Tucatinib (ara whakahaere waha)

Tukysa

Ka whakamahia te Tucatinib hei whakakotahitanga me te trastuzumab me te capecitabine hei whakaora i te mate pukupuku u i te HER2-pai (te mate pukupuku kua horapa atu, tae atu ki te roro) te mate pukupuku ranei kaore e taea te tango ma te pokanga i roto i nga turoro kua whiwhi i tetahi maimoatanga ranei neke atu i tetahi maimoatanga mate pukupuku anti-HER2. Ka whakamahia ano te Tucatinib hei whakakotahitanga me te trastuzumab hei whakaora i te mate pukupuku colorectal HER2 pai-pai o te RAS (te mate pukupuku o te korokoro, o te tūtae ranei) kua horapa puta noa i te tinana (metastatic) kaore ranei e taea te tango ma te pokanga (advanced). Ka whakamahi to taakuta i tetahi whakamatautau motuhake hei titiro mo enei rerekētanga. Ka hoatu ki nga turoro kua whiwhi i etahi atu maimoatanga mate pukupuku (hei tauira, fluoropyrimidine, oxaliplatin, me te irinotecan) kaore i pai te mahi. Kei roto i te roopu rongoa te Tucatinib, e kiia nei he antineoplastics. Ka whakakore i te tipu o nga pūtau mate pukupuku, ka whakangaromia i te mutunga. Na te mea ka pa ano te tipu o nga pūtau noa ki te rongoa, ka puta ano etahi atu pānga kaore e hiahiatia. Ko etahi o enei pea ka nui te kino me te ripoata ki to taakuta. Kei te waatea tenei rongoa ma te whakahaunga a to taakuta anake. Kei te waatea tenei hua i roto i nga momo horoinga e whai ake nei:

I roto i te whakatau ki te whakamahi i te rongoā, me whakarite te kino o te tango i te rongoā ki te pai ka mahia. Koinei te whakatau ka mahia e koe me tō tākuta. Mō tēnei rongoā, me whakaarohia enei mea e whai ake nei: Korero atu ki tō tākuta mēnā kua pāngia koe e tetahi āhuatanga rerekē, ā, rānei, ki tēnei rongoā, ki ētahi atu rongoā rānei. Korero atu hoki ki tō kaimahi hauora mēnā kei a koe ētahi atu momo mate pāwera, pēnei i ngā kai, ngā tae, ngā whakaora, ngā kararehe rānei. Mō ngā hua kore-whakahaunga, panuihia te tohu, ngā kai o te kete rānei, kia ata. Kāohore i mahia ngā rangahau tika mō te hononga o te tau ki ngā pānga o te tucatinib ki te hunga tamariki. Kāohore i whakatūria te ora me te whai hua. Kāohore i whakaatu ngā rangahau tika i mahia tae noa ki tēnei wā ngā raruraru motuhake ki ngā kaumātua ka āhei te whakaiti i te whakamahinga o te tucatinib ki ngā kaumātua. Heoi, he nui ake te tūpono o ngā kaumātua ki te whara kino (hei tauira, te ruaki, te whakapairuaki, me te ruaki), ka hiahiatia pea te tupato ki ngā turoro e whiwhi ana i tēnei rongoā. Kāohore he rangahau tika mō ngā wāhine hei whakatau i te tūpono o te pēpi ina whakamahi i tēnei rongoā i te wā e whāngai u. Whakaritea ngā painga pea ki ngā tūponotanga pea i mua i te tango i tēnei rongoā i te wā e whāngai u ana. Ahakoa kāohore e whakamahia tahi etahi rongoā, i etahi atu wā ka taea te whakamahi tahi i ētahi rongoā rerekē ahakoa ka puta pea te pānga. I enei take, ka hiahia pea tō tākuta ki te whakarereke i te horo, ki te hiahiatia rānei ētahi atu tupato. I te wā e tango ana koe i tēnei rongoā, he mea nui rawa atu kia mohio tō kaimahi hauora mēnā kei te tango koe i tetahi o ngā rongoā e whakarārangihia ana i raro nei. Kua tohua ngā pānga e whai ake nei i runga i te nui o te tūpono, ā, ehara i te mea katoa. E kore e tūtohutia te whakamahi i tēnei rongoā me tetahi o ngā rongoā e whai ake nei. Ka whakatau pea tō tākuta ki te kore e whakaora i a koe ki tēnei rongoā, ki te whakarereke rānei i ētahi o ngā rongoā e tangohia ana e koe. Ko te whakamahi i tēnei rongoā me tetahi o ngā rongoā e whai ake nei e kore e tūtohutia, engari ka hiahiatia pea i etahi wā. Mena ka tohua tahi ngā rongoā e rua, ka whakarereke pea tō tākuta i te horo, i te auau rānei e whakamahi ana koe i tetahi, i ngā rongoā e rua rānei. Ko te whakamahi i tēnei rongoā me tetahi o ngā rongoā e whai ake nei ka nui ake pea te tūpono o ētahi pānga, engari ko te whakamahi i ngā rongoā e rua pea te rongoā pai mōu. Mena ka tohua tahi ngā rongoā e rua, ka whakarereke pea tō tākuta i te horo, i te auau rānei e whakamahi ana koe i tetahi, i ngā rongoā e rua rānei. Kāohore e whakamahia etahi rongoā i te wā e kai ana, i te taha rānei o te kai, i te kai rānei i ētahi momo kai, no te mea ka puta pea ngā pānga. Ko te whakamahi i te waipiro, i te tapeka rānei me ētahi rongoā ka puta pea ngā pānga. Kōrero atu ki tō kaimahi hauora te whakamahinga o tō rongoā me te kai, te waipiro, te tapeka rānei. Ko te whai i ētahi atu raruraru hauora ka pā pea ki te whakamahinga o tēnei rongoā. Kia tino kī atu koe ki tō tākuta mēnā kei a koe ētahi atu raruraru hauora, ina koa: