He aha te Ustekinumab: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

He rongoā whakatakoto a Ustekinumab e āwhina ana ki te whakamārie i tētahi pūnaha ārai mate e kaha rawa ana. No tētahi rōpū rongoā e kīia ana ko te koiora, he mea hanga mai i ngā pūtau ora, ā, e mahi ana mā te aro ki ngā pūmua motuhake e pā ana ki te mumura i tō tinana.

He tino whai hua tēnei rongoā mō te hunga e pā ana ki ngā āhuatanga ārai mate i te wā e whakaeke hē ana te pūnaha ārai mate i ngā kiko hauora. Whakaarohia he rongoā whai wāhi e āwhina ana ki te whakahoki i te taurite ki tō urupare ārai mate, kaua ki te aukati i tō pūnaha ārai mate katoa.

He aha te Ustekinumab e whakamahia ana mō?

E rongoā ana a Ustekinumab i ētahi āhuatanga ārai mate e whai wāhi nui ana te mumura. Ka tohutohu pea tō tākuta i tēnei rongoā i te wā kāore anō ētahi atu rongoā i whai hua, i te wā rānei e hiahia ana koe ki tētahi huarahi whai wāhi ake ki te whakahaere i tō āhuatanga.

Kua whakaaetia te rongoā e te FDA mō te rongoā i te psoriasis pātea mō te āhua waenga ki te kaha, he āhuatanga kiri e pā ana ki te pūtake, ngā wāhi pūtake. E whakamahia ana hoki mō te pūtake o te arthritis, e pā ana ki tō kiri me ō hononga, e pā ana ki te mamae me te mārō.

I tua atu, e āwhina ana a ustekinumab ki te whakahaere i te mate a Crohn me te colitis ulcerative, e rua ngā momo mate mumura i te puku e pā ana ki te mumura mau tonu i tō ara kūnatu. Ka taea e ēnei āhuatanga te pā kaha ki tō kounga o te oranga, ā, e tuku ana a ustekinumab i te tūmanako mō te whakahaere tohu pai ake.

Me pēhea te mahi a Ustekinumab?

E mahi ana a Ustekinumab mā te aukati i ngā pūmua motuhake e kīia ana ko te interleukin-12 me te interleukin-23, he tāngata matua e whakatū ana i te mumura. Ko ēnei pūmua te āwhina i tō pūnaha ārai mate ki te whawhai i ngā mate, engari i roto i ngā mate ārai mate, ka kaha rawa atu, ka pā ana ki te mumura kino.

Mā te aukati i ēnei pūmua, ka āwhina a ustekinumab ki te whakaiti i te urupare mumura e arahi ana ki ngā tohu pēnei i te pānga kiri, te mamae tahi, me te mumura o te ara kūnatu. Ko tēnei huarahi whāinga he rongoā kaha, e āhei ana ki te whai hua nui mō te tokomaha.

Kāore te rongoā e rongoa i ēnei āhuatanga, engari ka āwhina ki te whakahaere i ngā tohu me te whakaroa i te haere o te mate. He tokomaha ngā tāngata e kite ana i te whakapai ake i ō rātou tohu i roto i te 12 ki te 16 wiki i muri i te tīmatanga o te rongoā.

Me pēhea taku tango i te Ustekinumab?

Ka tukuna a Ustekinumab hei werohanga, i raro i tō kiri (subcutaneous) rānei, ki roto rānei i te uaua (intravenous). Mā tō tākuta e whakatau ko tēhea tikanga te mea pai mōu i runga i tō āhuatanga me ngā whāinga rongoā.

Mō ngā werohanga subcutaneous, ka whiwhi koe i te rongoā ia 8 ki te 12 wiki i muri i te wā uta tuatahi. Mā tō kaiwhakarato hauora e ako ki a koe me pēhea te tuku i ēnei werohanga ki a koe i te kāinga, ā, ka tukuna pea i roto i te whare haumanu.

Ko ngā whakawhitinga intravenous te tikanga ka tukuna i roto i te whare hauora, ā, ka roa te tata ki te kotahi hāora ki te whakaoti. Kei runga i tō āhuatanga te auau, engari te tikanga ia 8 wiki i muri i ngā horopeta tuatahi.

Ka taea e koe te tango i te ustekinumab me te kore kai rānei, nā te mea kāore e pānga ki te pai o te mahi o te rongoā. Heoi, he mea nui kia noho mā ngā wāhi werohanga, me te huri i a rātou kia kore ai e riri.

Kia pehea te roa e tango ana ahau i te Ustekinumab?

Ko te tikanga he rongoā wā-roa a Ustekinumab, ā, me haere tonu te nuinga o ngā tāngata ki te tango i te rongoā mō te kore mutunga ki te pupuri i te whakahaere tohu. Mā tō tākuta e aroturuki tō urupare ki te rongoā, ā, ka whakatika pea i tō mahere rongoā i te wā.

Ka tīmata pea koe ki te kite i ngā whakapai ake i roto i te 4 ki te 6 wiki, engari ka kitea ngā painga katoa i te 12 ki te 16 wiki. Ko ētahi tāngata e kite ana i te whakapai ake i muri i ngā marama maha o te rongoā.

Ka arotakehia e tō tākuta i ngā wā katoa mēnā e whai hua ana te rongoā mō koe. Ki te kore koe e kite i te whakapai ake i muri i te 16 wiki, ka whakaaro pea rātou ki te whakatika i tō horopeta, ki te tūhura rānei i ētahi atu rongoā.

He aha ngā pānga taha o te Ustekinumab?

Pērā i ngā rongoā katoa, ka pānga taha te ustekinumab, ahakoa he maha ngā tāngata e pai ana ki te tango. Mā te māramatanga ki ngā mea e tūmanakohia ana ka āwhina koe ki te whai māia ki tō rongoā, me te mōhio ki te wā ki te whakapā atu ki tō kaiwhakarato hauora.

Ngā pānga taha noa ka pā ki a koe:

• Ngā mate o te ara rārangi o runga pērā i te makariri, i te mate sinus rānei
• Ngā mamae o te upoko he ngawari noa iho ki te āhua
• Te ngenge, te pōuri rānei
• Ngā tauhohenga i te wāhi werohanga pērā i te whero, te pūhi, te mamae ngawari rānei
• Te whakapairuaki, te pōuri puku ngawari rānei
• Te mamae o te tuara, te mamae uaua rānei

Ko ēnei pānga taha noa e taea ana te whakahaere, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā.

Ka puta pea ngā pānga taha nui ake, ahakoa he iti noa iho. Me whai wāhi tonu ēnei ki te rongoā, me ngā mea e whai ake nei:

• Ngā tohu o ngā mate nui pērā i te kirika, te wiri, te mare tonu rānei
• Ngā huringa rerekē i tō kiri, pērā i ngā tipu hou, i ngā huringa rānei i ngā mōkihi o nāianei
• Ngā tauhohenga mate pāwera nui tae atu ki te uaua ki te manawa, te pūhi rānei o tō mata
• Ngā tohu o te mumura o te mate puku ki te whai koe i te mate a Crohn
• Ngā tohu neurological pērā i te rangirua, ngā huringa tirohanga, te mamae nui o te upoko rānei

Ngā pānga taha onge engari nui ko te piki ake o te tūponotanga o ētahi momo mate pukupuku me ngā mate nui. Ka aroturukihia koe e tō tākuta mō ēnei raruraru pea mā ngā arotake i ngā wā katoa me ngā whakamātautau toto.

Ko wai e kore e tango i te Ustekinumab?

Kāore a Ustekinumab e tika ana mō te katoa, ā, ka āta arotake tō tākuta mēnā e tika ana mōu. Ko ētahi āhuatanga hauora me ngā āhuatanga ka kore e tika tēnei rongoā, me āta aroturuki rānei.

Kāore koe e tango i te ustekinumab mēnā he mate pāwera tōna, ina koa ngā mate nui pēnei i te mate kohi, te hepatitis B rānei. Ka whakamātau tō tākuta mō ēnei āhuatanga i mua i te tīmatanga o te rongoā.

Ko ngā tāngata he hītori mō te mate pukupuku, ina koa te lymphoma, te mate pukupuku kiri rānei, me āta arotake i mua i te whakamahi i te ustekinumab. Ka pā te rongoā ki te kaha o tō pūnaha ārai mate ki te kite me te whawhai i ngā pūtau mate pukupuku.

Mēnā kei te hapū koe, kei te whāngai ū rānei, kōrerohia ngā tūponotanga me ngā painga ki tō tākuta. Ahakoa ka whakamahia te ustekinumab i te wā e hapū ana i ētahi āhuatanga, me āta aroturuki.

Ko te hunga he mate ate, mate tākihi rānei, ka hiahia pea ki te whakatika i te horopeta, ki ētahi atu rongoā rānei. Ka whakaaro tō tākuta ki tō āhua hauora whānui i te whakatau mēnā e tika ana te ustekinumab mōu.

Ngā Ingoa Waitohu o Ustekinumab

Kei te wātea a Ustekinumab i raro i te ingoa waitohu Stelara, nā Janssen Biotech i hanga. Koinei te momo rongoā e tino tohua ana.

Ko te putanga biosimilar, ustekinumab-auub, e hokohoko ana i raro i te ingoa waitohu Wezlana. He tino rite ngā biosimilars ki te rongoā taketake engari he rerekētanga iti pea i ngā kai kore hohe.

E mahi ana ngā putanga e rua i te ara kotahi, ā, he rite te whai huatanga me ngā kōrero haumaru. Ka āwhina tō tākuta me tō kaiwhakarato inihua ki te whakatau ko tēhea kōwhiringa te mea pai mō tō āhuatanga motuhake.

Ngā Kōwhiringa kē mō Ustekinumab

He maha ngā rongoā kē e wātea ana mēnā kāore a ustekinumab e tika ana mōu, kāore rānei e whakarato i te mana whakahaere tohu. E mahi ana ēnei kōwhiringa kē mā ngā tikanga rerekē engari e whai ana i ngā ara mumura rite.

Ko ētahi atu rongoā koiora ko te adalimumab (Humira), te infliximab (Remicade), me te secukinumab (Cosentyx). He painga me ngā pānga taha ō rātou ake, ā, mā tō tākuta koe e āwhina ki te whiriwhiri i te kōwhiringa e tika ana.

Ko ngā rongoā kē atu i te koiora ko te methotrexate, te sulfasalazine, me ngā momo rongoā ā-rohe mō ngā āhuatanga kiri. He rerekē te mahi a ēnei rongoā, ā, ka taea te whakakotahi ki ngā rongoā koiora mō te whakanui i te whai huatanga.

Ka whakaaro tō tākuta ki ngā āhuatanga pēnei i tō āhuatanga motuhake, ngā urupare ki ngā rongoā o mua, me te hauora whānui i te wā e tūtohu ana i ngā rongoā kē atu. I ētahi wā ka whakamātau i ngā rongoā rerekē hei kimi i te rongoā tino whai hua mō ō hiahia takitahi.

He pai ake te Ustekinumab i te Adalimumab?

He whai hua ngā rongoā koiora e rua, te ustekinumab me te adalimumab, engari he rerekē te mahi, ā, he pai ake pea mō ngā tāngata rerekē. Kāore tētahi i te pai ake i tētahi.

Ka aukati te Ustekinumab i te interleukin-12 me te interleukin-23, i te wā e whai ana te adalimumab i te tumor necrosis factor-alpha. Ko te tikanga o tēnei rerekētanga ka pai ake pea mō ngā momo mumura rerekē, i roto rānei i ngā tāngata kāore i urupare ki tētahi, ki tētahi rānei.

Ko te tikanga ka hoatu te Ustekinumab i te wā iti iho i te adalimumab, he mea e kitea ana e ētahi tāngata he watea ake. Heoi anō, kua roa te adalimumab e wātea ana, ā, he nui ake ngā raraunga haumaru mō te wā roa.

Ka whakaaro tō tākuta ki tō āhuatanga motuhake, ngā urupare ki ngā rongoā o mua, me ngā hiahia whaiaro i te wā e whiriwhiri ana i waenga i ēnei rongoā. I ētahi wā ka huri ngā tāngata mai i tētahi ki tētahi mēnā kāore i te whai mana whakahaere i ngā tohumate.

Ngā Pātai e Pātai pinepine ana mō te Ustekinumab

He haumaru te Ustekinumab mō ngā tāngata e mate huka ana?

Ka taea te whakamahi i te Ustekinumab i roto i ngā tāngata e mate huka ana, engari me mātakitaki pai. Kāore te rongoā tonu e pā tika ana ki ngā taumata huka toto, engari ka uaua ake i te mate huka te whakahaere i ngā mate.

I te mea e pā ana te ustekinumab ki tō pūnaha ārai mate, tērā pea ka nui ake tō tūponotanga ki ngā mate, ka uaua pea te whakahaere i te mate huka. Ka mātakitaki tō tākuta i a koe, ā, tērā pea ka tūtohu kia maha ake ngā whakamātautau huka toto.

He mea nui kia mau tonu te mana whakahaere i te mate huka i te wā e tango ana koe i te ustekinumab, nā te mea ka āwhina tēnei ki te whakaiti i tō tūponotanga ki te mate. Kia mau ki tō tiaki mate huka i ia rā, ā, whakamōhio atu ki tō tākuta mō ngā tohumate e pā ana ki a koe.

Me pēhea taku mahi mēnā ka whakamahi au i te nui rawa o te Ustekinumab?

Mēnā ka werohia e koe te nui rawa o te ustekinumab, whakapā atu ki tō kaiwhakarato hauora tonu, waea atu rānei ki te pokapū whakahaere paitini. Ahakoa he onge te nui rawa o te horopeta ki tēnei rongoā, he mea nui kia whiwhi tohutohu hauora ngaio.

Kaua e ngana ki te

Me mutu anake te tango i te ustekinumab i raro i te tohutohu a tō tākuta, nā te mea ka mutu te rongoā ka puta he tohu. Ko te nuinga o te tangata me haere tonu te rongoā mo te wā roa kia mau tonu ai te whakahaere tohu.

Ka whakaaro pea tō tākuta ki te whakamutu i te rongoā mena ka pā koe i ngā pānga taha kino, ki te kore e whai hua ana, ki te haere rānei tō āhuatanga ki te murunga roa. Me whakatau tēnei whakatau i ngā wā katoa i te mahi tahi me tō rōpū hauora.

Mena ka mutu te tango i te ustekinumab, ka mātakitaki pea tō tākuta i a koe mō te hokinga mai o ngā tohu, ā, ka tūtohu pea i ētahi atu rongoā hei pupuri i tō hauora me te kounga o te oranga.

Ka Taea e Au te Tango i ngā Kano ārai mate i te wā e tango ana i te Ustekinumab?

Ka taea e koe te tango i te nuinga o ngā kano ārai mate i te wā e tango ana i te ustekinumab, engari he mea nui te wā me te momo kano ārai mate. Ka waihanga tō tākuta i tētahi mahere kano ārai mate e mahi tahi ana me tō mahere rongoā.

Ko ngā kano ārai mate ora pēnei i te MMR, i te kano ārai mate varicella rānei me karo i te wā e tango ana i te ustekinumab, nā te mea ka puta pea he mate. Ko ngā kano ārai mate kore pērā i te werohanga rewharewha te tikanga he haumaru, ā, e tūtohutia ana.

He pai ake te whakaoti i ngā kano ārai mate e tika ana i mua i te tīmatanga o te ustekinumab i te wā e taea ana. Mena e hiahia ana koe ki ngā kano ārai mate i te wā e rongoā ana, kōrerohia te wā me tō tākuta kia mōhio ai koe ki te tiaki pai me te haumaru.