Maal Fedratinib: Fayyadamni, Qusannaa, Dhibeewwan Gamaa fi Dabalataa

Fedratinib qoricha kaansarii kan xiyyeeffatedha kan gargaaru kaansarii dhiigaa tokko tokko kan yaaluun, proteeniin addaa kan guddina dhukkubaa kakaasan ugguruun. Qorichi afaaniin fudhatamu kun garee JAK2 inhibitors jedhamu keessatti kan argamu yoo ta'u, kunis hojii kan hojjetu mallattoowwan kanneen seelota kaansarii akka baay'atan itti himan kan akka dhiigaa guddatanii fi dadhabbii cimaa fiduun.

Doktarri kee fedratinib siif barreessuu danda'a yeroo myelofibrosis qabdu, kaansarii dhiigaa kan nadiraa kan dandeettii marimaanii lafee keetii akka hin hojjanne kan taasisu seelota dhiigaa fayyaa oomishuu. Yeroo qorannoon kun nama sodaachisuu danda'u, fedratinib garuu abdii ni kenna sababa dhukkuboota keetii xiyyeeffachuun fi qulqullina jireenya keetii deebisuun.

Fedratinib Maaliif Fayyadamu?

Fedratinib myelofibrosis yaala, gosa kaansarii dhiigaa kan marimaanni lafee keetii miidhamee seelota dhiigaa akkaataa sirriin oomishuu hin dandeenye. Haalli kun akka tiruu kee guddatu kan taasisu yoo ta'u, kunis mallattoowwan nama hin gammachiisne kan jireenya guyyaa guyyaa kee irratti dhiibbaa qaban fida.

Doktarri kee keessumaa fedratinib kan siif barreessu myelofibrosis jalqabaa kan walakkaa-2 ykn balaa guddaa qabuuf, ykn myelofibrosis lammaffaa kan dhukkuboota dhiigaa biroo irraa uumameef. Qorichi kun tiruu kee kan guddate akka xiqqatuu fi mallattoowwan dadhabsiisoo kan akka dadhabbii cimaa, dhidhimuu halkanii, fi nyaata xiqqaa erga nyaattee booda guutuu ta'uu akka hir'isu gargaara.

Yeroo tokko tokko, fedratinib yoo qoricha JAK inhibitors kan biroo akka ruxolitinib yaalte garuu dhibeewwan gamaa argatte ykn yaalli sun hojii irra hin oolle ykn bu'aa hin qabu ta'e ni gorfama. Kunis yeroo haala rakkisaa kana keessa jirtu filannoo yaalaa biraa siif kenna.

Fedratinib Akkamitti Hojjeta?

Fedratinib proteeniin JAK2 ugguruun hojjeta, kanneen myelofibrosis keessatti baay'atan fi mallattoowwan yeroo hundaa qaamni kee seelota dhiigaa hin baratamne akka oomishuuf ergan. JAK2 akka switch kan "on" irratti maxxanfamee jiruutti yaadi, kunis akka marimaanni lafee keetii karaa dogoggoraa hojjetu fi tiruun kee akka guddatu taasisa.

Qorichi kun yaala cimaa, kan xiyyeeffannoo qabu kan jijjiirama geneetikii myelofibrosis kee oofaa ta'e akka ta'etti ilaallama. Mallattoowwan kana ugguruudhaan, fedratinib guddina tiruu xiqqeessuu, ba'aa mallattoolee hir'isuu, fi guddina dhukkubaa suursuuf gargaara.

Qorichi erga afaaniin fudhattee booda dhiiga kee keessa kan seenu yoo ta'u, qaama kee keessa guutumaatti imaluudhaan seelota miidhaman bira ga'a. Namoonni baay'een yaala ji'oota muraasa keessatti fooyya'iinsa mallattoolee ni hubatu, garuu deebiin namootaa adda addaa ta'uu danda'a.

Fedratinib Akkamitti Fudhadha?

Fedratinib akkaataa doktorri kee ajajetti fudhadhu, yeroo baay'ee guyyaatti yeroo tokko yeroo wal fakkaataa guyyaa hundaa. Nyaata waliin ykn malee fudhachuu dandeessa, garuu nyaata waliin fudhachuun yoo qufaan si mudate gargaarsa garaacha hir'isuu danda'a.

Kaapsuloota guutummaatti bishaanii guutuun liqimsuu - hin cabsin, hin cini'in, ykn hin banin kunis akkaataa qorichi itti hojjetu irratti dhiibbaa waan qabuuf. Yoo kaapsuloota liqimsuun si rakkise, kaapsuloota mataa keetii jijjiiruu yaaluu mannaa filannoowwan biroo ilaalchisee doktara kee dubbisi.

Fedratinib jalqabuu kee dura, doktorri kee sadarkaa thiamine (vitamiin B1) kee ni ilaala, akkasumas dabalata ni gorsa. Kun barbaachisaa dha, sababiin isaas fedratinib thiamine qaama kee keessatti dhiibbaa geessisuu danda'a, sadarkaa ga'aa eeguun ammoo dhiibbaa gamaa hamaa ittisuu gargaara.

Qoricha kee ho'a keessatti, bishaan irraa fagaadhu. Eegumsaaf konkolaataa jalqabaa keessatti, daa'immanii fi horii irraa fagaadhu.

Fedratinib Yeroo Meqaaf Fudhadha?

Yeroo baay'ee fedratinib kan fudhattu yeroo itti fayyadamuun mallattoolee myelofibrosis kee to'achuu itti fufuu fi qaamni kee gaarii ta'ee itti danda'u. Namoonni baay'een qoricha kana ji'oota irraa hanga waggootaatti fudhatu, sababiin isaas myelofibrosis haala yeroo dheeraa kan yaala itti fufaa barbaadu dha.

Doktarri kee deebii kee qorannaa dhiigaa yeroo yeroon godhamuufi qorannaa qaamaa yeroo yeroon godhamuun kan hordofamu ta'ee, qorichi kun akkamitti akka hojjetu ni ilaala. Guddina tiruu keetii ni safara, akkasumas mallattoowwan kee ni ilaala, fedratinib siif faayidaa qabaachuu isaa ni murteessa.

Yoo miidhaa gama tokkoo guddaa ta'e ykn qorichi kun mallattoowwan kee to'achuu dhaabuu baate, doktarri kee doozii kee jijjiru ykn yaala biraa ilaaluu danda'a. Fedratinib akka tasaa fudhachuu hin dhaabin, duraan dursitee garee fayyaa kee waliin mari'achuu malee.

Miidhaa Fedratinib Maal Fa'i?

Qorichoota hundumaa akka ta'etti, fedratinib miidhaa gama tokkoo geessisuu danda'a, garuu namni hundumtuu isaan hin muudatu. Miidhaan gama tokkoo baay'een to'atamuu danda'a, hordoffii sirrii ta'ee fi kunuunsa deeggartuu garee fayyaa kee irraa argamuun.

Kunooti miidhaa gama tokkoo yeroo baay'ee fudhachaa jirtu:

• Garaa kaasaa, salphaa irraa hanga cimaatti ta'uu danda'a
• Qoma gadi bu'uu fi kusaa
• Anemia (lakkoofsa selii dhiigaa diimaa gadi aanaa)
• Lakkoofsa pileetii gadi aanaa, kan balaa dhiiguu dabaluu danda'u
• Dadhabinaa fi laafina
• Infekshinii daandii fincaanii
• Spasmii maashaalee
• Dizziness

Miidhaan gama tokkoo kun yeroo baay'ee qaamni kee qoricha kanaaf yeroo of tolchutti fooyya'a, doktarri kee isaan to'achuuf yaala kennuu danda'a.

Miidhaan gama tokkoo muraasni garuu cimaan xiyyeeffannaa fayyaa hatattamaa barbaada. Yeroo sanatti doktar kee qunnami, yoo wal'aansoo, rakkoo yaadaa, xiyyeeffannaa dhabuu, ykn mallattoowwan infekshinii akka fever ykn qufaan itti fufiinsaa muudatte.

Haalli baay'ee dhifamaa ta'e garuu cimaan, kan Wernicke encephalopathy jedhamu, yoo sadarkaan thiamine kee gadi bu'e ta'uu danda'a. Kanaaf doktarri kee sadarkaa thiamine kee ni hordofa, akkasumas dabalata kennuu danda'a - kun tarkaanfii nageenyaa murteessaa ta'ee, wal'aansoo kana ittisuu gargaara.

Eenyutu Fedratinib Fudhachuu Hin Qabu?

Fedratinib namni hundumaaf hin ta'u, akkasumas doktarri kee seenaa fayyaa keetii fi haala fayyaa yeroo ammaa jiru irratti hundaa'uun, kan siif nageenya ta'uu isaa sirritti ni ilaala. Haalli ykn haalli tokko tokko qorichi kun akka balaa ta'u gochuu danda'u.

Yoo dhukkuba kalee hamaa qabaatte fedratinib hin fudhachuu qabdu, sababiin isaas qaamni kee qoricha sirritti hojjechuu hin danda'u ta'a. Doktarri kee qoricha kana dura kennuun dura hojii kalee keetii ni ilaala.

Namoonni dhukkuboota cimaa fi ho'aa qaban fedratinib jalqabuu hin qaban, sababiin isaas sirna ittisa qaamaa kee ukkamsuu fi dhukkuboota akka hamaa ta'an gochuu danda'a. Doktarri kee duraan dursanii dhukkuboota kamiyyuu ni yaala, qoricha kana ilaaluun dura.

Yoo ulfooftu ykn harma hoosiftu taate, fedratinib daa'ima kee miidhuu danda'a, akkasumas hin gorfamu. Dubartoonni umrii daa'ima godhachuu danda'an qoricha kana fudhachaa ykn erga fudhachuu dhaabanis ji'a tokkoof too'annaa ulfaa gaarii fayyadamuu qabu.

Doktarri kee yoo dhukkuba tiruu hamaa, dhukkuboota onnee tokko tokko, ykn walnyaatinsa hamaa duraanii kan qorichoota JAK inhibitor jedhamaniif qabaatte, fedratinib kennuu irratti of eeggannoo ni godha.

Maqaa Brandii Fedratinib

Fedratinib biyya United States fi biyyoota biroo tokko tokkotti maqaa brandii Inrebic jedhamuun gurgurama. Kun maqaa brandii jalqabaa kan qoricha kee irratti argituu fi qoricha kee itti fayyadamtuudha.

Yeroo ammaa, Inrebic brandii guddaa kan argamu yoo ta'u, garuu waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan hayyamaa yoo xiqqaate, waraqaan 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Qorannoon wal'aansa biraa myelofibrosis kan fedratinib siif hin taane ykn hojii irraa dhaabatu yoo jiraatan ni jira. Doktarri kee haala kee addaa, wal'aansa duraanii, fi fayyaa waliigalaa kee yeroo filannoo wal'aansaa biraa siif kennu ilaala.

Ruxolitinib (Jakafi) yeroo baay'ee wal'aansa jalqabaa myelofibrosis'f kan ta'u yoo ta'u, karaa proteeniin JAK itti dhorkuun fedratinib wajjin wal fakkaata. Namoonni baay'een ruxolitinib jalqaba yaalu, dura fedratinib yaaluun dura, keessumaa yoo duraan wal'aansa dhorkaa JAK hin fudhatin ta'e.

Pacritinib (Vonjo) dhorkaa JAK biraa yoo ta'u, lakkoofsi platelet'ii kee baay'ee yoo xiqqaate, kunis namoota dhorkaa JAK kan biroo fudhachuu hin dandeenye, sababa thrombocytopenia cimaa ta'eef kan qophaa'edha.

Namoota tokko tokkoof, tarkaanfiiwwan kunuunsa deeggarsa akka dhiiga dabarsuu, qorichoota mallattoolee to'atan, ykn illee traansipilaantii marroo lafee, umrii, fayyaa waliigalaa, fi hamaa dhukkubaa irratti hundaa'uun ilaalamuu danda'a.

Fedratinib Ruxolitinib Caalaa Gaarii Dhaa?

Fedratinib fi ruxolitinib lamaanuu dhorkaa JAK myelofibrosis wal'aansuu keessatti bu'a qabeessa, garuu tokkoon tokkoon isaanii haala kee addaa irratti hundaa'uun faayidaa addaa qabu. Tokkoon isaanii guutummaatti "caalaa gaarii" miti - filannoon kun haala kee fi seenaa wal'aansaa irratti hundaa'a.

Ruxolitinib yeroo baay'ee jalqaba kan kennamu waan yeroo dheeraaf argamaa tureef, muuxannoo kilinikaa bal'aa qabu. Haa ta'u malee, fedratinib filatamaa ta'uu danda'a yoo ruxolitinib yaalte ta'ee fi miidhaa argatte ykn yoo qorichi siif hojii irraa dhaabate.

Fedratinib haala tokko tokko keessatti faayidaa kennuu danda'a, akka yoo miidhaa addaa barbaachisu ykn yoo dhukkubni kee amaloota addaa kan fedratinib caalaatti siif madaalessu qabaate. Namoonni tokko tokko mala hojii fedratinib's gaarii ta'een deebii kennu.

Doktarri kee yeroo qoricha kana filatu lakkoofsa dhiiga keetii, yaala duraanii, hojii kalee keetii fi fayyaa kee waliigalaa ni ilaala. Filannoon "gaarii" ta'e kan mallattoowwan kee to'achuu danda'u yoo ta'u, kanneen dhibee walxaxaa siif hin fidne dha.

Gaaffiiwwan Yeroo Baay'ee Fedratinib Irratti Gaafatamaniif

Fedratinib Dhukkuba Kaleetiif Nageenyaa?

Fedratinib yoo dhukkuba kalee qabaattee eegamuu qaba, sababiin isaas kaleen kee qoricha kana qaama kee keessaa hojjechuu fi balleessuuf gargaara. Doktarri kee dura fedratinib kennuun dura qorannoo dhiigaan hojii kalee kee ni ilaala.

Yoo rakkoo kalee salphaa hanga giddu galeessaa qabaatte, doktarri kee fedratinib siif kennuu danda'a, garuu si dhuunfaatti ni hordofa, akkasumas doosii kee ni jijjiira. Haa ta'u malee, yoo dhukkuba kalee cimaa qabaatte, fedratinib siif hin eegamu ta'a, sababiin isaas qaama kee keessatti sadarkaa balaa qabuun walitti qabamuu danda'a.

Yeroo hundumaa rakkoo kalee kamiyyuu doktaricha keessanitti himaa, isaanis haala keessaniif karaa nageenya qabu ni murteessu. Hordoffiin yeroo hundumaa qorichi nageenya qabu fi siif hojjetu akka ta'u gargaara.

Fedratinib Baay'ee Yoo Akka Kanaan Osoo Hin Beekne Fayyadame Maalan Godha?

Yoo akka kanaan osoo hin beekne fedratinib baay'ee fudhatte, hatattamaan doktaricha keessan ykn giddugala to'annoo summii bilbilaa, yoo fayyaa ta'e illee. Baay'ee fudhachuun balaa dhibee walxaxaa guddisuu danda'a.

Doosii fuulduraa dabsuun "guutuu" yaaluu hin qabdu - kun balaa ta'uu danda'a, akkasumas bu'aa yaala keessan irratti dhiibbaa geessisuu danda'a. Kanaa mannaa, karaa nageenya qabuun sagantaa yaala keessan itti fufuuf qajeelfama doktaricha keessan hordofaa.

Mallattoowwan fedratinib baay'ee fudhachuu dhibee hamaa, kusaa, fincaan, ykn dadhabbii hin baratamne dabalata. Qoricha dabalataa fudhachuu keessan booda mallattoowwan yaaddessaa kamiyyuu yoo argattan hatattamaan yaala fayyaa barbaadaa.

Fedratinib Doosii Yoo Dabse Maalan Godha?

Yoo doosii fedratiniibii dagatte, akkuma yaadattetti fudhadhu, yoo yeroon doosii itti aanuuf karoorfame dhihoo ta'uu baate. Haala kanaan, doosii dagatame sana darbiitii sagantaa kee yeroo hundaa itti fufi.

Yeroo kamiyyuu doosii lama walitti fudhachuu hin qabdu doosii dagatame bakka buusuuf, kunimmoo balaa dhibeewwan qaamaa dabaluu waan danda'uuf. Doosii lama fudhachuun balaa qabaachuu danda'a, akkasumas rakkoowwan cimaa fiduu danda'a.

Yoo yeroo baay'ee doosii dagattu, yaadachiisa bilbilaa dhaabuuf ykn qindeessaa qorichaatti fayyadamuun akka sirritti hordofaa jirtu si gargaaruu danda'a. Guyyaa guyyaatti qoricha fudhachuun bu'aa qorichichaa myelofibrosis kee to'achuuf barbaachisaa dha.

Yeroo Fedratiniibii Fudhachuu Dhiisuu Danda'u?

Fedratiniibii fudhachuu kan dhiisuu qabdu qajeelfama doktaroota keetii jalatti qofa, sababiin isaas tasa dhaabuun mallattoowwan myelofibrosis keetii akka deebi'an ykn akka hamaan ta'an gochuu danda'a. Doktarri kee yeroo hundaa qorichi sun siif bu'aa akka qabu ni ilaala.

Doktarri kee fedratiniibii akka dhiistu si gorsuu danda'a yoo dhibeewwan qaamaa cimaa to'achuu hin dandeenye sitti dhaga'ame, yoo qorichi sun mallattoowwan kee to'achuu dhiise, ykn fayyaan kee guutummaatti yoo jijjiirame.

Fudhachuu dura, doktarri kee filannoowwan wal'aansaa biroo ni mari'ata akka yaala sirrii myelofibrosis keetiif argattuuf. Rakkoowwan kamiyyuu hir'isuuf jecha doosii kee suuta suutaan hir'isuu danda'u, tasa dhaabuu mannaa.

Qoricha Fedratiniibii Qorichoota Biraa Wajjin Fudhachuu Danda'aa?

Fedratiniibii qorichoota biroo wajjin walitti dhufeenya qabaachuu danda'a, kanaaf qorichoota doktarri siif barreesse, qorichoota bituun hin barbaachisneefi nyaata dabalataa hunda doktaroota keetti himuun barbaachisaa dha. Walitti makamuun tokko tokko dhibeewwan qaamaa dabaluu ykn bu'aa hir'isuu danda'u.

Qorichoonni tokko tokko dandeettii tiruun qorichoota itti fayyadamuuf qabu jijjiiruun doosii jijjiiruu ykn yaala biroo barbaachisa. Doktarri kee qorichoota kee hunda ni ilaala walitti makamniin nageenya qabu akka ta'uuf.

Qoricha haaraan kamiyyuu, kanneen akka qorichoota biqiltootaa ykn vitaaminotaa, fedratinibiin yeroo fudhattan dura, ogeessa fayyaa keessanii ykn faarmaasistii keessanitti mari'achuu qabdu. Tarsiimoon salphaan kun walitti dhufeenya qorichaa kan balaa qabu ittisuu fi yaalli keessan akka nagaa fi bu'a qabeessa ta'u mirkaneessa.