Valacyclovir ku buherihe: Urutonde rw'inzira, Igihe cy'amasaha 72, n'icyo wakora niba wararenze

Valacyclovir ku buherihe isanzwe itangwa nka 1.000 mg inshuro eshatu ku munsi mu gihe cy'iminsi irindwi, itangizwa mu masaha 72 nyuma y'uko uruhu rutangiye kugaragara. Nyuma y'amasaha 72, biracyari ngombwa guhamagara: abaganga akenshi bakomeza kuvura niba ibisebe bishya bigikomeje kwiyongera cyangwa uruhu ruri hafi y'ijisho.

Mvugishijwe muri make: Ibintu by'ingenzi ugomba kwibuka

• Urugero rusanzwe ku bakuze: 1.000 mg (1 g) inshuro eshatu ku munsi mu gihe cy'iminsi 7, itangwa ku nyandiko y'umuganga gusa, nta gikorerwa mu giro cyo ku rwego rwo hejuru cyangwa igicuruzwa cyoroheje gisa.
• Umugoroba wa zeru ni umunsi uruhu rutangiye kugaragara, si umunsi gutwika cyangwa kumirwa byatangiye.
• Wararengeje amasaha 72? Ibisebe bishya, uruhu ruri hafi y'ijisho, cyangwa sisitemu yawe y'ubwirinzi irasanywe intege nke byose bikikomeza gutuma uba ukwiye kuvurwa.
• Imikorere mibi y'impyiko isobanura ko urutonde rugomba kugabanywa. Urutonde rutariho impinduka rutera urujijo n'ibyangiritse ku mpyiko, cyane cyane ku bantu bakuze.
• Kuvura hakiri kare kugabanya indwara neza kandi bikorohesha ububabare bukomeye. Ntabwo byemeza ko uzahunga ububabare buhamye bw'imitsi.

Valacyclovir ku buherihe bugabanya indwara; ntibwirukana virusi

Valacyclovir ku buherihe ni urukingo rutangwa ku nyandiko y'umuganga, rugurishwa nka Valtrex, rutangwa kuri 1.000 mg inshuro eshatu ku munsi mu gihe cy'iminsi irindwi. Ni cyiza cyane iyo gitangiye mu masaha 72 nyuma y'uko uruhu rutangiye kugaragara. Komeza kugikiza ibisebe, kugabanya ibisebe bishya no kumeneka kwa virusi, kandi bikorohesha ububabare bukomeye. Ntibwirukana virusi ihari mu mitsi mu buryo bw'igihe kirekire.

Iki ni ikibazo gisanzwe, si ikidasanzwe. CDC ivuga ko umuntu umwe kuri batatu mu bagihugu by'Abanyamerika azahura n'ubuherehe mu buzima bwe, kandi abarenga 99% by'Abanyamerika bavutse mbere ya 1980 bafite virusi ihari itera ubuherehe. Valtrex ku buherihe na valacyclovir rusange ni rumwe; rusange ni rwo abantu benshi bahabwa. Valacyclovir ni urukingo rwa acyclovir, bisobanura ko umubiri uwohindura nyuma yo kwinjiza, kandi kuko kwinjiza neza gusumba, ishobora gutangwa inshuro eshatu ku munsi aho acyclovir ivuye inshuro eshanu.

Ibyo umuti ukora ni byo bike ugereranije n'uko abantu benshi babitekereza. CDC's clinical overview irashimira urukingo rutanga ibisubizo bwo gukiza ibisebe byihuse, kugabanya ibisebe bishya no kumeneka kwa virusi, no kugabanya ububabare bukomeye. Kugabanya kumeneka bifitiye akamaro abantu bagukikuje, ibyo bikwiriye gusobanukirwa niba uri gutekereza ubuherehe bukora iki ku bantu mu gihe bafatanije ahantu.

Nk'uko bisanzwe: nta urukingo ruhagarika virusi ya varicella zoster mu mitsi. Virus yo irahaguma. Ubuherehe bushobora gusubira.

Amasaha 72 ni igihe cyo kugira akamaro kanini, si iherezo

Niba urukingo ruhereye ku masaha 72 ruziko rukurikirana, benshi bagera hano bashaka gusubiza, kandi igisubizo nyacyo ni yego, hamwe n'ibibazo.

CDC ivuga ko kuvurwa na acyclovir, valacyclovir, cyangwa famciclovir ari byiza mu masaha 72 nyuma y'uko ibimenyetso bigaragaye. Ibyo ni uko akamaro kaba kari hejuru, si ko biba byarangiye. Igihe cy'amasaha 72 ni kubera amasezerano yo mu bushakashatsi bwa kliniki: abashakashatsi bagombaga guhagarara, kandi abantu bake cyane bagombaga kugeragezwa ku munsi wa gatanu, ku buryo ibihamya byo hanze y'igihe cyagenwe ari bike, aho kuvuga ko bifite ingaruka mbi. Kugaragaza virusi ntibihagarara ku isaha ya 73.

AAFP guidance ivuga neza ko kuvurwa bikomeza kwemezwa hanze y'igihe cy'amasaha 72 niba ibisebe bishya bikomeje kugaragara cyangwa niba ibibazo by'amaso cyangwa ubwonko biriho. Ibintu bitatu by'ingenzi bikurikira:

• Ibisebe bishya byagaragaye mu masaha 24 ashize, bisobanura ko virusi igikomeje kugaragara.
• Uruhu ruba rurengana ku gahanga, ku jisho, cyangwa ku mazuru ku ruhande rumwe.
• Ufite sisitemu yawe y'ubwirinzi irasanywe intege nke: kwihindurira ingingo zose cyangwa kwihindurira amaraso, kuvura kanseri, HIV iri ku rwego rwo hejuru, cyangwa imiti ikomeye yo kwirinda.

Bityo ku munsi wa 4 cyangwa 5, hamagara umuganga. Ntuzigere wivura wenyine mu kwibwira ko igihe cyarenze; icyemezo gihamagara umuntu ushobora kureba uruhu rwawe.

Umugoroba wa zeru ni umunsi uruhu rugaragara, si umunsi ububabare bwatangiye

Igihe cyo gutangira urukingo ku buherihe bitewe n'uko ubarira umunsi wa zeru, kandi abantu benshi barabibara nabi. Umunsi wa zeru ni umunsi ibisebe cyangwa uruhu byagaragaye. Ntabwo ari igipfubiro, gutwika, kumirwa, cyangwa kwishimagura byashobora kugaragara imbere y'uruhu kuva ku munsi umwe kugeza ku itanu. Ntabwo ari n'umunsi wagaragaye.

Iryo tandukaniro rihindura imibare burundu. Umuntu wumvise ububabare bw'imitsi ku wa mbere kandi akabona ibisebe ku wa kane aba ari ku munsi wa mbere, aho kuba ku munsi wa kane, kandi yari mu gihe cyagenwe.

FDA prescribing information for Valtrex ni kare cyane kuruta CDC: kuvurwa bigomba gutangizwa vuba uko bishoboka nyuma y'ubuvuzi kandi bikagirira akamaro cyane iyo bitangijwe mu masaha 48 nyuma y'uko uruhu rugaragaye. Bura impeta zombi. Mu gihe cyagenwe, kare birushaho kuba byiza, kandi amasaha arashobora kugira akamaro, aho kuba iminsi gusa. Ibi ni byo bifitanye isano n'ikigereranyo ko Tamiflu ni byiza mu masaha 48 nyuma y'ibimenyetso.

Ikibazo kimwe gikoreshwa: kwivuza mbere y'uko uruhu rugaragaye ntibisanzwe bigaragaza ubuherehe ku kureba gusa. Ntabwo ushobora kumenya mbere. Gusuzumwa kumwe ku munsi uruhu rugaragaye ni intego nyayo.

Niba ufite uruhu kandi ufite umunsi wa zeru wemewe, gusuzumwa videwo kumwe ku munsi ni inzira nziza. August's $39 online urgent care visit ikuhuza na muganga ufite uruhushya muri Amerika ushobora kureba uruhu rwawe, igihe, n'amateka yawe ya mbere kandi akemeza niba urukingo ari ngombwa. Ni icyemezo cy'umuganga, aho guhabwa urukingo byemejwe. Kandi akarenge gato ko gutangaza neza: ikiganiro cya videwo ntikishobora kureba ijisho ryawe. Niba uruhu rugera ku gahanga, ku jisho, cyangwa ku mazuru, cyangwa kugererwa kwawe kw'amaso cyangwa iryoshya ry'ijisho byahindutse, uba ukeneye ubuvuzi bwo mu rugo cyangwa ubutabazi uyu munsi.

Fata 1 gramu inshuro eshatu ku munsi mu gihe cy'iminsi 7, kandi urangize urugendo

Urugero rusanzwe rwa Valtrex ku buherihe ku bakuze ni 1.000 mg (1 g) itwarwa mu kanwa inshuro eshatu ku munsi mu gihe cy'iminsi 7, nk'uko byanditswe ku nyandiko ya FDA. Urutonde rwa valacyclovir ku buherihe ni rumwe, kuko ikirango n'urusanzwe bifite ikimwe kimwe ku rwego rumwe.

Amategeko akoreshwa afite akamaro kuruta uko basa. Gereranya ibinini hafi buri masaha umunani aho kubahuriza hamwe n'ibyo kurya. Ushobora gufata valacyclovir n'ibyo kurya cyangwa utabirya, nubwo ibyo kurya bihindura iseseme akenshi. Anywa amazi yuzuye mu cyumweru cyose, kuko gutakaza amazi ari kimwe mu bitera ibibazo by'impyiko kuri uyu muti.

Wibagiwe gufata ikinini? Fata igihe wibutse, usige niba ikinini gikurikira hafi kwegera, kandi ntuzigere ubikuba.

Rangiiza iminsi irindwi yose. Ibisebe akenshi bitangira kwiryoherwa ku munsi wa kabiri cyangwa wa gatatu, ni igihe abantu bahagarara, kandi guhagarara hakiri kare bitakaza igice cy'urugendo rwo kugikiza kugaragara kwa virusi. Nta verisiyo y'uyu muti yo mu giro.

Niba impyiko zawe zifite ikibazo, urutonde rusanzwe ni byinshi cyane

Urugero rwa valacyclovir rw'impinduka ku mikorere y'impyiko ntabwo ari impamvu y'uyu muti. Inyandiko ya FDA yashyizeho urutonde rw'ubuherehe n'umusaruro w'amazi: creatinine clearance: ku burengerazuba mu rundi ruhande:

Ibi birakomeye cyane kuko imikorere y'impyiko igabanuka uko imyaka yiyongera kandi ubuherehe bukaba bwinshi ku bantu bakuze. AAFP ivuga ko abarenga kimwe cya kabiri cy'abantu batakingiye bafite imyaka 85 na hejuru bazahura n'ubuherehe. Gutanga urutonde rutariho impinduka mu mpyiko zifite intege byongera ingorane yo guhura na neurotoxicity (urujijo, guhishura, guhinduka) n'ibyangiritse ku mpyiko, cyane cyane hamwe no gutakaza amazi. Vuga ku rwungano rwawe ku ndwara z'impyiko, dialysis, n'imiti ya nephrotoxic nka NSAIDs cyangwa diuretics isanzwe.

Kuvura hakiri kare bigabanya ububabare bukomeye, ariko ububabare bw'imitsi burashobora kuba butameze nk'uko wabyumvise

Kwirinda postherpetic neuralgia ni icyo washobora kugeraho ku gihe cyihutirwa, ni cyo gituma gikwiye igisubizo cy'ukuri aho kugusubiza neza. AAFP ivuga ko hafi 20% by'abantu bafite ubuherehe bagira postherpetic neuralgia, kandi hafi 80% by'abo bantu bafite imyaka 50 cyangwa bakiri bakuze.

Ibyo urukingo hakiri kare rwemeje gutanga ni urutonde rwa CDC: gukiza ibisebe byihuse, ibisebe bishya bike, kumeneka kwa virusi bike, no ububabare bukomeye buke. Ibyo ni ibyiza by'ukuri, kandi ni impamvu ihagije yo kurebwaho uyu munsi.

Dore ibyo imbata nyinshi zizakubwira: ibihamya ko valacyclovir yakwirinda ububabare bw'igihe kirekire bw'imitsi ni buke kuruta uko kwihutira gusaba bisaba. Ubushakashatsi bwa 2025 bwakorewe mu bushakashatsi bwa Zoster Eye Disease Study bwagaragaje ko umwaka umwe wo gukoresha valacyclovir ku rugero rwo hasi, 1.000 mg ku munsi, ntibyagabanyije impamvu zose za postherpetic neuralgia ugereranije na placebo, nubwo abantu bari munsi ya 60 bafite herpes zoster ophthalmicus yo mu gihe kirekire bagize uburyo bwo kugabanya ububabare kandi bakoresheje imiti mike y'ububabare bw'imitsi.

Soma icyo kigereranyo neza. Yagerageje gusubika urugendo rurerure ku rugero rwo hasi, aho kuvuga ko kuvurwa hakiri kare bidafite akamaro.

Icyemezo gishobora kwemerwa: kuvura hakiri kare ku bubabare bukomeye n'ibibazo, kandi ntuzitegure ko utazahura n'ububabare bw'igihe kirekire. Urkingo rwa recombinant zoster rukomeza kuba inzira nziza yo kwirinda ibi byombi.

Ibinini byinshi ni byoroheje, ariko urujijo si rumwe rwo kwihanganira

Ibinini bisanzwe bya valacyclovir ku buherihe ni ibidasanzwe kandi akenshi birashoboka: umutwe, iseseme, ububabare mu gifu, n'ubwire. Guhata buri kinini n'ibyo kurya bihanisha ibikoresho byinshi.

Ibibazo bidashoboka ni ibyo ugomba kwibuka. Ibikoresho byo mu mutima, harimo urujijo, guhishura, guhinduka, n'uburakari, bigaragara cyane cyane ku bantu bakuze no ku bantu bafite impyiko zitameze neza. Ibyangiritse ku mpyiko ni ikindi, kandi gutakaza amazi ni mugenzi wayo wa kera. Inyandiko ya FDA iraburira kandi ko thrombotic thrombocytopenic purpura na hemolytic uremic syndrome byabayeho ku bantu bafite intege nke cyane bahabwa ibinini byinshi.

Itegeko ry'ibikorwa ni rito. Urujijo rushya, guhishura, kugabanuka cyane mu mikorere y'inkari, cyangwa guhagarika utazi bisobanura guhagarika umuti no guhamagara umuganga mu munsi, aho kurangiza icyumweru.

Ibindi: anywa amazi, kandi ushireho ibinini bisanzwe by'ibuprofen, naproxen, cyangwa ibindi bikoresho bidasanzwe bikoreshwa mu gihe cy'iminsi irindwi niba umuganga wawe yemeye ko wabikora.

Uruhu rw'ubuherehe rumwe rushobora gusabwa gusuzumwa ijisho uyu munsi, aho kuvurwa ejo

Hamagara 911 cyangwa jya ku bitaro by'ubutabazi ubu:

• Uruhu cyangwa ibisebe bigaragara ku zuru, ku ruhande, cyangwa ku mazuru, hafi y'ijisho, cyangwa ku gahanga ku ruhande rumwe n'uruhu. CDC isaba gusuzuma no kuvura ibi hakiri kare kugira ngo bwirukane ibibazo bikomeje kwiyongera ku jisho no gutakaza ubuhanga bwo kubona.
• Ububabare bw'ijisho, kurambagurika, kwirundibiza, cyangwa kumurika bifatana n'uruhu rw'ubuherehe.
• Ibihe byo kwanduza byarenze uruganda rumwe rw'uruhu, cyane cyane niba ufite sisitemu y'ubwirinzi irasanywe intege nke.
• Guhinduka mu maso bibaho n'ububabare bw'amatwi, impinduka zo kumva, cyangwa vertigo.
• Umutwe ukomeye, kwizinga ku ijosi, urujijo, cyangwa intege nke nshya bigaragara.
• Kwandura kwaguka, kwishyushya, amashyira, cyangwa ibicurane bigaragara hejuru y'uruhu.

Shyira igihe cyo gusuzumwa mu cyumweru gitaha niba:

• Ububabare bukomeza nyuma y'uko uruhu rugerwa.
• Ni ubwa kabiri ufite ubuherehe.
• Wagaragaje ubuherehe mbere y'imyaka 50.
• Ushaka gutegura urukingo rw'ubuherehe nyuma yo kwiryoherwa.

Vugana n'umuganga mbere y'uko utangira niba:

• Ufite indwara z'impyiko cyangwa uri kuri dialysis.
• Uri kumwe n'umugore cyangwa utera amata.
• Ufite sisitemu y'ubwirinzi irasanywe intege nke yo kwihindurira ingingo, kuvura kanseri, cyangwa HIV iri ku rwego rwo hejuru.
• Ufata NSAIDs cyangwa diuretics buri gihe.
• Ufite hejuru ya 65 kandi ufata imiti myinshi.

Ibibazo bikunze kwibazwa

Valacyclovir rusange ni umuti wa Valtrex kimwe ku buherihe?

Yego. Valacyclovir rusange igomba kwemerwa na FDA mu bisubizo bya bioequivalence, ku buryo ikinini rusange cya 1 g gitanga umuti wa actif kimwe n'ikinini cya Valtrex. Itandukaniro ni igiciro, aho kugira ngo ibisubizo byihute. Amaduka asimburana rusange mu ntara nyinshi, kandi nta mpamvu y'ubuvuzi yo gusaba ikirango mu rugendo rw'iminsi irindwi.

Valacyclovir ku buherihe ni buhenze hatari ubwishingizi?

Ntabwo bikunze. Rusange rurahari mu myaka myinshi kandi urugendo rw'iminsi irindwi rugaragara nk'urwo ku bikoresho bike uzahabwa, ariko ibiciro by'akanama k'ikinini kimwe bigenda bitandukanye cyane hagati y'amaduka. Hamagara abiri mbere yo kwakira, kandi usabe byihariye igiciro rusange cy'akanama aho kugira ngo ugire ikirango.

Nzakoresha acyclovir cyangwa famciclovir aho kugira valacyclovir?

Rimwe na rimwe. Bose batatu ni inzira z'ibanze ku buherihe kandi nta n'umwe muri bo ufite akamaro kuruta abandi. Itandukaniro rya praktike ni urutonde rwo gufata: acyclovir isaba inshuro eshanu ku munsi, mu gihe valacyclovir na famciclovir bisaba eshatu. Mu gihe cy'iminsi irindwi, inshuro nke zishobora gutuma utibagiza, ni cyo gituma valacyclovir akenshi ari inzira nziza.

Nshobora gufata valacyclovir ku buherihe nkiri umugore utwite cyangwa utera amata?

Rimwe na rimwe. Antivirals ikoreshwa mu gihe cy'umugore utwite n'igiti ku bikoresho by'umubyeyi aho akamaro k'ibyitezwe kaba kagomba kuba kahagije, kandi acyclovir ifite amateka menshi yo kwirinda muri ibyo bihe. Ni ikiganiro ugomba kugirana na muganga wawe w'umubyeyi aho kugira ngo ube uzitirwa ku rupapuro rwo kwinjira, cyane cyane mu gihembwe cya mbere cyangwa ufite intege nke ku mpyiko.

Nzigerwa meza mu munsi umwe nyuma yo gutangira valacyclovir?

Ntabwo bikunze. Abantu benshi babona uruhu ruhagaze kugenda kandi rutangiye kwiryoherwa mu minsi ibiri cyangwa itatu, mu gihe ububabare bugenda buhoro kandi butameze kimwe. Antivirals zigabanya indwara; ntabwo ari ibinini by'ububabare. Saba ku buryo bwo kugabanya ububabare nk'urukingo rwitandukanye, kuko ububabare bukomeye bw'ubuherehe akenshi busaba ubuvuzi bwawo.

Ndateganya valacyclovir niba narikingije urukingo rwa Shingrix?

Yego. Kwinyubaha kugabanya cyane ingorane yawe ariko ntibwirukana, kandi ubuherehe bwo kwirinda biravurwa ku rugero rumwe n'abandi. Kwikingiza bihangana n'ikipe nkeya ndetse n'igihe cyo kwirinda, aho kuvuga ko ubuherehe budakeneye kuvurwa na gato. Kwihutira gutangira mu minsi ya mbere birakomeza.

Valacyclovir ihagarika ubuherehe kugira ngo budakwirakire?

Oya. Biragabanya kumeneka kwa virusi ariko ntibigukiza kwandura. Amazi avuye mu bibase byahagaragaye ashobora kwanduza virusi ya varicella zoster ku bantu bose batigeze bagira inkware cyangwa urukingo, bigatera inkware aho kugira ubuherehe muri bo. Guma uruhu rwarinzwe kandi uharwe nk'uko byanduye kugeza igihe ibisebe byose byose byiryoherwa.

Umwanzuro w'ukuri: valacyclovir ku buherihe ni 1 g inshuro eshatu ku munsi mu gihe cy'iminsi irindwi, itangizwa vuba uko bishoboka ku ibisebe bya mbere, kandi irangira nubwo uruhu rugitangira kwiryoherwa. Niba wararengeje amasaha 72, hamagara. Ibisebe bishya, guhura n'ijisho, cyangwa sisitemu yawe y'ubwirinzi idafite intege byose bihindura uko ubara. Kora igenzura ry'impyiko zawe n'umuganga, kandi kuvura ibimenyetso by'ijisho nk'ubuvuzi bwo ku munsi.

Ikibazo: Ingingo iyi iragenewe kumenyesha gusa kandi ntibisobanura ko ari ubuvuzi. Guhora wiyegurira umuganga ufite ubushobozi bwo gusuzuma no kuvura ibyemezo. Niba uri kugeramo ubugome bwo kwa muganga, hamagara 911 cyangwa jya ku bitaro by'ubutabazi byegereye ubu.