Utubazo twa GLP-1: Birakora?

Utubazo twa GLP-1 ntukubamo imiti ya GLP 1. Niwo murongo umwe ufungura cyane muri iyi nkuru, kandi byose biri hasi biyubaka kuri uwo.

Ibyo bikoresho bigurishwa online nk'"utubazo twa GLP 1" ni utuyiko twambara ku ruhu tubamo ibirungo by'ibimera nka beriberi, icyayi cy'icyatsi, n'ikinnamon. Ntibituyimo semaglutide. Ntabwo bituyimo tirzepatide. Ntabwo byemewe na FDA. Ntabwo byandikwa na muganga. Kandi nta b evidence z'ubushakashatsi zerekana ko bitera kugabanya ibiro mu buryo bugaragara.

Niba washakishije "utubazo twa GLP-1" wifuza kubona inzira idakoresha urushinge, ihendutse ya Ozempic cyangwa Wegovy, ntabwo wowe wenyine. Miliyoni z'abantu bashakishije ibi. Ibyo bikoresho bibaho kuko isaba ni nyinshi. Ariko ubushakashatsi ntububaho, kandi gusobanukirwa impamvu birashobora kugutabara amafaranga n'agahinda. Mworozi wigishijwe hano harimo ibyo utubazo twinjiye, impamvu imiti nyayo ya GLP 1 idashobora gutangwa binyuze mu kabobo, n'ibyo koko bikora niba wifuza kwirinda kwiruma.

Utubazo twa GLP 1 turakora?

Oya. Nta evidence y'ubuvuzi ko utubazo twa GLP 1 tuboneka ku isoko itera kugabanya ibiro bigereranywa n'imiti ya GLP-1 yandikwa na muganga.

Impamvu ni ibijyanye n'ibinyabuzima, si uburenganzira gusa. Abanywanyi ba GLP-1 nk' semaglutide-subcutaneous-route" target="_blank" rel="noopener noreferrer">semaglutide na tirzepatide-subcutaneous-route" target="_blank" rel="noopener noreferrer">tirzepatide ni molekile nini za peptide. Ni nini cyane, ni zishobora gukwirakwizwa mu mazi cyane, kandi ni zishobora kwirundura cyane kugira ngo zinjire mu ruhu rwawe (stratum corneum) kandi zinjire mu maraso yawe. Dr. Sheldon Markowitz, umuyobozi w'ibijyanye n'ubuvuzi bwa diyabeti muri Episcopal Health Services muri New York, yavuze ko n'ubwo kabobo yakaba irimo imiti nyayo ya GLP 1, ntibyashoboka kuyitanga binyuze mu ruhu hakoreshejwe ikoranabuhanga rya none.

Ibyo si ikibazo gusa ku tubazo. Ni impamvu buri muti wa GLP-1 wemewe na FDA ari cyangwa se urushinge (runderera uruhu rwose) cyangwa se ifunguro ryateguwe neza (rikoresha ikoranabuhanga ryongera ubwonko mu gifu). Nta bundi buryo bwa gatatu bukora ubu.

Bimwe mu birungo muri utwo tubazo, nka beriberi, bifite ubushakashatsi bucye kuri ingaruka ku isukari mu maraso iyo bifashishijwe mu kanwa. Ariko "kwifashishwa mu kanwa" ni ijambo ryingenzi. Ubushakashatsi bwerekanaga ko beriberi igabanya isukari mu maraso bwabajijemo abantu bahirira kapsule, atari kwambara utubazo ku maboko. Niba beriberi cyangwa icyayi cy'icyatsi gikwirakwizwa binyuze mu ruhu mu bihe bifatika byarashakishijwe.

Ni iki cyo aribyo kiri mu tubazo twa GLP 1?

Urukwavu rw'ibintu ku tubazo twinshi twa GLP-1 rubamo ikombine y'ibi bikurikira:

• Beriberi (ikirungo cy'igihingwa gishobora kugira ingaruka ku isukari mu maraso iyo kihiriye)

• Igice cy'icyayi cy'icyatsi (EGCG, ikintu kibyutsa kandi gikiza)

• Igice cy'ikinnamon

• Garcinia cambogia

• Igice cy'ikimore

• Intungamubiri ya apple cider

• L-glutamine (amino acid)

• B vitamins

• Igice cy'umuzi w'ikinyobwa

Nta na kimwe muri ibi kiri mu miti yandikwa na muganga. Nta na kimwe kiri mu banywanyi ba GLP-1. FDA yemeje ko nta tubazo twa GLP-1 twemewe na FDA kandi nta bifite imiti y'ibinyobwa byemewe na FDA birimo beriberi.

Birakwiriye gusobanukirwa icyo beriberi, ikintu cyakoreshejwe cyane, gikora iyo gikoreshejwe nk'igikoresho mu kanwa. Ubushakashatsi bwagaragaje ko kapsule za beriberi zishobora kugabanya isukari mu maraso n'imikoko mu buryo buciriritse ku bantu bafite diyabeti yo mu bwoko bwa 2. Ibyo bikorwa nyabyo ariko biragoye, bigereranywa n'umuti wa diyabeti metformin cyangwa se munini. Ariko ubwo bushakashatsi bwabajijemo abantu bahirira 500 kugeza 1500 mg buri munsi mu buryo bwa kapsule. Beriberi ikwirakwizwa binyuze mu ruhu? Ntabwo byakoreweho ubushakashatsi mu bushakashatsi ubwo ari bwo bwose bushobora gushyirwa ahagaragara ku bantu. Nta muntu wagaragaje ko ubona igipimo gifite agaciro k'ubuvuzi binyuze mu kabobo.

Igice cy'icyayi cy'icyatsi (EGCG) gifite ubushakashatsi buciriritse kuri izindi ngaruka ku mikorere y'umubiri iyo kinyobwa nk'icyo cyangwa kapsule. Ibyo bikorwa ni nk'ibiro 1 kugeza 3 mu mezi make. Nanone, ibyo ni iyo kihiriye. Niba EGCG ikwirakwizwa mu ruhu mu bihe bifatika binyuze mu kabobo kadufasha ntibiramenyekana.

Rimwe na rimwe cyane cyane cyane ibyo bihinga byatangiye guhindura izina ry'ibyo bikoresho byabo. Kind Patches, imwe mu bikoresho bizwi cyane kuri TikTok, yahinduye "utubazo twa GLP 1" nk'"utubazo twa beriberi" nyuma yo gucyebye, nubwo ingano yabo idahinduka. Kwihindura kwabo kwerekana uko uburyo bwo kumenyesha bwari bumeze.

Kuki utubazo twa GLP-1 bizwi cyane niba bidakora?

Impamvu eshatu, kandi zose zifite ubusobanuro ku mukoresha.

Ubwa mbere, imiti ya GLP-1 yandikwa na muganga ihenze cyane. Nubwo hari gahunda z'abakora, igiciro cyo hasi cy'ibintu bizwi ni 149$ ku kwezi. Utubazo twa GLP-1 tugurishwa ku 20$ kugeza 40$ ku kwezi. Niba utabasha kwishyura imiti nyayo, kabobo ka 30$ kavuga ko gakora ikintu bisa birashishura.

Ubwa kabiri, abantu benshi ntibashaka kwiruma. Gutinya urushinge ni ibintu bisanzwe. Kabobo wambara ku ruhu yumva byoroshye, byoroshye kwivura, byoroshye gutinywa.

Ubwa gatatu, uburyo bwo kumenyesha burakomeye. Iyamamaza ku mbuga nkoranyambaga kuri ibi bikoresho byateguwe kugira ngo bisane n'imiti ya GLP-1 yandikwa na muganga. Bakoresha ururimi rumwe ("kontoroli y'inzara," "ubwishingizi bw'umubiri," "GLP-1 boost") n'uburyo bumwe bwo kugaragara. Niba utarasomye imirongo minini, waba wemera wihuse ko ugura iyindi version ihendutse y'ikintu kimwe.

Ikibazo si ko abantu bashaka uburyo bworoshye. Ibyo ni ibyifuzo byemewe. Ikibazo ni uko ibi bikoresho bitakomeza icyo bivugwa. Ikoranabuhanga ry'imiti itwikirwa ku ruhu ntiryishyigikiye ibintu by'ubunini bumeze gutya.

Harimo utubazo twa nyayo twa GLP-1 bitezwe?

Yego. Abashakashatsi mu buvuzi barimo bakora ku ikoranabuhanga ry'utubazo tw'udushinge duto duto dushobora kuzajya twinjiza imiti ya GLP-1 binyuze mu ruhu. Utu tubuto twakoresha urutonde rw'udushinge duto cyane (ntibigoye kubyumva) zidutambuka gato kugera ku rwego ruri munsi y'uruhu rwo hanze, aho imiti ishobora kwinjira mu maraso.

Ubusobanuro bwo mu mwaka wa 2024 mu kinyamakuru Advanced Drug Delivery Reviews bwagenzuye uko ikoranabuhanga ry'udushinge duto duto ryagenze ku miti ya peptide, harimo abanywanyi ba GLP-1. Itsinda ry'ubushakashatsi ryagaragaje ko rigikomeye mu byifuzo by'inyamaswa, kandi nibura gahunda imwe yo mu rwego rw'ubuvuzi (ya exenatide) yagerageje utubazo tw'udushinge duto duto ku bantu bifite ibisubizo byiza mu ntangiriro.

Ariko nta na kimwe muri ibi kiraboneka ku isoko. Ikoranabuhanga rikiri mu bushakashatsi bw'ubuvuzi, kandi ntawemewe na FDA ku kabobo k'udushinge duto duto ka GLP-1 karashyirwa ahagaragara kandi ntibitezwemo mu gihe gitoya. Niba isosiyete nyayo y'ubuvuzi ibona ikintu nk'icyo, kizaba kitemewe na muganga, ntabwo kizaba ikintu ugura kuri TikTok ku 30$.

Ni iki gikora koko niba utashaka kwiruma?

Niba ikibazo cyawe gikomeye ku miti ya GLP-1 ari urushinge, ubu hariho ibyo bitemewe na FDA mu kanwa bidakeneye kwiruma na gato. Ku bantu baba bafite ububyibuho bashakishaga ikintu cyoroshye kuruta urushinge rw'icyumweru, ibi bifunguro nibyo byegereye ibyo utubazo twa GLP-1 bivuga, uretse ko koko bifite imiti nyayo kandi bifite amakuru ayishyigikiye.

Ifunguro rya Wegovy (semaglutide mu kanwa) ni ifunguro ry'umunsi ryemewe ku kugabanya ibiro. Binyuze muri NovoCare Pharmacy, igiciro cyo kwishyura kibanza kuri 149$ ku kwezi ku biheto byo hasi. Bifite ibyo bisabwa by'igipimo gikomeye: uba ugomba kubifata ku gifu cy'umuntu ufite amazi make kandi ugategereza iminota 30 mbere yo kurya cyangwa kunywa ikindi kintu.

Foundayo (orforglipron) ni ifunguro ry'umunsi ryemewe ku kugabanya ibiro ryatangiye gushyirwa ku isoko mu ntangiriro za 2026. Bibanza kuri 149$ ku kwezi binyuze mu bigo bimwe na bimwe. Bitandukanye n'ifunguro rya semaglutide, Foundayo ntabwo bisaba kumva kugeza igihe ufata mu gifu kidafite icyo cyiriho. Urashobora kubifata igihe icyo ari cyo cyose, ufite cyangwa utafite ibyo kurya, bikabigira uburyo bwo gutwara bwa GLP-1 buriho ubu.

Byombi byemewe na FDA, imiti yandikwa na muganga ifite ubushakashatsi bwerekana kugabanya ibiro ku 10 kugeza 18%. Bihenze kuruta utubazo, ariko bikora binyuze mu buryo bwageragejwe ku bantu ibihumbi mirongo itanu.

Niba igiciro ari ikibazo kuruta urushinge, semaglutide yateguwe y'urushinge binyuze mu bigo by'ibitaro biboneye bihenda ku 129$ kugeza 269$ ku kwezi, bitewe n'urubuga n'igipimo. Ibyo biracyari byinshi kuruta utubazo, ariko ni imiti nyayo ya GLP 1 ifite ibikorwa nyakuri.

Ni iki ugomba kwitondera mugura ibikoresho byo kugabanya ibiro?

Isoko ry'utubazo twa GLP-1 ryuzuye ibimenyetso bibi. Dore ibyo ugomba kureba mbere yo kugura ikintu cyose cyagenewe kugabanya ibiro online.

Niba igikoresho kivuga "GLP-1" ku irangi ariko nticyandikwe na muganga, ntikibamo imiti ya GLP 1. Imiti yose nyayo ya GLP 1 isaba kwandikwa na muganga wemewe. Nta bwoko.

Niba ku irangi havuga "ni ubushakashatsi gusa" cyangwa "ntabwo bubereye abantu", ibyo ni uburyo bwo kunesha amategeko. Bisobanura ko igikoresho kitaremejwe ku bw'umutekano cyangwa uburyo bwo kugipima.

Niba uburyo bwo kumenyesha buvuga ko igikoresho "gishyigikira urwego rwa GLP-1" cyangwa "gukomeza GLP-1 kamere," ibyo ni ururimi rw'ibirungo, ntabwo ari ururimi rw'imiti. Umubiri wawe utanga GLP-1 kamere buri gihe urya. Hemo rya hormone rimara amasegonda kugeza ku minota mu maraso yawe. Imiti ya GLP 1 yandikwa na muganga yateguwe kugira ngo ikore icyumweru cyose. Ikirungo cyihuta cyane GLP-1 yawe kamere ku kigereranyo gito ntikora ikintu kimwe.

Niba igikoresho gifite ubugenzuzi bwiza kuri TikTok cyangwa Amazon ariko nta bushakashatsi bw'ubuvuzi bwashyizwe ahagaragara, ibisubizo abantu bavuga bishobora kuba igisubizo cya placebo. Kwambara kabobo bishobora gutuma umuntu atekereza cyane ku byo afata, kandi gutekereza gutyo gushobora gutera impinduka nke za kiro. Ibyo ntibisobanura ko kabobo kakora ikintu na kimwe ku bijyanye n'imiti. Niba igikoresho gifite ingaruka zo kugabanya ibiro, cyari cyakorewe ubushakashatsi mu gihe cyo kwiga kandi cyashyizwe ahagaragara mu kinyamakuru cy'abagenzi. Kuba ayo makuru nta kibazo, ni inkuru yose.

Niba igiciro cyo kigaragara cyiza cyane kuruta uko byagombye kuba, ni ko biri. Imiti ya GLP 1 yandikwa na muganga igura uko igura kubera ko kuyiteza imbere, kuyigerageza, kuyikora, no kuyigenzura bihenda. Kabobo ka 30$ kavuga ko gakora ikintu kimwe n'umuti wigura 149$ kugeza 1349$ ku kwezi ni ntacyo kiba gikoreshwa. Ni igikoresho gitandukanye rwose.

Nuko rero bigeze he?

Utubazo twa GLP 1 dukora kugabanya ibiro? Oya. Ntabwo binyuze mu buryo ubwo ari bwo bwose bwagaragaye mu bushakashatsi bw'ubuvuzi. Molekile mu miti nyayo ya GLP-1 ni nini cyane kugira ngo zambuke uruhu rwawe. Ibikoresho mu tubuto twa GLP-1 ntibyagaragaye ko bitera kugabanya ibiro bifatika iyo bitanzwe binyuze ku ruhu. Kandi FDA yemeje ko nta kabobo ka GLP 1 kemejwe kabaho.

Utubazo twa GLP 1 ni urwego rw'ibicuruzwa ruhari kubera isaba, atari kubera ubushakashatsi. Abantu bashaka ubufasha bwo kugabanya ibiro budahenze kandi budakoresha urushinge, kandi iryo shaka ni ryo ryemewe rwose. Utubuto ubwazo si igisubizo.

Niba ushaka uburyo bwo gutwara GLP 1 budakoresha urushinge, ifunguro rya Wegovy na Foundayo ni imiti nyayo, yemewe na FDA irahari ubu. Niba ushaka intangiriro ihendutse cyane, byombi bibanza kuri 149$ ku kwezi. Niba ushaka gusobanukirwa uburyo bwose bwa GLP-1 nyakuri bugereranywa mbere yo gufata icyemezo, mworozi wigishijwe ku miti ya GLP-1 yerekana buri muti wemewe ku ruhande.

Muganga wawe ashobora kugufasha kumenya niba imiti ya GLP 1 ari myiza kuri wowe kandi ni uburyo bwo gutwara bukugwa neza mu buzima bwawe. Ikiganiro gitoya ni ubuntu mu biro byinshi by'ubuvuzi bw'ibanze n'uburyo bwo kuvura ku kure, kandi gifite agaciro kuruta kabobo ka 30$.