He aha te Tepotinib: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

Ko te Tepotinib he rongoā mate pukupuku e whai ana i ngā pūmua motuhake e āwhina ana i ētahi momo mate pukupuku pūkahukahu kia tipu. He rongoā hou tēnei i hangaia mō te hunga e mate ana i te mate pukupuku pūkahukahu kore-iti-iti e whai ana i tētahi huringa ira motuhake e kīia ana ko te MET exon 14 skipping mutation.

He rerekē te mahi a tēnei rongoā i te rongoā matū tuku iho mā te arotahi ki te raruraru ngota e akiaki ana i te tipu o tō mate pukupuku. Whakaarohia he taputapu tika, kaua he huarahi whānui, he maha ngā wā ka iti ake ngā pānga taha i te wā e whai hua tonu ana ki te mate pukupuku.

He aha te Tepotinib e whakamahia ana mō?

Ka rongoā te Tepotinib i tētahi momo motuhake o te mate pukupuku pūkahukahu kore-iti-iti kua piki ake. Ka tohua tēnei rongoā e tō tākuta mēnā he huringa ira motuhake tō mate pukupuku e kīia ana ko te MET exon 14 skipping.

Ka puta tēnei huringa ira i roto i te 3-4% o ngā mate pukupuku pūkahukahu kore-iti-iti, he mea onge. Ka pā te huringa ki ngā pūtau mate pukupuku kia tipu me te horapa kaha ake mā te pānga ki te mahi o ētahi pūmua i roto i ō pūtau.

Ka whakamātau tō rōpū hauora i tō kiko mate pukupuku hei whakapūmau kei a koe tēnei huringa motuhake i mua i te tīmatanga o te tepotinib. Ko tēnei tukanga whakamātau, e kīia ana ko te whakamātau biomarker, e whakapūmau ana ka whiwhi koe i te rongoā e tika ana mō tō momo mate pukupuku.

Me pēhea te mahi a te Tepotinib?

Ka aukati te Tepotinib i tētahi pūmua e kīia ana ko te MET e āwhina ana i ngā pūtau mate pukupuku kia tipu me te ora. Ka kaha rawa tēnei pūmua i te huringa ira, ka tukuna ngā tohu e kī ana ki ngā pūtau mate pukupuku kia tere te whakaputa.

Mā te aukati i ēnei tohu, ka tapahia e te tepotinib ngā tohutohu tipu o te mate pukupuku. Mā tēnei huarahi whai i te whāinga ka taea te whakaiti, te aukati rānei i te horapa o te mate pukupuku ki ētahi atu wāhanga o tō tinana.

He rongoā whāinga a Tepotinib, ā, e mōhiotia ana he rongoā kaha, whai hua mō te momo mate pukupuku pūkahukahu e rongoatia ana e ia. Heoi anō, he rerekē tana mahi mai i te rongoā matū tuku iho, ā, he maha ngā momo pānga taha e puta ana, he ngāwari ake te whakahaere.

Me pēhea taku tango i te Tepotinib?

Tangohia te tepotinib i runga i ngā tohutohu a tō tākuta, ko te tikanga kotahi i te rā me te kai. Mā te tango me te kai ka pai ake te uru o te rongoā ki tō tinana, ā, ka whakaiti pea i ngā pānga taha e pā ana ki te puku.

Horomia ngā papa katoa me te karaihe wai – kaua e kuru, e ngaungau, e whati rānei. Ki te uaua ki a koe te horomi i ngā papa, kōrerohia ki tō rōpū hauora mō ngā otinga ka taea.

Whakamātauria te tango i te tepotinib i te wā kotahi i ia rā kia mau tonu ai ngā taumata i tō tinana. Ka taea e koe te tango me tētahi kai, engari he maha ngā tāngata e kite ana he māmā ake te mahara ina tangohia me te parakuihi, te tina rānei.

Kaua e kai karepe, inu wai karepe rānei i te wā e tango ana i te tepotinib, nā te mea ka raru pea tō tinana ki te tukatuka i te rongoā. Mā tēnei pānga ka iti ake te whai hua o te rongoā, ka nui ake rānei ngā pānga taha.

Kia pēhea te roa e tango ana ahau i te Tepotinib?

Ka haere tonu koe ki te tango i te tepotinib i te wā e whai hua ana, ā, e pai ana tō tinana ki te rongoā. Ko tēnei huarahi e kīia ana ko te

Pērā i ngā rongoā mate pukupuku katoa, ka pānga ngā pānga taha ki te tepotinib, ahakoa kāore e pā ana ki te katoa. Ko te nuinga o ngā pānga taha ka taea te whakahaere mā te tautoko tika me te aroturuki mai i tō rōpū hauora.

Koinei ngā pānga taha tino noa ka pā ki a koe, e pā ana ki te neke atu i te 20% o te hunga e tango ana i te tepotinib:

• Te pūhi i ō waewae, ngā rekereke, rānei, ngā waewae (edema)
• Te ngenge me te pōuri
• Te whakapairuaki me te ruaki i ētahi wā
• Te korere, te tūtae rānei
• Te iti o te hiahia kai
• Te poto o te manawa
• Te mamae o te uaua, o te hononga rānei

Ko ēnei pānga taha noa he ngawari ki te āhua, ā, he pai ake i te wā e urutau ana tō tinana ki te rongoā. Ka taea e tō rōpū hauora te whakarato rautaki hei āwhina i te whakahaere i ēnei tohumate.

Ka pā pea ki ētahi tāngata ngā pānga taha nui ake e hiahia ana kia tere te rongoā, ahakoa kāore ēnei i te noa:

• Ngā raruraru pūkahukahu nui (pneumonitis) me te mare tonu, te uaua rānei ki te manawa
• Ngā raruraru ate me te kōwhai o te kiri, o ngā kanohi rānei
• Te pūhi nui kāore e pai ake i te whakatō
• Ngā tohu o te mate me te kirika, te wiri, te ngoikore rānei
• Te korere nui e arahi ana ki te maroke

Whakapā atu ki tō rōpū hauora tonu mēnā ka pā ki a koe ētahi o ēnei tohumate nui ake. Ka taea e te wawaotanga wawe te āwhina i te aukati i ngā raruraru me te noho haumaru i a koe e mau ana i tō rongoā.

Ko wai kāore e tika kia tango Tepotinib?

Kāore te Tepotinib e tika ana mō te katoa, ā, ka āta arotake tō tākuta i tō hītori hauora i mua i te whakarite. Ko te hunga e pā ana ki ētahi āhuatanga, me karo pea i tēnei rongoā, me whakamahi rānei me te tūpato atu.

Kāore koe e tango i te tepotinib mēnā he pānga tōna ki a koe, ki ētahi o ōna kai rānei. Hei tāpiri, kāore tēnei rongoā i te tūtohutia mēnā kei te hapū koe, kei te whāngai ū rānei, nā te mea ka pānga ki ngā pēpi e whanake ana.

Ka whakamahi tō tākuta i te tūpato anō ina tohua te tepotinib mō koe mēnā he:

• He mate ate nui, he raruraru rānei i te mahi ate
• He mate tākihi nui
• He hītori mō ngā raruraru pūkahukahu, he uaua rānei ki te hā
• He raruraru ngākau, he take rānei mō te pupuri wai
• Ngā mate kaha, he pūnaha ārai mate rānei kua ngoikore

Ka taea e ētahi rongoā te pāhekoheko ki te tepotinib, ka kore pea e whai hua, ka nui ake rānei ngā pānga taha. Me kōrero tonu ki tō rōpū hauora mō ngā rongoā katoa, ngā tāpiringa, me ngā hua otaota e inu ana koe.

Ingoa Waitohu Tepotinib

Ka hokona te Tepotinib i raro i te ingoa waitohu Tepmetko i te United States me Europe. Mā tēnei ingoa waitohu e āwhina te wehe i tēnei rongoā i ētahi atu rongoā mate pukupuku, me te whakarite kia whiwhi koe i te hanganga tika.

Ina tiki koe i tō rongoā, me tātari anō kei te whiwhi koe i te Tepmetko (tepotinib), kaua i tētahi rongoā kē. I ētahi wā ka mau ngā whare rongoā i ngā rongoā he rite ō rātou ingoa, nō reira ka āwhina te whakamārama i tō haumaru.

Ka pā te inihua me te whare rongoā ki te wātea me te utu. Mēnā he āwangawanga āu mō te uru atu ki te Tepmetko, pātai ki tō rōpū hauora mō ngā hōtaka āwhina tūroro ka āwhina pea.

Ngā Kōwhiringa kē mō te Tepotinib

Ahakoa i hangaia te tepotinib mō ngā huringa MET exon 14, kei te noho tonu ētahi atu kōwhiringa maimoatanga mō te mate pukupuku pūkahukahu. Ka whakaaro pea tō tākuta i ngā kōwhiringa kē i runga i tō āhuatanga motuhake me te pai o te mahi a te tepotinib.

Ko ētahi atu rongoā whāinga mō te mate pukupuku pūkahukahu ko te capmatinib (Tabrecta), e whāinga ana hoki ki ngā huringa MET engari he rerekē te mahi. Ka pai ake pea te urupare a ētahi tāngata ki tētahi rongoā i tētahi atu.

Ko ngā maimoatanga tuku iho pērā i te rongoā matū, te rongoā ārai mate, te rāpoi rānei, ka waiho pea hei kōwhiringa mēnā kāore e tika te rongoā whāinga. Ka kōrero tō tākuta mate pukupuku i te huarahi pai rawa atu i runga i ngā āhuatanga o tō mate pukupuku me tō hauora whānui.

Ngā whakamātau haumanu

Ka whai wāhi pea ngā whakamātau haumanu ki ngā rongoā whakamātau hou. Pātai atu ki tō rōpū hauora mēnā he rangahau e tika ana mō tō āhuatanga.

He pai ake te Tepotinib i te Capmatinib?

E rua ngā rongoā, te tepotinib me te capmatinib, e whai ana i te pūmua MET kotahi, engari he rerekē te mahi, ā, he rerekē pea ngā pānga taha. Kāore tētahi rongoā e tino pai ake ana i tētahi atu - ka whakawhirinaki te whiriwhiri ki ō āhuatanga takitahi.

Ka pai ake te urupare a ētahi tāngata ki te tepotinib, ā, ka pai ake pea ngā hua o ētahi atu ki te capmatinib. Ka whai whakaaro tō tākuta ki ngā āhuatanga pēnei i tō huringa motuhake, te hauora whānui, ētahi atu rongoā e tango ana koe, me ngā pānga taha pea i te wā e whiriwhiri ana i waenga i a rāua.

Mēnā ka mutu te mahi a tētahi rongoā, ka pā rānei ngā pānga taha e kore e taea te whakawhāiti, ka huri pea tō tākuta i a koe ki tētahi atu. Ko tēnei ngāwari e whai wāhi atu ana ki a koe ki ētahi atu kōwhiringa rongoā me te tūmanako mō te whakahaere tonu i te mate pukupuku.

Kua whakaatu ngā rongoā e rua i te whai huatanga rite i ngā whakamātau haumanu, me ngā reiti urupare tata ki te 40-50% mō ngā tāngata whai huringa MET exon 14 e ngaro ana. Ka aroturuki tō rōpū hauora i tō ahunga whakamua me te whakatika i te rongoā i te mea e tika ana.

Ngā Pātai Auau mō Tepotinib

He haumaru te Tepotinib mō ngā tāngata whai mate huka?

Ka taea te whakamahi i te tepotinib i roto i ngā tāngata whai mate huka, engari me āta aroturuki. Kāore te rongoā e pā tika ana ki ngā taumata huka toto, engari ko ētahi pānga taha pēnei i te iti o te hiahia kai, te whakapairuaki rānei, ka pā pea ki ō tauira kai.

Ka mahi tahi tō rōpū hauora me koe ki te aroturuki i tō rongoā mate pukupuku me te whakahaere mate huka. Me whakatika pea e rātou ō rongoā mate huka, te wā rānei e aroturuki ana koe i te wā e tango ana koe i te tepotinib.

Mēnā ka pūhi koe (edema) mai i te tepotinib, ka uaua pea te whakahaere mate huka i ētahi wā. Ka taea e tō tākuta te whakarato i ngā rautaki hei whakahaere i ngā āhuatanga e rua i te wā e mau tonu ana tō rongoā mate pukupuku.

He aha taku mahi ki te tango pohehe i te nui rawa o Tepotinib?

Mena ka tango pohehe koe i te nui rawa o te tepotinib i whakaritea, whakapā atu ki tō kaiwhakarato hauora, ki te pokapū whakahaere paitini rānei i te wā tonu. Kaua e tatari kia kite mena ka puta he tohu – he pai ake te wawaotanga wawe.

Ko te tango i te nui rawa o te tepotinib ka piki ake pea te tūponotanga o ngā pānga taha pēnei i te whakapairuaki nui, te ruaki, te pūhi rānei. Ka hiahia pea tō rōpū hauora ki te aroturuki i a koe kia tata ake, ki te whakarato rānei i te manaaki tautoko hei āwhina i te whakahaere i ngā tohu.

Puritia te tepotinib i roto i tōna ipu taketake me te tapanga mārama hei āwhina i te aukati i te nui rawa o te horopeta. Whakaarohia te whakamahi i te kaiwhakarite pire, te whakatakoto rānei i ngā whakamaharatanga waea hei āwhina i a koe ki te tango i te horopeta tika i te wā tika.

He aha taku mahi ki te ngaro i te horopeta o Tepotinib?

Mena ka ngaro koe i te horopeta o te tepotinib, tangohia i te wā tonu ka mahara koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua keehi, pekehia te horopeta i ngaro, ka haere tonu ki tō hōtaka auau.

Kaua rawa e tango e rua ngā horopeta i te wā kotahi hei utu mō te horopeta i ngaro – ka piki ake pea tēnei i tō tūponotanga o ngā pānga taha. Ki te kore koe e mōhio ana ki te wā, whakapā atu ki tō rōpū hauora mō te ārahitanga.

Mena ka wareware koe i ngā horopeta, whakaarohia te whakatakoto i ngā whakaoho ia rā, te whakamahi rānei i tētahi taupānga whakamahara rongoā. Ko te horopeta rite tonu ka āwhina i te pupuri i ngā taumata pumau o te rongoā i roto i tō tinana mō te whai huatanga pai.

Āhea ka taea e au te whakamutu i te tango Tepotinib?

Me whakamutu noa koe i te tango tepotinib i te wā e whakatau ana tō tākuta he tika, te tikanga i te wā e piki ana te mate pukupuku ahakoa te rongoā, ka kore rānei e taea te whakahaere i ngā pānga taha. Kaua rawa e whakamutu i te tango tepotinib i runga i a koe anō, ahakoa kei te pai ake koe.

Ka whakamahi tō rōpū hauora i ngā karapa auau me ngā whakamātautau toto hei aroturuki i te pai o te mahi a te tepotinib. Ki te kei te whakahaere te rongoā i tō mate pukupuku i runga i te whai huatanga, me te pai o tō whakawātea, ka haere tonu pea koe ki te tango mō te wā mutunga kore.

Ki te hiahia koe ki te whakamutu i te tepotinib, ka kōrero tō tākuta i ngā mahi e whai ake nei me ngā kōwhiringa rongoā kē. Kāore he take ki te whakaiti i te horopeta i te wā - ka taea e koe te whakamutu tonu i te wā e tika ana i te taha hauora.

Ka taea e au te inu waipiro i te wā e tango ana i te Tepotinib?

Ahakoa kāore he pānga tika i waenga i te tepotinib me te waipiro, he pai ake te whakaiti i te inu waipiro i te wā o te rongoā mate pukupuku. Ka taea e te waipiro te whakapōrearea i ētahi pānga taha pēnei i te whakapairuaki, te ngenge, me te pēhanga ate.

Mēnā ka whiriwhiria e koe te inu waipiro i ētahi wā, kōrerohia tēnei ki tō rōpū hauora i te tuatahi. Ka taea e rātou te whakarato i ngā tohutohu whaiaro i runga i tō hauora whānui me te pai o tō whakamanawanui i te tepotinib.

Kia mahara ka taea hoki e te waipiro te whakararu i tō pūnaha ārai mate me te kounga o te moe, he mea nui ēnei e rua mō te kaha o tō tinana ki te whawhai i te mate pukupuku me te ora mai i te rongoā.