngā kaiwhakarato hauora ki te aha me te nui i inumia e koe.

Me Pēhea Taku Mahi Mēnā Kua Ngaro i Ahau tētahi Inenga o Thalidomide?

Mēnā kua ngaro i a koe tētahi inenga o te thalidomide, tangohia i te wā e mahara ana koe, engari mēnā kei roto i te 12 hāora o tō wā i whakaritea. Mēnā kua pahure i te 12 hāora, waiho te inenga i ngaro, ka tango i tō inenga i whakaritea i te wā tika.

Kaua rawa e tango i ngā inenga e rua i te wā kotahi hei utu mō te inenga i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga taha kino. Mēnā he maha ngā wā e wareware ana koe ki ngā inenga, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i a koe kia noho i runga i te ara.

Āhea Āhei Ai au ki te Kati te Tango Thalidomide?

Me kati anake te tango i te thalidomide i te wā e whakatau ana tō tākuta he haumaru, he tika hoki te mahi. E whakatakoto ana tēnei whakatau i runga i te pai o te urupare o tō āhuatanga ki te rongoā, ngā pānga taha e pā ana ki a koe, me tō āhua hauora whānui.

Mō te rongoā mate pukupuku, ko te kati wawe rawa pea ka tuku i te mate kia haere tonu. Mō ngā āhuatanga mumura, ko te kati ohorere pea ka whakahoki mai i ngā tohumate. Mā tō tākuta koe e āwhina ki te whakawhanake i tētahi mahere mō te whakamutu haumaru i te rongoā i te wā e tika ana.

Ka Āhei Au ki te Inu waipiro i te wā e Tango ana i te Thalidomide?

He pai ake te karo i te waipiro i te wā e tango ana i te thalidomide nā te mea ka pā te moe me te whanoke ki te rua. Ko te whakakotahi i a rāua ka nui ake ngā pānga nei, ka piki ake tō tūponotanga ki te hinga, ki ngā aitua rānei.

Mēnā ka whiriwhiri koe ki te inu i ētahi wā, inu mārire, ā, kia tūpato rawa ki ngā mahi e hiahia ana kia tūpato. Me kōrero tonu te whakamahi waipiro ki tō tākuta, nā te mea he tohutohu motuhake pea ā rātou i runga i tō āhuatanga takitahi me ētahi atu rongoā e tango ana koe.