He aha te Brexanolone: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te Brexanolone he rongoā hou i hangaia hei rongoā i te pouri nui i muri i te whānautanga i roto i ngā whaea hou. Ka whakahaerehia mā te whakauru IV i roto i ngā hāora 60 i roto i te hōhipera, koinei te rongoā tuatahi i whakaaetia e te FDA e aro ana ki ngā huringa matū roro ahurei ka puta i muri i te whānautanga.

E whai wāhi ana tēnei rongoā mō ngā whaea e pā ana ki te pouri e ngāwari ana i muri i te whānautanga o te pēpi. Kāore i rite ki ngā rongoā anti-depressant tuku iho e roa ana te wiki ki te mahi, ka whai wāhi te brexanolone i roto i ngā rā, e āwhina ana ki te whakahoki i te hononga kare-ā-roto i waenga i te whaea me te tamaiti i tēnei wā whakahirahira.

He aha te Brexanolone?

Ko te Brexanolone he putanga waihanga o te allopregnanolone, he homoni tūturu e whakaputaina ana e tō roro i te wā e hapū ana koe. He wāhi nui tēnei homoni ki te whakahaere i te ahua me te taumata o te āwangawanga, ā, ka heke nui i muri i te whānautanga.

Ka tae mai te rongoā hei otinga mārama, kāore he tae e tika ana kia tukuna mā te whakauru IV tonu. Ka hangaia i raro i te ingoa waitohu Zulresso me te tohu i tētahi huarahi hou ki te rongoā i te pouri i muri i te whānautanga mā te whakakapi tika i te homoni ngaro, kaua ki te ngana ki te whakanui i ētahi atu matū roro.

Ko te mea e motuhake ana te brexanolone ko te mahi i runga i ngā kaiwhakawhiwhi GABA i tō roro. Ka āwhina ēnei kaiwhakawhiwhi ki te whakamārie i te mahi neural me te whakaiti i ngā kare o te āwangawanga me te pouri e taea ai te whakangāwari i ngā whaea hou.

He aha te Brexanolone e whakamahia ana?

Kua whakaaetia te Brexanolone mō te rongoā i te pouri i muri i te whānautanga i roto i ngā wāhine kua whānau. Kua hangaia mō ngā whaea e pā ana ki te pouri ngāwari ki te nui e pā ana ki te mahi o ia rā me te kaha ki te tiaki i a rātou me ā rātou pēpi.

Ka tūtohu pea tō tākuta i te brexanolone mēnā kei te pā koe i te pōuri tonu, te āwangawanga, te kore tūmanako rānei i muri i te whānautanga kāore e pai ake i ngā rongoā paerewa. He tino whai hua te rongoā mō ngā whaea e pōuri ana ki ā rātou pēpi, e uaua ana rānei ki te whawhai i ngā kare-ā-roto nui o te kore e tika.

Ka whakaarohia hoki tēnei rongoā i te wā kāore anō kia whai hua ētahi atu rongoā anti-pōuri, i te wā rānei e hiahiatia ana te whakapai ake tere. E kitea ana e ētahi whaea he roa rawa te wā e pau ana i ngā rongoā tuku iho ki te whai oranga i tēnei wā whakahirahira ki te hono ki ā rātou pēpi hou.

Me pēhea te mahi a Brexanolone?

Ka mahi a Brexanolone mā te whai i te allopregnanolone, he homoni e piki ana i te wā e hapū ana, ka heke koi tonu i muri i te whānautanga. Ka taea e tēnei huringa homoni nui te whakaoho i te pōuri nui i ētahi wāhine, ā, ka āwhina a brexanolone ki te whakahoki i te taurite homoni i roto i te roro.

Ka mahi te rongoā i ngā kaiwhiwhi GABA, he rite ki te pūnaha pūhui o tō roro. Ki te whakahohehia ēnei kaiwhiwhi, ka āwhina rātou ki te whakamārie i ngā ara neural e kaha rawa ana e whai wāhi ana ki te pōuri me te āwangawanga. Ka waihanga tēnei i tētahi pānga whakamārie ka taea te hiki i te wairua me te whakaiti i te mamae kare-ā-roto.

Kāore i rite ki ngā rongoā anti-pōuri tuku iho e mahi ana i te serotonin, i ētahi atu neurotransmitters rānei, ka whai a brexanolone i te taurite homoni motuhake e puta ana i muri i te whānautanga. He maha ngā wā ka hua mai i tēnei huarahi whai i ngā hua tere ake, me te maha o ngā wāhine e whai ana i te whakapai ake i roto i te 24 ki te 48 hāora i muri i te tīmatanga o te rongoā.

Me pēhea taku tango i te Brexanolone?

Me hoatu a Brexanolone i roto i te hōhipera mā te whakauru IV tonu mō te 60 hāora. Me noho koe i roto i te hōhipera mō te wā rongoā katoa, e pā ana ki te 2.5 rā, kia taea ai e ngā kaimahi hauora te aro turuki i a koe.

Ka tīmata te rongoā i tētahi horopeta iti, ka piki haere i te rā tuatahi, katahi ka mau tonu te taumata i mua i te heke haere. Kāore he mea motuhake hei mahi ki te kai, ki te inu rānei, engari me karo rawa te waipiro i te wā e rongoā ana, me ngā rā i muri mai.

I te wā e rongoā ana, ka honoa koe ki ngā taputapu aroturuki e whai ana i ō tohu nui me te titiro mō ngā tohu e pā ana. Ka āta whakau te rārangi IV kia taea e koe te hīkoi i tō rūma me te okioki pai i te wā e rongoā ana.

Ka tirotirohia koe e tō rōpū hauora i ngā wā katoa i te wā 60-haora. Ka arotakehia tō āhua, ka aroturukihia ngā pānga taha, me te whakarite kia haumaru te haere o te rongoā. Ka taea e koe te whai manuhiri me te whai wāhi ki ngā mahi māmā, engari me noho koe i roto i te wāhi e aroturukihia ana.

Kia Pēhea te Roa e Tango Ana au i te Brexanolone?

Ka hoatu te Brexanolone hei akoranga rongoā kotahi 60-haora, ā, kāore e hiahiatia e te nuinga o ngā wāhine ngā rongoā tukurua. I hangaia te rongoā hei whakarato i te whakamaoritanga pumau mai i ngā tohu pouri i muri i te whānautanga ka taea te haere tonu mō ngā wiki, mō ngā marama rānei i muri i te mutunga o te rongoā.

E whakaatu ana ngā rangahau haumanu he maha ngā wāhine e pā ana ki te whakapai ake i te iti rawa 30 rā i muri i te otinga o te rongoā. E kitea ana e ētahi whaea ka roa ake ngā painga, e āwhina ana i a rātou i ngā marama tuatahi o te whaea, i te wā e tino nui ana te hononga me te urutau.

Mēnā ka hoki mai ō tohu i muri i ētahi wiki, ka whakaaro pea tō tākuta ki tētahi akoranga rongoā tuarua, ahakoa he iti noa iho tēnei. Ka mahi rātou ki a koe ki te whakatau mēnā he pai ake te brexanolone atu, ētahi atu rongoā rānei mō tō āhuatanga motuhake.

He Aha ngā Pānga Taha o te Brexanolone?

Ka taea e te Brexanolone te pānga taha, engari he ngawari te nuinga, he wā poto noa iho. Ko ngā pānga taha tino noa ko te moe me te whanoke, koinei te take me noho koe i te hōhipera i te wāhi e taea ai e ngā kaimahi hauora te tiaki i a koe.

Anei ngā pānga taha ka pā ki a koe i te wā o te rongoā, ā, he mea noa te āwangawanga mō ēnei mea ka pā:

• Te pōrangi me te ngenge ka mōmona ai koe
• Te whanoke, te kore tū tika rānei i te tū, i te haere rānei
• Te mangai maroke me te rerekē o te reka
• Te whakapairuaki, te puku riri rānei
• Te ānini, he ngawari, he āhua kaha rānei te nuinga
• Te wera, te whiti wera rānei
• Ngā pānga ki te wāhi weronga i te wāhi i tū ai te IV

Ko ēnei pānga taha noa ka pai ake i te wā e urutau ana tō tinana ki te rongoā, ā, ka ngaro katoa i roto i ngā rā torutoru i muri i te otinga o te rongoā.

He pānga taha onge anō, engari he kaha ake, e hiahia ana kia āwhina tonu i te tākuta. Ahakoa kāore ēnei e pā ana i te nuinga o te wā, he mea nui kia mōhio koe ki a rātou kia taea ai e koe te whakamōhio tonu ki tō rōpū hauora:

• Te moe nui e uaua ai te ara ake, te noho mataara rānei
• Te ngaro ohorere o te māramatanga, te ngaro rānei
• Te uaua ki te hā, te poto rānei o te manawa
• Te mamae o te uma, te tere rānei o te ngākau
• Ngā pānga pāwera kaha me te pāwera, te pūhi rānei, te uaua rānei ki te horo
• Te rangirua, te kore rānei o te whakatakotoranga e ahua rereke ana

Ko te aroturuki i te hōhipera e whakarite ana kia tere te kite i ngā pānga taha nui, kia tika hoki te whakahaere. Ko tō haumaru te mea nui i te wā o te rongoā katoa.

Ko wai kāore e tika kia tango Brexanolone?

Kāore a Brexanolone e tika ana mō te katoa, ā, ka āta arotake e tō tākuta mēnā he haumaru mōu. E hiahia ana te rongoā kia āta aroturukihia nā te mea ka pā te moe nui, ka mōmona pea i ētahi tāngata.

Kāore koe e whiwhi brexanolone mēnā he hītori tōu mō ngā pānga pāwera nui ki te rongoā, ki ētahi wāhanga rānei. Ko ngā wāhine e pā ana ki ētahi mate ngākau, ngā raruraru hā, te mate ate rānei, me whai rongoā kē anō.

Ka whakaarohia hoki e tō tākuta mēnā kei te tango koe i ētahi atu rongoā ka pāhekoheko kino ki te brexanolone. Ko ētahi rongoā e pā ana ki te moe, pēnei i ētahi rongoā mamae, i ngā rongoā moe rānei, ka piki ake te tūponotanga o te nui rawa o te moe i te wā e honoa ana ki tēnei rongoā.

Mēnā kei te whāngai ū koe, me kōrero koe i ngā tūponotanga me ngā painga ki tō kaiwhakarato hauora. Ahakoa ka uru ētahi wāhanga iti o te brexanolone ki te waiu ū, ko te wā poto o te rongoā te tikanga he iti noa te pānga ki tō pēpi.

Ingoa Waitohu Brexanolone

Kei te wātea te Brexanolone i raro i te ingoa waitohu Zulresso, he mea hanga e Sage Therapeutics. Koinei anake te ingoa waitohu e wātea ana mō tēnei rongoā, i te mea he rongoā hou tēnei i whakawhiwhia ki te whakaaetanga a te FDA i te tau 2019.

Kei te wātea noa te Zulresso mā ngā whare hauora whaimana kua oti i a rātou ngā hōtaka whakangungu motuhake. Mā tēnei ka mōhio ngā kaimahi hauora ki te āhua o te whakahaere i te rongoā me te aroturuki i ngā tūroro puta noa i te wā o te whakauru i te rongoā mō te 60 hāora.

Kāore anō he putanga whānui o te brexanolone e wātea ana, ko te tikanga ko te Zulresso anake te kōwhiringa mō tēnei rongoā motuhake. Ka āwhina pea tō inihua me ngā hōtaka awhina pūtea ki ngā utu o tēnei rongoā motuhake.

Ngā Kōwhiringa kē mō te Brexanolone

Mēnā kāore te brexanolone i te pai mōu, he maha ētahi atu rongoā whai hua e wātea ana mō te pōuri i muri i te whānautanga. Ko ngā rongoā anti-pōuri tuku iho pēnei i te sertraline, i te paroxetine rānei, he rongoā tuatahi tonu, ā, ka taea te whakamahi i te wā e whāngai ū ana.

He tino whai hua te hinengaro, ina koa ko te rongoā whanonga hinengaro me te rongoā whanaungatanga, mō te pōuri i muri i te whānautanga. Mā ēnei huarahi ka āwhina koe ki te whakawhanake i ngā rautaki whakatika me te whakatika i ngā wero aronganui o te whaea hou me te kore rongoā.

He pai pea te rongoā taiaki mō ētahi wāhine, inā koa e pātata ana te pōuri ki ngā huringa taiaki i muri i te whānautanga. Ka tūtohu pea tō tākuta i ngā pātara estrogen, i ngā tāpiringa progesterone rānei hei wāhanga o te mahere rongoā whānui.

Ka taea hoki e ngā rōpū tautoko me te tohutohu ā-hoa te whakarato tautoko aronganui whai hua i tēnei wā uaua. He maha ngā whaea e kite ana mā te hono atu ki ētahi atu e mōhio ana ki ō rātou wheako ka āwhina i te whakaiti i ngā āhuatanga o te noho wehe me te whakama.

He Pai Anei a Brexanolone i Ētahi Atu Rongoā Whakawātea Pōuri?

He painga motuhake a Brexanolone i ngā rongoā whakawātea pōuri tuku iho, inā koa tōna tere o te mahi. Ahakoa e 4-6 wiki te roa o te nuinga o ngā rongoā whakawātea pōuri ki te whakaatu i ngā pānga katoa, ka whai hua tonu a brexanolone i roto i te 24-48 haora i muri i te tīmatanga o te rongoā.

E aro ana hoki te rongoā ki ngā huringa taiaki motuhake ka puta i muri i te whānautanga, e tika ana mō te pōuri i muri i te whānautanga. E mahi ana ngā rongoā whakawātea pōuri tuku iho i ngā matū roro rerekē, ā, kāore pea e aro ki te tauritenga taiaki pūtake e whai wāhi ana ki ngā mate ā-wairua i muri i te whānautanga.

Heoi, me noho ki te hōhipera me te aroturuki kaha a brexanolone, kāore i te whai hua mō ngā wāhine katoa. Ka taea te tango i ngā rongoā whakawātea pōuri tuku iho i te kāinga, ā, kāore e hiahiatia te wā mai i tō pēpi me tō whānau, e pai ake ai mō te nuinga o ngā whaea.

Ko te whiriwhiri i waenga i te brexanolone me ētahi atu rongoā e whakawhirinaki ana ki ō āhuatanga motuhake, tae atu ki te kaha o tō pōuri, tō pūnaha tautoko, me tō kaha ki te noho wā i te hōhipera. Ka āwhina tō tākuta i a koe ki te whakatau i ēnei āhuatanga hei whakatau i te huarahi pai mō tō āhuatanga.

Ngā Pātai Auau mō Brexanolone

He Haumaru Anei a Brexanolone mō te Whāngai U?

Ka taea te whakamahi i te Brexanolone i te wa e whakangote ana, engari me matapaki e koe te wa ki to kaiwhakarato hauora. He iti noa nga rongoa ka uru ki roto i te waiu u, engari ko nga taumata e kiia ana he haumaru mo nga pepi.

Na te mea e 60 haora noa te roa o te maimoatanga, ko nga paanga ki to peepi na roto i te waiu u he wa poto noa. He maha nga whaea e whakangote tonu ana i te wa e rongoa ana, ina koa na te mea ko nga painga o te rongoa i te pouri i muri i te whanautanga he nui ake i nga tupono iti ki te peepi.

Ma to taakuta koe e awhina ki te whakatau i runga i to ahuatanga me te hauora o to peepi. Ka kii pea ratou ki te papu me te penapena i te waiu u i mua i te maimoatanga, ki te whakamahi ranei i te tātai i te wa o te wa whakauru.

Me aha ahau ki te whiwhi ohorere ahau i te nui rawa o te Brexanolone?

Kaore koe e manukanuka ki te whiwhi ohorere i te nui rawa o te brexanolone na te mea ka tukuna te rongoa e nga tohunga rongoa whakangungu e whakamahi ana i nga papu whakauru tika. Ka aroturukihia e nga kaimahi o te hōhipera te reeti whakauru i nga wa katoa, a he tikanga haumaru hei aukati i te horopeta nui.

Mena ka pa ki a koe te hiamoe rereke, te uaua ki te noho mataara, te raru ranei o te manawa i te wa o to whakaurunga, whakamohio tonu ki to roopu hauora. Koinei pea nga tohu kei te whiwhi koe i te nui rawa o te rongoa, kei te tino tairongo ranei to tinana ki te maimoatanga.

Ka whakatikahia e nga kaimahi rongoa to reeti whakauru ki te tika, a ka taea e ratou te whakarato i te manaaki tautoko hei awhina i a koe kia pai ake te noho. Kia mahara kei roto koe i te taiao haumaru, e aroturukihia ana puta noa i te mahinga maimoatanga katoa.

Me aha ahau ki te ngaro ahau i te horopeta o te Brexanolone?

Ko te ngaro i te horopeta ehara i te mea e pa ana ki te brexanolone na te mea ka tukuna hei whakaurunga tonu i te hōhipera. Ka rere tonu te rongoa i roto i to raina IV mo te wa katoa e 60 haora, no reira kaore he horopeta takitahi hei mahara, hei ngaro ranei.

Mena ka momotu tō rārangi IV, ka mutu rānei te mahi tika, ka kite tonu tō rōpū hauora mā te taputapu aroturuki. Ka tere ratou te hono anō, te whakakapi rānei i te rārangi kia mōhio ai koe kei te whiwhi koe i te rongoā katoa i te mea kua whakaritea.

Ka mau tonu ngā kaimahi o te hōhipera i ngā rekoata mō te nui o te rongoā kua whiwhi koe, ā, ka whakatika i te whakaurunga mēnā ka puta he aukati. Kua hangaia tō mahere rongoā hei whakaaro mō ngā take hangarau iti ka puta pea i te wā 60-haora.

Āhea ka taea e au te whakamutu i te tango Brexanolone?

Kāore koe e hiahia ki te whakatau i ngā whakatau mō te whakamutu i te brexanolone nā te mea ka hoatu hei akoranga rongoā kotahi, kua whakatauhia. Ka heke aunoa te whakaurunga, ka mutu i muri i te 60 haora, e whai ana i te mahere i hangaia āta.

Kua hangaia te rongoā hei whakarato i ngā painga pumau e haere tonu ana mō ngā wiki, marama rānei i muri i te mutunga o te whakaurunga. Kāore koe e pā ki ngā tohu tangohanga i te wā e mutu ana te rongoā nā te mea ka āwhina te tukanga whakaiti i tō tinana ki te whakatika haere.

Mēnā he āwangawanga ō koe mō te whakamutu wawe i te whakaurunga nā te pānga taha, kōrerohia tēnei ki tō rōpū hauora. Ka taea e rātou te whakatika i te mahere rongoā mēnā e tika ana, engari ka taea e te nuinga o ngā wāhine te whakaoti i te akoranga 60-haora katoa kāore he raruraru nui.

E hia te utu o Brexanolone?

He rongoā utu nui a Brexanolone, ko ngā utu e $20,000 ki te $35,000 mō te whakaurunga 60-haora katoa me te noho hōhipera. Heoi, he maha ngā mahere inihua e hipoki ana i tēnei rongoā, ina koa ka whakaarohia he mea tika ā-hauora mō te pouri whai muri i te whānautanga.

Ka whakawhirinaki tō inihua ki tō mahere motuhake me te mēnā ka taea e tō tākuta te whakaatu kāore anō kia whai hua ētahi atu rongoā. He maha ngā kamupene inihua e hiahia ana i te whakaaetanga i mua, ko te tikanga me tuku e tō tākuta ngā tuhinga e whakamārama ana i te aha e hiahia ana koe i tēnei rongoā motuhake.

Ki te kore te inihua e hipoki i nga utu katoa, tera pea ka wātea ngā hōtaka awhina tūroro mā te kaihanga, ngā rōpū kore-pāinga rānei. Ka taea e tō rōpū hauora te āwhina i a koe ki te tūhura i ngā kōwhiringa pūtea me te tono mō ngā hōtaka awhina ka whakaiti i ō whakapaunga mai i tō pūtea ake.